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Items: 39

1.

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease.

Lanthier C, Payan H, Liparulo I, Hatat B, Lecoutey C, Since M, Davis A, Bergamini C, Claeysen S, Dallemagne P, Bolognesi ML, Rochais C.

Eur J Med Chem. 2019 Aug 6;182:111596. doi: 10.1016/j.ejmech.2019.111596. [Epub ahead of print]

PMID:
31419776
2.

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease.

Toublet FX, Lecoutey C, Lalut J, Hatat B, Davis A, Since M, Corvaisier S, Freret T, Sopkova de Oliveira Santos J, Claeysen S, Boulouard M, Dallemagne P, Rochais C.

Molecules. 2019 Jul 31;24(15). pii: E2786. doi: 10.3390/molecules24152786.

3.
4.

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie.

Dallemagne P, Rochais C, Marchand P, Besson T.

Pharmaceuticals (Basel). 2019 May 16;12(2). pii: E73. doi: 10.3390/ph12020073.

5.

A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth.

Laggoun F, Dardelle F, Dehors J, Falconet D, Driouich A, Rochais C, Dallemagne P, Lehner A, Mollet JC.

BMC Plant Biol. 2019 Apr 22;19(1):152. doi: 10.1186/s12870-019-1743-9.

6.

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.

Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman J, Weik M, Maurice T, Dallemagne P, Rochais C.

Eur J Med Chem. 2019 Jan 15;162:234-248. doi: 10.1016/j.ejmech.2018.10.064. Epub 2018 Nov 8.

PMID:
30447434
7.

Attentional state and brain processes: state-dependent lateralization of EEG profiles in horses.

Rochais C, Sébilleau M, Menoret M, Oger M, Henry S, Hausberger M, Cousillas H.

Sci Rep. 2018 Jul 5;8(1):10153. doi: 10.1038/s41598-018-28334-9.

8.

Spontaneous attention-capture by auditory distractors as predictor of distractibility: a study of domestic horses (Equus caballus).

Rochais C, Henry S, Hausberger M.

Sci Rep. 2017 Nov 10;7(1):15283. doi: 10.1038/s41598-017-15654-5.

9.

A novel test for evaluating horses' spontaneous visual attention is predictive of attention in operant learning tasks.

Rochais C, Sébilleau M, Houdebine M, Bec P, Hausberger M, Henry S.

Naturwissenschaften. 2017 Aug;104(7-8):61. doi: 10.1007/s00114-017-1480-6. Epub 2017 Jul 5.

PMID:
28681089
10.

An Ambulatory Electroencephalography System for Freely Moving Horses: An Innovating Approach.

Cousillas H, Oger M, Rochais C, Pettoello C, Ménoret M, Henry S, Hausberger M.

Front Vet Sci. 2017 May 2;4:57. doi: 10.3389/fvets.2017.00057. eCollection 2017.

11.

Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.

Lalut J, Karila D, Dallemagne P, Rochais C.

Future Med Chem. 2017 May;9(8):781-795. doi: 10.4155/fmc-2017-0031. Epub 2017 May 15. Review.

PMID:
28504917
12.

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment.

Jourdan JP, Since M, El Kihel L, Lecoutey C, Corvaisier S, Legay R, Sopková-de Oliveira Santos J, Cresteil T, Malzert-Fréon A, Rochais C, Dallemagne P.

ChemMedChem. 2017 Jun 21;12(12):913-916. doi: 10.1002/cmdc.201700102. Epub 2017 Apr 12.

PMID:
28342294
13.

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.

Yahiaoui S, Hamidouche K, Ballandonne C, Davis A, de Oliveira Santos JS, Freret T, Boulouard M, Rochais C, Dallemagne P.

Eur J Med Chem. 2016 Oct 4;121:283-293. doi: 10.1016/j.ejmech.2016.05.048. Epub 2016 May 26.

PMID:
27266998
14.

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography.

Lalut J, Tournier BB, Cailly T, Lecoutey C, Corvaisier S, Davis A, Ballandonne C, Since M, Millet P, Fabis F, Dallemagne P, Rochais C.

Eur J Med Chem. 2016 Jun 30;116:90-101. doi: 10.1016/j.ejmech.2016.03.059. Epub 2016 Mar 25.

PMID:
27060761
15.

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.

Jourdan JP, Since M, El Kihel L, Lecoutey C, Corvaisier S, Legay R, Sopkova-de Oliveira Santos J, Cresteil T, Malzert-Fréon A, Rochais C, Dallemagne P.

Eur J Med Chem. 2016 May 23;114:365-79. doi: 10.1016/j.ejmech.2016.03.023. Epub 2016 Mar 12.

PMID:
27046230
16.

Lower attention to daily environment: a novel cue for detecting chronic horses' back pain?

Rochais C, Fureix C, Lesimple C, Hausberger M.

Sci Rep. 2016 Jan 29;6:20117. doi: 10.1038/srep20117.

17.

Investigating attentional processes in depressive-like domestic horses (Equus caballus).

Rochais C, Henry S, Fureix C, Hausberger M.

Behav Processes. 2016 Mar;124:93-6. doi: 10.1016/j.beproc.2015.12.010. Epub 2015 Dec 29.

PMID:
26739514
18.

3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression.

Rizza P, Pellegrino M, Caruso A, Iacopetta D, Sinicropi MS, Rault S, Lancelot JC, El-Kashef H, Lesnard A, Rochais C, Dallemagne P, Saturnino C, Giordano F, Catalano S, Andò S.

Eur J Med Chem. 2016 Jan 1;107:275-87. doi: 10.1016/j.ejmech.2015.11.004. Epub 2015 Nov 10.

PMID:
26599533
19.

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances.

Quiedeville A, Boulouard M, Hamidouche K, Da Silva Costa-Aze V, Nee G, Rochais C, Dallemagne P, Fabis F, Freret T, Bouet V.

Behav Brain Res. 2015 Oct 15;293:10-7. doi: 10.1016/j.bbr.2015.07.020. Epub 2015 Jul 14.

PMID:
26187692
20.

Therapeutic Potential of 5-HT6 Receptor Agonists.

Karila D, Freret T, Bouet V, Boulouard M, Dallemagne P, Rochais C.

J Med Chem. 2015 Oct 22;58(20):7901-12. doi: 10.1021/acs.jmedchem.5b00179. Epub 2015 Jul 2. Review.

PMID:
26099069
21.

Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities.

de Fatima Pereira M, Rochais C, Dallemagne P.

Anticancer Agents Med Chem. 2015;15(9):1080-91. Review.

PMID:
25991426
22.

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.

Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T, Bouet V, Dauphin F, Sopkova de Oliveira Santos J, Ballandonne C, Corvaisier S, Malzert-Fréon A, Legay R, Boulouard M, Claeysen S, Dallemagne P.

J Med Chem. 2015 Apr 9;58(7):3172-87. doi: 10.1021/acs.jmedchem.5b00115. Epub 2015 Mar 31.

PMID:
25793650
23.

Indenopyrazole oxime ethers: synthesis and β1-adrenergic blocking activity.

Angelone T, Caruso A, Rochais C, Caputo AM, Cerra MC, Dallemagne P, Filice E, Genest D, Pasqua T, Puoci F, Saturnino C, Sinicropi MS, El-Kashef H.

Eur J Med Chem. 2015 Mar 6;92:672-81. doi: 10.1016/j.ejmech.2015.01.037. Epub 2015 Jan 20.

PMID:
25618014
24.

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.

Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Fréon A, Mignani S, Cresteil T, Boulouard M, Claeysen S, Rochais C, Dallemagne P.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3825-30. doi: 10.1073/pnas.1410315111. Epub 2014 Aug 25.

25.

Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: a species comparison.

Camus SM, Rochais C, Blois-Heulin C, Li Q, Hausberger M, Bezard E.

Front Behav Neurosci. 2014 Feb 19;8:47. doi: 10.3389/fnbeh.2014.00047. eCollection 2014.

26.

Visual attention, an indicator of human-animal relationships? A study of domestic horses (Equus caballus).

Rochais C, Henry S, Sankey C, Nassur F, Góracka-Bruzda A, Hausberger M.

Front Psychol. 2014 Feb 13;5:108. doi: 10.3389/fpsyg.2014.00108. eCollection 2014.

27.

Birth origin differentially affects depressive-like behaviours: are captive-born cynomolgus monkeys more vulnerable to depression than their wild-born counterparts?

Camus SM, Rochais C, Blois-Heulin C, Li Q, Hausberger M, Bezard E.

PLoS One. 2013 Jul 4;8(7):e67711. doi: 10.1371/journal.pone.0067711. Print 2013.

28.

MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.

Rochais C, Cresteil T, Perri V, Jouanne M, Lesnard A, Rault S, Dallemagne P.

Cancer Lett. 2013 Apr 30;331(1):92-8. doi: 10.1016/j.canlet.2012.12.017. Epub 2012 Dec 23.

PMID:
23268332
29.

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.

Chosson E, Santoro F, Rochais C, Santos JS, Legay R, Thoret S, Cresteil T, Sinicropi MS, Besson T, Dallemagne P.

Bioorg Med Chem. 2012 Apr 15;20(8):2614-23. doi: 10.1016/j.bmc.2012.02.043. Epub 2012 Mar 3.

PMID:
22429510
30.

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Freret T, Bouet V, Quiedeville A, Nee G, Dallemagne P, Rochais C, Boulouard M.

Behav Brain Res. 2012 Apr 21;230(1):304-8. doi: 10.1016/j.bbr.2012.02.012. Epub 2012 Feb 14.

PMID:
22348892
32.

Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library.

Sopkova-de Oliveira Santos J, Lesnard A, Agondanou JH, Dupont N, Godard AM, Stiebing S, Rochais C, Fabis F, Dallemagne P, Bureau R, Rault S.

J Chem Inf Model. 2010 Mar 22;50(3):422-8. doi: 10.1021/ci900491t.

PMID:
20196555
33.

Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.

Perri V, Rochais C, Sopkova-de Oliveira Santos J, Legay R, Cresteil T, Dallemagne P, Rault S.

Eur J Med Chem. 2010 Mar;45(3):1146-50. doi: 10.1016/j.ejmech.2009.12.021. Epub 2009 Dec 21.

PMID:
20053482
34.

Synthesis, reactivity and biological evaluation of novel halogenated tripentones.

Perri V, Rochais C, Cresteil T, Dallemagne P, Rault S.

Bioorg Med Chem. 2009 Nov 15;17(22):7783-8. doi: 10.1016/j.bmc.2009.09.027. Epub 2009 Sep 19.

PMID:
19822434
35.

Tripentones: a promising series of potent anti-cancer agents.

Rochais C, Dallemagne P, Rault S.

Anticancer Agents Med Chem. 2009 May;9(4):369-80. Review.

PMID:
19442038
36.

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.

Rochais C, Duc NV, Lescot E, Sopkova-de Oliveira Santos J, Bureau R, Meijer L, Dallemagne P, Rault S.

Eur J Med Chem. 2009 Feb;44(2):708-16. doi: 10.1016/j.ejmech.2008.05.011. Epub 2008 May 23.

PMID:
18586356
37.

Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents.

Rochais C, Lisowski V, Dallemagne P, Rault S.

Bioorg Med Chem. 2006 Dec 15;14(24):8162-75. Epub 2006 Sep 29.

PMID:
17011196
38.

3D-QSAR and docking studies of selective GSK-3beta inhibitors. Comparison with a thieno[2,3-b]pyrrolizinone derivative, a new potential lead for GSK-3beta ligands.

Lescot E, Bureau R, Sopkova-de Oliveira Santos J, Rochais C, Lisowski V, Lancelot JC, Rault S.

J Chem Inf Model. 2005 May-Jun;45(3):708-15.

PMID:
15921460
39.

Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors.

Rochais C, Lescot E, Lisowski V, Lepailleur A, Santos JS, Bureau R, Dallemagne P, Meijer L, Rault S.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):585-93.

PMID:
15662962

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