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Items: 43


Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy.

Mcilroy GD, Mitchell SE, Han W, Delibegović M, Rochford JJ.

Dis Model Mech. 2020 Jan 17;13(1). pii: dmm042655. doi: 10.1242/dmm.042655.


The burden of metabolic syndrome on osteoarthritic joints.

Dickson BM, Roelofs AJ, Rochford JJ, Wilson HM, De Bari C.

Arthritis Res Ther. 2019 Dec 16;21(1):289. doi: 10.1186/s13075-019-2081-x. Review.


Discovering metabolic disease gene interactions by correlated effects on cellular morphology.

Jiao Y, Ahmed U, Sim MFM, Bejar A, Zhang X, Talukder MMU, Rice R, Flannick J, Podgornaia AI, Reilly DF, Engreitz JM, Kost-Alimova M, Hartland K, Mercader JM, Georges S, Wagh V, Tadin-Strapps M, Doench JG, Edwardson JM, Rochford JJ, Rosen ED, Majithia AR.

Mol Metab. 2019 Jun;24:108-119. doi: 10.1016/j.molmet.2019.03.001. Epub 2019 Mar 13.


Promethin Is a Conserved Seipin Partner Protein.

Castro IG, Eisenberg-Bord M, Persiani E, Rochford JJ, Schuldiner M, Bohnert M.

Cells. 2019 Mar 21;8(3). pii: E268. doi: 10.3390/cells8030268.


Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.

Mcilroy GD, Mitchell SE, Han W, Delibegović M, Rochford JJ.

Sci Rep. 2018 Dec 14;8(1):17863. doi: 10.1038/s41598-018-36078-9.


Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake.

D'Agostino G, Lyons D, Cristiano C, Lettieri M, Olarte-Sanchez C, Burke LK, Greenwald-Yarnell M, Cansell C, Doslikova B, Georgescu T, Martinez de Morentin PB, Myers MG Jr, Rochford JJ, Heisler LK.

Cell Metab. 2018 Oct 2;28(4):619-630.e5. doi: 10.1016/j.cmet.2018.07.017. Epub 2018 Aug 23.


Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease.

Mcilroy GD, Suchacki K, Roelofs AJ, Yang W, Fu Y, Bai B, Wallace RJ, De Bari C, Cawthorn WP, Han W, Delibegović M, Rochford JJ.

Mol Metab. 2018 Apr;10:55-65. doi: 10.1016/j.molmet.2018.01.019. Epub 2018 Jan 31.


Lorcaserin improves glycemic control via a melanocortin neurocircuit.

Burke LK, Ogunnowo-Bada E, Georgescu T, Cristiano C, de Morentin PBM, Valencia Torres L, D'Agostino G, Riches C, Heeley N, Ruan Y, Rubinstein M, Low MJ, Myers MG, Rochford JJ, Evans ML, Heisler LK.

Mol Metab. 2017 Oct;6(10):1092-1102. doi: 10.1016/j.molmet.2017.07.004. Epub 2017 Jul 21.


Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons.

Burke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, Martinez de Morentin PB, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS, Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, Low MJ, Rochford JJ, Myers MG, Evans ML, Heisler LK.

Mol Metab. 2016 Jan 22;5(3):245-252. doi: 10.1016/j.molmet.2016.01.005. eCollection 2016 Mar.


Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis.

Talukder MM, Sim MF, O'Rahilly S, Edwardson JM, Rochford JJ.

Mol Metab. 2015 Jan 6;4(3):199-209. doi: 10.1016/j.molmet.2014.12.013. eCollection 2015 Mar.


Mouse models of lipodystrophy and their significance in understanding fat regulation.

Rochford JJ.

Curr Top Dev Biol. 2014;109:53-96. doi: 10.1016/B978-0-12-397920-9.00005-6. Review.


Analyzing the functions and structure of the human lipodystrophy protein seipin.

Sim MF, Talukder MU, Dennis RJ, Edwardson JM, Rochford JJ.

Methods Enzymol. 2014;537:161-75. doi: 10.1016/B978-0-12-411619-1.00009-4.


γ-synuclein is a novel player in the control of body lipid metabolism.

Millership S, Ninkina N, Rochford JJ, Buchman VL.

Adipocyte. 2013 Oct 1;2(4):276-80. doi: 10.4161/adip.25162. Epub 2013 May 28.


Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms.

Sim MF, Talukder MM, Dennis RJ, O'Rahilly S, Edwardson JM, Rochford JJ.

Diabetologia. 2013 Nov;56(11):2498-506. doi: 10.1007/s00125-013-3029-3. Epub 2013 Aug 30.


Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis.

Lowe CE, Zhang Q, Dennis RJ, Aubry EM, O'Rahilly S, Wakelam MJ, Rochford JJ.

Obesity (Silver Spring). 2013 Sep;21(9):1823-9. doi: 10.1002/oby.20297. Epub 2013 May 23.


Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2 : C48R: A Novel Mutation in AGPAT2.

Ramanathan N, Ahmed M, Raffan E, Stewart CL, O'Rahilly S, Semple RK, Raef H, Rochford JJ.

JIMD Rep. 2013;9:73-80. doi: 10.1007/8904_2012_181. Epub 2012 Oct 21. Erratum in: JIMD Rep. 2013;9:E3.


Erratum to: Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2 : C48R: A Novel Mutation in AGPAT2.

Ramanathan N, Ahmed M, Raffan E, Stewart CL, O'Rahilly S, Semple RK, Raef H, Rochford JJ.

JIMD Rep. 2013;9:E3. doi: 10.1007/978-3-642-35518-9_196. Epub 2012 Aug 21. No abstract available.


Increased lipolysis and altered lipid homeostasis protect γ-synuclein-null mutant mice from diet-induced obesity.

Millership S, Ninkina N, Guschina IA, Norton J, Brambilla R, Oort PJ, Adams SH, Dennis RJ, Voshol PJ, Rochford JJ, Buchman VL.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20943-8. doi: 10.1073/pnas.1210022110. Epub 2012 Dec 3. Erratum in: Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5269. Brambilla, Ricardo [corrected to Brambilla, Riccardo].


Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain.

Garfield AS, Chan WS, Dennis RJ, Ito D, Heisler LK, Rochford JJ.

PLoS One. 2012;7(9):e45790. doi: 10.1371/journal.pone.0045790. Epub 2012 Sep 25.


The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1.

Sim MF, Dennis RJ, Aubry EM, Ramanathan N, Sembongi H, Saudek V, Ito D, O'Rahilly S, Siniossoglou S, Rochford JJ.

Mol Metab. 2012 Dec 26;2(1):38-46. doi: 10.1016/j.molmet.2012.11.002. eCollection 2012.


Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis.

Lowe CE, Dennis RJ, Obi U, O'Rahilly S, Rochford JJ.

Int J Obes (Lond). 2012 Sep;36(9):1248-51. doi: 10.1038/ijo.2011.233. Epub 2011 Nov 29.


Setting the tone: reactive oxygen species and the control of appetitive melanocortin neurons.

Rochford JJ, Myers MG Jr, Heisler LK.

Cell Metab. 2011 Nov 2;14(5):573-4. doi: 10.1016/j.cmet.2011.10.004.


Adipogenesis at a glance.

Lowe CE, O'Rahilly S, Rochford JJ.

J Cell Sci. 2011 Aug 15;124(Pt 16):2681-6. doi: 10.1242/jcs.079699. Review. No abstract available. Erratum in: J Cell Sci. 2011 Nov 1;124(Pt 21):3726.


Lipodystrophy: metabolic insights from a rare disorder.

Huang-Doran I, Sleigh A, Rochford JJ, O'Rahilly S, Savage DB.

J Endocrinol. 2010 Dec;207(3):245-55. doi: 10.1677/JOE-10-0272. Epub 2010 Sep 24. Review.


Molecular mechanisms controlling human adipose tissue development: insights from monogenic lipodystrophies.

Rochford JJ.

Expert Rev Mol Med. 2010 Aug 2;12:e24. doi: 10.1017/S1462399410001547. Review.


Analysis of TBC1D4 in patients with severe insulin resistance.

Dash S, Langenberg C, Fawcett KA, Semple RK, Romeo S, Sharp S, Sano H, Lienhard GE, Rochford JJ, Howlett T, Massoud AF, Hindmarsh P, Howell SJ, Wilkinson RJ, Lyssenko V, Groop L, Baroni MG, Barroso I, Wareham NJ, O'Rahilly S, Savage DB.

Diabetologia. 2010 Jun;53(6):1239-42. doi: 10.1007/s00125-010-1724-x. Epub 2010 Mar 27. No abstract available.


C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis.

Payne VA, Au WS, Lowe CE, Rahman SM, Friedman JE, O'Rahilly S, Rochford JJ.

Biochem J. 2009 Dec 14;425(1):215-23. doi: 10.1042/BJ20091112.


A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CS, Soos MA, Clark J, Rodin A, Langenberg C, Druet C, Fawcett KA, Tung YC, Wareham NJ, Barroso I, Lienhard GE, O'Rahilly S, Savage DB.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9350-5. doi: 10.1073/pnas.0900909106. Epub 2009 May 22.


Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.

Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S.

J Biol Chem. 2008 Oct 24;283(43):29166-74. doi: 10.1074/jbc.M804278200. Epub 2008 Aug 11.


The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation.

Payne VA, Grimsey N, Tuthill A, Virtue S, Gray SL, Dalla Nora E, Semple RK, O'Rahilly S, Rochford JJ.

Diabetes. 2008 Aug;57(8):2055-60. doi: 10.2337/db08-0184. Epub 2008 May 5.


The NR4A family of orphan nuclear receptors are not required for adipogenesis.

Au WS, Payne VA, O'Rahilly S, Rochford JJ.

Int J Obes (Lond). 2008 Feb;32(2):388-92. Epub 2007 Dec 11.


Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK.

Endocrinology. 2008 Mar;149(3):1323-8. Epub 2007 Nov 26.


Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways.

Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, Oksanen LJ, Thornton-Jones ZD, Clifton PG, Yueh CY, Evans ML, McCrimmon RJ, Elmquist JK, Butler AA, Heisler LK.

Cell Metab. 2007 Nov;6(5):398-405.


Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis.

Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ.

J Biol Chem. 2007 Jul 20;282(29):21005-14. Epub 2007 May 14.


ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis.

Rochford JJ, Semple RK, Laudes M, Boyle KB, Christodoulides C, Mulligan C, Lelliott CJ, Schinner S, Hadaschik D, Mahadevan M, Sethi JK, Vidal-Puig A, O'Rahilly S.

Mol Cell Biol. 2004 Nov;24(22):9863-72.


A family with severe insulin resistance and diabetes due to a mutation in AKT2.

George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, Dunger DB, Barford D, Umpleby AM, Wareham NJ, Davies HA, Schafer AJ, Stoffel M, O'Rahilly S, Barroso I.

Science. 2004 May 28;304(5675):1325-8.


Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700. Epub 2004 Mar 15.


Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis.

Laudes M, Christodoulides C, Sewter C, Rochford JJ, Considine RV, Sethi JK, Vidal-Puig A, O'Rahilly S.

J Biol Chem. 2004 Mar 19;279(12):11711-8. Epub 2003 Dec 30.


Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways.

Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, Van Obberghen E.

J Biol Chem. 2000 Jul 14;275(28):21695-702.


Control of glycogen synthesis in cultured human muscle cells.

Halse R, Rochford JJ, McCormack JG, Vandenheede JR, Hemmings BA, Yeaman SJ.

J Biol Chem. 1999 Jan 8;274(2):776-80.


Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes.

Peak M, Rochford JJ, Borthwick AC, Yeaman SJ, Agius L.

Diabetologia. 1998 Jan;41(1):16-25.


Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis.

Hurel SJ, Rochford JJ, Borthwick AC, Wells AM, Vandenheede JR, Turnbull DM, Yeaman SJ.

Biochem J. 1996 Dec 15;320 ( Pt 3):871-7.


Inhibition of glycogen synthase kinase-3 by insulin in cultured human skeletal muscle myoblasts.

Borthwick AC, Wells AM, Rochford JJ, Hurel SJ, Turnbull DM, Yeaman SJ.

Biochem Biophys Res Commun. 1995 May 25;210(3):738-45.


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