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Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence.

Fleury H, Malaquin N, Tu V, Gilbert S, Martinez A, Olivier MA, Sauriol A, Communal L, Leclerc-Desaulniers K, Carmona E, Provencher D, Mes-Masson AM, Rodier F.

Nat Commun. 2019 Jun 11;10(1):2556. doi: 10.1038/s41467-019-10460-1.


Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging.

Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, Freund AM, Rodier F, Wu JD, Desprez PY, Raulet DH, Nelson PS, van 't Veer LJ, Campisi J, Coppé JP.

JCI Insight. 2019 Jun 11;5. pii: 124716. doi: 10.1172/jci.insight.124716.


Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures.

Nadeau S, Cheng A, Colmegna I, Rodier F.

Methods Mol Biol. 2019 Apr 25. doi: 10.1007/7651_2019_217. [Epub ahead of print]


Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP).

Malaquin N, Tu V, Rodier F.

Methods Mol Biol. 2019;1896:45-55. doi: 10.1007/978-1-4939-8931-7_6.


Cellular senescence, geroscience, cancer and beyond.

Rodier F, Zhou D, Ferbeyre G.

Aging (Albany NY). 2018 Sep 7;10(9):2233-2242. doi: 10.18632/aging.101546. No abstract available.


Sensitive molecular detection of small nodal metastasis in uterine cervical cancer using HPV16-E6/CK19/MUC1 cancer biomarkers.

Samouëlian V, Mechtouf N, Leblanc E, Cardin GB, Lhotellier V, Querleu D, Révillion F, Rodier F.

Oncotarget. 2018 Apr 24;9(31):21641-21654. doi: 10.18632/oncotarget.24956. eCollection 2018 Apr 24.


Four PTEN-targeting co-expressed miRNAs and ACTN4- targeting miR-548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue.

Berania I, Cardin GB, Clément I, Guertin L, Ayad T, Bissada E, Nguyen-Tan PF, Filion E, Guilmette J, Gologan O, Soulieres D, Rodier F, Wong P, Christopoulos A.

Int J Cancer. 2017 Dec 1;141(11):2318-2328. doi: 10.1002/ijc.30915. Epub 2017 Aug 18.


A Proinflammatory Secretome Mediates the Impaired Immunopotency of Human Mesenchymal Stromal Cells in Elderly Patients with Atherosclerosis.

Kizilay Mancini Ö, Lora M, Shum-Tim D, Nadeau S, Rodier F, Colmegna I.

Stem Cells Transl Med. 2017 Apr;6(4):1132-1140. doi: 10.1002/sctm.16-0221. Epub 2017 Feb 14.


Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization.

Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, Vezina M, Bussières M, Vaucher E, Sapieha P, Hickson G, Hammamji K, Lapointe R, Rodier F, Tremblay S, Royal I, Cailhier JF, Chemtob S, Hardy P.

Sci Rep. 2016 Nov 22;6:37391. doi: 10.1038/srep37391.


Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype.

Malaquin N, Martinez A, Rodier F.

Exp Gerontol. 2016 Sep;82:39-49. doi: 10.1016/j.exger.2016.05.010. Epub 2016 May 25. Review.


Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis.

O'Hagan-Wong K, Nadeau S, Carrier-Leclerc A, Apablaza F, Hamdy R, Shum-Tim D, Rodier F, Colmegna I.

Oncotarget. 2016 Mar 22;7(12):13285-96. doi: 10.18632/oncotarget.7690.


Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.


Premature aging/senescence in cancer cells facing therapy: good or bad?

Gonzalez LC, Ghadaouia S, Martinez A, Rodier F.

Biogerontology. 2016 Feb;17(1):71-87. doi: 10.1007/s10522-015-9593-9. Epub 2015 Sep 2. Review.


Manipulating senescence in health and disease: emerging tools.

Cheng S, Rodier F.

Cell Cycle. 2015;14(11):1613-4. doi: 10.1080/15384101.2015.1039359. No abstract available.


Therapeutic targeting of replicative immortality.

Yaswen P, MacKenzie KL, Keith WN, Hentosh P, Rodier F, Zhu J, Firestone GL, Matheu A, Carnero A, Bilsland A, Sundin T, Honoki K, Fujii H, Georgakilas AG, Amedei A, Amin A, Helferich B, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Niccolai E, Aquilano K, Ashraf SS, Nowsheen S, Yang X.

Semin Cancer Biol. 2015 Dec;35 Suppl:S104-S128. doi: 10.1016/j.semcancer.2015.03.007. Epub 2015 Apr 11. Review.


DDR-mediated crosstalk between DNA-damaged cells and their microenvironment.

Malaquin N, Carrier-Leclerc A, Dessureault M, Rodier F.

Front Genet. 2015 Mar 12;6:94. doi: 10.3389/fgene.2015.00094. eCollection 2015. Review.


An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J.

Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11.


Mitochondrial DNA damage induces apoptosis in senescent cells.

Laberge RM, Adler D, DeMaria M, Mechtouf N, Teachenor R, Cardin GB, Desprez PY, Campisi J, Rodier F.

Cell Death Dis. 2013 Jul 18;4:e727. doi: 10.1038/cddis.2013.199.


Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.

Chouinard G, Clément I, Lafontaine J, Rodier F, Schmitt E.

Cell Div. 2013 May 16;8(1):7. doi: 10.1186/1747-1028-8-7.


First studies directed towards the diastereoselective synthesis of the BCD tricyclic core of brownin F.

Rodier F, Parrain JL, Chouraqui G, Commeiras L.

Org Biomol Chem. 2013 Jul 7;11(25):4178-85. doi: 10.1039/c3ob40363g.


p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.

Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J.

J Cell Biol. 2013 May 13;201(4):613-29. doi: 10.1083/jcb.201206006. Epub 2013 May 6.


Diastereoselective access to polyoxygenated polycyclic spirolactones through a rhodium-catalyzed [3+2] cycloaddition reaction: experimental and theoretical studies.

Rodier F, Rajzmann M, Parrain JL, Chouraqui G, Commeiras L.

Chemistry. 2013 Feb 11;19(7):2467-77. doi: 10.1002/chem.201203155. Epub 2013 Jan 7.


Detection of the senescence-associated secretory phenotype (SASP).

Rodier F.

Methods Mol Biol. 2013;965:165-73. doi: 10.1007/978-1-62703-239-1_10.


Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein.

Peuchmaur M, Lacour MA, Sévalle J, Lisowski V, Touati-Jallabe Y, Rodier F, Martinez J, Checler F, Hernandez JF.

Bioorg Med Chem. 2013 Feb 15;21(4):1018-29. doi: 10.1016/j.bmc.2012.11.045. Epub 2012 Dec 5.


ATM suppresses SATB1-induced malignant progression in breast epithelial cells.

Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T.

PLoS One. 2012;7(12):e51786. doi: 10.1371/journal.pone.0051786. Epub 2012 Dec 10.


The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?

Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA.

J Pharmacol Exp Ther. 2012 Dec;343(3):763-78. doi: 10.1124/jpet.112.197590. Epub 2012 Aug 27.


Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress.

Lafontaine J, Tchakarska G, Rodier F, Mes-Masson AM.

BMC Cancer. 2012 Jun 12;12:234. doi: 10.1186/1471-2407-12-234.


Dramatic influence of the substitution of alkylidene-5H-furan-2-ones in Diels-Alder cycloadditions with o-quinonedimethide as diene partner: en route to the CDEF polycyclic ring system of lactonamycin.

Dubois S, Rodier F, Blanc R, Rahmani R, Héran V, Thibonnet J, Commeiras L, Parrain JL.

Org Biomol Chem. 2012 Jun 28;10(24):4712-9. doi: 10.1039/c2ob25299f. Epub 2012 May 14.


Glucocorticoids suppress selected components of the senescence-associated secretory phenotype.

Laberge RM, Zhou L, Sarantos MR, Rodier F, Freund A, de Keizer PL, Liu S, Demaria M, Cong YS, Kapahi P, Desprez PY, Hughes RE, Campisi J.

Aging Cell. 2012 Aug;11(4):569-78. doi: 10.1111/j.1474-9726.2012.00818.x. Epub 2012 Apr 17.


Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest.

Lafontaine J, Rodier F, Ouellet V, Mes-Masson AM.

PLoS One. 2012;7(2):e31916. doi: 10.1371/journal.pone.0031916. Epub 2012 Feb 15.


Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J.

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.


Four faces of cellular senescence.

Rodier F, Campisi J.

J Cell Biol. 2011 Feb 21;192(4):547-56. doi: 10.1083/jcb.201009094. Epub 2011 Feb 14. Review.


Construction of spirolactones with concomitant formation of the fused quaternary centre--application to the synthesis of natural products.

Bartoli A, Rodier F, Commeiras L, Parrain JL, Chouraqui G.

Nat Prod Rep. 2011 Apr;28(4):763-82. doi: 10.1039/c0np00053a. Epub 2011 Feb 2. Review.


DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.

Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J.

J Cell Sci. 2011 Jan 1;124(Pt 1):68-81. doi: 10.1242/jcs.071340. Epub 2010 Nov 30.


p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells.

Bazarov AV, Van Sluis M, Hines WC, Bassett E, Beliveau A, Campeau E, Mukhopadhyay R, Lee WJ, Melodyev S, Zaslavsky Y, Lee L, Rodier F, Chicas A, Lowe SW, Benhattar J, Ren B, Campisi J, Yaswen P.

Aging Cell. 2010 Oct;9(5):736-46. doi: 10.1111/j.1474-9726.2010.00599.x. Epub 2010 Jul 14.


Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.

Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM.

Aging Cell. 2010 Jun;9(3):398-409. doi: 10.1111/j.1474-9726.2010.00567.x. Epub 2010 Mar 13.


A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

Coppé JP, Patil CK, Rodier F, Krtolica A, Beauséjour CM, Parrinello S, Hodgson JG, Chin K, Desprez PY, Campisi J.

PLoS One. 2010 Feb 12;5(2):e9188. doi: 10.1371/journal.pone.0009188.


MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.

Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J.

Aging (Albany NY). 2009 Apr;1(4):402-11.


When DNA damage goes invisible.

Rodier F, Campisi J.

Cell Cycle. 2009 Nov 15;8(22):3632-3. No abstract available.


A versatile viral system for expression and depletion of proteins in mammalian cells.

Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, Campisi J, Yaswen P, Cooper PK, Kaufman PD.

PLoS One. 2009 Aug 6;4(8):e6529. doi: 10.1371/journal.pone.0006529.


Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J.

Nat Cell Biol. 2009 Aug;11(8):973-9. doi: 10.1038/ncb1909. Epub 2009 Jul 13. Erratum in: Nat Cell Biol. 2009 Oct;11(10):1272. Dosage error in article text.


Chronic antiplatelet therapy and mortality among patients with infective endocarditis.

Pepin J, Tremblay V, Bechard D, Rodier F, Walker C, Dufresne D, Lafontaine A, Li N, Lacroix C, Lanthier L.

Clin Microbiol Infect. 2009 Feb;15(2):193-9. doi: 10.1111/j.1469-0691.2008.02665.x. Epub 2009 Jan 22.


The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity.

Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, Rodier F, Bernier G.

J Neurosci. 2009 Jan 14;29(2):529-42. doi: 10.1523/JNEUROSCI.5303-08.2009.


Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J.

PLoS Biol. 2008 Dec 2;6(12):2853-68. doi: 10.1371/journal.pbio.0060301.


Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.

Holcomb VB, Rodier F, Choi Y, Busuttil RA, Vogel H, Vijg J, Campisi J, Hasty P.

Cancer Res. 2008 Nov 15;68(22):9497-502. doi: 10.1158/0008-5472.CAN-08-2085.


Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.

Busuttil RA, Muñoz DP, Garcia AM, Rodier F, Kim WH, Suh Y, Hasty P, Campisi J, Vijg J.

PLoS One. 2008;3(10):e3458. doi: 10.1371/journal.pone.0003458. Epub 2008 Oct 20.


Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.

Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beausejour C, Kaminker P, Yannone SM, Campisi J.

J Cell Biol. 2008 May 5;181(3):447-60. doi: 10.1083/jcb.200710028. Epub 2008 Apr 28.


DiMoVo: a Voronoi tessellation-based method for discriminating crystallographic and biological protein-protein interactions.

Bernauer J, Bahadur RP, Rodier F, Janin J, Poupon A.

Bioinformatics. 2008 Mar 1;24(5):652-8. doi: 10.1093/bioinformatics/btn022. Epub 2008 Jan 19.


Two faces of p53: aging and tumor suppression.

Rodier F, Campisi J, Bhaumik D.

Nucleic Acids Res. 2007;35(22):7475-84. Epub 2007 Oct 16. Review.


Peptide segments in protein-protein interfaces.

Pal A, Chakrabarti P, Bahadur R, Rodier F, Janin J.

J Biosci. 2007 Jan;32(1):101-11. Erratum in: J Biosci. 2007 Jun;32(4):805.

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