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Items: 11

1.

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

Li X, Hernandez V, Rock FL, Choi W, Mak YSL, Mohan M, Mao W, Zhou Y, Easom EE, Plattner JJ, Zou W, Pérez-Herrán E, Giordano I, Mendoza-Losana A, Alemparte C, Rullas J, Angulo-Barturen I, Crouch S, Ortega F, Barros D, Alley MRK.

J Med Chem. 2017 Oct 12;60(19):8011-8026. doi: 10.1021/acs.jmedchem.7b00631. Epub 2017 Sep 27.

PMID:
28953378
2.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.

3.

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ.

Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7.

4.

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.

Xu H, Sullivan TJ, Sekiguchi J, Kirikae T, Ojima I, Stratton CF, Mao W, Rock FL, Alley MR, Johnson F, Walker SG, Tonge PJ.

Biochemistry. 2008 Apr 8;47(14):4228-36. doi: 10.1021/bi800023a. Epub 2008 Mar 13.

5.

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR.

Science. 2007 Jun 22;316(5832):1759-61.

6.

A family of human receptors structurally related to Drosophila Toll.

Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF.

Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):588-93.

7.

Molecular characterization and modular analysis of human MyD88.

Hardiman G, Rock FL, Balasubramanian S, Kastelein RA, Bazan JF.

Oncogene. 1996 Dec 5;13(11):2467-75.

PMID:
8957090
8.

Binding of leptin to the soluble ectodomain of recombinant leptin receptor: a kinetic analysis by surface plasmon resonance.

Rock FL, Peterson D, Weig BC, Kastelein RA, Bazan JF.

Horm Metab Res. 1996 Dec;28(12):748-50. No abstract available.

PMID:
9013756
9.

The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond.

Rock FL, Altmann SW, van Heek M, Kastelein RA, Bazan JF.

Horm Metab Res. 1996 Dec;28(12):649-52.

PMID:
9013735
10.

Expression and purification of a synthetic human obese gene product.

Altmann SW, Timans JC, Rock FL, Bazan JF, Kastelein RA.

Protein Expr Purif. 1995 Dec;6(6):722-6.

PMID:
8746623
11.

Roles of disulfide bonds in recombinant human interleukin 6 conformation.

Rock FL, Li X, Chong P, Ida N, Klein M.

Biochemistry. 1994 May 3;33(17):5146-54.

PMID:
8172889

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