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Assembly of α-synuclein aggregates on phospholipid bilayers.

Lv Z, Hashemi M, Banerjee S, Zagorski K, Rochet JC, Lyubchenko YL.

Biochim Biophys Acta Proteins Proteom. 2019 Sep;1867(9):802-812. doi: 10.1016/j.bbapap.2019.06.006. Epub 2019 Jun 19.


Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease.

Sanyal A, Dutta S, Camara A, Chandran A, Koller A, Watson BG, Sengupta R, Ysselstein D, Montenegro P, Cannon J, Rochet JC, Mattoo S.

J Mol Biol. 2019 May 31;431(12):2266-2282. doi: 10.1016/j.jmb.2019.04.026. Epub 2019 Apr 27.


Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease.

Ambaw A, Zheng L, Tambe MA, Strathearn KE, Acosta G, Hubers SA, Liu F, Herr SA, Tang J, Truong A, Walls E, Pond A, Rochet JC, Shi R.

Mol Cell Neurosci. 2018 Apr;88:70-82. doi: 10.1016/j.mcn.2018.01.006. Epub 2018 Feb 3.


Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.

Cruz-Hernandez A, Agim ZS, Montenegro PC, McCabe GP, Rochet JC, Cannon JR.

Neurotoxicology. 2018 Mar;65:68-84. doi: 10.1016/j.neuro.2018.01.009.


β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR.

Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934.


Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.

Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL.

Neurobiol Dis. 2017 Oct;106:191-204. doi: 10.1016/j.nbd.2017.07.007. Epub 2017 Jul 12.


A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces.

Banerjee S, Hashemi M, Lv Z, Maity S, Rochet JC, Lyubchenko YL.

Sci Rep. 2017 Mar 30;7:45592. doi: 10.1038/srep45592.


Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms.

de Rus Jacquet A, Timmers M, Ma SY, Thieme A, McCabe GP, Vest JHC, Lila MA, Rochet JC.

J Ethnopharmacol. 2017 Jul 12;206:408-425. doi: 10.1016/j.jep.2017.02.021. Epub 2017 Feb 15.


Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms.

de Rus Jacquet A, Tambe MA, Ma SY, McCabe GP, Vest JHC, Rochet JC.

J Ethnopharmacol. 2017 Jul 12;206:393-407. doi: 10.1016/j.jep.2017.01.001. Epub 2017 Jan 11.


Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.

Ysselstein D, Dehay B, Costantino IM, McCabe GP, Frosch MP, George JM, Bezard E, Rochet JC.

Acta Neuropathol Commun. 2017 Jan 10;5(1):3. doi: 10.1186/s40478-016-0403-7.


Printed optics: phantoms for quantitative deep tissue fluorescence imaging: publisher's note.

Bentz BZ, Bowen AG, Lin D, Ysselstein D, Huston DH, Rochet JC, Webb KJ.

Opt Lett. 2016 Dec 1;41(23):5575. doi: 10.1364/OL.41.005575.


Printed optics: phantoms for quantitative deep tissue fluorescence imaging.

Bentz BZ, Bowen AG, Lin D, Ysselstein D, Huston DH, Rochet JC, Webb KJ.

Opt Lett. 2016 Nov 15;41(22):5230-5233. doi: 10.1364/OL.41.005230.


Effect of acidic pH on the stability of α-synuclein dimers.

Lv Z, Krasnoslobodtsev AV, Zhang Y, Ysselstein D, Rochet JC, Blanchard SC, Lyubchenko YL.

Biopolymers. 2016 Oct;105(10):715-24. doi: 10.1002/bip.22874.


Expression and Transport of α-Synuclein at the Blood-Cerebrospinal Fluid Barrier and Effects of Manganese Exposure.

Bates CA, Fu S, Ysselstein D, Rochet JC, Zheng W.

ADMET DMPK. 2015;3(1):15-33. Epub 2015 Mar 31.


Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process.

Tsai CJ, Aslam K, Drendel HM, Asiago JM, Goode KM, Paul LN, Rochet JC, Hazbun TR.

J Biol Chem. 2015 Oct 9;290(41):24816-34. doi: 10.1074/jbc.M115.678367. Epub 2015 Aug 25.


Cu(II) promotes amyloid pore formation.

Zhang H, Rochet JC, Stanciu LA.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):342-7. doi: 10.1016/j.bbrc.2015.06.156. Epub 2015 Jun 28.


Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity.

Ysselstein D, Joshi M, Mishra V, Griggs AM, Asiago JM, McCabe GP, Stanciu LA, Post CB, Rochet JC.

Neurobiol Dis. 2015 Jul;79:150-63. doi: 10.1016/j.nbd.2015.04.007. Epub 2015 Apr 27.


Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis.

Lv Z, Krasnoslobodtsev AV, Zhang Y, Ysselstein D, Rochet JC, Blanchard SC, Lyubchenko YL.

Biophys J. 2015 Apr 21;108(8):2038-47. doi: 10.1016/j.bpj.2015.03.010.


Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.

Anandhan A, Rodriguez-Rocha H, Bohovych I, Griggs AM, Zavala-Flores L, Reyes-Reyes EM, Seravalli J, Stanciu LA, Lee J, Rochet JC, Khalimonchuk O, Franco R.

Neurobiol Dis. 2015 Sep;81:76-92. doi: 10.1016/j.nbd.2014.11.018. Epub 2014 Dec 8.


Combined holography and thermography in a single sensor through image-plane holography at thermal infrared wavelengths.

Georges MP, Vandenrijt JF, Thizy C, Alexeenko I, Pedrini G, Vollheim B, Lopez I, Jorge I, Rochet J, Osten W.

Opt Express. 2014 Oct 20;22(21):25517-29. doi: 10.1364/OE.22.025517.


Detection of the amoeba Entamoeba gingivalis in periodontal pockets.

Bonner M, Amard V, Bar-Pinatel C, Charpentier F, Chatard JM, Desmuyck Y, Ihler S, Rochet JP, Roux de La Tribouille V, Saladin L, Verdy M, Gironès N, Fresno M, Santi-Rocca J.

Parasite. 2014;21:30. doi: 10.1051/parasite/2014029. Epub 2014 Jul 2.


2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro.

Griggs AM, Agim ZS, Mishra VR, Tambe MA, Director-Myska AE, Turteltaub KW, McCabe GP, Rochet JC, Cannon JR.

Toxicol Sci. 2014 Jul;140(1):179-89. doi: 10.1093/toxsci/kfu060. Epub 2014 Apr 9. Erratum in: Toxicol Sci. 2014 Oct;141(2):560.


Nepalese traditional medicine and symptoms related to Parkinson's disease and other disorders: Patterns of the usage of plant resources along the Himalayan altitudinal range.

de Rus Jacquet A, Subedi R, Ghimire SK, Rochet JC.

J Ethnopharmacol. 2014 Apr 11;153(1):178-89. doi: 10.1016/j.jep.2014.02.016. Epub 2014 Feb 17.


Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.

Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, Callaway K, Anderson JP, Jobling MF, Buell AK, Yednock TA, Knowles TP, Vendruscolo M, Christodoulou J, Dobson CM, Schenk D, McConlogue L.

PLoS One. 2014 Feb 14;9(2):e87133. doi: 10.1371/journal.pone.0087133. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e99274.


Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease.

Strathearn KE, Yousef GG, Grace MH, Roy SL, Tambe MA, Ferruzzi MG, Wu QL, Simon JE, Lila MA, Rochet JC.

Brain Res. 2014 Mar 25;1555:60-77. doi: 10.1016/j.brainres.2014.01.047. Epub 2014 Feb 3.


Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S.

Science. 2013 Nov 22;342(6161):979-83. doi: 10.1126/science.1245321. Epub 2013 Oct 24.


α-Synuclein misfolding assessed with single molecule AFM force spectroscopy: effect of pathogenic mutations.

Krasnoslobodtsev AV, Volkov IL, Asiago JM, Hindupur J, Rochet JC, Lyubchenko YL.

Biochemistry. 2013 Oct 22;52(42):7377-86. doi: 10.1021/bi401037z. Epub 2013 Oct 10.


In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu(2+)-dependent aggregation pathway.

Zhang H, Griggs A, Rochet JC, Stanciu LA.

Biophys J. 2013 Jun 18;104(12):2706-13. doi: 10.1016/j.bpj.2013.04.050.


[The surgical treatment of pressure ulcers].

Gaucher S, Rochet JM.

Soins Gerontol. 2013 May-Jun;(101):30-3. French.


Reusable photocatalytic titanium dioxide-cellulose nanofiber films.

Snyder A, Bo Z, Moon R, Rochet JC, Stanciu L.

J Colloid Interface Sci. 2013 Jun 1;399:92-8. doi: 10.1016/j.jcis.2013.02.035. Epub 2013 Mar 6.


What determines Alnus-associated ectomycorrhizal community diversity and specificity? A comparison of host and habitat effects at a regional scale.

Roy M, Rochet J, Manzi S, Jargeat P, Gryta H, Moreau PA, Gardes M.

New Phytol. 2013 Jun;198(4):1228-38. doi: 10.1111/nph.12212. Epub 2013 Mar 15.


Severe adult burn survivors. What information about skin allografts?

Gaucher S, Duchange N, Jarraya M, Magne J, Rochet JM, Stéphanazzi J, Hervé C, Moutel G.

Cell Tissue Bank. 2013 Sep;14(3):505-10. doi: 10.1007/s10561-012-9350-0. Epub 2012 Nov 16.


What is the best support surface in prevention and treatment, as of 2012, for a patient at risk and/or suffering from pressure ulcer sore? Developing French guidelines for clinical practice.

Colin D, Rochet JM, Ribinik P, Barrois B, Passadori Y, Michel JM.

Ann Phys Rehabil Med. 2012 Oct;55(7):466-81. doi: 10.1016/ Epub 2012 Sep 7. Review. Erratum in: Ann Phys Rehabil Med. 2013 Feb;56(1):81.


New insights into lysosomal dysfunction in Parkinson’s disease: an emerging role for ATP13A2.

Rochet JC.

Mov Disord. 2012 Aug;27(9):1092. No abstract available.


Effect of spermidine on misfolding and interactions of alpha-synuclein.

Krasnoslobodtsev AV, Peng J, Asiago JM, Hindupur J, Rochet JC, Lyubchenko YL.

PLoS One. 2012;7(5):e38099. doi: 10.1371/journal.pone.0038099. Epub 2012 May 25.


Molecular insights into Parkinson's disease.

Rochet JC, Hay BA, Guo M.

Prog Mol Biol Transl Sci. 2012;107:125-88. doi: 10.1016/B978-0-12-385883-2.00011-4. Review.


Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1.

Madian AG, Hindupur J, Hulleman JD, Diaz-Maldonado N, Mishra VR, Guigard E, Kay CM, Rochet JC, Regnier FE.

Mol Cell Proteomics. 2012 Feb;11(2):M111.010892. doi: 10.1074/mcp.M111.010892. Epub 2011 Nov 21.


Membrane proteins in four acts: function precedes structure determination.

Cramer WA, Zakharov SD, Saif Hasan S, Zhang H, Baniulis D, Zhalnina MV, Soriano GM, Sharma O, Rochet JC, Ryan C, Whitelegge J, Kurisu G, Yamashita E.

Methods. 2011 Dec;55(4):415-20. doi: 10.1016/j.ymeth.2011.11.001. Epub 2011 Nov 10.


α-Synuclein-induced tubule formation in lipid bilayers.

Pandey AP, Haque F, Rochet JC, Hovis JS.

J Phys Chem B. 2011 May 19;115(19):5886-93. doi: 10.1021/jp1121917. Epub 2011 Apr 27.


Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

Cullen V, Sardi SP, Ng J, Xu YH, Sun Y, Tomlinson JJ, Kolodziej P, Kahn I, Saftig P, Woulfe J, Rochet JC, Glicksman MA, Cheng SH, Grabowski GA, Shihabuddin LS, Schlossmacher MG.

Ann Neurol. 2011 Jun;69(6):940-53. doi: 10.1002/ana.22400. Epub 2011 Apr 6.


Comparative phylogenies and host specialization in the alder ectomycorrhizal fungi Alnicola, Alpova and Lactarius (Basidiomycota) in Europe.

Rochet J, Moreau PA, Manzi S, Gardes M.

BMC Evol Biol. 2011 Feb 9;11:40. doi: 10.1186/1471-2148-11-40.


Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.

Dumitriu A, Pacheco CD, Wilk JB, Strathearn KE, Latourelle JC, Goldwurm S, Pezzoli G, Rochet JC, Lindquist S, Myers RH.

Hum Mol Genet. 2011 Apr 15;20(8):1478-87. doi: 10.1093/hmg/ddr026. Epub 2011 Jan 21.


PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR; Global PD Gene Expression (GPEX) Consortium.

Sci Transl Med. 2010 Oct 6;2(52):52ra73. doi: 10.1126/scitranslmed.3001059.


Adsorption of alpha-synuclein on lipid bilayers: modulating the structure and stability of protein assemblies.

Haque F, Pandey AP, Cambrea LR, Rochet JC, Hovis JS.

J Phys Chem B. 2010 Mar 25;114(11):4070-81. doi: 10.1021/jp1006704.


Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.

Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S.

Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208. doi: 10.1242/dmm.004267. Epub 2009 Dec 28.


Fabrication of ZnS nanoparticle chains on a protein template.

Padalkar S, Hulleman J, Kim SM, Tumkur T, Rochet JC, Stach E, Stanciu L.

J Nanopart Res. 2009 Nov 1;11(8):2031-2041.


[Supports to help the prevention and treatment of sores].

Masanovic MG, Roques C, Meaume S, Rochet JM.

Soins. 2009 Jan-Feb;(732):40-3. French. No abstract available.


Path dependence of three-phase or two-phase end points in fluid binary lipid mixtures.

Lamberson ER, Cambrea LR, Rochet JC, Hovis JS.

J Phys Chem B. 2009 Mar 19;113(11):3431-6. doi: 10.1021/jp810326w.


Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.

Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet JC, Lindquist S.

Nat Genet. 2009 Mar;41(3):308-15. doi: 10.1038/ng.300. Epub 2009 Feb 1.


Clustering of alpha-synuclein on supported lipid bilayers: role of anionic lipid, protein, and divalent ion concentration.

Pandey AP, Haque F, Rochet JC, Hovis JS.

Biophys J. 2009 Jan;96(2):540-51. doi: 10.1016/j.bpj.2008.10.011.

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