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Items: 1 to 50 of 60

1.

Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation.

Poupin N, Corlu A, Cabaton NJ, Dubois-Pot-Schneider H, Canlet C, Person E, Bruel S, Frainay C, Vinson F, Maurier F, Morel F, Robin MA, Fromenty B, Zalko D, Jourdan F.

J Proteome Res. 2018 Nov 19. doi: 10.1021/acs.jproteome.8b00524. [Epub ahead of print]

PMID:
30394098
2.

Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes.

Quesnot N, Bucher S, Gade C, Vlach M, Vene E, Valença S, Gicquel T, Holst H, Robin MA, Loyer P.

Arch Toxicol. 2018 Oct;92(10):3077-3091. doi: 10.1007/s00204-018-2300-2. Epub 2018 Aug 27.

PMID:
30151596
3.

Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo.

Bucher S, Tête A, Podechard N, Liamin M, Le Guillou D, Chevanne M, Coulouarn C, Imran M, Gallais I, Fernier M, Hamdaoui Q, Robin MA, Sergent O, Fromenty B, Lagadic-Gossmann D.

Sci Rep. 2018 Apr 13;8(1):5963. doi: 10.1038/s41598-018-24403-1.

4.

Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.

Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B.

Environ Toxicol. 2017 Mar;32(3):1024-1036. doi: 10.1002/tox.22301. Epub 2016 Jun 20.

5.

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.

Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B.

Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55. doi: 10.1016/j.taap.2015.12.020. Epub 2015 Dec 29.

6.

Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells.

Quesnot N, Rondel K, Audebert M, Martinais S, Glaise D, Morel F, Loyer P, Robin MA.

Mutagenesis. 2016 Jan;31(1):43-50. doi: 10.1093/mutage/gev059. Epub 2015 Aug 17.

PMID:
26282955
7.

Modulation of metabolizing enzymes by bisphenol a in human and animal models.

Quesnot N, Bucher S, Fromenty B, Robin MA.

Chem Res Toxicol. 2014 Sep 15;27(9):1463-73. doi: 10.1021/tx500087p. Epub 2014 Aug 29. Review.

PMID:
25142872
8.

Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.

Savary CC, Jossé R, Bruyère A, Guillet F, Robin MA, Guillouzo A.

Drug Metab Dispos. 2014 Aug;42(8):1235-40. doi: 10.1124/dmd.114.057786. Epub 2014 May 15.

PMID:
24832206
9.

Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.

Michaut A, Moreau C, Robin MA, Fromenty B.

Liver Int. 2014 Aug;34(7):e171-9. doi: 10.1111/liv.12514. Epub 2014 Mar 21. Review.

PMID:
24575957
10.

Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.

Anthérieu S, Le Guillou D, Coulouarn C, Begriche K, Trak-Smayra V, Martinais S, Porceddu M, Robin MA, Fromenty B.

Toxicol Appl Pharmacol. 2014 Apr 1;276(1):63-72. doi: 10.1016/j.taap.2014.01.019. Epub 2014 Feb 11.

11.

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.

Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B.

Hepatology. 2013 Oct;58(4):1497-507. doi: 10.1002/hep.26226. Epub 2013 Aug 7. Review.

PMID:
23299992
12.

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

Anthérieu S, Bachour-El Azzi P, Dumont J, Abdel-Razzak Z, Guguen-Guillouzo C, Fromenty B, Robin MA, Guillouzo A.

Hepatology. 2013 Apr;57(4):1518-29. doi: 10.1002/hep.26160. Epub 2013 Mar 4.

PMID:
23175273
13.

Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.

Aubert J, Begriche K, Delannoy M, Morel I, Pajaud J, Ribault C, Lepage S, McGill MR, Lucas-Clerc C, Turlin B, Robin MA, Jaeschke H, Fromenty B.

J Pharmacol Exp Ther. 2012 Sep;342(3):676-87. doi: 10.1124/jpet.112.193813. Epub 2012 May 30.

PMID:
22647274
14.

Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver.

Knockaert L, Berson A, Ribault C, Prost PE, Fautrel A, Pajaud J, Lepage S, Lucas-Clerc C, Bégué JM, Fromenty B, Robin MA.

Lab Invest. 2012 Mar;92(3):396-410. doi: 10.1038/labinvest.2011.193. Epub 2011 Dec 12.

15.

Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.

Josse R, Dumont J, Fautrel A, Robin MA, Guillouzo A.

Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87. doi: 10.1016/j.taap.2011.10.019. Epub 2011 Nov 4.

PMID:
22100608
16.

Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.

Knockaert L, Fromenty B, Robin MA.

FEBS J. 2011 Nov;278(22):4252-60. doi: 10.1111/j.1742-4658.2011.08357.x. Epub 2011 Oct 12. Review.

17.

Central role of mitochondria in drug-induced liver injury.

Pessayre D, Fromenty B, Berson A, Robin MA, Lettéron P, Moreau R, Mansouri A.

Drug Metab Rev. 2012 Feb;44(1):34-87. doi: 10.3109/03602532.2011.604086. Epub 2011 Sep 6. Review.

PMID:
21892896
18.

Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.

Massart J, Robin MA, Noury F, Fautrel A, Lettéron P, Bado A, Eliat PA, Fromenty B.

Br J Pharmacol. 2012 Mar;165(5):1361-74. doi: 10.1111/j.1476-5381.2011.01580.x.

19.

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.

Aubert J, Begriche K, Knockaert L, Robin MA, Fromenty B.

Clin Res Hepatol Gastroenterol. 2011 Oct;35(10):630-7. doi: 10.1016/j.clinre.2011.04.015. Epub 2011 Jun 12. Review.

PMID:
21664213
20.

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells.

Anthérieu S, Rogue A, Fromenty B, Guillouzo A, Robin MA.

Hepatology. 2011 Jun;53(6):1895-905. doi: 10.1002/hep.24290. Epub 2011 May 2.

PMID:
21391224
21.

Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

Begriche K, Massart J, Robin MA, Borgne-Sanchez A, Fromenty B.

J Hepatol. 2011 Apr;54(4):773-94. doi: 10.1016/j.jhep.2010.11.006. Epub 2010 Nov 17. Review.

22.

Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen.

Knockaert L, Descatoire V, Vadrot N, Fromenty B, Robin MA.

Toxicol In Vitro. 2011 Mar;25(2):475-84. doi: 10.1016/j.tiv.2010.11.019. Epub 2010 Dec 2.

PMID:
21130154
23.

Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease.

Mitchell C, Mahrouf-Yorgov M, Mayeuf A, Robin MA, Mansouri A, Fromenty B, Gilgenkrantz H.

Lab Invest. 2011 Feb;91(2):273-82. doi: 10.1038/labinvest.2010.163. Epub 2010 Sep 20.

24.

Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.

Dumont J, Jossé R, Lambert C, Anthérieu S, Laurent V, Loyer P, Robin MA, Guillouzo A.

Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100. doi: 10.1016/j.taap.2010.08.027. Epub 2010 Sep 15.

PMID:
20816883
25.

Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells.

Dumont J, Jossé R, Lambert C, Anthérieu S, Le Hegarat L, Aninat C, Robin MA, Guguen-Guillouzo C, Guillouzo A.

Toxicol Appl Pharmacol. 2010 Jun 1;245(2):256-63. doi: 10.1016/j.taap.2010.03.008. Epub 2010 Mar 20.

PMID:
20307560
26.

Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice.

Mitchell C, Robin MA, Mayeuf A, Mahrouf-Yorgov M, Mansouri A, Hamard M, Couton D, Fromenty B, Gilgenkrantz H.

Am J Pathol. 2009 Nov;175(5):1929-37. doi: 10.2353/ajpath.2009.090332. Epub 2009 Oct 1.

27.

Chronic ethanol consumption lessens the gain of body weight, liver triglycerides, and diabetes in obese ob/ob mice.

Fromenty B, Vadrot N, Massart J, Turlin B, Barri-Ova N, Lettéron P, Fautrel A, Robin MA.

J Pharmacol Exp Ther. 2009 Oct;331(1):23-34. doi: 10.1124/jpet.109.155168. Epub 2009 Jul 8.

PMID:
19587315
28.

Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.

Robin MA, Descatoire V, Pessayre D, Berson A.

Toxicol In Vitro. 2008 Sep;22(6):1511-9. doi: 10.1016/j.tiv.2008.05.009. Epub 2008 Jul 7.

PMID:
18603402
29.

Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation.

Cazanave S, Vadrot N, Tinel M, Berson A, Lettéron P, Larosche I, Descatoire V, Feldmann G, Robin MA, Pessayre D.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):336-43. doi: 10.1016/j.taap.2008.05.010. Epub 2008 May 20.

PMID:
18572215
30.

Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice.

Begriche K, Lettéron P, Abbey-Toby A, Vadrot N, Robin MA, Bado A, Pessayre D, Fromenty B.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E939-51. doi: 10.1152/ajpendo.00379.2007. Epub 2008 Mar 18.

31.

High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes.

Igoudjil A, Massart J, Begriche K, Descatoire V, Robin MA, Fromenty B.

Toxicol In Vitro. 2008 Jun;22(4):887-98. doi: 10.1016/j.tiv.2008.01.011. Epub 2008 Jan 26.

PMID:
18299183
32.

High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice.

Igoudjil A, Abbey-Toby A, Begriche K, Grodet A, Chataigner K, Peytavin G, Maachi M, Colin M, Robin MA, Lettéron P, Feldmann G, Pessayre D, Fromenty B.

Antivir Ther. 2007;12(3):389-400.

PMID:
17591029
33.

In vivo altered unfolded protein response and apoptosis in livers from lipopolysaccharide-challenged cirrhotic rats.

Tazi KA, Bièche I, Paradis V, Guichard C, Laurendeau I, Dargère D, Legrand A, Fay M, Pedruzzi E, Robin MA, Cazals-Hatem D, Tellier Z, Bernuau D, Feldmann G, Vidaud M, Lebrec D, Ogier-Denis E, Moreau R.

J Hepatol. 2007 Jun;46(6):1075-88. Epub 2007 Feb 28.

PMID:
17399843
34.

High hepatic glutathione stores alleviate Fas-induced apoptosis in mice.

Cazanave S, Berson A, Haouzi D, Vadrot N, Fau D, Grodet A, Lettéron P, Feldmann G, El-Benna J, Fromenty B, Robin MA, Pessayre D.

J Hepatol. 2007 May;46(5):858-68. Epub 2006 Dec 18.

PMID:
17275124
35.

Role of protein kinase C-mediated protein phosphorylation in mitochondrial translocation of mouse CYP1A1, which contains a non-canonical targeting signal.

Dasari VR, Anandatheerthavarada HK, Robin MA, Boopathi E, Biswas G, Fang JK, Nebert DW, Avadhani NG.

J Biol Chem. 2006 Oct 13;281(41):30834-47. Epub 2006 Aug 9.

36.

Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes.

Robin MA, Sauvage I, Grandperret T, Descatoire V, Pessayre D, Fromenty B.

FEBS Lett. 2005 Dec 19;579(30):6895-902. Epub 2005 Dec 1.

37.

Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice.

Robin MA, Demeilliers C, Sutton A, Paradis V, Maisonneuve C, Dubois S, Poirel O, Lettéron P, Pessayre D, Fromenty B.

Hepatology. 2005 Dec;42(6):1280-90.

PMID:
16317704
38.

The ins and outs of mitochondrial dysfunction in NASH.

Fromenty B, Robin MA, Igoudjil A, Mansouri A, Pessayre D.

Diabetes Metab. 2004 Apr;30(2):121-38. Review.

PMID:
15223984
40.
41.

Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70.

Robin MA, Prabu SK, Raza H, Anandatheerthavarada HK, Avadhani NG.

J Biol Chem. 2003 May 23;278(21):18960-70. Epub 2003 Mar 19.

42.
43.

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.

Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NB, Gordon DM, Pain D, Avadhani NG.

J Biol Chem. 2002 Oct 25;277(43):40583-93. Epub 2002 Aug 20.

44.
45.

Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points.

Anandatheerthavarada HK, Amuthan G, Biswas G, Robin MA, Murali R, Waterman MR, Avadhani NG.

EMBO J. 2001 May 15;20(10):2394-403.

46.

Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity.

Robin MA, Anandatheerthavarada HK, Fang JK, Cudic M, Otvos L, Avadhani NG.

J Biol Chem. 2001 Jul 6;276(27):24680-9. Epub 2001 Apr 26.

47.

Vesicular transport of newly synthesized cytochromes P4501A to the outside of rat hepatocyte plasma membranes.

Robin MA, Descatoire V, Le Roy M, Berson A, Lebreton FP, Maratrat M, Ballet F, Loeper J, Pessayre D.

J Pharmacol Exp Ther. 2000 Sep;294(3):1063-9.

PMID:
10945860
48.

Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes.

Haouzi D, Lekéhal M, Moreau A, Moulis C, Feldmann G, Robin MA, Lettéron P, Fau D, Pessayre D.

Hepatology. 2000 Aug;32(2):303-11.

PMID:
10915737
49.

Withdrawal of life support, altruistic suicide, fratricidal killing and euthanasia by lymphocytes: different forms of drug-induced hepatic apoptosis.

Pessayre D, Haouzi D, Fau D, Robin MA, Mansouri A, Berson A.

J Hepatol. 1999 Oct;31(4):760-70. Review. No abstract available.

PMID:
10551404
50.

Interleukin-2 overexpresses c-myc and down-regulates cytochrome P-450 in rat hepatocytes.

Tinel M, Elkahwaji J, Robin MA, Fardel N, Descatoire V, Haouzi D, Berson A, Pessayre D.

J Pharmacol Exp Ther. 1999 May;289(2):649-55.

PMID:
10215635

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