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Items: 1 to 50 of 111

1.

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness.

Hulpia F, Mabille D, Campagnaro GD, Schumann G, Maes L, Roditi I, Hofer A, de Koning HP, Caljon G, Van Calenbergh S.

Nat Commun. 2019 Dec 5;10(1):5564. doi: 10.1038/s41467-019-13522-6.

PMID:
31804484
2.

Flagellar cAMP signaling controls trypanosome progression through host tissues.

Shaw S, DeMarco SF, Rehmann R, Wenzler T, Florini F, Roditi I, Hill KL.

Nat Commun. 2019 Feb 18;10(1):803. doi: 10.1038/s41467-019-08696-y.

3.

Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei.

Florini F, Naguleswaran A, Gharib WH, Bringaud F, Roditi I.

Nucleic Acids Res. 2019 Feb 28;47(4):1725-1739. doi: 10.1093/nar/gky1255.

4.

RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stages.

Naguleswaran A, Doiron N, Roditi I.

BMC Genomics. 2018 Apr 2;19(1):227. doi: 10.1186/s12864-018-4600-6.

5.

Rodent-free cyclical transmission of Trypanosoma brucei brucei.

Naguleswaran A, Roditi I.

Mol Biochem Parasitol. 2017 Oct;217:16-18. doi: 10.1016/j.molbiopara.2017.08.005. Epub 2017 Aug 24.

PMID:
28843782
6.

Remote Sensing of Potential Biosignatures from Rocky, Liquid, or Icy (Exo)Planetary Surfaces.

Poch O, Frey J, Roditi I, Pommerol A, Jost B, Thomas N.

Astrobiology. 2017 Mar;17(3):231-252. doi: 10.1089/ast.2016.1523. Epub 2017 Mar 10.

PMID:
28282216
7.

Zinc finger nuclease technology: A stable tool for high efficiency transformation in bloodstream form T. brucei.

Schumann G, Kangussu-Marcolino MM, Doiron N, Käser S, de Assis Burle-Caldas G, DaRocha WD, Teixeira SM, Roditi I.

Mol Biochem Parasitol. 2017 Apr;213:12-15. doi: 10.1016/j.molbiopara.2017.02.002. Epub 2017 Feb 20.

PMID:
28232060
8.

Editing the Trypanosoma cruzi genome with zinc finger nucleases.

Burle-Caldas GA, Grazielle-Silva V, Soares-Simões M, Schumann Burkard G, Roditi I, DaRocha WD, Teixeira SM.

Mol Biochem Parasitol. 2017 Mar;212:28-32. doi: 10.1016/j.molbiopara.2017.01.002. Epub 2017 Jan 17.

PMID:
28108186
9.

High Resolution non-Markovianity in NMR.

Bernardes NK, Peterson JP, Sarthour RS, Souza AM, Monken CH, Roditi I, Oliveira IS, Santos MF.

Sci Rep. 2016 Sep 27;6:33945. doi: 10.1038/srep33945.

10.

Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?

Imhof S, Fragoso C, Hemphill A, von Schubert C, Li D, Legant W, Betzig E, Roditi I.

F1000Res. 2016 Apr 14;5:682. doi: 10.12688/f1000research.8249.1. eCollection 2016.

11.

The languages of parasite communication.

Roditi I.

Mol Biochem Parasitol. 2016 Jul;208(1):16-22. doi: 10.1016/j.molbiopara.2016.05.008. Epub 2016 May 17. Review.

PMID:
27211242
12.

Environmental sensing by African trypanosomes.

Roditi I, Schumann G, Naguleswaran A.

Curr Opin Microbiol. 2016 Aug;32:26-30. doi: 10.1016/j.mib.2016.04.011. Epub 2016 Apr 27. Review.

PMID:
27131101
13.

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes.

Wenzler T, Schumann Burkard G, Schmidt RS, Mäser P, Bergner A, Roditi I, Brun R.

Sci Rep. 2016 Mar 2;6:22451. doi: 10.1038/srep22451.

14.

Experimental realization of the Yang-Baxter Equation via NMR interferometry.

Vind FA, Foerster A, Oliveira IS, Sarthour RS, Soares-Pinto DO, Souza AM, Roditi I.

Sci Rep. 2016 Feb 10;6:20789. doi: 10.1038/srep20789.

15.

The Social Life of African Trypanosomes.

Imhof S, Roditi I.

Trends Parasitol. 2015 Oct;31(10):490-498. doi: 10.1016/j.pt.2015.06.012. Review.

PMID:
26433252
16.

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1.

Vanwalleghem G, Fontaine F, Lecordier L, Tebabi P, Klewe K, Nolan DP, Yamaryo-Botté Y, Botté C, Kremer A, Burkard GS, Rassow J, Roditi I, Pérez-Morga D, Pays E.

Nat Commun. 2015 Aug 26;6:8078. doi: 10.1038/ncomms9078.

17.

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.

de Macêdo JP, Schumann Burkard G, Niemann M, Barrett MP, Vial H, Mäser P, Roditi I, Schneider A, Bütikofer P.

PLoS Pathog. 2015 May 6;11(5):e1004875. doi: 10.1371/journal.ppat.1004875. eCollection 2015 May.

18.

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway.

Bühlmann M, Walrad P, Rico E, Ivens A, Capewell P, Naguleswaran A, Roditi I, Matthews KR.

Nucleic Acids Res. 2015 May 19;43(9):4491-504. doi: 10.1093/nar/gkv330. Epub 2015 Apr 14.

19.

A Glycosylation Mutant of Trypanosoma brucei Links Social Motility Defects In Vitro to Impaired Colonization of Tsetse Flies In Vivo.

Imhof S, Vu XL, Bütikofer P, Roditi I.

Eukaryot Cell. 2015 Jun;14(6):588-92. doi: 10.1128/EC.00023-15. Epub 2015 Apr 10.

20.

Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure.

Naguleswaran A, Gunasekera K, Schimanski B, Heller M, Hemphill A, Ochsenreiter T, Roditi I.

MBio. 2015 Mar 17;6(2):e00114. doi: 10.1128/mBio.00114-15.

21.

Spin squeezing in a quadrupolar nuclei NMR system.

Auccaise R, Araujo-Ferreira AG, Sarthour RS, Oliveira IS, Bonagamba TJ, Roditi I.

Phys Rev Lett. 2015 Jan 30;114(4):043604. Epub 2015 Jan 29.

PMID:
25679893
22.

Social motility of African trypanosomes is a property of a distinct life-cycle stage that occurs early in tsetse fly transmission.

Imhof S, Knüsel S, Gunasekera K, Vu XL, Roditi I.

PLoS Pathog. 2014 Oct 30;10(10):e1004493. doi: 10.1371/journal.ppat.1004493. eCollection 2014 Oct.

23.

Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum.

Lecordier L, Uzureau P, Tebabi P, Pérez-Morga D, Nolan D, Schumann Burkard G, Roditi I, Pays E.

Mol Microbiol. 2014 Nov;94(3):625-36. doi: 10.1111/mmi.12783. Epub 2014 Sep 25.

24.

Functional characterization of the trypanosome translational repressor SCD6.

Cristodero M, Schimanski B, Heller M, Roditi I.

Biochem J. 2014 Jan 1;457(1):57-67. doi: 10.1042/BJ20130747.

PMID:
24087925
25.

Insights into the regulation of GPEET procyclin during differentiation from early to late procyclic forms of Trypanosoma brucei.

Knüsel S, Roditi I.

Mol Biochem Parasitol. 2013 Oct;191(2):66-74. doi: 10.1016/j.molbiopara.2013.09.004. Epub 2013 Sep 27.

26.

Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation in Trypanosoma brucei.

Schumann Burkard G, Käser S, de Araújo PR, Schimanski B, Naguleswaran A, Knüsel S, Heller M, Roditi I.

Mol Microbiol. 2013 May;88(4):827-40. doi: 10.1111/mmi.12227. Epub 2013 Apr 26.

27.

MAP kinase kinase 1 (MKK1) is essential for transmission of Trypanosoma brucei by Glossina morsitans.

Morand S, Renggli CK, Roditi I, Vassella E.

Mol Biochem Parasitol. 2012 Nov;186(1):73-6. doi: 10.1016/j.molbiopara.2012.09.001. Epub 2012 Sep 8.

PMID:
22985893
28.

Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery.

Mani J, Güttinger A, Schimanski B, Heller M, Acosta-Serrano A, Pescher P, Späth G, Roditi I.

PLoS One. 2011;6(7):e22463. doi: 10.1371/journal.pone.0022463. Epub 2011 Jul 21.

29.

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.

Schumann Burkard G, Jutzi P, Roditi I.

Mol Biochem Parasitol. 2011 Jan;175(1):91-4. doi: 10.1016/j.molbiopara.2010.09.002. Epub 2010 Sep 22.

PMID:
20851719
30.

Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei.

Nilsson D, Gunasekera K, Mani J, Osteras M, Farinelli L, Baerlocher L, Roditi I, Ochsenreiter T.

PLoS Pathog. 2010 Aug 5;6(8):e1001037. doi: 10.1371/journal.ppat.1001037.

31.

Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei.

Oberle M, Balmer O, Brun R, Roditi I.

PLoS Pathog. 2010 Jul 29;6(7):e1001023. doi: 10.1371/journal.ppat.1001023.

32.

Identification of bracovirus particle proteins and analysis of their transcript levels at the stage of virion formation.

Wetterwald C, Roth T, Kaeslin M, Annaheim M, Wespi G, Heller M, Mäser P, Roditi I, Pfister-Wilhelm R, Bézier A, Gyapay G, Drezen JM, Lanzrein B.

J Gen Virol. 2010 Oct;91(Pt 10):2610-9. doi: 10.1099/vir.0.022699-0. Epub 2010 Jun 16.

PMID:
20554796
33.

tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans.

Aeby E, Ullu E, Yepiskoposyan H, Schimanski B, Roditi I, Mühlemann O, Schneider A.

Nucleic Acids Res. 2010 Sep;38(17):5833-43. doi: 10.1093/nar/gkq345. Epub 2010 May 5.

34.

PSSA-2, a membrane-spanning phosphoprotein of Trypanosoma brucei, is required for efficient maturation of infection.

Fragoso CM, Schumann Burkard G, Oberle M, Renggli CK, Hilzinger K, Roditi I.

PLoS One. 2009 Sep 17;4(9):e7074. doi: 10.1371/journal.pone.0007074.

35.

Bidirectional silencing of RNA polymerase I transcription by a strand switch region in Trypanosoma brucei.

Haenni S, Studer E, Burkard GS, Roditi I.

Nucleic Acids Res. 2009 Aug;37(15):5007-18. doi: 10.1093/nar/gkp513. Epub 2009 Jun 16.

36.

Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel.

Rufener L, Mäser P, Roditi I, Kaminsky R.

PLoS Pathog. 2009 Apr;5(4):e1000380. doi: 10.1371/journal.ppat.1000380. Epub 2009 Apr 10.

37.

Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse.

Vassella E, Oberle M, Urwyler S, Renggli CK, Studer E, Hemphill A, Fragoso C, Bütikofer P, Brun R, Roditi I.

PLoS One. 2009;4(2):e4493. doi: 10.1371/journal.pone.0004493. Epub 2009 Feb 18.

38.

Polydnaviruses of braconid wasps derive from an ancestral nudivirus.

Bézier A, Annaheim M, Herbinière J, Wetterwald C, Gyapay G, Bernard-Samain S, Wincker P, Roditi I, Heller M, Belghazi M, Pfister-Wilhem R, Periquet G, Dupuy C, Huguet E, Volkoff AN, Lanzrein B, Drezen JM.

Science. 2009 Feb 13;323(5916):926-30. doi: 10.1126/science.1166788.

39.

Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei.

Goldshmidt H, Sheiner L, Bütikofer P, Roditi I, Uliel S, Günzel M, Engstler M, Michaeli S.

J Biol Chem. 2008 Nov 14;283(46):32085-98. doi: 10.1074/jbc.M801499200. Epub 2008 Sep 2.

40.

Interactions between trypanosomes and tsetse flies.

Roditi I, Lehane MJ.

Curr Opin Microbiol. 2008 Aug;11(4):345-51. doi: 10.1016/j.mib.2008.06.006. Epub 2008 Jul 30. Review.

PMID:
18621142
41.

Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei.

Spoerri I, Chadwick R, Renggli CK, Matthews K, Roditi I, Burkard G.

Mol Biochem Parasitol. 2007 Jul;154(1):110-4. Epub 2007 Apr 18. No abstract available.

42.

Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei.

Burkard G, Fragoso CM, Roditi I.

Mol Biochem Parasitol. 2007 Jun;153(2):220-3. Epub 2007 Mar 2. No abstract available.

PMID:
17408766
43.

A mitogen-activated protein kinase of Trypanosoma brucei confers resistance to temperature stress.

Güttinger A, Schwab C, Morand S, Roditi I, Vassella E.

Mol Biochem Parasitol. 2007 Jun;153(2):203-6. Epub 2007 Feb 16. No abstract available.

PMID:
17368580
44.

A family of stage-specific alanine-rich proteins on the surface of epimastigote forms of Trypanosoma brucei.

Urwyler S, Studer E, Renggli CK, Roditi I.

Mol Microbiol. 2007 Jan;63(1):218-28.

45.

The procyclin-associated genes of Trypanosoma brucei are not essential for cyclical transmission by tsetse.

Haenni S, Renggli CK, Fragoso CM, Oberle M, Roditi I.

Mol Biochem Parasitol. 2006 Dec;150(2):144-56. Epub 2006 Jul 31.

PMID:
16930740
46.

Trypanosoma congolense procyclins: unmasking cryptic major surface glycoproteins in procyclic forms.

Utz S, Roditi I, Kunz Renggli C, Almeida IC, Acosta-Serrano A, Bütikofer P.

Eukaryot Cell. 2006 Aug;5(8):1430-40.

47.

A Mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei.

Domenicali Pfister D, Burkard G, Morand S, Renggli CK, Roditi I, Vassella E.

Eukaryot Cell. 2006 Jul;5(7):1126-35.

48.

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei.

Urwyler S, Vassella E, Van Den Abbeele J, Renggli CK, Blundell P, Barry JD, Roditi I.

PLoS Pathog. 2005 Nov;1(3):e22. Epub 2005 Nov 4.

49.
50.

Role of the N-terminal domains of EP and GPEET procyclins in membrane targeting and the establishment of midgut infections by Trypanosoma brucei.

Liniger M, Urwyler S, Studer E, Oberle M, Renggli CK, Roditi I.

Mol Biochem Parasitol. 2004 Oct;137(2):247-51. No abstract available.

PMID:
15383295

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