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Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis.

Erkes DA, Cai W, Sanchez IM, Purwin TJ, Rogers C, Field CO, Berger AC, Hartsough EJ, Rodeck U, Alnemri ES, Aplin AE.

Cancer Discov. 2019 Dec 3. pii: CD-19-0672. doi: 10.1158/2159-8290.CD-19-0672. [Epub ahead of print]


Metformin effects on FOXP3+ and CD8+ T cell infiltrates of head and neck squamous cell carcinoma.

Amin D, Richa T, Mollaee M, Zhan T, Tassone P, Johnson J, Luginbuhl A, Cognetti D, Martinez-Outschoorn U, Stapp R, Solomides C, Rodeck U, Curry J.

Laryngoscope. 2019 Oct 8. doi: 10.1002/lary.28336. [Epub ahead of print]


Prognostic Significance of Tumor-Associated Macrophage Content in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.

Kumar AT, Knops A, Swendseid B, Martinez-Outschoom U, Harshyne L, Philp N, Rodeck U, Luginbuhl A, Cognetti D, Johnson J, Curry J.

Front Oncol. 2019 Jul 23;9:656. doi: 10.3389/fonc.2019.00656. eCollection 2019.


Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth.

DeRita RM, Sayeed A, Garcia V, Krishn SR, Shields CD, Sarker S, Friedman A, McCue P, Molugu SK, Rodeck U, Dicker AP, Languino LR.

iScience. 2019 Apr 26;14:199-209. doi: 10.1016/j.isci.2019.03.022. Epub 2019 Mar 27.


Loss of CD169+ Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Topf MC, Harshyne L, Tuluc M, Mardekian S, Vimawala S, Cognetti DM, Curry JM, Rodeck U, Luginbuhl A.

Otolaryngol Head Neck Surg. 2019 Jul;161(1):67-73. doi: 10.1177/0194599819829741. Epub 2019 Feb 12.


Metformin Clinical Trial in HPV+ and HPV- Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate.

Curry JM, Johnson J, Mollaee M, Tassone P, Amin D, Knops A, Whitaker-Menezes D, Mahoney MG, South A, Rodeck U, Zhan T, Harshyne L, Philp N, Luginbuhl A, Cognetti D, Tuluc M, Martinez-Outschoorn U.

Front Oncol. 2018 Oct 11;8:436. doi: 10.3389/fonc.2018.00436. eCollection 2018.


Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin.

Gubbiotti MA, Seifert E, Rodeck U, Hoek JB, Iozzo RV.

J Biol Chem. 2018 Oct 26;293(43):16940-16950. doi: 10.1074/jbc.RA118.004563. Epub 2018 Jul 26.


Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress.

Flickinger JC Jr, Rodeck U, Snook AE.

Vaccines (Basel). 2018 Jul 25;6(3). pii: E48. doi: 10.3390/vaccines6030048. Review.


STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.

Maranto C, Udhane V, Hoang DT, Gu L, Alexeev V, Malas K, Cardenas K, Brody JR, Rodeck U, Bergom C, Iczkowski KA, Jacobsohn K, See W, Schmitt SM, Nevalainen MT.

Clin Cancer Res. 2018 Apr 15;24(8):1917-1931. doi: 10.1158/1078-0432.CCR-17-2768. Epub 2018 Feb 26.


Global mapping of transcription factor motifs in human aging.

Alfego D, Rodeck U, Kriete A.

PLoS One. 2018 Jan 2;13(1):e0190457. doi: 10.1371/journal.pone.0190457. eCollection 2018.


Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma.

Curry J, Tassone P, Gill K, Tuluc M, BarAd V, Mollaee M, Whitaker-Menezes D, Rodeck U, Luginbuhl A, Cognetti D, Keane W, Martinez-Outschoorn U.

Otolaryngol Head Neck Surg. 2017 Nov;157(5):798-807. doi: 10.1177/0194599817709224. Epub 2017 Jun 13.


Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts.

Yalamanchili N, Kriete A, Alfego D, Danowski KM, Kari C, Rodeck U.

Front Genet. 2016 Oct 4;7:171. eCollection 2016.


β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation.

Sayeed A, Lu H, Liu Q, Deming D 2nd, Duffy A, McCue P, Dicker AP, Davis RJ, Gabrilovich D, Rodeck U, Altieri DC, Languino LR.

Oncotarget. 2016 Aug 16;7(33):52618-52630. doi: 10.18632/oncotarget.10522.


Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.

Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB.

Biochem J. 2015 Oct 1;471(1):37-51. doi: 10.1042/BJ20150325. Epub 2015 Jul 22.


The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice.

Goldman DC, Alexeev V, Lash E, Guha C, Rodeck U, Fleming WH.

Radiat Res. 2015 Mar;183(3):338-44. doi: 10.1667/RR13900.1. Epub 2015 Mar 4.


Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.

Alexeev V, Lash E, Aguillard A, Corsini L, Bitterman A, Ward K, Dicker AP, Linnenbach A, Rodeck U.

Mol Cancer Ther. 2014 Dec;13(12):2968-77. doi: 10.1158/1535-7163.MCT-14-0354. Epub 2014 Nov 14.


Skinflammation and drug toxicity--a delicate balance.

Lacouture ME, Rodeck U.

Sci Transl Med. 2013 Aug 21;5(199):199fs33. doi: 10.1126/scitranslmed.3006993.


Skin toxicity of targeted cancer agents: mechanisms and intervention.

Belum VR, Fontanilla Patel H, Lacouture ME, Rodeck U.

Future Oncol. 2013 Aug;9(8):1161-70. doi: 10.2217/fon.13.62. Review.


Immunotargeting and eradication of orthotopic melanoma using a chemokine-enhanced DNA vaccine.

Igoucheva O, Grazzini M, Pidich A, Kemp DM, Larijani M, Farber M, Lorton J, Rodeck U, Alexeev V.

Gene Ther. 2013 Sep;20(9):939-48. doi: 10.1038/gt.2013.17. Epub 2013 Apr 4.


Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells.

Le K, Blomain ES, Rodeck U, Aplin AE.

Pigment Cell Melanoma Res. 2013 Jul;26(4):509-17. doi: 10.1111/pcmr.12092. Epub 2013 Apr 8.


Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma.

Fertig EJ, Ren Q, Cheng H, Hatakeyama H, Dicker AP, Rodeck U, Considine M, Ochs MF, Chung CH.

BMC Genomics. 2012 May 1;13:160.


Integration of investigative dermatology into the global biomedical research enterprise: past, present, and future.

Uitto J, Rodeck U.

J Invest Dermatol. 2012 Mar;132(3 Pt 2):1029-32. doi: 10.1038/jid.2011.401.


Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.

Chan TO, Pascal JM, Armen RS, Rodeck U.

Cell Cycle. 2012 Feb 1;11(3):475-8. doi: 10.4161/cc.11.3.19059. Epub 2012 Feb 1. Review.


Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1120-7. doi: 10.1073/pnas.1109879108. Epub 2011 Oct 26.


A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity.

Cheng H, Kari G, Dicker AP, Rodeck U, Koch WJ, Force T.

Circ Res. 2011 Dec 9;109(12):1401-9. doi: 10.1161/CIRCRESAHA.111.255695. Epub 2011 Oct 13.


PET imaging of EGFR expression in nude mice bearing MDA-MB-468, a human breast adenocarcinoma.

Sadri K, Ren Q, Zhang K, Paudyal B, Devadhas D, Rodeck U, Thakur M.

Nucl Med Commun. 2011 Jul;32(7):563-9. doi: 10.1097/MNM.0b013e3283419523.


A novel class of compounds with cutaneous wound healing properties.

Zhou Z, Joslin S, Dellinger A, Ehrich M, Brooks B, Ren Q, Rodeck U, Lenk R, Kepley CL.

J Biomed Nanotechnol. 2010 Oct;6(5):605-11.


Differential regulation of p53 function by the N-terminal ΔNp53 and Δ113p53 isoforms in zebrafish embryos.

Davidson WR, Kari C, Ren Q, Daroczi B, Dicker AP, Rodeck U.

BMC Dev Biol. 2010 Oct 7;10:102. doi: 10.1186/1471-213X-10-102.


Progress in epidermolysis bullosa research: toward treatment and cure.

Uitto J, McGrath JA, Rodeck U, Bruckner-Tuderman L, Robinson EC.

J Invest Dermatol. 2010 Jul;130(7):1778-84. doi: 10.1038/jid.2010.90. Epub 2010 Apr 15. Review.


Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies.

Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC.

Cancer Biol Ther. 2009 Nov;8(22):2147-52. Epub 2009 Nov 7.


Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.

Daroczi B, Kari G, Ren Q, Dicker AP, Rodeck U.

Mol Cancer Ther. 2009 Sep;8(9):2625-34. doi: 10.1158/1535-7163.MCT-09-0198. Epub 2009 Sep 1.


Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice.

Surguladze D, Deevi D, Claros N, Corcoran E, Wang S, Plym MJ, Wu Y, Doody J, Mauro DJ, Witte L, Busam KJ, Pytowski B, Rodeck U, Tonra JR.

Cancer Res. 2009 Jul 15;69(14):5643-7. doi: 10.1158/0008-5472.CAN-09-0487. Epub 2009 Jul 7.


Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.

Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC.

PLoS One. 2009 Jun 26;4(6):e6025. doi: 10.1371/journal.pone.0006025.


Nature's design: A blueprint for engineered therapeutic antibodies.

Rodeck U, Williams JC.

Cancer Biol Ther. 2008 Nov;7(11):1751-2. Epub 2008 Nov 8. No abstract available.


Skin toxicity caused by EGFR antagonists-an autoinflammatory condition triggered by deregulated IL-1 signaling?

Rodeck U.

J Cell Physiol. 2009 Jan;218(1):32-4. doi: 10.1002/jcp.21585. Review.


Biochemical and structural characterization of the Pak1-LC8 interaction.

Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T, Williams JC.

J Biol Chem. 2008 Oct 3;283(40):27314-24. doi: 10.1074/jbc.M800758200. Epub 2008 Jul 23.


Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity.

Kriete A, Mayo KL, Yalamanchili N, Beggs W, Bender P, Kari C, Rodeck U.

Immun Ageing. 2008 Jul 16;5:5. doi: 10.1186/1742-4933-5-5.


Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425.

Kamat V, Donaldson JM, Kari C, Quadros MR, Lelkes PI, Chaiken I, Cocklin S, Williams JC, Papazoglou E, Rodeck U.

Cancer Biol Ther. 2008 May;7(5):726-33. Epub 2008 May 14.


Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.

Davidson W, Ren Q, Kari G, Kashi O, Dicker AP, Rodeck U.

Cell Cycle. 2008 May 1;7(9):1224-30. Epub 2008 Feb 11.


Cells expressing partially unfolded R789C/p.R989C type II procollagen mutant associated with spondyloepiphyseal dysplasia undergo apoptosis.

Hintze V, Steplewski A, Ito H, Jensen DA, Rodeck U, Fertala A.

Hum Mutat. 2008 Jun;29(6):841-51. doi: 10.1002/humu.20736.


Receptor tyrosine kinases: the emerging tip of systems control.

Seger R, Rodeck U, Yarden Y.

IET Syst Biol. 2008 Jan;2(1):1-4. doi: 10.1049/iet-syb:20070048.


Gene expression profiles as markers of aggressive disease-EGFR as a factor.

Chung CH, Parker J, Levy S, Slebos RJ, Dicker AP, Rodeck U.

Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S102-5. No abstract available.


Zebrafish: an emerging model system for human disease and drug discovery.

Kari G, Rodeck U, Dicker AP.

Clin Pharmacol Ther. 2007 Jul;82(1):70-80. Epub 2007 May 9. Review.


Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes.

Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T, Uitto J, Rodeck U, Mahoney MG.

J Cell Sci. 2007 Mar 1;120(Pt 5):758-71. Epub 2007 Feb 6.


In vivo radioprotection by the fullerene nanoparticle DF-1 as assessed in a zebrafish model.

Daroczi B, Kari G, McAleer MF, Wolf JC, Rodeck U, Dicker AP.

Clin Cancer Res. 2006 Dec 1;12(23):7086-91.


Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells.

Bellone G, Carbone A, Smirne C, Scirelli T, Buffolino A, Novarino A, Stacchini A, Bertetto O, Palestro G, Sorio C, Scarpa A, Emanuelli G, Rodeck U.

J Immunol. 2006 Sep 1;177(5):3448-60.


Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos.

McAleer MF, Duffy KT, Davidson WR, Kari G, Dicker AP, Rodeck U, Wickstrom E.

Int J Radiat Oncol Biol Phys. 2006 Oct 1;66(2):546-51. Epub 2006 Aug 14.


Malignant transformation of immortalized HaCaT keratinocytes through deregulated nuclear factor kappaB signaling.

Ren Q, Kari C, Quadros MR, Burd R, McCue P, Dicker AP, Rodeck U.

Cancer Res. 2006 May 15;66(10):5209-15.

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