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Items: 1 to 50 of 193

1.

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.

Kim J, Grotegut CA, Wisler JW, Li T, Mao L, Chen M, Chen W, Rosenberg PB, Rockman HA, Lefkowitz RJ.

Skelet Muscle. 2018 Dec 27;8(1):39. doi: 10.1186/s13395-018-0184-8.

2.

The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.

Yu SM, Jean-Charles PY, Abraham DM, Kaur S, Gareri C, Mao L, Rockman HA, Shenoy SK.

J Biol Chem. 2019 Feb 15;294(7):2500-2518. doi: 10.1074/jbc.RA118.004926. Epub 2018 Dec 11.

3.

G-Protein-Coupled Receptors in Heart Disease.

Wang J, Gareri C, Rockman HA.

Circ Res. 2018 Aug 31;123(6):716-735. doi: 10.1161/CIRCRESAHA.118.311403. Erratum in: Circ Res. 2018 Oct 26;123(10):e34.

PMID:
30355236
4.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7650. doi: 10.1126/scisignal.aat7650.

PMID:
30254056
5.

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.

Abraham DM, Lee TE, Watson LJ, Mao L, Chandok G, Wang HG, Frangakis S, Pitt GS, Shah SH, Wolf MJ, Rockman HA.

J Clin Invest. 2018 Nov 1;128(11):4843-4855. doi: 10.1172/JCI95945. Epub 2018 Oct 2.

6.

Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.

Wisler JW, Rockman HA, Lefkowitz RJ.

Circulation. 2018 May 29;137(22):2315-2317. doi: 10.1161/CIRCULATIONAHA.117.028194. No abstract available.

PMID:
29844068
7.

We're listening.

Rockman HA.

JCI Insight. 2018 Jan 25;3(2). pii: 99456. doi: 10.1172/jci.insight.99456. [Epub ahead of print] No abstract available.

8.

Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling.

Wang J, Hanada K, Gareri C, Rockman HA.

J Cell Biochem. 2018 Apr;119(4):3586-3597. doi: 10.1002/jcb.26552. Epub 2018 Jan 4.

9.

i is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.

Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA.

Nat Commun. 2017 Nov 22;8(1):1706. doi: 10.1038/s41467-017-01855-z.

10.

Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.

Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman HA, Shenoy SK.

JCI Insight. 2017 Sep 7;2(17). pii: 95998. doi: 10.1172/jci.insight.95998. [Epub ahead of print]

11.

לְדוֹר וָדוֹר.

Rockman HA.

J Clin Invest. 2017 Jun 1;127(6):2019-2020. doi: 10.1172/JCI94813. Epub 2017 Jun 1.

12.

A successful launch.

Rockman HA.

JCI Insight. 2017 Jan 26;2(2):e92800. doi: 10.1172/jci.insight.92800. No abstract available.

13.

β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.

Abraham DM, Davis RT 3rd, Warren CM, Mao L, Wolska BM, Solaro RJ, Rockman HA.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14426-14431. Epub 2016 Nov 28.

14.

Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation.

Watson LJ, Alexander KM, Mohan ML, Bowman AL, Mangmool S, Xiao K, Naga Prasad SV, Rockman HA.

Cell Signal. 2016 Oct;28(10):1580-92. doi: 10.1016/j.cellsig.2016.05.006. Epub 2016 May 8.

15.

G Protein-coupled Receptor Biased Agonism.

Hodavance SY, Gareri C, Torok RD, Rockman HA.

J Cardiovasc Pharmacol. 2016 Mar;67(3):193-202. doi: 10.1097/FJC.0000000000000356. Review.

16.

Pacemaker-induced transient asynchrony suppresses heart failure progression.

Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA.

Sci Transl Med. 2015 Dec 23;7(319):319ra207. doi: 10.1126/scitranslmed.aad2899.

17.

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.

Xu W, Barrientos T, Mao L, Rockman HA, Sauve AA, Andrews NC.

Cell Rep. 2015 Oct 20;13(3):533-545. doi: 10.1016/j.celrep.2015.09.023. Epub 2015 Oct 8.

18.

The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.

Wisler JW, Harris EM, Raisch M, Mao L, Kim J, Rockman HA, Lefkowitz RJ.

Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1516-27. doi: 10.1152/ajpheart.00291.2015. Epub 2015 Sep 14.

19.

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.

Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman HA.

Circulation. 2015 Jun 16;131(24):2120-30. doi: 10.1161/CIRCULATIONAHA.115.015687. Epub 2015 May 20.

20.

Happy birthday JCI.

Rockman HA.

J Clin Invest. 2014 Oct;124(10):4135-6. doi: 10.1172/JCI78708. Epub 2014 Oct 1.

21.

Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.

Tang W, Strachan RT, Lefkowitz RJ, Rockman HA.

J Biol Chem. 2014 Oct 10;289(41):28271-83. doi: 10.1074/jbc.M114.585067. Epub 2014 Aug 28.

22.

Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila.

Lee TE, Yu L, Wolf MJ, Rockman HA.

Genetics. 2014 Oct;198(2):591-603. doi: 10.1534/genetics.114.166777. Epub 2014 Jul 31.

23.

Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.

Ashton JR, Befera N, Clark D, Qi Y, Mao L, Rockman HA, Johnson GA, Badea CT.

Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):161-8. doi: 10.1002/cmmi.1557.

24.

Waste not, want not.

Rockman HA.

J Clin Invest. 2014 Feb;124(2):463. doi: 10.1172/JCI75011. Epub 2014 Feb 3.

25.

β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.

Kim IM, Wang Y, Park KM, Tang Y, Teoh JP, Vinson J, Traynham CJ, Pironti G, Mao L, Su H, Johnson JA, Koch WJ, Rockman HA.

Circ Res. 2014 Feb 28;114(5):833-44. doi: 10.1161/CIRCRESAHA.114.302766. Epub 2013 Dec 13.

26.

Normal cardiac function in mice with supraphysiological cardiac creatine levels.

Santacruz L, Hernandez A, Nienaber J, Mishra R, Pinilla M, Burchette J, Mao L, Rockman HA, Jacobs DO.

Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H373-81. doi: 10.1152/ajpheart.00411.2013. Epub 2013 Nov 22.

27.

Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.

Tang H, Xiao K, Mao L, Rockman HA, Marchuk DA.

J Mol Cell Cardiol. 2013 Jan;54:101-11. doi: 10.1016/j.yjmcc.2012.10.004. Epub 2012 Oct 16.

28.

β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.

Kim KS, Abraham D, Williams B, Violin JD, Mao L, Rockman HA.

Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H1001-10. doi: 10.1152/ajpheart.00475.2012. Epub 2012 Aug 10.

29.

p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.

Lee CL, Moding EJ, Cuneo KC, Li Y, Sullivan JM, Mao L, Washington I, Jeffords LB, Rodrigues RC, Ma Y, Das S, Kontos CD, Kim Y, Rockman HA, Kirsch DG.

Sci Signal. 2012 Jul 24;5(234):ra52. doi: 10.1126/scisignal.2002918.

30.

Animal models of heart failure: a scientific statement from the American Heart Association.

Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ; American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology.

Circ Res. 2012 Jun 22;111(1):131-50. doi: 10.1161/RES.0b013e3182582523. Epub 2012 May 17. Review. No abstract available. Erratum in: Circ Res. 2012 Jul 6;111(2):e54.

PMID:
22595296
31.

Great expectations.

Rockman HA.

J Clin Invest. 2012 Apr;122(4):1133. doi: 10.1172/JCI63462. Epub 2012 Apr 2.

32.

Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy.

Casad ME, Yu L, Daniels JP, Wolf MJ, Rockman HA.

Mol Genet Genomics. 2012 Apr;287(4):351-60. doi: 10.1007/s00438-012-0684-x. Epub 2012 Mar 8.

33.

Tradition, tradition.

Rockman HA.

J Clin Invest. 2012 Mar;122(3):785-6. doi: 10.1172/JCI63105. Epub 2012 Mar 1. No abstract available.

34.

Editorial position on publishing articles on human organ transplantation.

Caplan AL, Rockman HA, Turka LA.

J Clin Invest. 2012 Jan;122(1):2. doi: 10.1172/JCI61904. Epub 2012 Jan 3.

35.

Cardiovascular biology: heart fails without pump partner.

Shenoy SK, Rockman HA.

Nature. 2011 Sep 28;477(7366):546-7. doi: 10.1038/477546a. No abstract available.

PMID:
21956327
36.

Drosophila, genetic screens, and cardiac function.

Wolf MJ, Rockman HA.

Circ Res. 2011 Sep 16;109(7):794-806. doi: 10.1161/CIRCRESAHA.111.244897. Review.

37.

Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster.

Casad ME, Abraham D, Kim IM, Frangakis S, Dong B, Lin N, Wolf MJ, Rockman HA.

Genetics. 2011 Nov;189(3):861-70. doi: 10.1534/genetics.111.131482. Epub 2011 Sep 2.

38.

Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling.

Rockman HA, Lefkowitz RJ.

Circ Res. 2011 Jul 8;109(2):202-4. doi: 10.1161/CIRCRESAHA.110.231126. No abstract available.

39.

A method to measure myocardial calcium handling in adult Drosophila.

Lin N, Badie N, Yu L, Abraham D, Cheng H, Bursac N, Rockman HA, Wolf MJ.

Circ Res. 2011 May 27;108(11):1306-15. doi: 10.1161/CIRCRESAHA.110.238105. Epub 2011 Apr 14.

40.

β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.

Grotegut CA, Feng L, Mao L, Heine RP, Murtha AP, Rockman HA.

Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E468-77. doi: 10.1152/ajpendo.00390.2010. Epub 2010 Dec 7.

41.

Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.

Noor N, Patel CB, Rockman HA.

J Mol Cell Cardiol. 2011 Oct;51(4):534-41. doi: 10.1016/j.yjmcc.2010.11.005. Epub 2010 Nov 11. Review.

42.

Functional selectivity in adrenergic and angiotensin signaling systems.

Patel CB, Noor N, Rockman HA.

Mol Pharmacol. 2010 Dec;78(6):983-92. doi: 10.1124/mol.110.067066. Epub 2010 Sep 20. Review.

43.

beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.

Rakesh K, Yoo B, Kim IM, Salazar N, Kim KS, Rockman HA.

Sci Signal. 2010 Jun 8;3(125):ra46. doi: 10.1126/scisignal.2000769.

44.

Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.

Tilley DG, Nguyen AD, Rockman HA.

Biochem Biophys Res Commun. 2010 Jun 11;396(4):921-6. doi: 10.1016/j.bbrc.2010.05.023. Epub 2010 May 10.

45.

Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

Kim BE, Turski ML, Nose Y, Casad M, Rockman HA, Thiele DJ.

Cell Metab. 2010 May 5;11(5):353-63. doi: 10.1016/j.cmet.2010.04.003.

46.

beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.

Mangmool S, Shukla AK, Rockman HA.

J Cell Biol. 2010 May 3;189(3):573-87. doi: 10.1083/jcb.200911047. Epub 2010 Apr 26.

47.

Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.

Bucholz E, Ghaghada K, Qi Y, Mukundan S, Rockman HA, Johnson GA.

Magn Reson Med. 2010 Apr;63(4):979-87. doi: 10.1002/mrm.22259.

48.

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.

Kim IM, Wolf MJ, Rockman HA.

Circ Res. 2010 Apr 16;106(7):1233-43. doi: 10.1161/CIRCRESAHA.109.213785. Epub 2010 Mar 4.

49.

Drosophila melanogaster as a model system for genetics of postnatal cardiac function.

Wolf MJ, Rockman HA.

Drug Discov Today Dis Models. 2008 Oct 1;5(3):117-123.

50.

TRPC1 channels are critical for hypertrophic signaling in the heart.

Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn M, Abramowitz J, Rockman HA, Birnbaumer L, Rosenberg P.

Circ Res. 2009 Nov 6;105(10):1023-30. doi: 10.1161/CIRCRESAHA.109.206581. Epub 2009 Sep 24.

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