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[When everything is frozen, start moving again: the FIT@CHUV program].

Armengaud JB, Vaucher S, Roche O, Dahner L, Tarditi B, Luisier M, Hodot C, Mercier AA, Deppen A, Ambresin AE.

Rev Med Suisse. 2019 Jun 19;15(656):1276-1280. French.


Use of morselized allografts for acetabular reconstruction during THA revision: French multicenter study of 508 cases with 8 years' average follow-up.

Erivan R, Matthieu PA, Boyer B, Reina N, Rhame M, Rouchy RC, Moreau S, Sanchez T, Roche O, Caton J, Rouvillain JL, Missenard G, Ramdane N, Mulliez A, Descamps S, Boisgard S; French Society of Orthopedic and Traumatological Surgery (SoFCOT).

Orthop Traumatol Surg Res. 2019 Sep;105(5):957-966. doi: 10.1016/j.otsr.2019.02.025. Epub 2019 May 27.


P53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy.

Fernández-Aroca DM, Roche O, Sabater S, Pascual-Serra R, Ortega-Muelas M, Sánchez Pérez I, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R.

Cancer Lett. 2019 Jun 1;451:23-33. doi: 10.1016/j.canlet.2019.02.049. Epub 2019 Mar 11.


HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.

Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J.

Cell Rep. 2019 Feb 26;26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106.


Blockage of autophagic flux is associated with lymphocytosis and higher percentage of tumoral cells in chronic lymphocytic leukemia of B cells.

Romero-Macías JR, Pascual-Serra R, Roche O, Ruiz-Marcos F, Serrano-Martínez A, González-Aguado P, Belandia B, Ruiz-Hidalgo MJ, Sánchez-Prieto R.

Clin Transl Oncol. 2019 Sep;21(9):1280-1285. doi: 10.1007/s12094-019-02041-x. Epub 2019 Jan 24.


Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion.

Serrano-Oviedo L, Ortega-Muelas M, García-Cano J, Valero ML, Cimas FJ, Pascual-Serra R, Fernandez-Aroca DM, Roche O, Ruiz-Hidalgo MJ, Belandia B, Giménez-Bachs JM, Salinas AS, Sanchez-Prieto R.

PLoS One. 2018 Jul 26;13(7):e0200878. doi: 10.1371/journal.pone.0200878. eCollection 2018.


Study of mitochondrial function in placental insufficiency.

Lefebvre T, Roche O, Seegers V, Cherif M, Khiati S, Gueguen N, Desquiret-Dumas V, Geffroy G, Blanchet O, Reynier P, Legendre G, Lenaers G, Procaccio V, Gascoin G.

Placenta. 2018 Jul;67:1-7. doi: 10.1016/j.placenta.2018.05.007. Epub 2018 May 17.


Hypoxia-Inducible Factor 2-Dependent Pathways Driving Von Hippel-Lindau-Deficient Renal Cancer.

Meléndez-Rodríguez F, Roche O, Sanchez-Prieto R, Aragones J.

Front Oncol. 2018 Jun 8;8:214. doi: 10.3389/fonc.2018.00214. eCollection 2018. Review.


[Together we are stronger: management of complex functional disorders during adolescence].

Ambresin AE, Deppen A, Hofer M, Dahner L, Roche O, Huguenin Dezot M, Beltrami D, Nouvellet P, Armengaud JB.

Rev Med Suisse. 2018 Apr 18;14(603):839-842. French.


Assessment of a press-fit proximal femoral modular reconstruction implant (PFMR®) at 14.5 years. A 48-case series with a disturbing rate of implant fracture.

Dumoulin Q, Sabau S, Goetzmann T, Jacquot A, Sirveaux F, Mole D, Roche O.

Orthop Traumatol Surg Res. 2018 May;104(3):317-323. doi: 10.1016/j.otsr.2017.11.024. Epub 2018 Feb 21.


Global radiological score for femoral cementless revision stem.

Canovas F, Putman S, Girard J, Roche O, Bonnomet F, Le Béguec P.

Int Orthop. 2018 May;42(5):1007-1013. doi: 10.1007/s00264-017-3654-4. Epub 2017 Oct 7.


E1a is an exogenous in vivo tumour suppressor.

Cimas FJ, Callejas-Valera JL, García-Olmo DC, Hernández-Losa J, Melgar-Rojas P, Ruiz-Hidalgo MJ, Pascual-Serra R, Ortega-Muelas M, Roche O, Marcos P, Garcia-Gil E, Fernandez-Aroca DM, Ramón Y Cajal S, Gutkind JS, Sanchez-Prieto R.

Cancer Lett. 2017 Jul 28;399:74-81. doi: 10.1016/j.canlet.2017.04.010. Epub 2017 Apr 15.


Evaluation of the efficiency of hydroxychloroquine in treating children with immune thrombocytopenia (ITP).

Roche O, Aladjidi N, Rakotonjanahary J, Leverger G, Leblanc T, Thomas C, Pasquet M, Courcoux MF, Bayart S, Gilibert-Yvert M, Neven B, Quartier P, Pellier I.

Am J Hematol. 2017 May;92(5):E79-E81. doi: 10.1002/ajh.24698. No abstract available.


Relevance of Identifying JAG1 Mutations in Patients With Isolated Posterior Embryotoxon.

Orssaud C, Robert MP, Roche O.

J Glaucoma. 2016 Dec;25(12):923-925.


Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia.

Roche O, Deguiz ML, Tiana M, Galiana-Ribote C, Martinez-Alcazar D, Rey-Serra C, Ranz-Ribeiro B, Casitas R, Galera R, Fernández-Navarro I, Sánchez-Cuéllar S, Bernard V, Ancochea J, Wasserman WW, García-Rio F, Jimenez B, Del Peso L.

Nucleic Acids Res. 2016 Nov 2;44(19):9315-9330. Epub 2016 Sep 12.


Recurrent lacrimal gland choristoma of the ciliary body in an infant mimicking a medulloepithelioma.

Tauziède-Espariat A, Roche O, Dufier JL, Putterman M.

Eur J Ophthalmol. 2016 Nov 4;26(6):e145-e148. doi: 10.5301/ejo.5000798.


Patient selection does not improve the success rate of infected TKA one stage exchange.

Jenny JY, Barbe B, Cazenave A, Roche O, Massin P; French Society for Hip and Knee Surgery (SFHG).

Knee. 2016 Dec;23(6):1012-1015. doi: 10.1016/j.knee.2016.09.002. Epub 2016 Oct 4.


Developments in imaging methods used in hip arthroplasty: A diagnostic algorithm.

Blum A, Gondim-Teixeira P, Gabiache E, Roche O, Sirveaux F, Olivier P, Coudane H; Nancy Association for Prosthesis Exploration (NAPE), Raymond A, Louis M, Grandhaye M, Meyer JB, Mainard D, Molé D.

Diagn Interv Imaging. 2016 Jul-Aug;97(7-8):735-47. doi: 10.1016/j.diii.2016.07.001. Epub 2016 Jul 22.


p38MAPK and Chemotherapy: We Always Need to Hear Both Sides of the Story.

García-Cano J, Roche O, Cimas FJ, Pascual-Serra R, Ortega-Muelas M, Fernández-Aroca DM, Sánchez-Prieto R.

Front Cell Dev Biol. 2016 Jun 30;4:69. doi: 10.3389/fcell.2016.00069. eCollection 2016. Review.


Influence of fixation with two vs. three screws on union of arthroscopic tibio-talar arthrodesis: Comparative radiographic study of 111 cases.

Goetzmann T, Molé D, Jullion S, Roche O, Sirveaux F, Jacquot A.

Orthop Traumatol Surg Res. 2016 Sep;102(5):651-6. doi: 10.1016/j.otsr.2016.03.015. Epub 2016 May 12.


Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome.

Gerber S, Alzayady KJ, Burglen L, Brémond-Gignac D, Marchesin V, Roche O, Rio M, Funalot B, Calmon R, Durr A, Gil-da-Silva-Lopes VL, Ribeiro Bittar MF, Orssaud C, Héron B, Ayoub E, Berquin P, Bahi-Buisson N, Bole C, Masson C, Munnich A, Simons M, Delous M, Dollfus H, Boddaert N, Lyonnet S, Kaplan J, Calvas P, Yule DI, Rozet JM, Fares Taie L.

Am J Hum Genet. 2016 May 5;98(5):971-980. doi: 10.1016/j.ajhg.2016.03.004. Epub 2016 Apr 21.


Two-stage total hip arthroplasty for complex pelvic abnormalities: Example of hip arthrodesis conversion with concomitant treatment of pelvic and acetabular non-union.

Jacquot A, Goetzmann T, Jullion S, Sirveaux F, Molé D, Roche O.

Orthop Traumatol Surg Res. 2016 Jun;102(4):517-9. doi: 10.1016/j.otsr.2016.02.008. Epub 2016 Apr 1.


Slow-moving and far-travelled dense pyroclastic flows during the Peach Spring super-eruption.

Roche O, Buesch DC, Valentine GA.

Nat Commun. 2016 Mar 7;7:10890. doi: 10.1038/ncomms10890.


Infection recurrence factors in one- and two-stage total knee prosthesis exchanges.

Massin P, Delory T, Lhotellier L, Pasquier G, Roche O, Cazenave A, Estellat C, Jenny JY.

Knee Surg Sports Traumatol Arthrosc. 2016 Oct;24(10):3131-3139. Epub 2015 Nov 26.


Assessment of fixation in cementless femoral revision of total hip arthroplasty: comparison of the Engh score versus radiolucent line measurement.

Roche O, Girard J, Canovas F, Migaud H, Bonnomet F, Goldschild M, Le Béguec P.

Int Orthop. 2016 May;40(5):907-12. doi: 10.1007/s00264-015-3024-z. Epub 2015 Nov 17. Review.


[Acute dacryocystitis and infectious mononucleosis: An association not to be missed].

Martin G, Pon A, Robert M, Aymard PA, Reynaud C, Michel S, Roche O.

J Fr Ophtalmol. 2015 Dec;38(10):e245-6. doi: 10.1016/j.jfo.2015.01.024. Epub 2015 Nov 10. French. No abstract available.


Surgical management of the infected reversed shoulder arthroplasty: a French multicenter study of reoperation in 32 patients.

Jacquot A, Sirveaux F, Roche O, Favard L, Clavert P, Molé D.

J Shoulder Elbow Surg. 2015 Nov;24(11):1713-22. doi: 10.1016/j.jse.2015.03.007. Epub 2015 May 5.


Bone density and functional results after femoral revision with a cementless press-fit stem.

Canovas F, Roche O, Girard J, Bonnomet F, Goldschild M, Le Béguec P.

Orthop Traumatol Surg Res. 2015 May;101(3):283-7. doi: 10.1016/j.otsr.2015.01.009. Epub 2015 Mar 23.


Submicroscopic deletions at 13q32.1 cause congenital microcoria.

Fares-Taie L, Gerber S, Tawara A, Ramirez-Miranda A, Douet JY, Verdin H, Guilloux A, Zenteno JC, Kondo H, Moisset H, Passet B, Yamamoto K, Iwai M, Tanaka T, Nakamura Y, Kimura W, Bole-Feysot C, Vilotte M, Odent S, Vilotte JL, Munnich A, Regnier A, Chassaing N, De Baere E, Raymond-Letron I, Kaplan J, Calvas P, Roche O, Rozet JM.

Am J Hum Genet. 2015 Apr 2;96(4):631-9. doi: 10.1016/j.ajhg.2015.01.014. Epub 2015 Mar 12.


Bone stock in revision femoral arthroplasty: a new evaluation.

Canovas F, Girard J, Roche O, Migaud H, Bonnomet F, Goldschild M, Le Béguec P.

Int Orthop. 2015 Aug;39(8):1487-94. doi: 10.1007/s00264-014-2647-9. Epub 2015 Jan 8.


Assessment of diffusion-weighted imaging for characterizing focal liver lesions.

Parsai A, Zerizer I, Roche O, Gkoutzios P, Miquel ME.

Clin Imaging. 2015 Mar-Apr;39(2):278-84. doi: 10.1016/j.clinimag.2014.09.016. Epub 2014 Oct 22.


Is rotator cuff repair appropriate in patients older than 60 years of age? prospective, randomised trial in 103 patients with a mean four-year follow-up.

Jacquot A, Dezaly C, Goetzmann T, Roche O, Sirveaux F, Molé D; French Society for Shoulder, Elbow (SOFEC).

Orthop Traumatol Surg Res. 2014 Oct;100(6 Suppl):S333-8. doi: 10.1016/j.otsr.2014.04.004. Epub 2014 Aug 23.


Response to Dr Soleimani.

Orssaud C, Wermert D, Roux A, Laccourreye O, Sors H, Roche O, Dufier JL.

Eye (Lond). 2014 Nov;28(11):1385. doi: 10.1038/eye.2014.167. Epub 2014 Jul 25. No abstract available.


EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination.

Gómez-Maldonado L, Tiana M, Roche O, Prado-Cabrero A, Jensen L, Fernandez-Barral A, Guijarro-Muñoz I, Favaro E, Moreno-Bueno G, Sanz L, Aragones J, Harris A, Volpert O, Jimenez B, del Peso L.

Oncogene. 2015 May 14;34(20):2609-20. doi: 10.1038/onc.2014.200. Epub 2014 Jul 14.


Imaging of degenerative lumbar intervertebral discs; linking anatomy, pathology and imaging.

Adams A, Roche O, Mazumder A, Davagnanam I, Mankad K.

Postgrad Med J. 2014 Sep;90(1067):511-9. doi: 10.1136/postgradmedj-2013-132193. Epub 2014 Jun 25. Review.


Visual Impairment in Pseudoxanthoma Elasticum: A Survey of 40 Patients.

Orssaud C, Roche O, Dufier JL, Germain DP.

Ophthalmic Genet. 2015;36(4):327-32. doi: 10.3109/13816810.2014.886268. Epub 2014 Apr 21.


Urrets-Zavalia syndrome as a complication of ocular hypotonia due to intravenous cidofovir treatment.

Orssaud C, Wermert D, Roux A, Laccourreye O, Sors H, Roche O, Dufier JL.

Eye (Lond). 2014 Jun;28(6):776-7. doi: 10.1038/eye.2014.35. Epub 2014 Mar 28. No abstract available.


Genetic characterization of congenital tufting enteropathy: epcam associated phenotype and involvement of SPINT2 in the syndromic form.

Salomon J, Goulet O, Canioni D, Brousse N, Lemale J, Tounian P, Coulomb A, Marinier E, Hugot JP, Ruemmele F, Dufier JL, Roche O, Bodemer C, Colomb V, Talbotec C, Lacaille F, Campeotto F, Cerf-Bensussan N, Janecke AR, Mueller T, Koletzko S, Bonnefont JP, Lyonnet S, Munnich A, Poirier F, Smahi A.

Hum Genet. 2014 Mar;133(3):299-310. doi: 10.1007/s00439-013-1380-6. Epub 2013 Oct 19.


[Bilateral retinal folds and familial high hyperopia: a case report].

Xerri O, Orssaud C, Kaluszyner M, Dufier JL, Roche O.

J Fr Ophtalmol. 2013 Nov;36(9):e177-9. doi: 10.1016/j.jfo.2013.03.013. Epub 2013 Aug 8. French. No abstract available.


Ocular inflammation and corneal permeability alteration by benzalkonium chloride in rats: a protective effect of a myosin light chain kinase inhibitor.

Droy-Lefaix MT, Bueno L, Caron P, Belot E, Roche O.

Invest Ophthalmol Vis Sci. 2013 Apr 17;54(4):2705-10. doi: 10.1167/iovs.12-10193.


[From congenital glaucoma to chronic open angle glaucoma in adulthood: a clinical and genetic continuum].

Dufier JL, Rozet JM, Kaplan J, Roche O.

Bull Acad Natl Med. 2013 Jan;197(1):133-9; discussion 140-1. Review. French.


Pitfall in total hip arthroplasty: intraoperative migration of the trial femoral head through the iliopsoas muscle.

Hamoui M, Larbi A, Delannis Y, Roche O, Fauré P, Canovas F.

Eur J Orthop Surg Traumatol. 2012 Dec;22(8):713-6. doi: 10.1007/s00590-011-0802-1. Epub 2011 Apr 5.


Dynamics of dense granular flows of small-and-large-grain mixtures in an ambient fluid.

Meruane C, Tamburrino A, Roche O.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Aug;86(2 Pt 2):026311. Epub 2012 Aug 20.


Asymptomatic atrophy of the temporal median raphe of the retina associated with cerebral vasculopathy in homozygous sickle cell disease.

Robert MP, Ingster-Moati I, Roche O, Boddaert N, de Montalembert M, Brousse V, Kossorotoff M, Dufier JL, Faure C.

J AAPOS. 2012 Aug;16(4):394-7. doi: 10.1016/j.jaapos.2012.03.006.


Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy.

Perrault I, Hanein S, Zanlonghi X, Serre V, Nicouleau M, Defoort-Delhemmes S, Delphin N, Fares-Taie L, Gerber S, Xerri O, Edelson C, Goldenberg A, Duncombe A, Le Meur G, Hamel C, Silva E, Nitschke P, Calvas P, Munnich A, Roche O, Dollfus H, Kaplan J, Rozet JM.

Nat Genet. 2012 Sep;44(9):975-7. doi: 10.1038/ng.2357. Epub 2012 Jul 29.


Radiological appearances of gynaecological emergencies.

Roche O, Chavan N, Aquilina J, Rockall A.

Insights Imaging. 2012 Jun;3(3):265-75. doi: 10.1007/s13244-012-0157-0. Epub 2012 Apr 18.


Mainzer-Saldino syndrome is a ciliopathy caused by IFT140 mutations.

Perrault I, Saunier S, Hanein S, Filhol E, Bizet AA, Collins F, Salih MA, Gerber S, Delphin N, Bigot K, Orssaud C, Silva E, Baudouin V, Oud MM, Shannon N, Le Merrer M, Roche O, Pietrement C, Goumid J, Baumann C, Bole-Feysot C, Nitschke P, Zahrate M, Beales P, Arts HH, Munnich A, Kaplan J, Antignac C, Cormier-Daire V, Rozet JM.

Am J Hum Genet. 2012 May 4;90(5):864-70. doi: 10.1016/j.ajhg.2012.03.006. Epub 2012 Apr 12.


Dual mobility cups hip arthroplasty as a treatment for displaced fracture of the femoral neck in the elderly. A prospective, systematic, multicenter study with specific focus on postoperative dislocation.

Adam P, Philippe R, Ehlinger M, Roche O, Bonnomet F, Molé D, Fessy MH; French Society of Orthopaedic Surgery and Traumatology (SoFCOT).

Orthop Traumatol Surg Res. 2012 May;98(3):296-300. doi: 10.1016/j.otsr.2012.01.005. Epub 2012 Mar 29.


Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.

Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4892-7. doi: 10.1073/pnas.1112129109. Epub 2012 Mar 12.


Acetabular reconstruction using morselized allograft and a reinforcement ring for revision arthroplasty with Paprosky type II and III bone loss: survival analysis of 95 hips after 5 to 13 years.

Philippe R, Gosselin O, Sedaghatian J, Dezaly C, Roche O, Sirveaux F, Molé D.

Orthop Traumatol Surg Res. 2012 Apr;98(2):129-37. doi: 10.1016/j.otsr.2011.11.003. Epub 2012 Feb 19.

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