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Items: 1 to 50 of 349

1.

Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small cell lung cancer receiving 1st-line chemotherapy: a Phase 1b/randomized Phase 2 trial.

Weiss JM, Csoszi T, Maglakelidze M, Hoyer RJ, Beck JT, Gomez MD, Lowczak A, Aljumaily R, Lima CMR, Boccia RV, Hanna W, Nikolinakos P, Chiu VK, Owonikoko TK, Schuster SR, Hussein MA, Richards DA, Sawrycki P, Bulat I, Hamm JT, Hart LL, Adler S, Antal JM, Lai AY, Sorrentino JA, Yang Z, Malik RK, Morris SR, Roberts PJ, Dragnev KH; G1T28-02 Study Group.

Ann Oncol. 2019 Aug 27. pii: mdz278. doi: 10.1093/annonc/mdz278. [Epub ahead of print]

PMID:
31504118
2.

Standardised Warfarin Reversal Expedites Time to Theatre for Fractured Neck of Femur Surgery and Improves Mortality Rates: A Matched Cohort Study.

Moores TS, Chatterton BD, Walker MJ, Roberts PJ.

Adv Orthop. 2018 Oct 21;2018:4791214. doi: 10.1155/2018/4791214. eCollection 2018.

3.

Uncemented Thompson's hemiarthroplasty: safe, palliative and cost-effective surgery in the infirm patient-a consecutive series of 1445 cases.

Manoharan G, Chatterton BD, Moores TS, Roberts PJ.

Eur J Orthop Surg Traumatol. 2018 Aug;28(6):1103-1109. doi: 10.1007/s00590-018-2144-8. Epub 2018 Feb 8.

PMID:
29423867
4.

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.

Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK.

Cancer Discov. 2018 Feb;8(2):216-233. doi: 10.1158/2159-8290.CD-17-0915. Epub 2017 Nov 3.

5.

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.

He S, Roberts PJ, Sorrentino JA, Bisi JE, Storrie-White H, Tiessen RG, Makhuli KM, Wargin WA, Tadema H, van Hoogdalem EJ, Strum JC, Malik R, Sharpless NE.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaal3986. doi: 10.1126/scitranslmed.aal3986.

6.

Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.

Bisi JE, Sorrentino JA, Jordan JL, Darr DD, Roberts PJ, Tavares FX, Strum JC.

Oncotarget. 2017 Jun 27;8(26):42343-42358. doi: 10.18632/oncotarget.16216.

7.

Declines in benthic macroinvertebrate community metrics and microphytobenthic biomass in an estuarine lake following enrichment by hippo dung.

Dawson J, Pillay D, Roberts PJ, Perissinotto R.

Sci Rep. 2016 Nov 17;6:37359. doi: 10.1038/srep37359.

8.

Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression.

Bisi JE, Sorrentino JA, Roberts PJ, Tavares FX, Strum JC.

Mol Cancer Ther. 2016 May;15(5):783-93. doi: 10.1158/1535-7163.MCT-15-0775. Epub 2016 Jan 29.

9.

Preoperative warfarin reversal for early hip fracture surgery.

Moores TS, Beaven A, Cattell AE, Baker C, Roberts PJ.

J Orthop Surg (Hong Kong). 2015 Apr;23(1):33-6.

PMID:
25920640
10.

Cause of death and factors associated with early in-hospital mortality after hip fracture.

Chatterton BD, Moores TS, Ahmad S, Cattell A, Roberts PJ.

Bone Joint J. 2015 Feb;97-B(2):246-51. doi: 10.1302/0301-620X.97B2.35248.

PMID:
25628290
11.

Short-term follow-up of pertrochanteric fractures treated using the proximal femoral locking plate.

Johnson B, Stevenson J, Chamma R, Patel A, Rhee SJ, Lever C, Starks I, Roberts PJ.

J Orthop Trauma. 2014 May;28(5):283-7. doi: 10.1097/01.bot.0000435629.86640.6f.

PMID:
24751607
12.

Quality of life following laparoscopic Nissen fundoplication: assessing short-term and long-term outcomes.

Kellokumpu I, Voutilainen M, Haglund C, Färkkilä M, Roberts PJ, Kautiainen H.

World J Gastroenterol. 2013 Jun 28;19(24):3810-8. doi: 10.3748/wjg.v19.i24.3810.

13.

Predicting drug responsiveness in human cancers using genetically engineered mice.

Usary J, Zhao W, Darr D, Roberts PJ, Liu M, Balletta L, Karginova O, Jordan J, Combest A, Bridges A, Prat A, Cheang MC, Herschkowitz JI, Rosen JM, Zamboni W, Sharpless NE, Perou CM.

Clin Cancer Res. 2013 Sep 1;19(17):4889-99. doi: 10.1158/1078-0432.CCR-13-0522. Epub 2013 Jun 18.

14.

Prediction of lung cancer histological types by RT-qPCR gene expression in FFPE specimens.

Wilkerson MD, Schallheim JM, Hayes DN, Roberts PJ, Bastien RR, Mullins M, Yin X, Miller CR, Thorne LB, Geiersbach KB, Muldrew KL, Funkhouser WK, Fan C, Hayward MC, Bayer S, Perou CM, Bernard PS.

J Mol Diagn. 2013 Jul;15(4):485-97. doi: 10.1016/j.jmoldx.2013.03.007. Epub 2013 May 20.

15.

Clinical use of crizotinib for the treatment of non-small cell lung cancer.

Roberts PJ.

Biologics. 2013;7:91-101. doi: 10.2147/BTT.S29026. Epub 2013 Apr 26.

16.

KRAS mutation: should we test for it, and does it matter?

Roberts PJ, Stinchcombe TE.

J Clin Oncol. 2013 Mar 10;31(8):1112-21. doi: 10.1200/JCO.2012.43.0454. Epub 2013 Feb 11. Review.

PMID:
23401440
17.

Visualizing and quantifying dose distribution in a UV reactor using three-dimensional laser-induced fluorescence.

Gandhi VN, Roberts PJ, Kim JH.

Environ Sci Technol. 2012 Dec 18;46(24):13220-6. doi: 10.1021/es303133f. Epub 2012 Nov 28.

PMID:
23151024
18.

Inverse Laplace Transform of Multidimensional Relaxation Data Without Non-Negativity Constraint.

Granwehr J, Roberts PJ.

J Chem Theory Comput. 2012 Oct 9;8(10):3473-82. doi: 10.1021/ct3001393. Epub 2012 May 3.

PMID:
26592997
19.

Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumors.

Combest AJ, Roberts PJ, Dillon PM, Sandison K, Hanna SK, Ross C, Habibi S, Zamboni B, Müller M, Brunner M, Sharpless NE, Zamboni WC.

Oncologist. 2012;17(10):1303-16. doi: 10.1634/theoncologist.2012-0274. Epub 2012 Sep 19.

20.

Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models.

Roberts PJ, Usary JE, Darr DB, Dillon PM, Pfefferle AD, Whittle MC, Duncan JS, Johnson SM, Combest AJ, Jin J, Zamboni WC, Johnson GL, Perou CM, Sharpless NE.

Clin Cancer Res. 2012 Oct 1;18(19):5290-303. doi: 10.1158/1078-0432.CCR-12-0563. Epub 2012 Aug 7.

21.

The effect of care bundle development on surgical site infection after hemiarthroplasty: an 8-year review.

Johnson B, Starks I, Bancroft G, Roberts PJ.

J Trauma Acute Care Surg. 2012 May;72(5):1375-9. doi: 10.1097/TA.0b013e318245267c.

PMID:
22673269
22.

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.

Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, Wang S, Lee C, Nakada Y, Peña CG, Sun Y, Franchetti Y, Yao C, Saur A, Cameron MD, Nishino M, Hayes DN, Wilkerson MD, Roberts PJ, Lee CB, Bardeesy N, Butaney M, Chirieac LR, Costa DB, Jackman D, Sharpless NE, Castrillon DH, Demetri GD, Jänne PA, Pandolfi PP, Cantley LC, Kung AL, Engelman JA, Wong KK.

Nature. 2012 Mar 18;483(7391):613-7. doi: 10.1038/nature10937.

23.

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.

Roberts PJ, Bisi JE, Strum JC, Combest AJ, Darr DB, Usary JE, Zamboni WC, Wong KK, Perou CM, Sharpless NE.

J Natl Cancer Inst. 2012 Mar 21;104(6):476-87. doi: 10.1093/jnci/djs002. Epub 2012 Feb 1.

24.

Posttranslational lipid modification of Rho family small GTPases.

Mitin N, Roberts PJ, Chenette EJ, Der CJ.

Methods Mol Biol. 2012;827:87-95. doi: 10.1007/978-1-61779-442-1_6.

PMID:
22144269
25.

MMP-1 expression has an independent prognostic value in breast cancer.

Boström P, Söderström M, Vahlberg T, Söderström KO, Roberts PJ, Carpén O, Hirsimäki P.

BMC Cancer. 2011 Aug 11;11:348. doi: 10.1186/1471-2407-11-348.

26.

UV reactor flow visualization and mixing quantification using three-dimensional laser-induced fluorescence.

Gandhi V, Roberts PJ, Stoesser T, Wright H, Kim JH.

Water Res. 2011 Jul;45(13):3855-62. doi: 10.1016/j.watres.2011.04.041. Epub 2011 May 5.

PMID:
21612811
27.

Low loss broadband transmission in hypocycloid-core Kagome hollow-core photonic crystal fiber.

Wang YY, Wheeler NV, Couny F, Roberts PJ, Benabid F.

Opt Lett. 2011 Mar 1;36(5):669-71. doi: 10.1364/OL.36.000669.

PMID:
21368943
28.

Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy?

Roberts PJ, Stinchcombe TE, Der CJ, Socinski MA.

J Clin Oncol. 2010 Nov 1;28(31):4769-77. doi: 10.1200/JCO.2009.27.4365. Epub 2010 Oct 4. Review.

PMID:
20921461
29.

Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization.

Lennon SM, Rivero G, Matharu A, Howson PA, Jane DE, Roberts PJ, Kelly E.

Eur J Pharmacol. 2010 Dec 15;649(1-3):29-37. doi: 10.1016/j.ejphar.2010.08.038. Epub 2010 Sep 15.

PMID:
20826132
30.

Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types.

Wilkerson MD, Yin X, Hoadley KA, Liu Y, Hayward MC, Cabanski CR, Muldrew K, Miller CR, Randell SH, Socinski MA, Parsons AM, Funkhouser WK, Lee CB, Roberts PJ, Thorne L, Bernard PS, Perou CM, Hayes DN.

Clin Cancer Res. 2010 Oct 1;16(19):4864-75. doi: 10.1158/1078-0432.CCR-10-0199. Epub 2010 Jul 19.

31.

Stress induced birefringence in hybrid TIR/PBG guiding solid photonic crystal fibers.

Lyngsø JK, Mangan BJ, Olausson CB, Roberts PJ.

Opt Express. 2010 Jun 21;18(13):14031-40. doi: 10.1364/OE.18.014031.

PMID:
20588535
32.

Plume tracking and dilution of effluent from the Boston sewage outfall.

Hunt CD, Mansfield AD, Mickelson MJ, Albro CS, Geyer WR, Roberts PJ.

Mar Environ Res. 2010 Aug;70(2):150-61. doi: 10.1016/j.marenvres.2010.04.005. Epub 2010 Apr 18.

PMID:
20452014
33.

7-cell core hollow-core photonic crystal fibers with low loss in the spectral region around 2 microm.

Lyngsø JK, Mangan BJ, Jakobsen C, Roberts PJ.

Opt Express. 2009 Dec 21;17(26):23468-73. doi: 10.1364/OE.17.023468.

PMID:
20052054
34.

Theory of adiabatic pressure-gradient soliton compression in hollow-core photonic bandgap fibers.

Laegsgaard J, Roberts PJ.

Opt Lett. 2009 Dec 1;34(23):3710-2. doi: 10.1364/OL.34.003710.

PMID:
19953170
35.

Double photonic bandgap hollow-core photonic crystal fiber.

Light PS, Couny F, Wang YY, Wheeler NV, Roberts PJ, Benabid F.

Opt Express. 2009 Aug 31;17(18):16238-43. doi: 10.1364/OE.17.016238.

PMID:
19724623
36.

Closed double-lumen suction irrigation in the management of chronic diaphyseal osteomyelitis: long-term follow-up.

Caesar BC, Morgan-Jones RL, Warren RE, Wade RH, Roberts PJ, Richardson JB.

J Bone Joint Surg Br. 2009 Sep;91(9):1243-8. doi: 10.1302/0301-620X.91B9.21768.

PMID:
19721055
37.

Square-lattice large-pitch hollow-core photonic crystal fiber.

Couny F, Roberts PJ, Birks TA, Benabid F.

Opt Express. 2008 Dec 8;16(25):20626-36.

PMID:
19065202
38.

Fourth-order dispersion mediated solitonic radiations in HC-PCF cladding.

Benabid F, Biancalana F, Light PS, Couny F, Luiten A, Roberts PJ, Peng J, Sokolov AV.

Opt Lett. 2008 Nov 15;33(22):2680-2.

PMID:
19015707
39.

Nonlinear interaction between two different photonic bandgaps of a hybrid photonic crystal fiber.

Cerqueira S A Jr, Cordeiro CM, Biancalana F, Roberts PJ, Hernandez-Figueroa HE, Cruz CH.

Opt Lett. 2008 Sep 15;33(18):2080-2.

PMID:
18794937
40.

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.

Roberts PJ, Mitin N, Keller PJ, Chenette EJ, Madigan JP, Currin RO, Cox AD, Wilson O, Kirschmeier P, Der CJ.

J Biol Chem. 2008 Sep 12;283(37):25150-63. doi: 10.1074/jbc.M800882200. Epub 2008 Jul 9.

41.

Dispersive pulse compression in hollow-core photonic bandgap fibers.

Laegsgaard J, Roberts PJ.

Opt Express. 2008 Jun 23;16(13):9628-44.

PMID:
18575531
42.

The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans.

Roberts PJ, Rollins KD, Kashuba AD, Paine MF, Nelsen AC, Williams EE, Moran C, Lamba JK, Schuetz EG, Hawke RL.

Drug Metab Dispos. 2008 Aug;36(8):1465-9. doi: 10.1124/dmd.107.020065. Epub 2008 May 19.

43.

Backscattering target detection in a turbid medium by polarization discrimination.

Lewis GD, Jordan DL, Roberts PJ.

Appl Opt. 1999 Jun 20;38(18):3937-44.

PMID:
18320002
44.

Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.

Blanke CD, Demetri GD, von Mehren M, Heinrich MC, Eisenberg B, Fletcher JA, Corless CL, Fletcher CD, Roberts PJ, Heinz D, Wehre E, Nikolova Z, Joensuu H.

J Clin Oncol. 2008 Feb 1;26(4):620-5. doi: 10.1200/JCO.2007.13.4403.

PMID:
18235121
45.

Generation and photonic guidance of multi-octave optical-frequency combs.

Couny F, Benabid F, Roberts PJ, Light PS, Raymer MG.

Science. 2007 Nov 16;318(5853):1118-21.

46.

Changing prophylactic antibiotic use for Thompson's hemiarthroplasty may reduce infection rates.

Starks I, Carmont M, Roberts PJ.

J Hosp Infect. 2007 Jun;66(2):186-7. Epub 2007 May 21. No abstract available.

PMID:
17513008
47.

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

Roberts PJ, Der CJ.

Oncogene. 2007 May 14;26(22):3291-310. Review.

PMID:
17496923
48.

Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer.

Hilska M, Roberts PJ, Collan YU, Laine VJ, Kössi J, Hirsimäki P, Rahkonen O, Laato M.

Int J Cancer. 2007 Aug 15;121(4):714-23.

49.

Identification of Bloch-modes in hollow-core photonic crystal fiber cladding.

Couny F, Benabid F, Roberts PJ, Burnett MT, Maier SA.

Opt Express. 2007 Jan 22;15(2):325-38.

PMID:
19532248
50.

Mechanisms of glutamate receptor induced proliferation of astrocytes.

Kanumilli S, Roberts PJ.

Neuroreport. 2006 Dec 18;17(18):1877-81.

PMID:
17179862

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