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Poor glycemic control impairs the cardioprotective effects of red blood cells on myocardial ischemia/reperfusion injury.

Muessig JM, Moellhoff L, Noelle J, Kaya S, Pareja LH, Masyuk M, Roden M, Kelm M, Jung C.

Nitric Oxide. 2020 Jan 22. pii: S1089-8603(19)30336-2. doi: 10.1016/j.niox.2020.01.008. [Epub ahead of print]


DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-induced obesity.

Romacho T, Sell H, Indrakusuma I, Roehrborn D, Castañeda TR, Jelenik T, Markgraf D, Hartwig S, Weiß J, Al-Hasani H, Roden M, Eckel J.

Am J Physiol Endocrinol Metab. 2019 Dec 31. doi: 10.1152/ajpendo.00323.2019. [Epub ahead of print]


Diabetes and Fatty Liver.

Stefan N, Roden M.

Exp Clin Endocrinol Diabetes. 2019 Dec;127(S 01):S93-S96. doi: 10.1055/a-0984-5753. Epub 2019 Dec 20. No abstract available.


Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes.

Bódis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Müssig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schürmann A, Roden M, Szendroedi J; GDS study group.

J Clin Endocrinol Metab. 2019 Dec 15. pii: dgz267. doi: 10.1210/clinem/dgz267. [Epub ahead of print]


Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic mice.

Simon MC, Reinbeck AL, Wessel C, Heindirk J, Jelenik T, Kaul K, Arreguin-Cano J, Strom A, Blaut M, Bäckhed F, Burkart V, Roden M.

J Biol Chem. 2020 Jan 24;295(4):969-980. doi: 10.1074/jbc.RA119.010816. Epub 2019 Dec 10.


Deficits in systemic biomarkers of neuroinflammation and growth factors promoting nerve regeneration in patients with type 2 diabetes and polyneuropathy.

Ziegler D, Strom A, Bönhof GJ, Kannenberg JM, Heier M, Rathmann W, Peters A, Meisinger C, Roden M, Thorand B, Herder C.

BMJ Open Diabetes Res Care. 2019 Nov 27;7(1):e000752. doi: 10.1136/bmjdrc-2019-000752. eCollection 2019.


The integrative biology of type 2 diabetes.

Roden M, Shulman GI.

Nature. 2019 Dec;576(7785):51-60. doi: 10.1038/s41586-019-1797-8. Epub 2019 Dec 4. Review.


Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes.

Niersmann C, Carstensen-Kirberg M, Maalmi H, Holleczek B, Roden M, Brenner H, Herder C, Schöttker B.

Diabetologia. 2020 Feb;63(2):410-418. doi: 10.1007/s00125-019-05017-2. Epub 2019 Nov 9.


Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion.

Phielix E, Begovatz P, Gancheva S, Bierwagen A, Kornips E, Schaart G, Hesselink MKC, Schrauwen P, Roden M.

JCI Insight. 2019 Nov 1;4(21). pii: 127928. doi: 10.1172/jci.insight.127928.


Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial.

Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M.

Am J Clin Nutr. 2019 Nov 1;110(5):1098-1107. doi: 10.1093/ajcn/nqz191.


Diabetes clusters and risk of diabetes-associated diseases - Authors' reply.

Zaharia OP, Kuss O, Strassburger K, Burkart V, Szendroedi J, Roden M.

Lancet Diabetes Endocrinol. 2019 Nov;7(11):828-829. doi: 10.1016/S2213-8587(19)30319-5. No abstract available.


4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.

Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW.

Nat Metab. 2019 May;1(5):546-559. doi: 10.1038/s42255-019-0055-6. Epub 2019 Apr 22.


Hungry for your alanine: when liver depends on muscle proteolysis.

Sarabhai T, Roden M.

J Clin Invest. 2019 Nov 1;129(11):4563-4566. doi: 10.1172/JCI131931.


Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial.

Kahl S, Gancheva S, Straßburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, van Gemert T, Knebel B, Wolkersdorfer MF, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M.

Diabetes Care. 2020 Feb;43(2):298-305. doi: 10.2337/dc19-0641. Epub 2019 Sep 20.


Dynamic changes of muscle insulin sensitivity after metabolic surgery.

Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, Jähnert M, Weiss J, Strassburger K, Schlensak M, Schürmann A, Roden M.

Nat Commun. 2019 Sep 13;10(1):4179. doi: 10.1038/s41467-019-12081-0.


Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study.

Then C, Then H, Lechner A, Huth C, Meisinger C, Heier M, Peters A, Koenig W, Rathmann W, Herder C, Roden M, Scherberich J, Seissler J.

Endocr Connect. 2019 Sep 1. pii: EC-19-0352.R1. doi: 10.1530/EC-19-0352. [Epub ahead of print]


Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome.

Hatziagelaki E, Pergialiotis V, Kannenberg JM, Trakakis E, Tsiavou A, Markgraf DF, Carstensen-Kirberg M, Pacini G, Roden M, Dimitriadis G, Herder C.

Exp Clin Endocrinol Diabetes. 2019 Aug 28. doi: 10.1055/a-0992-9114. [Epub ahead of print]


Are Lifestyle Therapies Effective for NAFLD Treatment?

El-Agroudy NN, Kurzbach A, Rodionov RN, O'Sullivan J, Roden M, Birkenfeld AL, Pesta DH.

Trends Endocrinol Metab. 2019 Oct;30(10):701-709. doi: 10.1016/j.tem.2019.07.013. Epub 2019 Aug 15. Review.


Distinct trajectories of HbA1c in newly diagnosed Type 2 diabetes from the DPV registry using a longitudinal group-based modelling approach.

Rathmann W, Schwandt A, Hermann JM, Kuss O, Roden M, Laubner K, Best F, Ebner S, Plaumann M, Holl RW; DPV Initiative.

Diabet Med. 2019 Nov;36(11):1468-1477. doi: 10.1111/dme.14103. Epub 2019 Sep 23.


Augmented Corneal Nerve Fiber Branching in Painful Compared With Painless Diabetic Neuropathy.

Püttgen S, Bönhof GJ, Strom A, Müssig K, Szendroedi J, Roden M, Ziegler D.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):6220-6228. doi: 10.1210/jc.2019-01072.


Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study.

Zaharia OP, Strassburger K, Strom A, Bönhof GJ, Karusheva Y, Antoniou S, Bódis K, Markgraf DF, Burkart V, Müssig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Häring HU, Ziegler D, Kuss O, Szendroedi J, Roden M; German Diabetes Study Group.

Lancet Diabetes Endocrinol. 2019 Sep;7(9):684-694. doi: 10.1016/S2213-8587(19)30187-1. Epub 2019 Jul 22.


Evaluation of lipoprotein-associated phospholipase A2 as a marker for renal microvasculopathy in adolescents with Type 1 diabetes.

Seyfarth J, Herebian D, Reinauer C, Baechle C, Roden M, Holl RW, Reinehr T, Mayatepek E, Meissner T, Rosenbauer J.

Diabet Med. 2020 Jan;37(1):75-83. doi: 10.1111/dme.14086. Epub 2019 Aug 5.


Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction.

Thielen JW, Gancheva S, Hong D, Rohani Rankouhi S, Chen B, Apostolopoulou M, Anadol-Schmitz E, Roden M, Norris DG, Tendolkar I.

Hum Brain Mapp. 2019 Oct 1;40(14):4287-4295. doi: 10.1002/hbm.24702. Epub 2019 Jul 2.


1H-MRS of femoral red and yellow bone marrow fat composition and water content in healthy young men and women at 3 T.

Lundbom J, Bierwagen A, Bodis K, Apostolopoulou M, Szendroedi J, Müssig K, Hwang JH, Roden M.

MAGMA. 2019 Oct;32(5):591-597. doi: 10.1007/s10334-019-00750-6. Epub 2019 May 2.


Comparison of the diagnostic accuracy of the current guidelines for detecting insulinoma.

Dauben L, Simon MC, Strassburger K, Burkart V, Weber KS, Schinner S, Roden M, Müssig K.

Eur J Endocrinol. 2019 Jun 1;180(6):381-386. doi: 10.1530/EJE-18-0879.


[Diabetes mellitus-Definition, classification, diagnosis, screening and prevention (Update 2019)].

Harreiter J, Roden M.

Wien Klin Wochenschr. 2019 May;131(Suppl 1):6-15. doi: 10.1007/s00508-019-1450-4. Review. German.


[Antihyperglycemic treatment guidelines for diabetes mellitus type 2 (Update 2019)].

Clodi M, Abrahamian H, Brath H, Brix J, Drexel H, Fasching P, Föger B, Francesconi C, Fröhlich-Reiterer E, Harreiter J, Hofer SE, Hoppichler F, Huber J, Kaser S, Kautzky-Willer A, Lechleitner M, Ludvik B, Luger A, Mader JK, Paulweber B, Pieber T, Prager R, Rami-Merhar B, Resl M, Riedl M, Roden M, Saely CH, Schelkshorn C, Schernthaner G, Sourij H, Stechemesser L, Stingl H, Toplak H, Wascher TC, Weitgasser R, Winhofer-Stöckl Y, Zlamal-Fortunat S.

Wien Klin Wochenschr. 2019 May;131(Suppl 1):27-38. doi: 10.1007/s00508-019-1471-z. Review. German.


[Insulin therapy of type 2 diabetes mellitus (Update 2019)].

Lechleitner M, Clodi M, Abrahamian H, Brath H, Brix J, Drexel H, Fasching P, Föger B, Francesconi C, Fröhlich-Reiterer E, Harreiter J, Hofer SE, Hoppichler F, Huber J, Kaser S, Kautzky-Willer A, Ludvik B, Luger A, Mader JK, Paulweber B, Pieber T, Prager R, Rami-Merhar B, Resl M, Riedl M, Roden M, Saely CH, Schelkshorn C, Schernthaner G, Sourij H, Stechemesser L, Stingl H, Toplak H, Wascher TC, Weitgasser R, Winhofer-Stöckl Y, Zlamal-Fortunat S.

Wien Klin Wochenschr. 2019 May;131(Suppl 1):39-46. doi: 10.1007/s00508-019-1492-7. Review. German.


[Diagnosis and insulin therapy of type 1 diabetes mellitus (Update 2019)].

Lechleitner M, Kaser S, Hoppichler F, Roden M, Weitgasser R, Ludvik B, Fasching P, Winhofer-Stöckl Y, Kautzky-Willer A, Schernthaner G, Prager R, Wascher TC, Clodi M.

Wien Klin Wochenschr. 2019 May;131(Suppl 1):77-84. doi: 10.1007/s00508-019-1493-6. Review. German.


Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts.

Herder C, Roden M, Ziegler D.

Trends Endocrinol Metab. 2019 May;30(5):286-298. doi: 10.1016/j.tem.2019.02.007. Epub 2019 Mar 30. Review.


Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E.

Carstensen-Kirberg M, Röhrig K, Niersmann C, Ouwens DM, Belgardt BF, Roden M, Herder C.

PLoS One. 2019 Mar 28;14(3):e0213650. doi: 10.1371/journal.pone.0213650. eCollection 2019.


A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver.

Preuss C, Jelenik T, Bódis K, Müssig K, Burkart V, Szendroedi J, Roden M, Markgraf DF.

Cells. 2019 Mar 22;8(3). pii: E277. doi: 10.3390/cells8030277.


Impaired Glucose Metabolism in Primary Aldosteronism Is Associated With Cortisol Cosecretion.

Gerards J, Heinrich DA, Adolf C, Meisinger C, Rathmann W, Sturm L, Nirschl N, Bidlingmaier M, Beuschlein F, Thorand B, Peters A, Reincke M, Roden M, Quinkler M.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3192-3202. doi: 10.1210/jc.2019-00299.


High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure.

Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J.

Exp Mol Med. 2019 Feb 14;51(2):16. doi: 10.1038/s12276-019-0214-6.


[The Diabetic Heart and Heart Failure - Update on Mechanisms and Therapy].

Zweck E, Szendrödi J, Kelm M, Roden M.

Dtsch Med Wochenschr. 2019 Feb;144(3):175-179. doi: 10.1055/a-0646-7871. Epub 2019 Jan 31. German.


Correlates of Insulin-Stimulated Glucose Disposal in Recent-Onset Type 1 and Type 2 Diabetes.

Simon MC, Möller-Horigome A, Strassburger K, Nowotny B, Knebel B, Müssig K, Herder C, Szendroedi J, Roden MW; German Diabetes Study Group.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2295-2304. doi: 10.1210/jc.2018-02057.


GLP-1 receptor agonists and cardiovascular disease: drug-specific or class effects?

Zweck E, Roden M.

Lancet Diabetes Endocrinol. 2019 Feb;7(2):89-90. doi: 10.1016/S2213-8587(18)30351-6. No abstract available.


An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial.

Karusheva Y, Kunstein L, Bierwagen A, Nowotny B, Kabisch S, Groener JB, Fleitmann AK, Herder C, Pacini G, Strassburger K, Häring HU, Nawroth PP, Pfeiffer AFH, Burkart V, Müssig K, Roden M, Szendroedi J.

Nutr Metab (Lond). 2018 Dec 29;15:90. doi: 10.1186/s12986-018-0324-5. eCollection 2018.


Protein markers and risk of type 2 diabetes and prediabetes: a targeted proteomics approach in the KORA F4/FF4 study.

Huth C, von Toerne C, Schederecker F, de Las Heras Gala T, Herder C, Kronenberg F, Meisinger C, Rathmann W, Koenig W, Waldenberger M, Roden M, Peters A, Hauck SM, Thorand B.

Eur J Epidemiol. 2019 Apr;34(4):409-422. doi: 10.1007/s10654-018-0475-8. Epub 2018 Dec 31.


Incidence Rates of Type 2 Diabetes in People With Impaired Fasting Glucose (ADA vs. WHO Criteria) and Impaired Glucose Tolerance: Results From an Older Population (KORA S4/F4/FF4 Study).

Kowall B, Rathmann W, Bongaerts B, Kuss O, Stang A, Roden M, Herder C, Koenig W, Huth C, Heier M, Thorand B, Ladwig KH, Holle R, Meisinger C, Peters A.

Diabetes Care. 2019 Feb;42(2):e18-e20. doi: 10.2337/dc18-1473. Epub 2018 Dec 14. No abstract available.


General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort.

Schlesinger S, Herder C, Kannenberg JM, Huth C, Carstensen-Kirberg M, Rathmann W, Bönhof GJ, Koenig W, Heier M, Peters A, Meisinger C, Roden M, Thorand B, Ziegler D.

Diabetes Care. 2019 Feb;42(2):240-247. doi: 10.2337/dc18-1842. Epub 2018 Dec 6.


Exosomal proteins constitute an essential part of the human adipose tissue secretome.

Hartwig S, De Filippo E, Göddeke S, Knebel B, Kotzka J, Al-Hasani H, Roden M, Lehr S, Sell H.

Biochim Biophys Acta Proteins Proteom. 2019 Dec;1867(12):140172. doi: 10.1016/j.bbapap.2018.11.009. Epub 2018 Nov 28.


Regional differences of macrovascular disease in Northeast and South Germany: the population-based SHIP-TREND and KORA-F4 studies.

Ptushkina V, Jacobs E, Schipf S, Völzke H, Markus MRP, Nauck M, Meisinger C, Peters A, Maier W, Herder C, Roden M, Rathmann W.

BMC Public Health. 2018 Dec 3;18(1):1331. doi: 10.1186/s12889-018-6265-0.


In vivo 19F MR inflammation imaging after myocardial infarction in a large animal model at 3 T.

Rothe M, Jahn A, Weiss K, Hwang JH, Szendroedi J, Kelm M, Schrader J, Roden M, Flögel U, Bönner F.

MAGMA. 2019 Feb;32(1):5-13. doi: 10.1007/s10334-018-0714-8. Epub 2018 Nov 12.


A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes.

Rathmann W, Strassburger K, Bongaerts B, Kuss O, Müssig K, Burkart V, Szendroedi J, Kotzka J, Knebel B, Al-Hasani H, Roden M; GDS Group.

Diabetologia. 2019 Feb;62(2):286-291. doi: 10.1007/s00125-018-4759-z. Epub 2018 Nov 9.


What information needs do people with recently diagnosed diabetes mellitus have and what are the associated factors? A cross-sectional study in Germany.

Grobosch S, Kuske S, Linnenkamp U, Ernstmann N, Stephan A, Genz J, Begun A, Haastert B, Szendroedi J, Müssig K, Burkart V, Roden M, Icks A; GDS Group.

BMJ Open. 2018 Oct 31;8(10):e017895. doi: 10.1136/bmjopen-2017-017895.


Autoimmunity risk- and protection-associated IL7RA genetic variants differentially affect soluble and membrane IL-7Rα expression.

Lundtoft C, Seyfarth J, Oberstrass S, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Kummer S, Meissner T, Jacobsen M.

J Autoimmun. 2019 Feb;97:40-47. doi: 10.1016/j.jaut.2018.10.003. Epub 2018 Oct 17.


Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival.

Lorenz L, Axnick J, Buschmann T, Henning C, Urner S, Fang S, Nurmi H, Eichhorst N, Holtmeier R, Bódis K, Hwang JH, Müssig K, Eberhard D, Stypmann J, Kuss O, Roden M, Alitalo K, Häussinger D, Lammert E.

Nature. 2018 Oct;562(7725):128-132. doi: 10.1038/s41586-018-0522-3. Epub 2018 Sep 26.


Insulin Resistance and Vulnerability to Cardiac Ischemia.

Jelenik T, Flögel U, Álvarez-Hernández E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Müller-Wieland D, Moellendorf S, Gödecke A, Kelm M, Westenfeld R, Roden M, Szendroedi J.

Diabetes. 2018 Dec;67(12):2695-2702. doi: 10.2337/db18-0449. Epub 2018 Sep 26.


Emerging Biomarkers, Tools, and Treatments for Diabetic Polyneuropathy.

Bönhof GJ, Herder C, Strom A, Papanas N, Roden M, Ziegler D.

Endocr Rev. 2019 Feb 1;40(1):153-192. doi: 10.1210/er.2018-00107. Review.


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