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Items: 20

1.

TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.

Lafarga V, Sung HM, Haneke K, Roessig L, Pauleau AL, Bruer M, Rodriguez-Acebes S, Lopez-Contreras AJ, Gruss OJ, Erhardt S, Mendez J, Fernandez-Capetillo O, Stoecklin G.

EMBO Rep. 2019 Jan;20(1). pii: e46224. doi: 10.15252/embr.201846224. Epub 2018 Dec 11.

2.

Functional interplay between c-Myc and Max in B lymphocyte differentiation.

Pérez-Olivares M, Trento A, Rodriguez-Acebes S, González-Acosta D, Fernández-Antorán D, Román-García S, Martinez D, López-Briones T, Torroja C, Carrasco YR, Méndez J, Moreno de Alborán I.

EMBO Rep. 2018 Oct;19(10). pii: e45770. doi: 10.15252/embr.201845770. Epub 2018 Aug 20.

PMID:
30126925
3.

Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes.

Rodriguez-Acebes S, Mourón S, Méndez J.

J Biol Chem. 2018 Aug 17;293(33):12855-12861. doi: 10.1074/jbc.RA118.003740. Epub 2018 Jun 29.

4.

Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.

Garzón J, Rodríguez R, Kong Z, Chabes A, Rodríguez-Acebes S, Méndez J, Moreno S, García-Higuera I.

Oncogene. 2017 Oct 19;36(42):5808-5818. doi: 10.1038/onc.2017.186. Epub 2017 Jun 12.

PMID:
28604743
5.

In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias.

Muñoz S, Búa S, Rodríguez-Acebes S, Megías D, Ortega S, de Martino A, Méndez J.

Cell Rep. 2017 May 2;19(5):928-938. doi: 10.1016/j.celrep.2017.04.032.

6.

USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication.

Hernández-Pérez S, Cabrera E, Amoedo H, Rodríguez-Acebes S, Koundrioukoff S, Debatisse M, Méndez J, Freire R.

Mol Oncol. 2016 Oct;10(8):1196-206. doi: 10.1016/j.molonc.2016.05.008. Epub 2016 Jun 3.

7.

USP7 is a SUMO deubiquitinase essential for DNA replication.

Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2016 Apr;23(4):270-7. doi: 10.1038/nsmb.3185. Epub 2016 Mar 7.

8.

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J.

Nat Commun. 2015 Oct 12;6:8548. doi: 10.1038/ncomms9548.

9.

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.

Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O.

EMBO J. 2015 Nov 3;34(21):2604-19. doi: 10.15252/embj.201591829. Epub 2015 Oct 6.

10.

Disruption of the mevalonate pathway induces dNTP depletion and DNA damage.

Martín Sánchez C, Pérez Martín JM, Jin JS, Dávalos A, Zhang W, de la Peña G, Martínez-Botas J, Rodríguez-Acebes S, Suárez Y, Hazen MJ, Gómez-Coronado D, Busto R, Cheng YC, Lasunción MA.

Biochim Biophys Acta. 2015 Sep;1851(9):1240-53. doi: 10.1016/j.bbalip.2015.06.001. Epub 2015 Jun 5.

PMID:
26055626
11.

Functional reprogramming of polyploidization in megakaryocytes.

Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M.

Dev Cell. 2015 Jan 26;32(2):155-67. doi: 10.1016/j.devcel.2014.12.015.

12.

Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer.

Loddo M, Andryszkiewicz J, Rodriguez-Acebes S, Stoeber K, Jones A, Dafou D, Apostolidou S, Wollenschlaeger A, Widschwendter M, Sainsbury R, Tudzarova S, Williams GH.

J Pathol. 2014 Aug;233(4):344-56. doi: 10.1002/path.4393.

PMID:
24931331
13.

Repriming of DNA synthesis at stalled replication forks by human PrimPol.

Mourón S, Rodriguez-Acebes S, Martínez-Jiménez MI, García-Gómez S, Chocrón S, Blanco L, Méndez J.

Nat Struct Mol Biol. 2013 Dec;20(12):1383-9. doi: 10.1038/nsmb.2719. Epub 2013 Nov 17.

PMID:
24240614
14.

A proteomic characterization of factors enriched at nascent DNA molecules.

Lopez-Contreras AJ, Ruppen I, Nieto-Soler M, Murga M, Rodriguez-Acebes S, Remeseiro S, Rodrigo-Perez S, Rojas AM, Mendez J, Muñoz J, Fernandez-Capetillo O.

Cell Rep. 2013 Apr 25;3(4):1105-16. doi: 10.1016/j.celrep.2013.03.009. Epub 2013 Mar 28.

15.

Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation.

Daimiel LA, Fernández-Suárez ME, Rodríguez-Acebes S, Crespo L, Lasunción MA, Gómez-Coronado D, Martínez-Botas J.

Biosci Rep. 2012 Dec 6;33(1):57-69. doi: 10.1042/BSR20120095.

16.

Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: distinct expression of cell-cycle- and differentiation-related genes.

Rodríguez-Acebes S, Palacios N, Botella-Carretero JI, Olea N, Crespo L, Peromingo R, Gómez-Coronado D, Lasunción MA, Vázquez C, Martínez-Botas J.

BMC Med Genomics. 2010 Dec 23;3:61. doi: 10.1186/1755-8794-3-61.

17.

Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.

Rodriguez-Acebes S, Proctor I, Loddo M, Wollenschlaeger A, Rashid M, Falzon M, Prevost AT, Sainsbury R, Stoeber K, Williams GH.

Am J Pathol. 2010 Oct;177(4):2034-45. doi: 10.2353/ajpath.2010.100421. Epub 2010 Aug 19.

18.

Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.

Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, Rodriguez-Acebes S, Prevost AT, Ledermann JA, Stoeber K, Williams GH.

Clin Cancer Res. 2009 Apr 1;15(7):2417-25. doi: 10.1158/1078-0432.CCR-08-1276. Epub 2009 Mar 24.

19.

Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

Rodríguez-Acebes S, de la Cueva P, Fernández-Hernando C, Ferruelo AJ, Lasunción MA, Rawson RB, Martínez-Botas J, Gómez-Coronado D.

Biochem J. 2009 May 13;420(2):305-15. doi: 10.1042/BJ20081909.

20.

Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation.

Rodríguez-Acebes S, Cueva P, Ferruelo AJ, Fernández-Hernando C, Lasunción MA, Martínez-Botas J, Gómez-Coronado D.

Biochem Biophys Res Commun. 2008 Dec 12;377(2):484-488. doi: 10.1016/j.bbrc.2008.09.140. Epub 2008 Oct 11.

PMID:
18851952

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