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Items: 1 to 50 of 91

1.

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.

Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB, Schroder K.

Nat Chem Biol. 2019 Jun;15(6):556-559. doi: 10.1038/s41589-019-0277-7. Epub 2019 May 13.

PMID:
31086327
2.

Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes.

Skinner OP, Jurczyluk J, Baker PJ, Masters SL, Rios Wilks AG, Clearwater MS, Robertson AAB, Schroder K, Mehr S, Munoz MA, Rogers MJ.

J Allergy Clin Immunol. 2019 Jun;143(6):2315-2317.e3. doi: 10.1016/j.jaci.2019.02.013. Epub 2019 Feb 21. No abstract available.

3.

Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection.

Chitty JL, Edwards DJ, Robertson AAB, Butler MS, Duley JA, Cooper MA, Fraser JA.

Mycopathologia. 2019 Apr;184(2):273-281. doi: 10.1007/s11046-018-0315-0. Epub 2019 Feb 1.

PMID:
30707338
4.

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.

Schofield ZV, Croker D, Robertson AAB, Massey NL, Donovan C, Tee E, Edwards D, Woodruff TM, Halai R, Hansbro PM, Cooper MA.

Sci Rep. 2018 Dec 13;8(1):17819. doi: 10.1038/s41598-018-36242-1.

5.

Inhibiting Inflammasomes with Small Molecules.

Robertson AAB.

Exp Suppl. 2018;108:343-400. doi: 10.1007/978-3-319-89390-7_15.

PMID:
30536179
6.

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome.

Mathur A, Feng S, Hayward JA, Ngo C, Fox D, Atmosukarto II, Price JD, Schauer K, Märtlbauer E, Robertson AAB, Burgio G, Fox EM, Leppla SH, Kaakoush NO, Man SM.

Nat Microbiol. 2019 Feb;4(2):362-374. doi: 10.1038/s41564-018-0318-0. Epub 2018 Dec 10.

PMID:
30531979
7.

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.

Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM.

Sci Transl Med. 2018 Oct 31;10(465). pii: eaah4066. doi: 10.1126/scitranslmed.aah4066.

PMID:
30381407
8.

The Small Molecule NLRP3 Inflammasome Inhibitor MCC950 Does Not Alter Wound Healing in Obese Mice.

Lee JS, Robertson AAB, Cooper MA, Khosrotehrani K.

Int J Mol Sci. 2018 Oct 23;19(11). pii: E3289. doi: 10.3390/ijms19113289.

9.

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.

Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A.

Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252.

10.

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.

Kummari LK, Butler MS, Furlong E, Blundell R, Nouwens A, Silva AB, Kappler U, Fraser JA, Kobe B, Cooper MA, Robertson AAB.

Bioorg Med Chem. 2018 Nov 1;26(20):5408-5419. doi: 10.1016/j.bmc.2018.09.004. Epub 2018 Sep 5.

PMID:
30322754
11.

Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism.

Fauzia E, Barbhuyan TK, Shrivastava AK, Kumar M, Garg P, Khan MA, Robertson AAB, Raza SS.

Front Pharmacol. 2018 Sep 21;9:1034. doi: 10.3389/fphar.2018.01034. eCollection 2018.

12.

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages.

Thygesen SJ, Takizawa KE, Robertson AAB, Sester DP, Stacey KJ.

Immunol Cell Biol. 2019 Jan;97(1):17-28. doi: 10.1111/imcb.12193. Epub 2018 Aug 19.

PMID:
30052286
13.

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice.

Perera AP, Fernando R, Shinde T, Gundamaraju R, Southam B, Sohal SS, Robertson AAB, Schroder K, Kunde D, Eri R.

Sci Rep. 2018 Jun 5;8(1):8618. doi: 10.1038/s41598-018-26775-w.

14.

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection.

Alhallaf R, Agha Z, Miller CM, Robertson AAB, Sotillo J, Croese J, Cooper MA, Masters SL, Kupz A, Smith NC, Loukas A, Giacomin PR.

Cell Rep. 2018 Apr 24;23(4):1085-1098. doi: 10.1016/j.celrep.2018.03.097.

15.

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis.

Hill JR, Robertson AAB.

J Med Chem. 2018 Aug 23;61(16):6945-6963. doi: 10.1021/acs.jmedchem.7b01561. Epub 2018 May 9.

PMID:
29683660
16.

Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis.

Chen AC, Tran HB, Xi Y, Yerkovich ST, Baines KJ, Pizzutto SJ, Carroll M, Robertson AAB, Cooper MA, Schroder K, Simpson JL, Gibson PG, Hodge G, Masters IB, Buntain HM, Petsky HL, Prime SJ, Chang AB, Hodge S, Upham JW.

ERJ Open Res. 2018 Mar 23;4(1). pii: 00130-2017. doi: 10.1183/23120541.00130-2017. eCollection 2018 Jan.

17.

Racial differences in college-student drinking.

Gardner SK, Robertson AA, Tatch A, Walker CS.

J Ethn Subst Abuse. 2018 Mar 22:1-16. doi: 10.1080/15332640.2018.1446376. [Epub ahead of print]

PMID:
29565780
18.

Evidence against a role for NLRP3-driven islet inflammation in db/db mice.

Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA.

Mol Metab. 2018 Apr;10:66-73. doi: 10.1016/j.molmet.2018.02.001. Epub 2018 Feb 7.

19.

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.

Salla M, Butler MS, Massey NL, Reid JC, Cooper MA, Robertson AAB.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):793-795. doi: 10.1016/j.bmcl.2017.12.054. Epub 2017 Dec 26.

PMID:
29338910
20.

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.

Pavillard LE, Cañadas-Lozano D, Alcocer-Gómez E, Marín-Aguilar F, Pereira S, Robertson AAB, Muntané J, Ryffel B, Cooper MA, Quiles JL, Bullón P, Ruiz-Cabello J, Cordero MD.

Oncotarget. 2017 Sep 8;8(59):99740-99756. doi: 10.18632/oncotarget.20763. eCollection 2017 Nov 21.

21.

Predictors of justice system involvement: Maltreatment and education.

Robertson AA, Walker CS.

Child Abuse Negl. 2018 Feb;76:408-415. doi: 10.1016/j.chiabu.2017.12.002. Epub 2017 Dec 11.

PMID:
29241115
22.

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes.

Grinstein L, Endter K, Hedrich CM, Reinke S, Luksch H, Schulze F, Robertson AAB, Cooper MA, Rösen-Wolff A, Winkler S.

Clin Immunol. 2018 Jun;191:100-109. doi: 10.1016/j.clim.2017.11.011. Epub 2017 Nov 26.

PMID:
29183866
23.

Antimicrobial Octapeptin C4 Analogues Active against Cryptococcus Species.

Chitty JL, Butler MS, Suboh A, Edwards DJ, Cooper MA, Fraser JA, Robertson AAB.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e00986-17. doi: 10.1128/AAC.00986-17. Print 2018 Feb.

24.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.

PMID:
28848230
25.

The Benefits of Community and Juvenile Justice Involvement in Organizational Research.

Leukefeld CG, Cawood M, Wiley T, Robertson AA, Fisher JH, Arrigona N, Donohue P, Staples-Horne M, Harris PW, Dembo R, Roysden J, Marks KR; JJ-TRIALS Cooperative.

J Juv Justice. 2017;6(1):112-124.

26.

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.

Hill JR, Coll RC, Sue N, Reid JC, Dou J, Holley CL, Pelingon R, Dickinson JB, Biden TJ, Schroder K, Cooper MA, Robertson AAB.

ChemMedChem. 2017 Sep 7;12(17):1449-1457. doi: 10.1002/cmdc.201700270. Epub 2017 Aug 4.

PMID:
28703484
27.

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.

Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G.

Am J Transl Res. 2017 Jun 15;9(6):2723-2735. eCollection 2017.

28.

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.

Dinh QN, Drummond GR, Kemp-Harper BK, Diep H, De Silva TM, Kim HA, Vinh A, Robertson AAB, Cooper MA, Mansell A, Chrissobolis S, Sobey CG.

Aging (Albany NY). 2017 Jun 28;9(6):1595-1606. doi: 10.18632/aging.101255.

29.

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Chitty JL, Blake KL, Blundell RD, Koh YQAE, Thompson M, Robertson AAB, Butler MS, Cooper MA, Kappler U, Williams SJ, Kobe B, Fraser JA.

J Biol Chem. 2017 Jul 14;292(28):11829-11839. doi: 10.1074/jbc.M117.787994. Epub 2017 May 30.

30.

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN.

J Exp Med. 2017 Jun 5;214(6):1737-1752. doi: 10.1084/jem.20160462. Epub 2017 May 9.

31.

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.

PMID:
28252317
32.

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC.

J Hepatol. 2017 May;66(5):1037-1046. doi: 10.1016/j.jhep.2017.01.022. Epub 2017 Feb 3.

33.

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

Fontaine F, Overman J, Moustaqil M, Mamidyala S, Salim A, Narasimhan K, Prokoph N, Robertson AAB, Lua L, Alexandrov K, Koopman P, Capon RJ, Sierecki E, Gambin Y, Jauch R, Cooper MA, Zuegg J, Francois M.

Cell Chem Biol. 2017 Mar 16;24(3):346-359. doi: 10.1016/j.chembiol.2017.01.003. Epub 2017 Feb 2.

34.

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AA, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Smyth MJ, Cooper MA, Gambin Y, Francois M.

Elife. 2017 Jan 31;6. pii: e21221. doi: 10.7554/eLife.21221.

35.

The Juvenile Justice Behavioral Health Services Cascade: A new framework for measuring unmet substance use treatment services needs among adolescent offenders.

Belenko S, Knight D, Wasserman GA, Dennis ML, Wiley T, Taxman FS, Oser C, Dembo R, Robertson AA, Sales J.

J Subst Abuse Treat. 2017 Mar;74:80-91. doi: 10.1016/j.jsat.2016.12.012. Epub 2016 Dec 31.

36.

Inflammasomes in the lung.

Pinkerton JW, Kim RY, Robertson AAB, Hirota JA, Wood LG, Knight DA, Cooper MA, O'Neill LAJ, Horvat JC, Hansbro PM.

Mol Immunol. 2017 Jun;86:44-55. doi: 10.1016/j.molimm.2017.01.014. Epub 2017 Jan 24. Review.

PMID:
28129896
37.

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.

Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu CL, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AA, Cooper MA, Andrés V, Hirschi KK, Martin KA, Walsh K.

Science. 2017 Feb 24;355(6327):842-847. doi: 10.1126/science.aag1381. Epub 2017 Jan 19.

38.

Psychometric properties of the Short Inventory of Problems (SIP) with adjudicated DUI intervention participants.

Morse DT, Robertson AA.

Psychol Addict Behav. 2017 Feb;31(1):110-116. doi: 10.1037/adb0000249. Epub 2017 Jan 12.

PMID:
28080093
39.

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Chitty JL, Tatzenko TL, Williams SJ, Koh YQ, Corfield EC, Butler MS, Robertson AA, Cooper MA, Kappler U, Kobe B, Fraser JA.

J Biol Chem. 2017 Feb 17;292(7):3049-3059. doi: 10.1074/jbc.M116.767533. Epub 2017 Jan 6.

40.

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA.

Brain Behav Immun. 2017 Mar;61:306-316. doi: 10.1016/j.bbi.2016.12.014. Epub 2016 Dec 18.

PMID:
28003153
41.

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.

Salla M, Butler MS, Pelingon R, Kaeslin G, Croker DE, Reid JC, Baek JM, Bernhardt PV, Gillam EM, Cooper MA, Robertson AA.

ACS Med Chem Lett. 2016 Sep 27;7(12):1034-1038. eCollection 2016 Dec 8.

42.

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.

Pinar A, Dowling JK, Bitto NJ, Robertson AA, Latz E, Stewart CR, Drummond GR, Cooper MA, McAuley JL, Tate MD, Mansell A.

J Biol Chem. 2017 Jan 20;292(3):826-836. doi: 10.1074/jbc.M116.756379. Epub 2016 Dec 2.

43.

The Impact of Abuse Trauma on Alcohol and Drug Use: A Study of High-Risk Incarcerated Girls.

Rich SL, Wilson JK, Robertson AA.

J Child Adolesc Subst Abuse. 2016;25(3):194-205. Epub 2016 Feb 19.

44.

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA.

ACS Infect Dis. 2016 Sep 9;2(9):651-663. Epub 2016 Aug 17.

PMID:
27759389
45.

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.

Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O.

Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27.

46.

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.

Basiorka AA, McGraw KL, Eksioglu EA, Chen X, Johnson J, Zhang L, Zhang Q, Irvine BA, Cluzeau T, Sallman DA, Padron E, Komrokji R, Sokol L, Coll RC, Robertson AA, Cooper MA, Cleveland JL, O'Neill LA, Wei S, List AF.

Blood. 2016 Dec 22;128(25):2960-2975. doi: 10.1182/blood-2016-07-730556. Epub 2016 Oct 13.

47.

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction.

van Hout GP, Bosch L, Ellenbroek GH, de Haan JJ, van Solinge WW, Cooper MA, Arslan F, de Jager SC, Robertson AA, Pasterkamp G, Hoefer IE.

Eur Heart J. 2017 Mar 14;38(11):828-836. doi: 10.1093/eurheartj/ehw247.

PMID:
27432019
48.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.

Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

49.

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals.

Tucey TM, Verma-Gaur J, Nguyen J, Hewitt VL, Lo TL, Shingu-Vazquez M, Robertson AA, Hill JR, Pettolino FA, Beddoe T, Cooper MA, Naderer T, Traven A.

mSphere. 2016 May 25;1(3). pii: e00074-16. doi: 10.1128/mSphere.00074-16. eCollection 2016 May-Jun.

50.

Juvenile Justice-Translational Research on Interventions for Adolescents in the Legal System (JJ-TRIALS): a cluster randomized trial targeting system-wide improvement in substance use services.

Knight DK, Belenko S, Wiley T, Robertson AA, Arrigona N, Dennis M, Bartkowski JP, McReynolds LS, Becan JE, Knudsen HK, Wasserman GA, Rose E, DiClemente R, Leukefeld C; JJ-TRIALS Cooperative.

Implement Sci. 2016 Apr 29;11:57. doi: 10.1186/s13012-016-0423-5.

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