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Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology.

van Westering TLE, Lomonosova Y, Coenen-Stass AML, Betts CA, Bhomra A, Hulsker M, Clark LE, McClorey G, Aartsma-Rus A, van Putten M, Wood MJA, Roberts TC.

J Cachexia Sarcopenia Muscle. 2019 Dec 17. doi: 10.1002/jcsm.12506. [Epub ahead of print]


Potential Therapies Using Myogenic Stem Cells Combined with Bio-Engineering Approaches for Treatment of Muscular Dystrophies.

Motohashi N, Shimizu-Motohashi Y, Roberts TC, Aoki Y.

Cells. 2019 Sep 11;8(9). pii: E1066. doi: 10.3390/cells8091066. Review.


Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress.

Turunen TA, Roberts TC, Laitinen P, Väänänen MA, Korhonen P, Malm T, Ylä-Herttuala S, Turunen MP.

Sci Rep. 2019 Jul 17;9(1):10332. doi: 10.1038/s41598-019-46841-1.


The viral protein corona directs viral pathogenesis and amyloid aggregation.

Ezzat K, Pernemalm M, Pålsson S, Roberts TC, Järver P, Dondalska A, Bestas B, Sobkowiak MJ, Levänen B, Sköld M, Thompson EA, Saher O, Kari OK, Lajunen T, Sverremark Ekström E, Nilsson C, Ishchenko Y, Malm T, Wood MJA, Power UF, Masich S, Lindén A, Sandberg JK, Lehtiö J, Spetz AL, El Andaloussi S.

Nat Commun. 2019 May 27;10(1):2331. doi: 10.1038/s41467-019-10192-2.


Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics.

Coenen-Stass AML, Pauwels MJ, Hanson B, Martin Perez C, Conceição M, Wood MJA, Mäger I, Roberts TC.

RNA Biol. 2019 May;16(5):696-706. doi: 10.1080/15476286.2019.1582956. Epub 2019 Mar 5.


Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD.

Coenen-Stass AML, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutškov K, Hart JR, Westholm JO, O'Donovan L, Roos A, Lochmüller H, Puri PL, El Andaloussi S, Wood MJA, Roberts TC.

Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17.


Optimized arylomycins are a new class of Gram-negative antibiotics.

Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE.

Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12.


Biomarker Potential of Extracellular miRNAs in Duchenne Muscular Dystrophy.

Coenen-Stass AML, Wood MJA, Roberts TC.

Trends Mol Med. 2017 Nov;23(11):989-1001. doi: 10.1016/j.molmed.2017.09.002. Epub 2017 Oct 5. Review.


Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer.

Voutila J, Reebye V, Roberts TC, Protopapa P, Andrikakou P, Blakey DC, Habib R, Huber H, Saetrom P, Rossi JJ, Habib NA.

Mol Ther. 2017 Dec 6;25(12):2705-2714. doi: 10.1016/j.ymthe.2017.07.018. Epub 2017 Aug 4.


BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.

Roberts TC, Etxaniz U, Dall'Agnese A, Wu SY, Chiang CM, Brennan PE, Wood MJA, Puri PL.

Sci Rep. 2017 Jul 21;7(1):6153. doi: 10.1038/s41598-017-06483-7.


Corrigendum: Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics.

Coenen-Stass AM, McClorey G, Manzano R, Betts CA, Blain A, Saleh AF, Gait MJ, Lochmüller H, Wood MJ, Roberts TC.

Sci Rep. 2016 Dec 19;6:37047. doi: 10.1038/srep37047. No abstract available.


Selective release of muscle-specific, extracellular microRNAs during myogenic differentiation.

Coenen-Stass AM, Betts CA, Lee YF, Mäger I, Turunen MP, El Andaloussi S, Morgan JE, Wood MJ, Roberts TC.

Hum Mol Genet. 2016 Sep 15;25(18):3960-3974. doi: 10.1093/hmg/ddw237. Epub 2016 Jul 27.


mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration.

Roberts TC, Blomberg KE, Smith CI, El Andaloussi S, Wood MJ.

Genom Data. 2015 Dec 2;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar.


MINCR is not a MYC-induced lncRNA.

Hart JR, Weinberg MS, Morris KV, Roberts TC, Janda KD, Garner AL, Vogt PK.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E496-7. doi: 10.1073/pnas.1519903113. Epub 2016 Jan 25. No abstract available.


The microRNA Machinery.

Roberts TC.

Adv Exp Med Biol. 2015;887:15-30. doi: 10.1007/978-3-319-22380-3_2.


Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics.

Coenen-Stass AM, McClorey G, Manzano R, Betts CA, Blain A, Saleh AF, Gait MJ, Lochmüller H, Wood MJ, Roberts TC.

Sci Rep. 2015 Nov 23;5:17014. doi: 10.1038/srep17014. Erratum in: Sci Rep. 2016 Dec 19;6:37047.


Synthetic SiRNA Delivery: Progress and Prospects.

Roberts TC, Ezzat K, El Andaloussi S, Weinberg MS.

Methods Mol Biol. 2016;1364:291-310. doi: 10.1007/978-1-4939-3112-5_23. Review.


Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration.

Roberts TC, Johansson HJ, McClorey G, Godfrey C, Blomberg KE, Coursindel T, Gait MJ, Smith CI, Lehtiö J, El Andaloussi S, Wood MJ.

Hum Mol Genet. 2015 Dec 1;24(23):6756-68. doi: 10.1093/hmg/ddv381. Epub 2015 Sep 18.


Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR.

Roberts TC, Hart JR, Kaikkonen MU, Weinberg MS, Vogt PK, Morris KV.

Nat Protoc. 2015 Aug;10(8):1198-211. doi: 10.1038/nprot.2015.076. Epub 2015 Jul 16.


Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies.

Rouillon J, Poupiot J, Zocevic A, Amor F, Léger T, Garcia C, Camadro JM, Wong B, Pinilla R, Cosette J, Coenen-Stass AM, Mcclorey G, Roberts TC, Wood MJ, Servais L, Udd B, Voit T, Richard I, Svinartchouk F.

Hum Mol Genet. 2015 Sep 1;24(17):4916-32. doi: 10.1093/hmg/ddv214. Epub 2015 Jun 9.


Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice.

Betts CA, Saleh AF, Carr CA, Hammond SM, Coenen-Stass AM, Godfrey C, McClorey G, Varela MA, Roberts TC, Clarke K, Gait MJ, Wood MJ.

Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986.


HIV Latency and the noncoding RNA therapeutic landscape.

Saayman S, Roberts TC, Morris KV, Weinberg MS.

Adv Exp Med Biol. 2015;848:169-89. doi: 10.1007/978-1-4939-2432-5_9. Review.


MYC regulates the non-coding transcriptome.

Hart JR, Roberts TC, Weinberg MS, Morris KV, Vogt PK.

Oncotarget. 2014 Dec 30;5(24):12543-54.


The MicroRNA Biology of the Mammalian Nucleus.

Roberts TC.

Mol Ther Nucleic Acids. 2014 Aug 19;3:e188. doi: 10.1038/mtna.2014.40.


The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease.

Roberts TC, Morris KV, Wood MJ.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652). pii: 20130507. doi: 10.1098/rstb.2013.0507. Review.


Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.

Bestas B, Moreno PM, Blomberg KE, Mohammad DK, Saleh AF, Sutlu T, Nordin JZ, Guterstam P, Gustafsson MO, Kharazi S, Piątosa B, Roberts TC, Behlke MA, Wood MJ, Gait MJ, Lundin KE, El Andaloussi S, Månsson R, Berglöf A, Wengel J, Smith CI.

J Clin Invest. 2014 Sep;124(9):4067-81. doi: 10.1172/JCI76175. Epub 2014 Aug 8.


Detection and quantification of extracellular microRNAs in murine biofluids.

Roberts TC, Coenen-Stass AM, Betts CA, Wood MJ.

Biol Proced Online. 2014 Mar 14;16(1):5. doi: 10.1186/1480-9222-16-5.


Assessment of RT-qPCR normalization strategies for accurate quantification of extracellular microRNAs in murine serum.

Roberts TC, Coenen-Stass AM, Wood MJ.

PLoS One. 2014 Feb 19;9(2):e89237. doi: 10.1371/journal.pone.0089237. eCollection 2014.


From gut to brain: bioencapsulated therapeutic protein reduces amyloid load upon oral delivery.

Mäger I, Roberts TC, Wood MJ, El Andaloussi S.

Mol Ther. 2014 Mar;22(3):485-486. doi: 10.1038/mt.2014.13. No abstract available.


Design and application of bispecific splice-switching oligonucleotides.

Bestas B, McClorey G, Tedebark U, Moreno PM, Roberts TC, Hammond SM, Smith CI, Wood MJ, Andaloussi SE.

Nucleic Acid Ther. 2014 Feb;24(1):13-24. doi: 10.1089/nat.2013.0462.


Not so pseudo anymore: pseudogenes as therapeutic targets.

Roberts TC, Morris KV.

Pharmacogenomics. 2013 Dec;14(16):2023-34. doi: 10.2217/pgs.13.172.


Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs.

Roberts TC, Morris KV, Weinberg MS.

Epigenetics. 2014 Jan;9(1):13-20. doi: 10.4161/epi.26700. Epub 2013 Oct 22. Review.


Epigenetics and ncRNAs in brain function and disease: mechanisms and prospects for therapy.

Varela MA, Roberts TC, Wood MJ.

Neurotherapeutics. 2013 Oct;10(4):621-31. doi: 10.1007/s13311-013-0212-7. Review.


Extracellular microRNAs are dynamic non-vesicular biomarkers of muscle turnover.

Roberts TC, Godfrey C, McClorey G, Vader P, Briggs D, Gardiner C, Aoki Y, Sargent I, Morgan JE, Wood MJ.

Nucleic Acids Res. 2013 Nov;41(20):9500-13. doi: 10.1093/nar/gkt724. Epub 2013 Aug 14.


Therapeutic targeting of non-coding RNAs.

Roberts TC, Wood MJ.

Essays Biochem. 2013;54:127-45. doi: 10.1042/bse0540127. Review.


Expression analysis in multiple muscle groups and serum reveals complexity in the microRNA transcriptome of the mdx mouse with implications for therapy.

Roberts TC, Blomberg KE, McClorey G, El Andaloussi S, Godfrey C, Betts C, Coursindel T, Gait MJ, Smith CI, Wood MJ.

Mol Ther Nucleic Acids. 2012 Aug 14;1:e39. doi: 10.1038/mtna.2012.26.


Natural Antisense Makes Sense for Gene-specific Activation in Brain.

Varela MA, Roberts TC, Andaloussi SE, Wood MJ.

Mol Ther Nucleic Acids. 2012 May 15;1:e24. doi: 10.1038/mtna.2012.17. No abstract available.


Small RNA-Mediated Epigenetic Myostatin Silencing.

Roberts TC, Andaloussi SE, Morris KV, McClorey G, Wood MJ.

Mol Ther Nucleic Acids. 2012 May 15;1:e23. doi: 10.1038/mtna.2012.15.


The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.

Davies LA, Hyde SC, Nunez-Alonso G, Bazzani RP, Harding-Smith R, Pringle IA, Lawton AE, Abdullah S, Roberts TC, McCormick D, Sumner-Jones SG, Gill DR.

Biomaterials. 2012 Aug;33(22):5618-27. doi: 10.1016/j.biomaterials.2012.04.019. Epub 2012 May 8.


Initial efforts toward the optimization of arylomycins for antibiotic activity.

Roberts TC, Schallenberger MA, Liu J, Smith PA, Romesberg FE.

J Med Chem. 2011 Jul 28;54(14):4954-63. doi: 10.1021/jm1016126. Epub 2011 Jun 28.


Synthesis and biological characterization of arylomycin B antibiotics.

Roberts TC, Smith PA, Romesberg FE.

J Nat Prod. 2011 May 27;74(5):956-61. doi: 10.1021/np200163g. Epub 2011 May 5.


In vitro activities of arylomycin natural-product antibiotics against Staphylococcus epidermidis and other coagulase-negative staphylococci.

Smith PA, Powers ME, Roberts TC, Romesberg FE.

Antimicrob Agents Chemother. 2011 Mar;55(3):1130-4. doi: 10.1128/AAC.01459-10. Epub 2010 Dec 28.


Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations.

Smith PA, Roberts TC, Romesberg FE.

Chem Biol. 2010 Nov 24;17(11):1223-31. doi: 10.1016/j.chembiol.2010.09.009.


Type I signal peptidase and protein secretion in Staphylococcus epidermidis.

Powers ME, Smith PA, Roberts TC, Fowler BJ, King CC, Trauger SA, Siuzdak G, Romesberg FE.

J Bacteriol. 2011 Jan;193(2):340-8. doi: 10.1128/JB.01052-10. Epub 2010 Nov 12.


Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway.

Chen D, Lei L, Lu C, Flores R, DeLisa MP, Roberts TC, Romesberg FE, Zhong G.

Microbiology. 2010 Oct;156(Pt 10):3031-3040. doi: 10.1099/mic.0.040527-0. Epub 2010 Jun 3.


Structural and initial biological analysis of synthetic arylomycin A2.

Roberts TC, Smith PA, Cirz RT, Romesberg FE.

J Am Chem Soc. 2007 Dec 26;129(51):15830-8. Epub 2007 Dec 1.


Bayesian variable selection in multinomial probit models to identify molecular signatures of disease stage.

Sha N, Vannucci M, Tadesse MG, Brown PJ, Dragoni I, Davies N, Roberts TC, Contestabile A, Salmon M, Buckley C, Falciani F.

Biometrics. 2004 Sep;60(3):812-9.


Global analysis of transcription kinetics during competence development in Streptococcus pneumoniae using high density DNA arrays.

Rimini R, Jansson B, Feger G, Roberts TC, de Francesco M, Gozzi A, Faggioni F, Domenici E, Wallace DM, Frandsen N, Polissi A.

Mol Microbiol. 2000 Jun;36(6):1279-92.


Quantitative polymerase chain reaction to predict occurrence of symptomatic cytomegalovirus infection and assess response to ganciclovir therapy in renal transplant recipients.

Roberts TC, Brennan DC, Buller RS, Gaudreault-Keener M, Schnitzler MA, Sternhell KE, Garlock KA, Singer GG, Storch GA.

J Infect Dis. 1998 Sep;178(3):626-35.


Effects of storage temperature and time on qualitative and quantitative detection of cytomegalovirus in blood specimens by shell vial culture and PCR.

Roberts TC, Buller RS, Gaudreault-Keener M, Sternhell KE, Garlock K, Singer GG, Brennan DC, Storch GA.

J Clin Microbiol. 1997 Sep;35(9):2224-8.

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