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Items: 16


The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology.

Rockel JS, Kapoor M.

Metabolites. 2018 Dec 13;8(4). pii: E92. doi: 10.3390/metabo8040092. Review.


microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints.

Nakamura A, Rampersaud YR, Nakamura S, Sharma A, Zeng F, Rossomacha E, Ali SA, Krawetz R, Haroon N, Perruccio AV, Mahomed NN, Gandhi R, Rockel JS, Kapoor M.

Ann Rheum Dis. 2019 Jan;78(1):111-121. doi: 10.1136/annrheumdis-2018-213629. Epub 2018 Oct 4.


A classification modeling approach for determining metabolite signatures in osteoarthritis.

Rockel JS, Zhang W, Shestopaloff K, Likhodii S, Sun G, Furey A, Randell E, Sundararajan K, Gandhi R, Zhai G, Kapoor M.

PLoS One. 2018 Jun 29;13(6):e0199618. doi: 10.1371/journal.pone.0199618. eCollection 2018.


High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature.

Datta P, Zhang Y, Parousis A, Sharma A, Rossomacha E, Endisha H, Wu B, Kacprzak I, Mahomed NN, Gandhi R, Rockel JS, Kapoor M.

Sci Rep. 2017 Aug 15;7(1):8205. doi: 10.1038/s41598-017-07963-6.


Autophagy: controlling cell fate in rheumatic diseases.

Rockel JS, Kapoor M.

Nat Rev Rheumatol. 2017 Mar;13(3):193. doi: 10.1038/nrrheum.2017.17. Epub 2017 Feb 9. No abstract available.


Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration.

Nakamura A, Rampersaud YR, Sharma A, Lewis SJ, Wu B, Datta P, Sundararajan K, Endisha H, Rossomacha E, Rockel JS, Jurisica I, Kapoor M.

JCI Insight. 2016 Aug 4;1(12):e86820.


Autophagy: controlling cell fate in rheumatic diseases.

Rockel JS, Kapoor M.

Nat Rev Rheumatol. 2016 Sep;12(9):517-31. doi: 10.1038/nrrheum.2016.92. Epub 2016 Jun 23. Review. Erratum in: Nat Rev Rheumatol. 2017 Mar;13(3):193.


Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.

Rockel JS, Yu C, Whetstone H, Craft AM, Reilly K, Ma H, Tsushima H, Puviindran V, Al-Jazrawe M, Keller GM, Alman BA.

J Clin Invest. 2016 May 2;126(5):1649-63. doi: 10.1172/JCI80205. Epub 2016 Mar 28.


Generation of articular chondrocytes from human pluripotent stem cells.

Craft AM, Rockel JS, Nartiss Y, Kandel RA, Alman BA, Keller GM.

Nat Biotechnol. 2015 Jun;33(6):638-45. doi: 10.10.38/nbt.3210. Epub 2015 May 11.


Specification of chondrocytes and cartilage tissues from embryonic stem cells.

Craft AM, Ahmed N, Rockel JS, Baht GS, Alman BA, Kandel RA, Grigoriadis AE, Keller GM.

Development. 2013 Jun;140(12):2597-610. doi: 10.1242/dev.087890.


Don't hedge your bets: hedgehog signaling as a central mediator of endochondral bone development and cartilage diseases.

Rockel JS, Alman BA.

J Orthop Res. 2011 Jun;29(6):810-5. doi: 10.1002/jor.21372. Epub 2011 Feb 9.


Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes.

Rockel JS, Grol M, Bernier SM, Leask A.

Matrix Biol. 2009 Jul;28(6):354-64. doi: 10.1016/j.matbio.2009.05.005. Epub 2009 Jun 6.


Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling.

Rockel JS, Bernier SM, Leask A.

Arthritis Res Ther. 2009;11(1):R8. doi: 10.1186/ar2595. Epub 2009 Jan 14.


Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes.

Woods A, Pala D, Kennedy L, McLean S, Rockel JS, Wang G, Leask A, Beier F.

Osteoarthritis Cartilage. 2009 Mar;17(3):406-13. doi: 10.1016/j.joca.2008.07.002. Epub 2008 Aug 29.


Regulation of Sox9 activity by crosstalk with nuclear factor-kappaB and retinoic acid receptors.

Rockel JS, Kudirka JC, Guzi AJ, Bernier SM.

Arthritis Res Ther. 2008;10(1):R3. doi: 10.1186/ar2349. Epub 2008 Jan 9.


The induction of CCN2 by TGFbeta1 involves Ets-1.

Van Beek JP, Kennedy L, Rockel JS, Bernier SM, Leask A.

Arthritis Res Ther. 2006;8(2):R36. Epub 2006 Jan 16.

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