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The cysteine-rich domain of synaptosomal-associated protein of 23 kDa (SNAP-23) regulates its membrane association and regulated exocytosis from mast cells.

Agarwal V, Naskar P, Agasti S, Khurana GK, Vishwakarma P, Lynn AM, Roche PA, Puri N.

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1618-1633. doi: 10.1016/j.bbamcr.2019.06.015. Epub 2019 Jun 29.


Monitoring Protein Endocytosis and Recycling Using FACS-Based Assays.

Walseng E, Roche PA.

Methods Mol Biol. 2019;1988:279-288. doi: 10.1007/978-1-4939-9450-2_20.


Monitoring MHC-II Endocytosis and Recycling Using Cell-Surface Protein Biotinylation-Based Assays.

Cho KJ, Roche PA.

Methods Mol Biol. 2019;1988:271-277. doi: 10.1007/978-1-4939-9450-2_19.


Polydopamine encapsulation of fluorescent nanodiamonds for biomedical applications.

Jung HS, Cho KJ, Seol Y, Takagi Y, Dittmore A, Roche PA, Neuman KC.

Adv Funct Mater. 2018 Aug 15;28(33). pii: 1801252. doi: 10.1002/adfm.201801252. Epub 2018 Jun 20.


The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner.

Bhagwandin C, Ashbeck EL, Whalen M, Bandola-Simon J, Roche PA, Szajman A, Truong SM, Wertheim BC, Klimentidis YC, Ishido S, Renquist BJ, Lybarger L.

PLoS One. 2018 Oct 24;13(10):e0204898. doi: 10.1371/journal.pone.0204898. eCollection 2018.


Dysfunction of antigen processing and presentation by dendritic cells in cancer.

Bandola-Simon J, Roche PA.

Mol Immunol. 2019 Sep;113:31-37. doi: 10.1016/j.molimm.2018.03.025. Epub 2018 Apr 5.


Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.

Lei L, Bandola-Simon J, Roche PA.

J Biol Chem. 2018 Mar 16;293(11):3904-3912. doi: 10.1074/jbc.RA117.001322. Epub 2018 Feb 1.


A major isoform of the E3 ubiquitin ligase March-I in antigen-presenting cells has regulatory sequences within its gene.

Kaul S, Mittal SK, Roche PA.

J Biol Chem. 2018 Mar 23;293(12):4478-4485. doi: 10.1074/jbc.RA118.001775. Epub 2018 Jan 29.


Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis.

Klein O, Roded A, Zur N, Azouz NP, Pasternak O, Hirschberg K, Hammel I, Roche PA, Yatsu A, Fukuda M, Galli SJ, Sagi-Eisenberg R.

Sci Rep. 2017 Nov 10;7(1):15315. doi: 10.1038/s41598-017-15047-8.


Editorial Overview: Antigen Processing and Presentation; many fingers in many pies.

Cresswell P, Roche PA.

Curr Opin Immunol. 2017 Jun;46:v-vii. doi: 10.1016/j.coi.2017.07.002. Epub 2017 Jul 14. No abstract available.


Disruption of protein complexes containing protein phosphatase 2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells.

Da Q, Shaw T, Pradhan S, Roche PA, Cruz MA, Vijayan KV.

J Thromb Haemost. 2017 May;15(5):1032-1039. doi: 10.1111/jth.13671. Epub 2017 Apr 13.


Antigen Processing and Presentation Mechanisms in Myeloid Cells.

Roche PA, Cresswell P.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0008-2015. Review.


Transcutaneous Electrical Nerve Stimulation Improves Walking Performance in Patients With Intermittent Claudication.

Seenan C, McSwiggan S, Roche PA, Tan CW, Mercer T, Belch JJ.

J Cardiovasc Nurs. 2016 Jul-Aug;31(4):323-30. doi: 10.1097/JCN.0000000000000258.



Mittal SK, Cho KJ, Ishido S, Roche PA.

J Biol Chem. 2015 Nov 6;290(45):27158-67. doi: 10.1074/jbc.M115.682708. Epub 2015 Sep 25.


Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells.

Cho KJ, Walseng E, Ishido S, Roche PA.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10449-54. doi: 10.1073/pnas.1507981112. Epub 2015 Aug 3.


SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion.

Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, Evans CM, Guindani M, Roche PA, Rajagopal J, Chen J, Davis CW, Tuvim MJ, Dickey BF.

Biosci Rep. 2015 Apr 28;35(3). pii: e00220. doi: 10.1042/BSR20150004.


The ins and outs of MHC class II-mediated antigen processing and presentation.

Roche PA, Furuta K.

Nat Rev Immunol. 2015 Apr;15(4):203-16. doi: 10.1038/nri3818. Epub 2015 Feb 27. Review.


Expression of the SNARE protein SNAP-23 is essential for cell survival.

Kaul S, Mittal SK, Feigenbaum L, Kruhlak MJ, Roche PA.

PLoS One. 2015 Feb 23;10(2):e0118311. doi: 10.1371/journal.pone.0118311. eCollection 2015.


Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells.

Liu Z, Roche PA.

Front Physiol. 2015 Jan 30;6:1. doi: 10.3389/fphys.2015.00001. eCollection 2015. Review.


Suppression of antigen presentation by IL-10.

Mittal SK, Roche PA.

Curr Opin Immunol. 2015 Jun;34:22-7. doi: 10.1016/j.coi.2014.12.009. Epub 2015 Jan 16. Review.


MHC class II association with lipid rafts on the antigen presenting cell surface.

Anderson HA, Roche PA.

Biochim Biophys Acta. 2015 Apr;1853(4):775-80. doi: 10.1016/j.bbamcr.2014.09.019. Epub 2014 Sep 28. Review.


TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.

Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM.

Cell. 2014 Jul 31;158(3):506-21. doi: 10.1016/j.cell.2014.04.054.


Invariant chain-MHC class II complexes: always odd and never invariant.

Cresswell P, Roche PA.

Immunol Cell Biol. 2014 Jul;92(6):471-2. doi: 10.1038/icb.2014.36. Epub 2014 Apr 29. No abstract available.


Calpain-1 contributes to IgE-mediated mast cell activation.

Wu Z, Chen X, Liu F, Chen W, Wu P, Wieschhaus AJ, Chishti AH, Roche PA, Chen WM, Lin TJ.

J Immunol. 2014 Jun 1;192(11):5130-9. doi: 10.4049/jimmunol.1301677. Epub 2014 Apr 23.


Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination.

Cho KJ, Roche PA.

Front Immunol. 2013 Nov 13;4:369. doi: 10.3389/fimmu.2013.00369. Review.


Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation.

Furuta K, Walseng E, Roche PA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20188-93. doi: 10.1073/pnas.1312994110. Epub 2013 Nov 25.


Disruption of multivesicular body vesicles does not affect major histocompatibility complex (MHC) class II-peptide complex formation and antigen presentation by dendritic cells.

Bosch B, Berger AC, Khandelwal S, Heipertz EL, Scharf B, Santambrogio L, Roche PA.

J Biol Chem. 2013 Aug 23;288(34):24286-92. doi: 10.1074/jbc.M113.461996. Epub 2013 Jul 11.


IκB kinase phosphorylation of SNAP-23 controls platelet secretion.

Karim ZA, Zhang J, Banerjee M, Chicka MC, Al Hawas R, Hamilton TR, Roche PA, Whiteheart SW.

Blood. 2013 May 30;121(22):4567-74. doi: 10.1182/blood-2012-11-470468. Epub 2013 Apr 23.


Regulation of metabotropic glutamate receptor 7 (mGluR7) internalization and surface expression by Ser/Thr protein phosphatase 1.

Suh YH, Park JY, Park S, Jou I, Roche PA, Roche KW.

J Biol Chem. 2013 Jun 14;288(24):17544-51. doi: 10.1074/jbc.M112.439513. Epub 2013 Apr 23.


Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclusters.

Bosch B, Heipertz EL, Drake JR, Roche PA.

J Biol Chem. 2013 May 10;288(19):13236-42. doi: 10.1074/jbc.M112.442640. Epub 2013 Mar 26.


Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells.

Furuta K, Ishido S, Roche PA.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19380-5. doi: 10.1073/pnas.1213868109. Epub 2012 Nov 5.


Francisella tularensis elicits IL-10 via a PGE₂-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation.

Hunt D, Wilson JE, Weih KA, Ishido S, Harton JA, Roche PA, Drake JR.

PLoS One. 2012;7(5):e37330. doi: 10.1371/journal.pone.0037330. Epub 2012 May 17.


Talk of frustration in the narratives of people with chronic pain.

Dow CM, Roche PA, Ziebland S.

Chronic Illn. 2012 Sep;8(3):176-91. doi: 10.1177/1742395312443692. Epub 2012 Apr 2.


Modification of experimental, lower limb ischemic pain with transcutaneous electrical nerve stimulation.

Seenan C, Roche PA, Tan CW, Mercer T.

Clin J Pain. 2012 Oct;28(8):693-9. doi: 10.1097/AJP.0b013e318242fccb.


Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice.

Suh YH, Yoshimoto-Furusawa A, Weih KA, Tessarollo L, Roche KW, Mackem S, Roche PA.

PLoS One. 2011 Mar 29;6(3):e18444. doi: 10.1371/journal.pone.0018444.


Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells.

Walseng E, Furuta K, Bosch B, Weih KA, Matsuki Y, Bakke O, Ishido S, Roche PA.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20465-70. doi: 10.1073/pnas.1010990107. Epub 2010 Nov 8.


Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus.

Walseng E, Furuta K, Goldszmid RS, Weih KA, Sher A, Roche PA.

J Biol Chem. 2010 Dec 31;285(53):41749-54. doi: 10.1074/jbc.M110.157586. Epub 2010 Nov 3.


Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.

Khandelwal S, Roche PA.

J Biol Chem. 2010 Nov 12;285(46):35303-10. doi: 10.1074/jbc.M110.147793. Epub 2010 Sep 10.


Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.

Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T.

Blood. 2010 Nov 25;116(22):4395-403. doi: 10.1182/blood-2010-01-261503. Epub 2010 Jul 12.


Novel approach to probe subunit-specific contributions to N-methyl-D-aspartate (NMDA) receptor trafficking reveals a dominant role for NR2B in receptor recycling.

Tang TT, Badger JD 2nd, Roche PA, Roche KW.

J Biol Chem. 2010 Jul 2;285(27):20975-81. doi: 10.1074/jbc.M110.102210. Epub 2010 Apr 28.


A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking.

Suh YH, Terashima A, Petralia RS, Wenthold RJ, Isaac JT, Roche KW, Roche PA.

Nat Neurosci. 2010 Mar;13(3):338-43. doi: 10.1038/nn.2488. Epub 2010 Jan 31.


Ethical challenges encountered in genomic research.

Roche PA.

Circ Cardiovasc Genet. 2009 Jun;2(3):293-7. doi: 10.1161/CIRCGENETICS.108.846758. No abstract available.


Novel syntaxin 11 gene (STX11) mutation in three Argentinean patients with hemophagocytic lymphohistiocytosis.

Danielian S, Basile N, Rocco C, Prieto E, Rossi J, Barsotti D, Roche PA, Bernasconi A, Oleastro M, Zelazko M, Braier J.

J Clin Immunol. 2010 Mar;30(2):330-7. doi: 10.1007/s10875-009-9350-4. Epub 2009 Dec 5.


MHC class II transport at a glance.

Berger AC, Roche PA.

J Cell Sci. 2009 Jan 1;122(Pt 1):1-4. doi: 10.1242/jcs.035089. Review. No abstract available.


Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5.

Lee JH, Lee J, Choi KY, Hepp R, Lee JY, Lim MK, Chatani-Hinze M, Roche PA, Kim DG, Ahn YS, Kim CH, Roche KW.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12575-80. doi: 10.1073/pnas.0712033105. Epub 2008 Aug 20.


Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.

Suh YH, Pelkey KA, Lavezzari G, Roche PA, Huganir RL, McBain CJ, Roche KW.

Neuron. 2008 Jun 12;58(5):736-48. doi: 10.1016/j.neuron.2008.03.028.


Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathway.

Walseng E, Bakke O, Roche PA.

J Biol Chem. 2008 May 23;283(21):14717-27. doi: 10.1074/jbc.M801070200. Epub 2008 Mar 31.


Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms.

Puri N, Roche PA.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2580-5. doi: 10.1073/pnas.0707854105. Epub 2008 Feb 4.


Detection theory analysis of scaling and discrimination tasks: responses to noxious thermal stimuli.

Tan CW, Palmer ST, Martin DJ, Roche PA.

Percept Psychophys. 2007 Aug;69(6):994-1001.


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