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Items: 1 to 50 of 249


Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2017 Apr;42(5):1178. doi: 10.1038/npp.2016.263. No abstract available.


Deficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood.

Kirshenbaum GS, Idris NF, Dachtler J, Roder JC, Clapcote SJ.

J Neurogenet. 2016 Mar;30(1):42-9. doi: 10.1080/01677063.2016.1182525.


Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens.

Ng E, Varaschin RK, Su P, Browne CJ, Hermainski J, Le Foll B, Pongs O, Liu F, Trudeau LE, Roder JC, Wong AH.

Behav Brain Res. 2016 Mar 15;301:213-25. doi: 10.1016/j.bbr.2015.12.037. Epub 2015 Dec 29.


Ultrasonic Vocalizations in Mice During Exploratory Behavior are Context-Dependent.

Mun HS, Lipina TV, Roder JC.

Front Behav Neurosci. 2015 Dec 10;9:316. doi: 10.3389/fnbeh.2015.00316. eCollection 2015.


Self-directed exploration provides a Ncs1-dependent learning bonus.

Mun HS, Saab BJ, Ng E, McGirr A, Lipina TV, Gondo Y, Georgiou J, Roder JC.

Sci Rep. 2015 Dec 7;5:17697. doi: 10.1038/srep17697.


Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation.

Kirshenbaum GS, Dachtler J, Roder JC, Clapcote SJ.

Behav Neurosci. 2015 Dec;129(6):822-31. doi: 10.1037/bne0000097. Epub 2015 Oct 26.


Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I

Sinai L, Ivakine EA, Lam E, Deurloo M, Dida J, Zirngibl RA, Jung C, Aubin JE, Feng ZP, Yeomans J, McInnes RR, Osborne LR, Roder JC.

eNeuro. 2015 Mar 30;2(2). pii: ENEURO.0016-14.2015. doi: 10.1523/ENEURO.0016-14.2015. eCollection 2015 Mar-Apr.


Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood.

Kirshenbaum GS, Dachtler J, Roder JC, Clapcote SJ.

Neurogenetics. 2016 Jan;17(1):57-63. doi: 10.1007/s10048-015-0461-1. Epub 2015 Oct 13.


Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2016 Mar;41(4):1080-92. doi: 10.1038/npp.2015.240. Epub 2015 Aug 14. Erratum in: Neuropsychopharmacology. 2017 Apr;42(5):1178.


Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission.

Lipina TV, Prasad T, Yokomaku D, Luo L, Connor SA, Kawabe H, Wang YT, Brose N, Roder JC, Craig AM.

Neuropsychopharmacology. 2016 Feb;41(3):802-10. doi: 10.1038/npp.2015.206. Epub 2015 Jul 14.


Hippocampal place cell and inhibitory neuron activity in Disrupted-in-schizophrenia-1 mutant mice: implications for working memory deficits.

Mesbah-Oskui L, Georgiou J, Roder JC.

NPJ Schizophr. 2015 Apr 1;1. pii: doi:10.1038/npjschz.2015.11.


A Far-Red Emitting Probe for Unambiguous Detection of Mobile Zinc in Acidic Vesicles and Deep Tissue.

Rivera-Fuentes P, Wrobel AT, Zastrow ML, Khan M, Georgiou J, Luyben TT, Roder JC, Okamoto K, Lippard SJ.

Chem Sci. 2015;6(3):1944-1948.


Hippocampal place cell and inhibitory neuron activity in disrupted-in-schizophrenia-1 mutant mice: implications for working memory deficits.

Mesbah-Oskui L, Georgiou J, Roder JC.

NPJ Schizophr. 2015 Apr 1;1:15011. doi: 10.1038/npjschz.2015.11. eCollection 2015.


A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects.

Su P, Li S, Chen S, Lipina TV, Wang M, Lai TK, Lee FH, Zhang H, Zhai D, Ferguson SS, Nobrega JN, Wong AH, Roder JC, Fletcher PJ, Liu F.

Neuron. 2014 Dec 17;84(6):1302-16. doi: 10.1016/j.neuron.2014.11.007. Epub 2014 Nov 26.


Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models.

Lipina TV, Roder JC.

Neurosci Biobehav Rev. 2014 Sep;45:271-94. doi: 10.1016/j.neubiorev.2014.07.001. Epub 2014 Jul 9. Review.


Two-photon imaging of Zn2+ dynamics in mossy fiber boutons of adult hippocampal slices.

Khan M, Goldsmith CR, Huang Z, Georgiou J, Luyben TT, Roder JC, Lippard SJ, Okamoto K.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6786-91. doi: 10.1073/pnas.1405154111. Epub 2014 Apr 22.


DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.

Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, McIntosh AM, St Clair D, Blackwood DH.

Mol Psychiatry. 2014 Feb;19(2):141-3. doi: 10.1038/mp.2013.160. No abstract available.


α7nAchR/NMDAR coupling affects NMDAR function and object recognition.

Li S, Nai Q, Lipina TV, Roder JC, Liu F.

Mol Brain. 2013 Dec 20;6:58. doi: 10.1186/1756-6606-6-58.


Attenuation of mania-like behavior in Na(+),K(+)-ATPase α3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise.

Kirshenbaum GS, Burgess CR, Déry N, Fahnestock M, Peever JH, Roder JC.

Neuroscience. 2014 Feb 28;260:195-204. doi: 10.1016/j.neuroscience.2013.12.011. Epub 2013 Dec 14.


Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice.

Lipina TV, Zai C, Hlousek D, Roder JC, Wong AH.

J Neurosci. 2013 May 1;33(18):7654-66. doi: 10.1523/JNEUROSCI.0091-13.2013.


Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice.

Lee FH, Zai CC, Cordes SP, Roder JC, Wong AH.

Mol Brain. 2013 Apr 30;6:20. doi: 10.1186/1756-6606-6-20.


Using rodents to model schizophrenia and substance use comorbidity.

Ng E, McGirr A, Wong AH, Roder JC.

Neurosci Biobehav Rev. 2013 Jun;37(5):896-910. doi: 10.1016/j.neubiorev.2013.03.025. Epub 2013 Apr 6. Review.


Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice.

Kirshenbaum GS, Dawson N, Mullins JG, Johnston TH, Drinkhill MJ, Edwards IJ, Fox SH, Pratt JA, Brotchie JM, Roder JC, Clapcote SJ.

PLoS One. 2013;8(3):e60141. doi: 10.1371/journal.pone.0060141. Epub 2013 Mar 20.


Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice.

Lipina TV, Haque FN, McGirr A, Boutros PC, Berger T, Mak TW, Roder JC, Wong AH.

PLoS One. 2012;7(12):e51562. doi: 10.1371/journal.pone.0051562. Epub 2012 Dec 18.


Co-learning facilitates memory in mice: a new avenue in social neuroscience.

Lipina TV, Roder JC.

Neuropharmacology. 2013 Jan;64:283-93. doi: 10.1016/j.neuropharm.2012.06.054. Epub 2012 Jul 6.


Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice.

Lipina TV, Palomo V, Gil C, Martinez A, Roder JC.

Neuropharmacology. 2013 Jan;64:205-14. doi: 10.1016/j.neuropharm.2012.06.032. Epub 2012 Jun 28.


Social defeat interacts with Disc1 mutations in the mouse to affect behavior.

Haque FN, Lipina TV, Roder JC, Wong AH.

Behav Brain Res. 2012 Aug 1;233(2):337-44. doi: 10.1016/j.bbr.2012.05.037. Epub 2012 May 30.


Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPase α3 mutant mice.

Kirshenbaum GS, Clapcote SJ, Petersen J, Vilsen B, Ralph MR, Roder JC.

Genes Brain Behav. 2012 Jun;11(4):436-43. doi: 10.1111/j.1601-183X.2012.00800.x. Epub 2012 May 11.


Impaired social memories in 129P2 inbred mice are rescued by reduced Csk expression.

Sinai L, Mathew R, Roder JC.

Genes Brain Behav. 2012 Jul;11(5):559-67. doi: 10.1111/j.1601-183X.2012.00775.x. Epub 2012 Mar 21.


Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.

Thompson M, Marecki JC, Marinesco S, Labrie V, Roder JC, Barger SW, Crow JP.

J Neurochem. 2012 Feb;120(4):598-610. doi: 10.1111/j.1471-4159.2011.07601.x. Epub 2012 Jan 4.


Acute pharmacokinetics of memantine in the mouse.

Saab BJ, Roder JC.

Pharmacology. 2011;88(5-6):284-7. doi: 10.1159/000332829. Epub 2011 Nov 4.


Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.

Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC 3rd, Vilsen B, Peever JH, Ralph MR, Roder JC.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18144-9. doi: 10.1073/pnas.1108416108. Epub 2011 Oct 24. Erratum in: Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2174.


Parametric and pharmacological modulations of latent inhibition in mouse inbred strains.

Lipina TV, Rasquinha R, Roder JC.

Pharmacol Biochem Behav. 2011 Dec;100(2):244-52. doi: 10.1016/j.pbb.2011.08.023. Epub 2011 Aug 28.


Memantine affects cognitive flexibility in the Morris water maze.

Saab BJ, Luca RM, Yuen WB, Saab AM, Roder JC.

J Alzheimers Dis. 2011;27(3):477-82. doi: 10.3233/JAD-2011-110650.


Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice.

Lazar NL, Singh S, Paton T, Clapcote SJ, Gondo Y, Fukumura R, Roder JC, Cain DP.

Behav Brain Res. 2011 Oct 10;224(1):73-9. doi: 10.1016/j.bbr.2011.05.020. Epub 2011 May 27.


Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice.

Lee FH, Kaidanovich-Beilin O, Roder JC, Woodgett JR, Wong AH.

Schizophr Res. 2011 Jun;129(1):74-9. doi: 10.1016/j.schres.2011.03.032. Epub 2011 Apr 17.


A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel.

Bouhours M, Po MD, Gao S, Hung W, Li H, Georgiou J, Roder JC, Zhen M.

Mol Brain. 2011 Apr 13;4:16. doi: 10.1186/1756-6606-4-16.


Statistical and theoretical considerations for the platform re-location water maze.

Saab BJ, Saab AM, Roder JC.

J Neurosci Methods. 2011 May 15;198(1):44-52. doi: 10.1016/j.jneumeth.2011.03.008. Epub 2011 Mar 17.


Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress.

Kirshenbaum GS, Saltzman K, Rose B, Petersen J, Vilsen B, Roder JC.

Genes Brain Behav. 2011 Jul;10(5):542-50. doi: 10.1111/j.1601-183X.2011.00691.x. Epub 2011 Apr 13.


N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination.

Jin F, Dong B, Georgiou J, Jiang Q, Zhang J, Bharioke A, Qiu F, Lommel S, Feltri ML, Wrabetz L, Roder JC, Eyer J, Chen X, Peterson AC, Siminovitch KA.

Development. 2011 Apr;138(7):1329-37. doi: 10.1242/dev.058677.


Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.

Lipina TV, Wang M, Liu F, Roder JC.

Neuropharmacology. 2012 Mar;62(3):1252-62. doi: 10.1016/j.neuropharm.2011.02.020. Epub 2011 Mar 2.


Disc1 point mutations in mice affect development of the cerebral cortex.

Lee FH, Fadel MP, Preston-Maher K, Cordes SP, Clapcote SJ, Price DJ, Roder JC, Wong AH.

J Neurosci. 2011 Mar 2;31(9):3197-206. doi: 10.1523/JNEUROSCI.4219-10.2011.


Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia.

Brown SM, Clapcote SJ, Millar JK, Torrance HS, Anderson SM, Walker R, Rampino A, Roder JC, Thomson PA, Porteous DJ, Evans KL.

Mol Psychiatry. 2011 Jun;16(6):585-7. doi: 10.1038/mp.2010.134. Epub 2011 Feb 15. No abstract available. Erratum in: Mol Psychiatry. 2012 Apr;17(4):469.


Contributions of the D-serine pathway to schizophrenia.

Labrie V, Wong AH, Roder JC.

Neuropharmacology. 2012 Mar;62(3):1484-503. doi: 10.1016/j.neuropharm.2011.01.030. Epub 2011 Feb 2. Review.


Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708.

Saab BJ, Maclean AJ, Kanisek M, Zurek AA, Martin LJ, Roder JC, Orser BA.

Anesthesiology. 2010 Nov;113(5):1061-71. doi: 10.1097/ALN.0b013e3181f56228.


Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE.

Brain Res. 2010 Dec 17;1366:162-71. doi: 10.1016/j.brainres.2010.09.107. Epub 2010 Oct 26.


A new Kv1.2 channelopathy underlying cerebellar ataxia.

Xie G, Harrison J, Clapcote SJ, Huang Y, Zhang JY, Wang LY, Roder JC.

J Biol Chem. 2010 Oct 15;285(42):32160-73. doi: 10.1074/jbc.M110.153676. Epub 2010 Aug 9.


Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.

Lipina TV, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote SJ, Liu F, Woodgett JR, Roder JC.

Synapse. 2011 Mar;65(3):234-48. doi: 10.1002/syn.20839.


Src inhibition reduces NR2B surface expression and synaptic plasticity in the amygdala.

Sinai L, Duffy S, Roder JC.

Learn Mem. 2010 Jul 21;17(8):364-71. doi: 10.1101/lm.1765710. Print 2010 Aug.


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