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Items: 1 to 50 of 77

1.

Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation.

Haznadar M, Krausz KW, Margono E, Diehl CM, Bowman ED, Manna SK, Robles AI, Ryan BM, Gonzalez FJ, Harris CC.

Cancer Med. 2018 Jun;7(6):2764-2775. doi: 10.1002/cam4.1444. Epub 2018 May 3.

2.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC.

Nat Commun. 2018 Feb 22;9(1):771. doi: 10.1038/s41467-018-03224-w.

3.

Sputum-based DNA methylation biomarkers to guide lung cancer screening decisions.

Lissa D, Robles AI.

J Thorac Dis. 2017 Nov;9(11):4308-4310. doi: 10.21037/jtd.2017.10.78. No abstract available.

4.

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.

Li XL, Subramanian M, Jones MF, Chaudhary R, Singh DK, Zong X, Gryder B, Sindri S, Mo M, Schetter A, Wen X, Parvathaneni S, Kazandjian D, Jenkins LM, Tang W, Elloumi F, Martindale JL, Huarte M, Zhu Y, Robles AI, Frier SM, Rigo F, Cam M, Ambs S, Sharma S, Harris CC, Dasso M, Prasanth KV, Lal A.

Cell Rep. 2017 Sep 5;20(10):2408-2423. doi: 10.1016/j.celrep.2017.08.041.

5.

Interleukins as new prognostic genetic biomarkers in non-small cell lung cancer.

Pérez-Ramírez C, Cañadas-Garre M, Alnatsha A, Molina MÁ, Robles AI, Villar E, Delgado JR, Faus-Dáder MJ, Calleja-Hernández MÁ.

Surg Oncol. 2017 Sep;26(3):278-285. doi: 10.1016/j.suronc.2017.05.004. Epub 2017 May 22.

PMID:
28807247
6.

Seeing the Forest through the Phylogenetic Tree.

Robles AI, Zenklusen JC.

N Engl J Med. 2017 Jun 1;376(22):2190-2191. doi: 10.1056/NEJMe1704618. No abstract available.

PMID:
28564575
7.

Lung Cancer Field Cancerization: Implications for Screening by Low-Dose Computed Tomography.

Robles AI, Harris CC.

J Natl Cancer Inst. 2017 Jul 1;109(7). doi: 10.1093/jnci/djw328. No abstract available.

PMID:
28376183
8.

Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells.

Horikawa I, Park KY, Isogaya K, Hiyoshi Y, Li H, Anami K, Robles AI, Mondal AM, Fujita K, Serrano M, Harris CC.

Cell Death Differ. 2017 Jun;24(6):1017-1028. doi: 10.1038/cdd.2017.48. Epub 2017 Mar 31.

9.

Contribution of genetic factors to platinum-based chemotherapy sensitivity and prognosis of non-small cell lung cancer.

Pérez-Ramírez C, Cañadas-Garre M, Molina MÁ, Robles AI, Faus-Dáder MJ, Calleja-Hernández MÁ.

Mutat Res. 2017 Jan - Mar;771:32-58. doi: 10.1016/j.mrrev.2016.11.003. Epub 2016 Nov 23. Review.

PMID:
28342452
10.

Liquid biopsy in early stage lung cancer.

Pérez-Ramírez C, Cañadas-Garre M, Robles AI, Molina MÁ, Faus-Dáder MJ, Calleja-Hernández MÁ.

Transl Lung Cancer Res. 2016 Oct;5(5):517-524. Review.

11.

Methylation analyses in liquid biopsy.

Lissa D, Robles AI.

Transl Lung Cancer Res. 2016 Oct;5(5):492-504. Review.

12.

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.

Robles AI, Olsen KS, Tsui DW, Georgoulias V, Creaney J, Dobra K, Vyberg M, Minato N, Anders RA, Børresen-Dale AL, Zhou J, Sætrom P, Nielsen BS, Kirschner MB, Krokan HE, Papadimitrakopoulou V, Tsamardinos I, Røe OD.

J Transl Med. 2016 Oct 19;14(1):295.

13.

A Two-Gene Prognostic Classifier for Early-Stage Lung Squamous Cell Carcinoma in Multiple Large-Scale and Geographically Diverse Cohorts.

Noro R, Ishigame T, Walsh N, Shiraishi K, Robles AI, Ryan BM, Schetter AJ, Bowman ED, Welsh JA, Seike M, Gemma A, Skaug V, Mollerup S, Haugen A, Yokota J, Kohno T, Harris CC.

J Thorac Oncol. 2017 Jan;12(1):65-76. doi: 10.1016/j.jtho.2016.08.141. Epub 2016 Sep 6.

14.

Clinical Outcomes of TP53 Mutations in Cancers.

Robles AI, Jen J, Harris CC.

Cold Spring Harb Perspect Med. 2016 Sep 1;6(9). pii: a026294. doi: 10.1101/cshperspect.a026294. Review.

PMID:
27449973
15.

Integration of multiple "OMIC" biomarkers: A precision medicine strategy for lung cancer.

Robles AI, Harris CC.

Lung Cancer. 2017 May;107:50-58. doi: 10.1016/j.lungcan.2016.06.003. Epub 2016 Jun 14.

16.

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.

Tang W, Robles AI, Beyer RP, Gray LT, Nguyen GH, Oshima J, Maizels N, Harris CC, Monnat RJ Jr.

Hum Mol Genet. 2016 May 15;25(10):2060-2069. Epub 2016 Mar 16.

17.

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.

Robles AI, Traverso G, Zhang M, Roberts NJ, Khan MA, Joseph C, Lauwers GY, Selaru FM, Popoli M, Pittman ME, Ke X, Hruban RH, Meltzer SJ, Kinzler KW, Vogelstein B, Harris CC, Papadopoulos N.

Gastroenterology. 2016 Apr;150(4):931-43. doi: 10.1053/j.gastro.2015.12.036. Epub 2016 Jan 5.

18.

KRT81 miR-SNP rs3660 is associated with risk and survival of NSCLC.

Robles AI, Ryan BM.

Ann Oncol. 2016 Feb;27(2):360-1. doi: 10.1093/annonc/mdv552. Epub 2015 Nov 16. No abstract available.

19.

An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers.

Robles AI, Arai E, Mathé EA, Okayama H, Schetter AJ, Brown D, Petersen D, Bowman ED, Noro R, Welsh JA, Edelman DC, Stevenson HS, Wang Y, Tsuchiya N, Kohno T, Skaug V, Mollerup S, Haugen A, Meltzer PS, Yokota J, Kanai Y, Harris CC.

J Thorac Oncol. 2015 Jul;10(7):1037-48. doi: 10.1097/JTO.0000000000000560.

20.

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.

Iwakawa R, Kohno T, Totoki Y, Shibata T, Tsuchihara K, Mimaki S, Tsuta K, Narita Y, Nishikawa R, Noguchi M, Harris CC, Robles AI, Yamaguchi R, Imoto S, Miyano S, Totsuka H, Yoshida T, Yokota J.

Carcinogenesis. 2015 Jun;36(6):616-21. doi: 10.1093/carcin/bgv026. Epub 2015 Apr 11.

21.

Cigarette smoke mediates epigenetic repression of miR-217 during esophageal adenocarcinogenesis.

Xi S, Inchauste S, Guo H, Shan J, Xiao Z, Xu H, Miettenen M, Zhang MR, Hong JA, Raiji MT, Altorki NK, Casson AG, Beer DG, Robles AI, Bowman ED, Harris CC, Steinberg SM, Schrump DS.

Oncogene. 2015 Oct 29;34(44):5548-59. doi: 10.1038/onc.2015.10. Epub 2015 Feb 23.

PMID:
25703328
22.

A flexible reporter system for direct observation and isolation of cancer stem cells.

Tang B, Raviv A, Esposito D, Flanders KC, Daniel C, Nghiem BT, Garfield S, Lim L, Mannan P, Robles AI, Smith WI Jr, Zimmerberg J, Ravin R, Wakefield LM.

Stem Cell Reports. 2015 Jan 13;4(1):155-69. doi: 10.1016/j.stemcr.2014.11.002. Epub 2014 Dec 11.

23.

Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer.

Ryan BM, Robles AI, McClary AC, Haznadar M, Bowman ED, Pine SR, Brown D, Khan M, Shiraishi K, Kohno T, Okayama H, Modali R, Yokota J, Harris CC.

Cancer Res. 2015 Feb 1;75(3):566-75. doi: 10.1158/0008-5472.CAN-14-2101. Epub 2014 Dec 5.

24.

A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood.

Robles AI, Yang P, Jen J, McClary AC, Calhoun K, Bowman ED, Vähäkangas K, Greathouse KL, Wang Y, Olivo-Marston S, Wenzlaff AS, Deng B, Schwartz AG, Ryan BM.

Cancer Prev Res (Phila). 2014 Dec;7(12):1210-8. doi: 10.1158/1940-6207.CAPR-14-0158. Epub 2014 Oct 3.

25.

The expression of four genes as a prognostic classifier for stage I lung adenocarcinoma in 12 independent cohorts.

Okayama H, Schetter AJ, Ishigame T, Robles AI, Kohno T, Yokota J, Takenoshita S, Harris CC.

Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2884-94. doi: 10.1158/1055-9965.EPI-14-0182. Epub 2014 Sep 21.

26.

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.

Nguyen GH, Tang W, Robles AI, Beyer RP, Gray LT, Welsh JA, Schetter AJ, Kumamoto K, Wang XW, Hickson ID, Maizels N, Monnat RJ Jr, Harris CC.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9905-10. doi: 10.1073/pnas.1404807111. Epub 2014 Jun 23.

27.

A primate-specific microRNA enters the lung cancer landscape.

Robles AI, Harris CC.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18748-9. doi: 10.1073/pnas.1318740110. Epub 2013 Nov 4. No abstract available.

28.

Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

Ryan BM, Zanetti KA, Robles AI, Schetter AJ, Goodman J, Hayes RB, Huang WY, Gunter MJ, Yeager M, Burdette L, Berndt SI, Harris CC.

Int J Cancer. 2014 Mar 15;134(6):1399-407. doi: 10.1002/ijc.28457. Epub 2013 Nov 14.

29.

miRNA signature of mouse helper T cell hyper-proliferation.

Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.

PLoS One. 2013 Jun 25;8(6):e66709. doi: 10.1371/journal.pone.0066709. Print 2013.

30.

Combination of protein coding and noncoding gene expression as a robust prognostic classifier in stage I lung adenocarcinoma.

Akagi I, Okayama H, Schetter AJ, Robles AI, Kohno T, Bowman ED, Kazandjian D, Welsh JA, Oue N, Saito M, Miyashita M, Uchida E, Takizawa T, Takenoshita S, Skaug V, Mollerup S, Haugen A, Yokota J, Harris CC.

Cancer Res. 2013 Jul 1;73(13):3821-32. doi: 10.1158/0008-5472.CAN-13-0031. Epub 2013 May 2.

31.

Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling.

Achyut BR, Bader DA, Robles AI, Wangsa D, Harris CC, Ried T, Yang L.

PLoS Genet. 2013;9(2):e1003251. doi: 10.1371/journal.pgen.1003251. Epub 2013 Feb 7.

32.

Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.

Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.

PLoS One. 2012;7(9):e44156. doi: 10.1371/journal.pone.0044156. Epub 2012 Sep 6.

33.

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.

Tang Y, Horikawa I, Ajiro M, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng ZM, Harris CC.

Oncogene. 2013 May 30;32(22):2792-8. doi: 10.1038/onc.2012.288. Epub 2012 Jul 9.

PMID:
22777358
34.

Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.

Du X, Qian X, Papageorge A, Schetter AJ, Vass WC, Liu X, Braverman R, Robles AI, Lowy DR.

Cancer Res. 2012 Sep 1;72(17):4405-16. doi: 10.1158/0008-5472.CAN-12-0777. Epub 2012 Jun 12.

35.

KRAS-LCS6 genotype as a prognostic marker in early-stage CRC--letter.

Ryan BM, Robles AI, Harris CC.

Clin Cancer Res. 2012 Jun 15;18(12):3487-8; author reply 3489. doi: 10.1158/1078-0432.CCR-12-0250. Epub 2012 Jun 5. No abstract available.

36.

rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.

Ryan BM, McClary AC, Valeri N, Robinson D, Paone A, Bowman ED, Robles AI, Croce C, Harris CC.

PLoS One. 2012;7(5):e36306. doi: 10.1371/journal.pone.0036306. Epub 2012 May 11.

37.

MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer.

Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, Harris CC.

Int J Cancer. 2012 Dec 1;131(11):2710-6. doi: 10.1002/ijc.27573. Epub 2012 Apr 27.

38.

3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.

Zanetti KA, Haznadar M, Welsh JA, Robles AI, Ryan BM, McClary AC, Bowman ED, Goodman JE, Bernig T, Chanock SJ, Harris CC.

Cancer Res. 2012 Mar 15;72(6):1467-77. doi: 10.1158/0008-5472.CAN-11-3073. Epub 2012 Jan 26.

39.

Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.

Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC.

PLoS One. 2010 Nov 19;5(11):e15541. doi: 10.1371/journal.pone.0015541.

40.

Genetic variation in microRNA networks: the implications for cancer research.

Ryan BM, Robles AI, Harris CC.

Nat Rev Cancer. 2010 Jun;10(6):389-402. doi: 10.1038/nrc2867. Review. Erratum in: Nat Rev Cancer. 2010 Jul;10(7):523.

41.

Clinical outcomes and correlates of TP53 mutations and cancer.

Robles AI, Harris CC.

Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a001016. doi: 10.1101/cshperspect.a001016. Review.

42.

Microenvironmental modulation of asymmetric cell division in human lung cancer cells.

Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2195-200. doi: 10.1073/pnas.0909390107. Epub 2010 Jan 13.

43.

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.

Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A.

Nat Med. 2009 Dec;15(12):1369-76. doi: 10.1038/nm.2059. Epub 2009 Nov 22.

44.

WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.

Binet R, Ythier D, Robles AI, Collado M, Larrieu D, Fonti C, Brambilla E, Brambilla C, Serrano M, Harris CC, Pedeux R.

Cancer Res. 2009 Dec 15;69(24):9183-91. doi: 10.1158/0008-5472.CAN-09-1016.

45.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.

Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: 10.1073/pnas.0903392106. Epub 2009 May 5.

46.

A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.

Unoki M, Kumamoto K, Robles AI, Shen JC, Zheng ZM, Harris CC.

FEBS Lett. 2008 Nov 26;582(28):3868-74. doi: 10.1016/j.febslet.2008.10.024. Epub 2008 Oct 23.

47.

HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair.

Koll TT, Feis SS, Wright MH, Teniola MM, Richardson MM, Robles AI, Bradsher J, Capala J, Varticovski L.

Mol Cancer Ther. 2008 Jul;7(7):1985-92. doi: 10.1158/1535-7163.MCT-07-2104.

48.

Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1.

Wright MH, Robles AI, Herschkowitz JI, Hollingshead MG, Anver MR, Perou CM, Varticovski L.

Mol Cancer. 2008 Apr 7;7:29. doi: 10.1186/1476-4598-7-29.

49.

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.

Antony S, Agama KK, Miao ZH, Takagi K, Wright MH, Robles AI, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y.

Cancer Res. 2007 Nov 1;67(21):10397-405. Erratum in: Cancer Res. 2007 Dec 15;67(24):12034.

50.

Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.

Varticovski L, Hollingshead MG, Robles AI, Wu X, Cherry J, Munroe DJ, Lukes L, Anver MR, Carter JP, Borgel SD, Stotler H, Bonomi CA, Nunez NP, Hursting SD, Qiao W, Deng CX, Green JE, Hunter KW, Merlino G, Steeg PS, Wakefield LM, Barrett JC.

Clin Cancer Res. 2007 Apr 1;13(7):2168-77.

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