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Items: 35


Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry.

Walker JA, Jordan VE, Storer JM, Steely CJ, Gonzalez-Quiroga P, Beckstrom TO, Rewerts LC, St Romain CP, Rockwell CE, Rogers J, Jolly CJ, Konkel MK; Baboon Genome Analysis Consortium, Batzer MA.

Mob DNA. 2019 Nov 26;10:46. doi: 10.1186/s13100-019-0187-y. eCollection 2019.


Differential Sensitivity of Kupffer Cells and Hepatic Monocyte-Derived Macrophages to Bacterial Lipopolysaccharide.

Roth K, Rockwell CE, Copple BL.

Clin Exp Gastroenterol Hepatol. 2019 Jan-May;1(1). pii: 106. doi: 10.31531/edwiser.jcegh.1000106. Epub 2019 Sep 3.


Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.

Roth K, Strickland J, Joshi N, Deng M, Kennedy RC, Rockwell CE, Luyendyk JP, Billiar TR, Copple BL.

Am J Pathol. 2019 Oct;189(10):1986-2001. doi: 10.1016/j.ajpath.2019.07.003. Epub 2019 Aug 2.


Chronic low-level cadmium exposure in rats affects cytokine production by activated T cells.

Turley AE, Zagorski JW, Kennedy RC, Freeborn RA, Bursley JK, Edwards JR, Rockwell CE.

Toxicol Res (Camb). 2019 Jan 4;8(2):227-237. doi: 10.1039/c8tx00194d. eCollection 2019 Mar 1.


The Nrf2 activator tBHQ inhibits the activation of primary murine natural killer cells.

Boss AP, Freeborn RA, Duriancik DM, Kennedy RC, Gardner EM, Rockwell CE.

Food Chem Toxicol. 2018 Nov;121:231-236. doi: 10.1016/j.fct.2018.08.067. Epub 2018 Aug 30.


Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction.

Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski T.

Mol Pharmacol. 2018 Aug;94(2):876-884. doi: 10.1124/mol.118.112144. Epub 2018 May 11.


Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice.

Zhang D, Rennhack J, Andrechek ER, Rockwell CE, Liby KT.

Antioxid Redox Signal. 2018 Dec 1;29(16):1535-1552. doi: 10.1089/ars.2017.7201. Epub 2018 Apr 16.


Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation.

Zagorski JW, Turley AE, Freeborn RA, VanDenBerg KR, Dover HE, Kardell BR, Liby KT, Rockwell CE.

Biochem Pharmacol. 2018 Jan;147:67-76. doi: 10.1016/j.bcp.2017.11.005. Epub 2017 Nov 15.


Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2.

VanDenBerg KR, Freeborn RA, Liu S, Kennedy RC, Zagorski JW, Rockwell CE.

PLoS One. 2017 Oct 19;12(10):e0185579. doi: 10.1371/journal.pone.0185579. eCollection 2017.


Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing.

Zagorski JW, Maser TP, Liby KT, Rockwell CE.

J Pharmacol Exp Ther. 2017 May;361(2):259-267. doi: 10.1124/jpet.116.238899. Epub 2017 Mar 9.


Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.

Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD.

Food Chem Toxicol. 2017 Feb;100:24-33. doi: 10.1016/j.fct.2016.12.004. Epub 2016 Dec 8.


Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.

Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR.

Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11.


Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.

Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP.

Blood. 2016 Jun 2;127(22):2751-62. doi: 10.1182/blood-2015-09-670703. Epub 2016 Feb 26.


Individual bile acids have differential effects on bile acid signaling in mice.

Song P, Rockwell CE, Cui JY, Klaassen CD.

Toxicol Appl Pharmacol. 2015 Feb 15;283(1):57-64. doi: 10.1016/j.taap.2014.12.005. Epub 2015 Jan 9.


The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells.

Turley AE, Zagorski JW, Rockwell CE.

Cytokine. 2015 Feb;71(2):289-95. doi: 10.1016/j.cyto.2014.11.006. Epub 2014 Dec 5.


Enhanced allergic airway disease in old mice is associated with a Th17 response.

Brandenberger C, Li N, Jackson-Humbles DN, Rockwell CE, Wagner JG, Harkema JR.

Clin Exp Allergy. 2014 Oct;44(10):1282-92. doi: 10.1111/cea.12388.


Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo.

Lopez M, Kopec AK, Joshi N, Geddings JE, Cline H, Towery KL, Rockwell CE, Mackman N, Luyendyk JP.

Toxicol Sci. 2014 Oct;141(2):453-64. doi: 10.1093/toxsci/kfu139. Epub 2014 Jul 11.


Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.

Mochizuki A, Pace A, Rockwell CE, Roth KJ, Chow A, O'Brien KM, Albee R, Kelly K, Towery K, Luyendyk JP, Copple BL.

J Immunol. 2014 Apr 15;192(8):3847-3857. doi: 10.4049/jimmunol.1303195. Epub 2014 Mar 17.


IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis.

O'Brien KM, Allen KM, Rockwell CE, Towery K, Luyendyk JP, Copple BL.

Am J Pathol. 2013 Nov;183(5):1498-1507. doi: 10.1016/j.ajpath.2013.07.019. Epub 2013 Sep 5.


The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells.

Zagorski JW, Turley AE, Dover HE, VanDenBerg KR, Compton JR, Rockwell CE.

Toxicol Sci. 2013 Nov;136(1):63-71. doi: 10.1093/toxsci/kft172. Epub 2013 Aug 14.


Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice.

Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD.

Clin Exp Pharmacol. 2013;Suppl 4. pii: S4-002.


A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes.

Rockwell CE, Monaco JJ, Qureshi N.

Pharmacology. 2012;89(3-4):117-26. doi: 10.1159/000336335. Epub 2012 Mar 7.


Th2 skewing by activation of Nrf2 in CD4(+) T cells.

Rockwell CE, Zhang M, Fields PE, Klaassen CD.

J Immunol. 2012 Feb 15;188(4):1630-7. doi: 10.4049/jimmunol.1101712. Epub 2012 Jan 16.


Effect of bile duct ligation on bile acid composition in mouse serum and liver.

Zhang Y, Hong JY, Rockwell CE, Copple BL, Jaeschke H, Klaassen CD.

Liver Int. 2012 Jan;32(1):58-69. doi: 10.1111/j.1478-3231.2011.02662.x. Epub 2011 Oct 17.


Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.

Kassel KM, Owens AP 3rd, Rockwell CE, Sullivan BP, Wang R, Tawfik O, Li G, Guo GL, Mackman N, Luyendyk JP.

Am J Pathol. 2011 Nov;179(5):2278-89. doi: 10.1016/j.ajpath.2011.07.015. Epub 2011 Sep 9.


ChIPing the cistrome of PXR in mouse liver.

Cui JY, Gunewardena SS, Rockwell CE, Klaassen CD.

Nucleic Acids Res. 2010 Dec;38(22):7943-63. doi: 10.1093/nar/gkq654. Epub 2010 Aug 6.


Lipid A-mediated tolerance and cancer therapy.

Rockwell CE, Morrison DC, Qureshi N.

Adv Exp Med Biol. 2010;667:81-99. doi: 10.1007/978-1-4419-1603-7_8.


Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautou JE, Klaassen CD.

J Pharmacol Exp Ther. 2010 Oct;335(1):2-12. doi: 10.1124/jpet.110.170084. Epub 2010 Jul 6.


Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes.

Rockwell CE, Qureshi N.

Cytokine. 2010 Jul;51(1):12-7. doi: 10.1016/j.cyto.2010.03.018. Epub 2010 Apr 27.


A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model.

Reis J, Tan X, Yang R, Rockwell CE, Papasian CJ, Vogel SN, Morrison DC, Qureshi AA, Qureshi N.

Innate Immun. 2008 Oct;14(5):319-29. doi: 10.1177/1753425908096855.


A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells.

Rockwell CE, Raman P, Kaplan BL, Kaminski NE.

Biochem Pharmacol. 2008 Aug 1;76(3):353-61. doi: 10.1016/j.bcp.2008.05.005. Epub 2008 May 9.


Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2.

Rockwell CE, Snider NT, Thompson JT, Vanden Heuvel JP, Kaminski NE.

Mol Pharmacol. 2006 Jul;70(1):101-11. Epub 2006 Apr 12.


2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2.

Kaplan BL, Ouyang Y, Rockwell CE, Rao GK, Kaminski NE.

J Leukoc Biol. 2005 Jun;77(6):966-74. Epub 2005 Mar 17.


A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes.

Rockwell CE, Kaminski NE.

J Pharmacol Exp Ther. 2004 Nov;311(2):683-90. Epub 2004 Jul 29.


Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes.

Kaplan BL, Rockwell CE, Kaminski NE.

J Pharmacol Exp Ther. 2003 Sep;306(3):1077-85. Epub 2003 Jun 12.


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