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Items: 39

1.

Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.

Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02071-18. doi: 10.1128/AAC.02071-18. Print 2019 Apr.

2.

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.

Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M.

Life Sci Alliance. 2018 Jun 1;1(3):e201800025. doi: 10.26508/lsa.201800025. eCollection 2018 Jun.

3.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

4.

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, Ainsa J, Böttger EC, Lee RE.

ACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021/acsinfecdis.6b00158. Epub 2016 Nov 11.

5.

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models.

Robertson GT, Scherman MS, Bruhn DF, Liu J, Hastings C, McNeil MR, Butler MM, Bowlin TL, Lee RB, Lee RE, Lenaerts AJ.

J Antimicrob Chemother. 2017 Mar 1;72(3):770-777. doi: 10.1093/jac/dkw467.

6.

Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase.

Silvers MA, Robertson GT, Taylor CM, Waldrop GL.

J Med Chem. 2014 Nov 13;57(21):8947-59. doi: 10.1021/jm501082n. Epub 2014 Oct 15.

PMID:
25280369
7.

FTT0831c/FTL_0325 contributes to Francisella tularensis cell division, maintenance of cell shape, and structural integrity.

Robertson GT, Case ED, Dobbs N, Ingle C, Balaban M, Celli J, Norgard MV.

Infect Immun. 2014 Jul;82(7):2935-48. doi: 10.1128/IAI.00102-14. Epub 2014 Apr 28.

8.

IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A Francisella tularensis.

Robertson GT, Child R, Ingle C, Celli J, Norgard MV.

Infect Immun. 2013 Nov;81(11):4026-40. doi: 10.1128/IAI.00595-13. Epub 2013 Aug 19.

9.

Method for the isolation of Francisella tularensis outer membranes.

Huntley JF, Robertson GT, Norgard MV.

J Vis Exp. 2010 Jun 29;(40). pii: 2044. doi: 10.3791/2044.

10.

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

Robertson GT, Bonventre EJ, Doyle TB, Du Q, Duncan L, Morris TW, Roche ED, Yan D, Lynch AS.

Antimicrob Agents Chemother. 2008 Jul;52(7):2313-23. doi: 10.1128/AAC.01649-07. Epub 2008 Apr 28.

11.

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci.

Robertson GT, Bonventre EJ, Doyle TB, Du Q, Duncan L, Morris TW, Roche ED, Yan D, Lynch AS.

Antimicrob Agents Chemother. 2008 Jul;52(7):2324-34. doi: 10.1128/AAC.01651-07. Epub 2008 Apr 28.

12.

Bacterial and fungal biofilm infections.

Lynch AS, Robertson GT.

Annu Rev Med. 2008;59:415-28. Review.

PMID:
17937586
13.

A Novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM.

Robertson GT, Doyle TB, Du Q, Duncan L, Mdluli KE, Lynch AS.

J Bacteriol. 2007 Oct;189(19):6870-81. Epub 2007 Jul 20.

14.

New C25 carbamate rifamycin derivatives are resistant to inactivation by ADP-ribosyl transferases.

Combrink KD, Denton DA, Harran S, Ma Z, Chapo K, Yan D, Bonventre E, Roche ED, Doyle TB, Robertson GT, Lynch AS.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):522-6. Epub 2006 Oct 12.

PMID:
17070048
16.

Role of HdeA in acid resistance and virulence in Brucella abortus 2308.

Valderas MW, Alcantara RB, Baumgartner JE, Bellaire BH, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM 2nd.

Vet Microbiol. 2005 May 20;107(3-4):307-12.

PMID:
15863292
17.

The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice.

Gee JM, Valderas MW, Kovach ME, Grippe VK, Robertson GT, Ng WL, Richardson JM, Winkler ME, Roop RM 2nd.

Infect Immun. 2005 May;73(5):2873-80.

18.

Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.

Ng WL, Robertson GT, Kazmierczak KM, Zhao J, Gilmour R, Winkler ME.

Mol Microbiol. 2003 Dec;50(5):1647-63.

19.

Brucella stationary-phase gene expression and virulence.

Roop RM 2nd, Gee JM, Robertson GT, Richardson JM, Ng WL, Winkler ME.

Annu Rev Microbiol. 2003;57:57-76. Epub 2003 May 1. Review.

PMID:
12730323
20.

Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6.

Robertson GT, Ng WL, Gilmour R, Winkler ME.

J Bacteriol. 2003 May;185(9):2961-6.

22.

Vancomycin tolerance induced by erythromycin but not by loss of vncRS, vex3, or pep27 function in Streptococcus pneumoniae.

Robertson GT, Zhao J, Desai BV, Coleman WH, Nicas TI, Gilmour R, Grinius L, Morrison DA, Winkler ME.

J Bacteriol. 2002 Dec;184(24):6987-7000.

23.

Seeking a niche: putative contributions of the hfq and bacA gene products to the successful adaptation of the brucellae to their intracellular home.

Roop RM 2nd, Robertson GT, Ferguson GP, Milford LE, Winkler ME, Walker GC.

Vet Microbiol. 2002 Dec 20;90(1-4):349-63. Review.

PMID:
12414155
24.
25.
26.

Streptococcus pneumoniae as a genomics platform for broad-spectrum antibiotic discovery.

Glass JI, Belanger AE, Robertson GT.

Curr Opin Microbiol. 2002 Jun;5(3):338-42. Review.

PMID:
12057692
27.

Genome of the bacterium Streptococcus pneumoniae strain R6.

Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI.

J Bacteriol. 2001 Oct;183(19):5709-17.

28.

The Brucella abortus CcrM DNA methyltransferase is essential for viability, and its overexpression attenuates intracellular replication in murine macrophages.

Robertson GT, Reisenauer A, Wright R, Jensen RB, Jensen A, Shapiro L, Roop RM 2nd.

J Bacteriol. 2000 Jun;182(12):3482-9.

29.

The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice.

Robertson GT, Kovach ME, Allen CA, Ficht TA, Roop RM 2nd.

Mol Microbiol. 2000 Feb;35(3):577-88.

31.

A Brucella melitensis high-temperature-requirement A (htrA) deletion mutant is attenuated in goats and protects against abortion.

Phillips RW, Elzer PH, Robertson GT, Hagius SD, Walker JV, Fatemi MB, Enright FM, Roop RM 2nd.

Res Vet Sci. 1997 Sep-Oct;63(2):165-7.

PMID:
9429252
32.

Cloning and nucleotide sequence analysis of a Brucella abortus gene encoding an 18 kDa immunoreactive protein.

Kovach ME, Elzer PH, Robertson GT, Chirhart-Gilleland RL, Christensen MA, Peterson KM, Roop RM 2nd.

Microb Pathog. 1997 Apr;22(4):241-6.

PMID:
9140920
33.

The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes.

Elzer PH, Phillips RW, Robertson GT, Roop RM 2nd.

Infect Immun. 1996 Nov;64(11):4838-41.

35.

Behaviour of a high-temperature-requirement A (HtrA) deletion mutant of Brucella abortus in goats.

Elzer PH, Hagius SD, Robertson GT, Phillips RW, Walker JV, Fatemi MB, Enright FM, Roop RM 2nd.

Res Vet Sci. 1996 Jan;60(1):48-50.

PMID:
8745255
36.

Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes.

Kovach ME, Elzer PH, Hill DS, Robertson GT, Farris MA, Roop RM 2nd, Peterson KM.

Gene. 1995 Dec 1;166(1):175-6.

PMID:
8529885
37.

In vivo and in vitro stability of the broad-host-range cloning vector pBBR1MCS in six Brucella species.

Elzer PH, Kovach ME, Phillips RW, Robertson GT, Peterson KM, Roop RM 2nd.

Plasmid. 1995 Jan;33(1):51-7.

PMID:
7753908
38.

Gynaecological malignant disease in the eastern region of Scotland. 2. Malignant disease of the ovary.

MILLER MC, ROBERTSON GT, SWANSON WC, WALKER J.

Scott Med J. 1962 Sep;7:399-408. No abstract available.

PMID:
14474072
39.

Gynaecological malignant disease in the eastern region of Scotland. 1. Malignant disease of the body of the uterus.

MILLER MC, ROBERTSON GT, SWANSON WC, WALKER J.

J Obstet Gynaecol Br Emp. 1962 Aug;69:553-64. No abstract available.

PMID:
14474071

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