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Items: 1 to 50 of 106

1.

Phenotypic correlates and prognostic outcomes of TET2 mutations in myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: A comprehensive study of 504 adult patients.

Coltro G, Antelo G, Lasho TL, Finke CM, Pardanani A, Gangat N, Carr RM, Binder M, Mangaonkar AA, Ketterling R, Fernandez-Zapico ME, Robertson KD, Bosi A, Vannucchi AM, Tefferi A, Patnaik MM.

Am J Hematol. 2020 Jan 10. doi: 10.1002/ajh.25721. [Epub ahead of print] No abstract available.

PMID:
31925810
2.

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)-a study of 1084 patients.

Coltro G, Mangaonkar AA, Lasho TL, Finke CM, Pophali P, Carr R, Gangat N, Binder M, Pardanani A, Fernandez-Zapico M, Robertson KD, Bosi A, Droin N, Vannucchi AM, Tefferi A, Hunter A, Padron E, Solary E, Patnaik MM.

Leukemia. 2019 Dec 13. doi: 10.1038/s41375-019-0690-7. [Epub ahead of print]

PMID:
31836856
3.

CpGtools: A Python Package for DNA Methylation Analysis.

Wei T, Nie J, Larson NB, Ye Z, Eckel Passow JE, Robertson KD, Kocher JA, Wang L.

Bioinformatics. 2019 Dec 6. pii: btz916. doi: 10.1093/bioinformatics/btz916. [Epub ahead of print]

PMID:
31808791
4.

Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA.

Hlady RA, Zhao X, Pan X, Yang JD, Ahmed F, Antwi SO, Giama NH, Patel T, Roberts LR, Liu C, Robertson KD.

Theranostics. 2019 Sep 25;9(24):7239-7250. doi: 10.7150/thno.35573. eCollection 2019.

5.

DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma.

Zheng Y, Hlady RA, Joyce BT, Robertson KD, He C, Nannini DR, Kibbe WA, Achenbach CJ, Murphy RL, Roberts LR, Hou L.

Clin Epigenetics. 2019 Oct 21;11(1):145. doi: 10.1186/s13148-019-0733-y.

6.

In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma.

Yang M, Hlady RA, Zhou D, Ho TH, Robertson KD.

Cancer Med. 2019 Sep;8(12):5760-5768. doi: 10.1002/cam4.2402. Epub 2019 Jul 30.

7.

Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder.

Ho AM, Winham SJ, Armasu SM, Blacker CJ, Millischer V, Lavebratt C, Overholser JC, Jurjus GJ, Dieter L, Mahajan G, Rajkowska G, Vallender EJ, Stockmeier CA, Robertson KD, Frye MA, Choi DS, Veldic M.

J Psychiatr Res. 2019 Oct;117:45-54. doi: 10.1016/j.jpsychires.2019.05.030. Epub 2019 Jun 26.

8.

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq.

Zhong J, Ye Z, Clark CR, Lenz SW, Nguyen JH, Yan H, Robertson KD, Farrugia G, Zhang Z, Ordog T, Lee JH.

BMC Genomics. 2019 Mar 29;20(1):249. doi: 10.1186/s12864-019-5639-8.

9.

Esophageal Candidiasis.

Robertson KD, Mehta D.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2019 Dec 17.

10.

Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity.

Wang L, Marek GW 3rd, Hlady RA, Wagner RT, Zhao X, Clark VC, Fan AX, Liu C, Brantly M, Robertson KD.

Hepatology. 2019 Jul;70(1):51-66. doi: 10.1002/hep.30526. Epub 2019 Mar 20.

PMID:
30681738
11.

Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis.

Gutierrez Sanchez LH, Tomita K, Guo Q, Furuta K, Alhuwaish H, Hirsova P, Baheti S, Alver B, Hlady R, Robertson KD, Ibrahim SH.

Hepatol Commun. 2018 Oct 1;2(12):1493-1512. doi: 10.1002/hep4.1265. eCollection 2018 Dec.

12.

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation.

Liu J, Hanavan PD, Kras K, Ruiz YW, Castle EP, Lake DF, Chen X, O'Brien D, Luo H, Robertson KD, Gu H, Ho TH.

J Proteome Res. 2019 Jan 4;18(1):331-340. doi: 10.1021/acs.jproteome.8b00628. Epub 2018 Nov 27.

13.

DNA methylation age is accelerated in alcohol dependence.

Rosen AD, Robertson KD, Hlady RA, Muench C, Lee J, Philibert R, Horvath S, Kaminsky ZA, Lohoff FW.

Transl Psychiatry. 2018 Sep 5;8(1):182. doi: 10.1038/s41398-018-0233-4.

14.

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma.

Hlady RA, Sathyanarayan A, Thompson JJ, Zhou D, Wu Q, Pham K, Lee JH, Liu C, Robertson KD.

Hepatology. 2019 Feb;69(2):639-652. doi: 10.1002/hep.30211. Epub 2019 Jan 5.

15.

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation.

Thompson JJ, Kaur R, Sosa CP, Lee JH, Kashiwagi K, Zhou D, Robertson KD.

Nucleic Acids Res. 2018 Nov 2;46(19):10034-10051. doi: 10.1093/nar/gky682.

16.

A Three-Pronged Epigenetic Approach to the Treatment of Hepatocellular Carcinoma.

Hlady RA, Robertson KD.

Hepatology. 2018 Oct;68(4):1226-1228. doi: 10.1002/hep.30133. No abstract available.

PMID:
30070376
17.

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues.

Zhou D, Alver BM, Li S, Hlady RA, Thompson JJ, Schroeder MA, Lee JH, Qiu J, Schwartz PH, Sarkaria JN, Robertson KD.

Genome Biol. 2018 Mar 27;19(1):43. doi: 10.1186/s13059-018-1420-6.

18.

Capsule Endoscopy.

Robertson KD, Singh R.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2020 Jan 13.

19.

Use of the CRISPR/Cas9-based epigenetic gene activation system In Vivo: A new potential therapeutic modality.

Ibrahim SH, Robertson KD.

Hepatology. 2018 Sep;68(3):1191-1193. doi: 10.1002/hep.29860. Epub 2018 May 14. No abstract available.

20.

Genetic and Epigenetic Heterogeneity in Normal Liver Homeostasis and Its Implications for Liver Disease and Hepatocellular Cancer.

Hlady RA, Robertson KD.

Semin Liver Dis. 2018 Feb;38(1):41-50. doi: 10.1055/s-0037-1621712. Epub 2018 Feb 22. Review.

PMID:
29471564
21.

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application.

Zhong J, Ye Z, Lenz SW, Clark CR, Bharucha A, Farrugia G, Robertson KD, Zhang Z, Ordog T, Lee JH.

BMC Genomics. 2017 Dec 21;18(1):985. doi: 10.1186/s12864-017-4371-5.

22.

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer.

Hlady RA, Zhou D, Puszyk W, Roberts LR, Liu C, Robertson KD.

Epigenetics. 2017 Mar 4;12(3):215-225. doi: 10.1080/15592294.2016.1277297. Epub 2017 Jan 6.

23.

CAME: identification of chromatin accessibility from nucleosome occupancy and methylome sequencing.

Piao Y, Lee SK, Lee EJ, Robertson KD, Shi H, Ryu KH, Choi JH.

Bioinformatics. 2017 Apr 15;33(8):1139-1146. doi: 10.1093/bioinformatics/btw785.

24.

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver.

Zhou D, Hlady RA, Schafer MJ, White TA, Liu C, Choi JH, Miller JD, Roberts LR, LeBrasseur NK, Robertson KD.

Epigenetics. 2017 Jan 2;12(1):55-69. doi: 10.1080/15592294.2016.1261239. Epub 2016 Nov 18. Erratum in: Epigenetics. 2017 Apr 3;12 (4):304-305.

25.

Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevance.

Patnaik MM, Zahid MF, Lasho TL, Finke C, Ketterling RL, Gangat N, Robertson KD, Hanson CA, Tefferi A.

Blood Cancer J. 2016 Sep 23;6(9):e472. doi: 10.1038/bcj.2016.82. No abstract available.

26.

Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials.

Yun S, Vincelette ND, Abraham I, Robertson KD, Fernandez-Zapico ME, Patnaik MM.

Clin Epigenetics. 2016 Jun 14;8:68. doi: 10.1186/s13148-016-0233-2. eCollection 2016. Review.

27.

Nucleosome positioning changes during human embryonic stem cell differentiation.

Zhang W, Li Y, Kulik M, Tiedemann RL, Robertson KD, Dalton S, Zhao S.

Epigenetics. 2016 Jun 2;11(6):426-37. doi: 10.1080/15592294.2016.1176649. Epub 2016 Apr 18.

28.

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma.

Tiedemann RL, Hlady RA, Hanavan PD, Lake DF, Tibes R, Lee JH, Choi JH, Ho TH, Robertson KD.

Oncotarget. 2016 Jan 12;7(2):1927-46. doi: 10.18632/oncotarget.6481.

29.

Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss.

Sturzu AC, Rajarajan K, Passer D, Plonowska K, Riley A, Tan TC, Sharma A, Xu AF, Engels MC, Feistritzer R, Li G, Selig MK, Geissler R, Robertson KD, Scherrer-Crosbie M, Domian IJ, Wu SM.

Circulation. 2015 Jul 14;132(2):109-21. doi: 10.1161/CIRCULATIONAHA.114.011490. Epub 2015 May 20.

30.

iTagPlot: an accurate computation and interactive drawing tool for tag density plot.

Kim SH, Ezenwoye O, Cho HG, Robertson KD, Choi JH.

Bioinformatics. 2015 Jul 15;31(14):2384-7. doi: 10.1093/bioinformatics/btv166. Epub 2015 Mar 19.

31.

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome.

Tiedemann RL, Putiri EL, Lee JH, Hlady RA, Kashiwagi K, Ordog T, Zhang Z, Liu C, Choi JH, Robertson KD.

Cell Rep. 2014 Nov 20;9(4):1554-66. doi: 10.1016/j.celrep.2014.10.013. Epub 2014 Nov 6.

32.

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma.

Zhao X, Puszyk WM, Lu Z, Ostrov DA, George TJ, Robertson KD, Liu C.

Mol Cancer Ther. 2015 Jan;14(1):80-9. doi: 10.1158/1535-7163.MCT-14-0229. Epub 2014 Oct 24.

33.

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis.

Hlady RA, Tiedemann RL, Puszyk W, Zendejas I, Roberts LR, Choi JH, Liu C, Robertson KD.

Oncotarget. 2014 Oct 15;5(19):9425-43.

34.

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome.

Putiri EL, Tiedemann RL, Liu C, Choi JH, Robertson KD.

Oncotarget. 2014 Aug 15;5(15):6338-52.

35.

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.

Putiri EL, Tiedemann RL, Thompson JJ, Liu C, Ho T, Choi JH, Robertson KD.

Genome Biol. 2014 Jun 23;15(6):R81. doi: 10.1186/gb-2014-15-6-r81.

36.

Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells.

Jin B, Ernst J, Tiedemann RL, Xu H, Sureshchandra S, Kellis M, Dalton S, Liu C, Choi JH, Robertson KD.

Cell Rep. 2012 Nov 29;2(5):1411-24. doi: 10.1016/j.celrep.2012.10.017. Epub 2012 Nov 21.

37.

DNA methyltransferases, DNA damage repair, and cancer.

Jin B, Robertson KD.

Adv Exp Med Biol. 2013;754:3-29. doi: 10.1007/978-1-4419-9967-2_1. Review.

38.

Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor.

Yoo J, Kim JH, Robertson KD, Medina-Franco JL.

Adv Protein Chem Struct Biol. 2012;87:219-47. doi: 10.1016/B978-0-12-398312-1.00008-1. Review.

39.

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells.

Zimmerman MA, Singh N, Martin PM, Thangaraju M, Ganapathy V, Waller JL, Shi H, Robertson KD, Munn DH, Liu K.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1405-15. doi: 10.1152/ajpgi.00543.2011. Epub 2012 Apr 19.

40.

DNA methylation: superior or subordinate in the epigenetic hierarchy?

Jin B, Li Y, Robertson KD.

Genes Cancer. 2011 Jun;2(6):607-17. doi: 10.1177/1947601910393957.

41.

Epigenetic mechanisms and genome stability.

Putiri EL, Robertson KD.

Clin Epigenetics. 2011 Aug 1;2(2):299-314.

42.

Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing.

Lee EJ, Pei L, Srivastava G, Joshi T, Kushwaha G, Choi JH, Robertson KD, Wang X, Colbourne JK, Zhang L, Schroth GP, Xu D, Zhang K, Shi H.

Nucleic Acids Res. 2011 Oct;39(19):e127. doi: 10.1093/nar/gkr598. Epub 2011 Jul 23.

43.

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants.

Van Emburgh BO, Robertson KD.

Nucleic Acids Res. 2011 Jul;39(12):4984-5002. doi: 10.1093/nar/gkr116. Epub 2011 Mar 4.

44.

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery.

Ha K, Lee GE, Palii SS, Brown KD, Takeda Y, Liu K, Bhalla KN, Robertson KD.

Hum Mol Genet. 2011 Jan 1;20(1):126-40. doi: 10.1093/hmg/ddq451. Epub 2010 Oct 11.

45.

The transglutaminase 2 gene is aberrantly hypermethylated in glioma.

Dyer LM, Schooler KP, Ai L, Klop C, Qiu J, Robertson KD, Brown KD.

J Neurooncol. 2011 Feb;101(3):429-40. doi: 10.1007/s11060-010-0277-7. Epub 2010 Jul 3.

46.

A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding.

Gopalakrishnan S, Van Emburgh BO, Shan J, Su Z, Fields CR, Vieweg J, Hamazaki T, Schwartz PH, Terada N, Robertson KD.

Mol Cancer Res. 2009 Oct;7(10):1622-34. doi: 10.1158/1541-7786.MCR-09-0018. Epub 2009 Oct 13.

47.

Missteps in "tango" for epigenome targeting.

Robertson KD, Bhalla KN.

Blood. 2009 Sep 24;114(13):2569-70. doi: 10.1182/blood-2009-07-231662. No abstract available.

PMID:
19779044
48.

DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer.

Jin B, Yao B, Li JL, Fields CR, Delmas AL, Liu C, Robertson KD.

Cancer Res. 2009 Sep 15;69(18):7412-21. doi: 10.1158/0008-5472.CAN-09-0116. Epub 2009 Sep 1.

49.

Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD).

Zeng W, de Greef JC, Chen YY, Chien R, Kong X, Gregson HC, Winokur ST, Pyle A, Robertson KD, Schmiesing JA, Kimonis VE, Balog J, Frants RR, Ball AR Jr, Lock LF, Donovan PJ, van der Maarel SM, Yokomori K.

PLoS Genet. 2009 Jul;5(7):e1000559. doi: 10.1371/journal.pgen.1000559. Epub 2009 Jul 10.

50.

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.

Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H.

Lab Invest. 2009 Sep;89(9):983-93. doi: 10.1038/labinvest.2009.59. Epub 2009 Jun 22.

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