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Items: 40


Prospective international study of incidence and predictors of immune reconstitution inflammatory syndrome and death in people with HIV and severe lymphopenia.

Sereti I, Sheikh V, Shaffer D, Phanuphak N, Gabriel E, Wang J, Nason MC, Roby G, Ngeno H, Kirui F, Pau A, Mican JM, Rupert A, Bishop R, Agan B, Chomchey N, Teeratakulpisarn N, Tansuphaswadikul S, Langat D, Kosgei J, French M, Ananworanich J, Sawe F; IRIS NIAID/IDCRP team.

Clin Infect Dis. 2019 Sep 5. pii: ciz877. doi: 10.1093/cid/ciz877. [Epub ahead of print]


Humanized mouse models reveal an immunologic classification of idiopathic CD4 lymphocytopenia subtypes.

Perez-Diez A, Liu X, Sheikh V, Roby G, Stroncek DF, Sereti I.

JCI Insight. 2019 Jul 25;4(14). pii: 127802. doi: 10.1172/jci.insight.127802. eCollection 2019 Jul 25.


Emergence of Kaposi's Sarcoma Herpesvirus-Associated Complications Following Corticosteroid Use in TB-IRIS.

Manion M, Uldrick T, Polizzotto MN, Sheikh V, Roby G, Lurain K, Metzger D, Mican JM, Pau A, Lisco A, Laidlaw E, Hammoud DA, Whitby D, Yarchoan R, Sereti I.

Open Forum Infect Dis. 2018 Oct 12;5(10):ofy217. doi: 10.1093/ofid/ofy217. eCollection 2018 Oct.


Increased Metabolic Activity on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Human Immunodeficiency Virus-Associated Immune Reconstitution Inflammatory Syndrome.

Hammoud DA, Boulougoura A, Papadakis GZ, Wang J, Dodd LE, Rupert A, Higgins J, Roby G, Metzger D, Laidlaw E, Mican JM, Pau A, Lage S, Wong CS, Lisco A, Manion M, Sheikh V, Millo C, Sereti I.

Clin Infect Dis. 2019 Jan 7;68(2):229-238. doi: 10.1093/cid/ciy454.


Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia.

Sheikh V, Porter BO, DerSimonian R, Kovacs SB, Thompson WL, Perez-Diez A, Freeman AF, Roby G, Mican J, Pau A, Rupert A, Adelsberger J, Higgins J, Bourgeois JS Jr, Jensen SM, Morcock DR, Burbelo PD, Osnos L, Maric I, Natarajan V, Croughs T, Yao MD, Estes JD, Sereti I.

Blood. 2016 Feb 25;127(8):977-88. doi: 10.1182/blood-2015-05-645077. Epub 2015 Dec 16.


A Paradoxical Treatment for a Paradoxical Condition: Infliximab Use in Three Cases of Mycobacterial IRIS.

Hsu DC, Faldetta KF, Pei L, Sheikh V, Utay NS, Roby G, Rupert A, Fauci AS, Sereti I.

Clin Infect Dis. 2016 Jan 15;62(2):258-261. doi: 10.1093/cid/civ841. Epub 2015 Sep 22.


T-Cell Depletion in the Colonic Mucosa of Patients With Idiopathic CD4+ Lymphopenia.

Kovacs SB, Sheikh V, Thompson WL, Morcock DR, Perez-Diez A, Yao MD, Rupert AW, Utay NS, Roby G, Freeman AF, Estes JD, Sereti I.

J Infect Dis. 2015 Nov 15;212(10):1579-87. doi: 10.1093/infdis/jiv282. Epub 2015 May 20.


Clinically Indicated Corticosteroids Do Not Affect Bone Turnover During Immune Restoration of Severely Lymphopenic HIV-Infected Patients.

Grant PM, Sheikh V, DerSimonian R, Rupert A, Roby G, Pau A, Sneller MC, Rico SV, Brown TT, Sereti I.

AIDS Res Hum Retroviruses. 2015 Jul;31(7):739-44. doi: 10.1089/AID.2015.0028. Epub 2015 May 21.


Defective bone repair in mast cell deficient mice with c-Kit loss of function.

Behrends DA, Cheng L, Sullivan MB, Wang MH, Roby GB, Zayed N, Gao C, Henderson JE, Martineau PA.

Eur Cell Mater. 2014 Oct 6;28:209-21; discussion 221-2.


The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.

Jelicic K, Cimbro R, Nawaz F, Huang da W, Zheng X, Yang J, Lempicki RA, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang IY, Kehrl JH, Arthos J, Cicala C, Fauci AS.

Nat Immunol. 2013 Dec;14(12):1256-65. doi: 10.1038/ni.2746. Epub 2013 Oct 27.


Prevalence of Strongyloides stercoralis in an urban US AIDS cohort.

Nabha L, Krishnan S, Ramanathan R, Mejia R, Roby G, Sheikh V, McAuliffe I, Nutman T, Sereti I.

Pathog Glob Health. 2012 Aug;106(4):238-44. doi: 10.1179/2047773212Y.0000000031.


The CD8+ HLA-DR+ T cells expanded in HIV-1 infection are qualitatively identical to those from healthy controls.

Imamichi H, Lempicki RA, Adelsberger JW, Hasley RB, Rosenberg A, Roby G, Rehm CA, Nelson A, Krishnan S, Pavlick M, Woods CJ, Baseler MW, Lane HC.

Eur J Immunol. 2012 Oct;42(10):2608-20. doi: 10.1002/eji.201142046. Epub 2012 Aug 6.


Selective expansion of polyfunctional pathogen-specific CD4(+) T cells in HIV-1-infected patients with immune reconstitution inflammatory syndrome.

Mahnke YD, Greenwald JH, DerSimonian R, Roby G, Antonelli LR, Sher A, Roederer M, Sereti I.

Blood. 2012 Mar 29;119(13):3105-12. doi: 10.1182/blood-2011-09-380840. Epub 2012 Jan 4.


Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Kardava L, Moir S, Wang W, Ho J, Buckner CM, Posada JG, O'Shea MA, Roby G, Chen J, Sohn HW, Chun TW, Pierce SK, Fauci AS.

J Clin Invest. 2011 Jul;121(7):2614-24. doi: 10.1172/JCI45685.


CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.

Catalfamo M, Wilhelm C, Tcheung L, Proschan M, Friesen T, Park JH, Adelsberger J, Baseler M, Maldarelli F, Davey R, Roby G, Rehm C, Lane C.

J Immunol. 2011 Feb 15;186(4):2106-16. doi: 10.4049/jimmunol.1002000. Epub 2011 Jan 21.


Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.

Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, DerSimonian R, Greenwald JH, Roby G, Mican J, Sher A, Roederer M, Sereti I.

Blood. 2010 Nov 11;116(19):3818-27. doi: 10.1182/blood-2010-05-285080. Epub 2010 Jul 26.


d-Dimer and CRP levels are elevated prior to antiretroviral treatment in patients who develop IRIS.

Porter BO, Ouedraogo GL, Hodge JN, Smith MA, Pau A, Roby G, Kwan R, Bishop RJ, Rehm C, Mican J, Sereti I.

Clin Immunol. 2010 Jul;136(1):42-50. doi: 10.1016/j.clim.2010.02.010. Epub 2010 Mar 15. Erratum in: Clin Immunol. 2010 Sep;136(3):462.


Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infection.

Reitano KN, Kottilil S, Gille CM, Zhang X, Yan M, O'Shea MA, Roby G, Hallahan CW, Yang J, Lempicki RA, Arthos J, Fauci AS.

AIDS Res Hum Retroviruses. 2009 Oct;25(10):1029-37. doi: 10.1089/aid.2008.0311.


A comparison of adherence assessment methods utilized in the United States: perspectives of researchers, HIV-infected children, and their caregivers.

Martin S, Elliott-DeSorbo DK, Calabrese S, Wolters PL, Roby G, Brennan T, Wood LV.

AIDS Patient Care STDS. 2009 Aug;23(8):593-601. doi: 10.1089/apc.2009.0021.


Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells.

Kottilil S, Yan MY, Reitano KN, Zhang X, Lempicki R, Roby G, Daucher M, Yang J, Cortez KJ, Ghany M, Polis MA, Fauci AS.

Hepatology. 2009 Jul;50(1):34-45. doi: 10.1002/hep.23055.


Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, Rood JE, Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M, Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O'Shea MA, Mican J, Packard BZ, Komoriya A, Palmer S, Wiegand AP, Maldarelli F, Coffin JM, Mellors JW, Hallahan CW, Follman DA, Connors M.

Immunity. 2008 Dec 19;29(6):1009-21. doi: 10.1016/j.immuni.2008.10.010. Epub 2008 Dec 8.


HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells.

Catalfamo M, Di Mascio M, Hu Z, Srinivasula S, Thaker V, Adelsberger J, Rupert A, Baseler M, Tagaya Y, Roby G, Rehm C, Follmann D, Lane HC.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19851-6. doi: 10.1073/pnas.0810032105. Epub 2008 Dec 5.


The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands.

Kinter AL, Godbout EJ, McNally JP, Sereti I, Roby GA, O'Shea MA, Fauci AS.

J Immunol. 2008 Nov 15;181(10):6738-46.


Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals.

Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, O'Shea MA, Roby G, Kottilil S, Arthos J, Proschan MA, Chun TW, Fauci AS.

J Exp Med. 2008 Aug 4;205(8):1797-805. doi: 10.1084/jem.20072683. Epub 2008 Jul 14.


Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals.

Fogli M, Mavilio D, Brunetta E, Varchetta S, Ata K, Roby G, Kovacs C, Follmann D, Pende D, Ward J, Barker E, Marcenaro E, Moretta A, Fauci AS.

PLoS Pathog. 2008 Jul 11;4(7):e1000101. doi: 10.1371/journal.ppat.1000101.


CpG oligonucleotides enhance proliferative and effector responses of B Cells in HIV-infected individuals.

Malaspina A, Moir S, DiPoto AC, Ho J, Wang W, Roby G, O'Shea MA, Fauci AS.

J Immunol. 2008 Jul 15;181(2):1199-206.


Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy.

Chun TW, Nickle DC, Justement JS, Meyers JH, Roby G, Hallahan CW, Kottilil S, Moir S, Mican JM, Mullins JI, Ward DJ, Kovacs JA, Mannon PJ, Fauci AS.

J Infect Dis. 2008 Mar 1;197(5):714-20. doi: 10.1086/527324.


Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV disease.

Moir S, Malaspina A, Ho J, Wang W, Dipoto AC, O'Shea MA, Roby G, Mican JM, Kottilil S, Chun TW, Proschan MA, Fauci AS.

J Infect Dis. 2008 Feb 15;197(4):572-9. doi: 10.1086/526789.


The Antiretroviral Regimen Complexity Index. A novel method of quantifying regimen complexity.

Martin S, Wolters PL, Calabrese SK, Toledo-Tamula MA, Wood LV, Roby G, Elliott-DeSorbo DK.

J Acquir Immune Defic Syndr. 2007 Aug 15;45(5):535-44.


Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremia.

Kottilil S, Jackson JO, Reitano KN, O'Shea MA, Roby G, Lloyd M, Yang J, Hallahan CW, Rehm CA, Arthos J, Lempicki R, Fauci AS.

J Acquir Immune Defic Syndr. 2007 Oct 1;46(2):151-9.


Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells.

Meyers JH, Justement JS, Hallahan CW, Blair ET, Sun YA, O'Shea MA, Roby G, Kottilil S, Moir S, Kovacs CM, Chun TW, Fauci AS.

PLoS One. 2007 May 23;2(5):e458.


CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro.

Kinter AL, Horak R, Sion M, Riggin L, McNally J, Lin Y, Jackson R, O'shea A, Roby G, Kovacs C, Connors M, Migueles SA, Fauci AS.

AIDS Res Hum Retroviruses. 2007 Mar;23(3):438-50.


Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals.

Kinter A, McNally J, Riggin L, Jackson R, Roby G, Fauci AS.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3390-5. Epub 2007 Feb 21.


Patient, caregiver and regimen characteristics associated with adherence to highly active antiretroviral therapy among HIV-infected children and adolescents.

Martin S, Elliott-DeSorbo DK, Wolters PL, Toledo-Tamula MA, Roby G, Zeichner S, Wood LV.

Pediatr Infect Dis J. 2007 Jan;26(1):61-7.


Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanisms.

Ho J, Moir S, Malaspina A, Howell ML, Wang W, DiPoto AC, O'Shea MA, Roby GA, Kwan R, Mican JM, Chun TW, Fauci AS.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19436-41. Epub 2006 Dec 8.


Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7.

Malaspina A, Moir S, Ho J, Wang W, Howell ML, O'Shea MA, Roby GA, Rehm CA, Mican JM, Chun TW, Fauci AS.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2262-7. Epub 2006 Feb 6.


Could human papillomaviruses be spread through blood?

Bodaghi S, Wood LV, Roby G, Ryder C, Steinberg SM, Zheng ZM.

J Clin Microbiol. 2005 Nov;43(11):5428-34.


Exstrophy of bladder associated with unilateral renal agenesis and bicornuate uterus: a case report.

Dorairajan LN, Roby G, Kumar S, Singh H, Gowri D.

Int Urogynecol J Pelvic Floor Dysfunct. 2001;12(6):410-1.


Electrosurgical currents and their effects.

Roby G.

Dent Clin North Am. 1982 Oct;26(4):683-91. No abstract available.


Everyday uses of electrosurgery.

Roby GC.

CDS Rev. 1974 Nov;67(11):26-7. No abstract available.


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