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Pharmacokinetic basis for dosing high-dose methotrexate in infants and young children with malignant brain tumors.

Panetta JC, Roberts JK, Huang J, Lin T, Daryani VM, Harstead KE, Patel YT, Onar-Thomas A, Campagne O, Ward DA, Broniscer A, Robinson G, Gajjar A, Stewart CF.

Br J Clin Pharmacol. 2019 Oct 28. doi: 10.1111/bcp.14160. [Epub ahead of print]


Microbial HemG-type protoporphyrinogen IX oxidase enzymes for biotechnology applications in plant herbicide tolerance traits.

Larue CT, Ream JE, Zhou X, Moshiri F, Howe A, Goley M, Sparks OC, Voss ST, Hall E, Ellis C, Weihe J, Qi Q, Ribeiro D, Wei X, Guo S, Evdokimov AG, Varagona MJ, Roberts JK.

Pest Manag Sci. 2019 Sep 10. doi: 10.1002/ps.5613. [Epub ahead of print]


Effects of injectable dexmedetomidine-ketamine-midazolam and isoflurane inhalation anesthetic protocols on ocular variables in captive black-tailed prairie dogs (Cynomys ludovicianus).

Roberts JK, Meekins JM, Browning GR, Beaufrère H, Eshar D.

Am J Vet Res. 2019 Sep;80(9):878-884. doi: 10.2460/ajvr.80.9.878.


Clinical Practice Guideline: Sudden Hearing Loss (Update).

Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, Poling GL, Roberts JK, Stachler RJ, Zeitler DM, Corrigan MD, Nnacheta LC, Satterfield L.

Otolaryngol Head Neck Surg. 2019 Aug;161(1_suppl):S1-S45. doi: 10.1177/0194599819859885.


Clinical Practice Guideline: Sudden Hearing Loss (Update) Executive Summary.

Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, Poling GL, Roberts JK, Stachler RJ, Zeitler DM, Corrigan MD, Nnacheta LC, Satterfield L, Monjur TM.

Otolaryngol Head Neck Surg. 2019 Aug;161(2):195-210. doi: 10.1177/0194599819859883.


Normothermic Machine Perfusion Enhances Intraoperative Hepatocellular Synthetic Capacity: A Propensity Score-matched Analysis.

Ionescu MI, Tillakaratne S, Hodson J, Gunson B, Nasralla D, Pinter Carvalheiro da Silva Boteon A, Sermon K, Mergental H, Isaac JR, Roberts JK, Muiesan P, Friend P, Mirza DF, Bennett D, Perera MTPR.

Transplantation. 2019 Jul;103(7):e198-e207. doi: 10.1097/TP.0000000000002720.


Retrieval Practice or Overall Donor and Recipient Risk: What Impacts on Outcomes After Donation After Circulatory Death Liver Transplantation in the United Kingdom?

Boteon APCS, Schlegel A, Kalisvaart M, Boteon YL, Abradelo M, Mergental H, Roberts JK, Mirza DF, Perera MTPR, Isaac JR, Muiesan P.

Liver Transpl. 2019 Apr;25(4):545-558. doi: 10.1002/lt.25410.


Disabled insecticidal proteins: A novel tool to understand differences in insect receptor utilization.

Jerga A, Evdokimov AG, Moshiri F, Haas JA, Chen M, Clinton W, Fu X, Halls C, Jimenez-Juarez N, Kretzler CN, Panosian TD, Pleau M, Roberts JK, Rydel TJ, Salvador S, Sequeira R, Wang Y, Zheng M, Baum JA.

Insect Biochem Mol Biol. 2019 Feb;105:79-88. doi: 10.1016/j.ibmb.2018.12.006. Epub 2018 Dec 31.


Quality improvement in neurology: Neuro-otology quality measurement set.

Rizk H, Agrawal Y, Barthel S, Bennett ML, Doherty JK, Gerend P, Gold DR, Morrill D, Oas JG, Roberts JK, Woodson E, Zapala DA, Bennett A, Shenoy AM.

Neurology. 2018 Oct 9;91(15):697-701. doi: 10.1212/WNL.0000000000006217. Epub 2018 Aug 31. No abstract available.


Quality Improvement in Neurology: Neurotology Quality Measurement Set.

Rizk H, Agrawal Y, Barthel S, Bennett ML, Doherty JK, Gerend P, Gold DR, Morrill D, Oas JG, Roberts JK, Woodson E, Zapala DA, Bennett A, Shenoy AM.

Otolaryngol Head Neck Surg. 2018 Oct;159(4):603-607. doi: 10.1177/0194599818790947. Epub 2018 Aug 31. Review. No abstract available.


Multivariable analysis of predictors of unplanned hospital readmission after pancreaticoduodenectomy: development of a validated risk score.

Boteon APCS, Boteon YL, Hodson J, Osborne H, Isaac J, Marudanayagam R, Mirza DF, Muiesan P, Roberts JK, Sutcliffe RP.

HPB (Oxford). 2019 Jan;21(1):26-33. doi: 10.1016/j.hpb.2018.06.1802. Epub 2018 Jul 23.


Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice.

Ganguly S, Panetta JC, Roberts JK, Schuetz EG.

Drug Metab Dispos. 2018 Jul;46(7):1014-1022. doi: 10.1124/dmd.117.078360. Epub 2018 Apr 19.


Evident bias in a paracetamol metabolite population pharmacokinetic model applied to an external dataset.

Roberts JK, Linakis MW, Liu X, Sherwin CMT, van den Anker JN.

Br J Clin Pharmacol. 2018 Jul;84(7):1628-1630. doi: 10.1111/bcp.13588. Epub 2018 Apr 17. No abstract available.


Digital chalk-talk videos improve knowledge and satisfaction in renal physiology.

Roberts JK, Chudgar SM, Engle D, McClain EK, Jakoi E, Berkoben M, Lehrich RW.

Adv Physiol Educ. 2018 Mar 1;42(1):146-151. doi: 10.1152/advan.00131.2017.


Burnout in Nephrology: Implications on Recruitment and the Workforce.

Roberts JK.

Clin J Am Soc Nephrol. 2018 Feb 7;13(2):328-330. doi: 10.2215/CJN.09870917. Epub 2018 Jan 11. No abstract available.


Interventions to improve psychosocial well-being for children affected by HIV and AIDS: a systematic review.

Skeen S, Sherr L, Tomlinson M, Croome N, Ghandi N, Roberts JK, Macedo A.

Vulnerable Child Youth Stud. 2017;12(2):91-116. doi: 10.1080/17450128.2016.1276656. Epub 2017 Feb 14.


Baclofen Toxicity in Kidney Disease.

Wolf E, Kothari NR, Roberts JK, Sparks MA.

Am J Kidney Dis. 2018 Feb;71(2):275-280. doi: 10.1053/j.ajkd.2017.07.005. Epub 2017 Sep 9.


Population pharmacokinetic model of transdermal nicotine delivered from a matrix-type patch.

Linakis MW, Rower JE, Roberts JK, Miller EI, Wilkins DG, Sherwin CMT.

Br J Clin Pharmacol. 2017 Dec;83(12):2709-2717. doi: 10.1111/bcp.13393. Epub 2017 Sep 6.


Derivation of new equations to estimate glomerular filtration rate in pediatric oncology patients.

Millisor VE, Roberts JK, Sun Y, Tang L, Daryani VM, Gregornik D, Cross SJ, Ward D, Pauley JL, Molinelli A, Brennan RC, Stewart CF.

Pediatr Nephrol. 2017 Sep;32(9):1575-1584. doi: 10.1007/s00467-017-3693-5. Epub 2017 Jun 2.


Case-controlled study comparing peri-operative and cancer-related outcomes after major hepatectomy and parenchymal sparing hepatectomy for metastatic colorectal cancer.

Lordan JT, Roberts JK, Hodson J, Isaac J, Muiesan P, Mirza DF, Marudanayagam R, Sutcliffe RP.

HPB (Oxford). 2017 Aug;19(8):688-694. doi: 10.1016/j.hpb.2017.04.007. Epub 2017 May 9.


Comparative Efficacy of Coronary Revascularization Procedures for Multivessel Coronary Artery Disease in Patients With Chronic Kidney Disease.

Roberts JK, Rao SV, Shaw LK, Gallup DS, Marroquin OC, Patel UD.

Am J Cardiol. 2017 May 1;119(9):1344-1351. doi: 10.1016/j.amjcard.2017.01.029. Epub 2017 Feb 9.


Ten Year Experience of Radioiodine Dosimetry: is it Useful in the Management of Metastatic Differentiated Thyroid Cancer?

Sun F, Gerrard GE, Roberts JK, Telford T, Namini S, Waller M, Flux G, Gill VM.

Clin Oncol (R Coll Radiol). 2017 May;29(5):310-315. doi: 10.1016/j.clon.2017.01.002. Epub 2017 Jan 27.


Antiinflammatory Effects of Budesonide in Human Fetal Lung.

Barrette AM, Roberts JK, Chapin C, Egan EA, Segal MR, Oses-Prieto JA, Chand S, Burlingame AL, Ballard PL.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):623-632.


Medical student attitudes toward kidney physiology and nephrology: a qualitative study.

Roberts JK, Sparks MA, Lehrich RW.

Ren Fail. 2016 Nov;38(10):1683-1693. doi: 10.1080/0886022X.2016.1230459. Epub 2016 Oct 19.


Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction.

Hemmersbach-Miller M, Duronville J, Sethi S, Miller SE, Howell DN, Henshaw N, Alexander BD, Roberts JK.

Am J Transplant. 2017 Jan;17(1):287-291. doi: 10.1111/ajt.14022. Epub 2016 Sep 14.


Population pharmacokinetic/pharmacodynamic modeling of histamine response measured by histamine iontophoresis laser Doppler.

Liu X, Jones BL, Roberts JK, Sherwin CM.

J Pharmacokinet Pharmacodyn. 2016 Aug;43(4):385-93. doi: 10.1007/s10928-016-9478-9. Epub 2016 Jun 15.


The sequence, structural, and functional diversity within a protein family and implications for specificity and safety: The case for ETX_MTX2 insecticidal proteins.

Moar WJ, Evans AJ, Kessenich CR, Baum JA, Bowen DJ, Edrington TC, Haas JA, Kouadio JK, Roberts JK, Silvanovich A, Yin Y, Weiner BE, Glenn KC, Odegaard ML.

J Invertebr Pathol. 2017 Jan;142:50-59. doi: 10.1016/j.jip.2016.05.007. Epub 2016 May 25.


Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant.

Roberts JK, Birg AV, Lin T, Daryani VM, Panetta JC, Broniscer A, Robinson GW, Gajjar AJ, Stewart CF.

Drug Metab Dispos. 2016 Jul;44(7):1116-22. doi: 10.1124/dmd.115.068676. Epub 2016 Apr 6.


Outcome following Resection of Biliary Cystadenoma: A Single Centre Experience and Literature Review.

Pitchaimuthu M, Aidoo-Micah G, Coldham C, Sutcliffe R, Roberts JK, Muiesan P, Isaac J, Mirza D, Marudanayagam R.

Int J Hepatol. 2015;2015:382315. doi: 10.1155/2015/382315. Epub 2015 Dec 29.


Use of Modeling and Simulation in the Design and Conduct of Pediatric Clinical Trials and the Optimization of Individualized Dosing Regimens.

Stockmann C, Barrett JS, Roberts JK, Sherwin C.

CPT Pharmacometrics Syst Pharmacol. 2015 Nov;4(11):630-40. doi: 10.1002/psp4.12038. Epub 2015 Nov 13.


Determination of Methotrexate, 7-Hydroxymethotrexate, and 2,4-Diamino-N10-methylpteroic Acid by LC-MS/MS in Plasma and Cerebrospinal Fluid and Application in a Pharmacokinetic Analysis of High-Dose Methotrexate.

Roberts MS, Selvo NS, Roberts JK, Daryani VM, Owens TS, Harstead KE, Gajjar A, Stewart CF.

J Liq Chromatogr Relat Technol. 2016;39(16):745-751. doi: 10.1080/10826076.2016.1243558. Epub 2016 Oct 10.


Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target.

Bhongsatiern J, Stockmann C, Roberts JK, Yu T, Korgenski KE, Spigarelli MG, Desai PB, Sherwin CM.

Ther Drug Monit. 2015 Dec;37(6):756-65. doi: 10.1097/FTD.0000000000000216.


Pharmacokinetics of Budesonide Administered with Surfactant in Premature Lambs: Implications for Neonatal Clinical Trials.

Roberts JK, Stockmann C, Dahl MJ, Albertine KH, Egan E, Lin Z, Reilly CA, Ballard PL, Ballard RA, Ward RM.

Curr Clin Pharmacol. 2016;11(1):53-61.


A propensity-matched cohort study of vancomycin-associated nephrotoxicity in neonates.

Constance JE, Balch AH, Stockmann C, Linakis MW, Korgenski EK, Roberts JK, Ward RM, Sherwin CM, Spigarelli MG.

Arch Dis Child Fetal Neonatal Ed. 2016 May;101(3):F236-43. doi: 10.1136/archdischild-2015-308459. Epub 2015 Sep 23.


Exploring student preferences with a Q-sort: the development of an individualized renal physiology curriculum.

Roberts JK, Hargett CW, Nagler A, Jakoi E, Lehrich RW.

Adv Physiol Educ. 2015 Sep;39(3):149-57. doi: 10.1152/advan.00028.2015.


A Population Pharmacokinetic Analysis of Dextroamphetamine in the Plasma and Hair of Healthy Adults.

Roberts JK, Cook SF, Stockmann C, Rollins DE, Wilkins DG, Sherwin CM.

Clin Drug Investig. 2015 Oct;35(10):633-43. doi: 10.1007/s40261-015-0323-5.


Challenges Associated with Route of Administration in Neonatal Drug Delivery.

Linakis MW, Roberts JK, Lala AC, Spigarelli MG, Medlicott NJ, Reith DM, Ward RM, Sherwin CM.

Clin Pharmacokinet. 2016 Feb;55(2):185-96. doi: 10.1007/s40262-015-0313-z. Review.


Population Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) in Preterm and Term Neonates: Model Development and External Evaluation.

Cook SF, Roberts JK, Samiee-Zafarghandy S, Stockmann C, King AD, Deutsch N, Williams EF, Allegaert K, Wilkins DG, Sherwin CM, van den Anker JN.

Clin Pharmacokinet. 2016 Jan;55(1):107-19. doi: 10.1007/s40262-015-0301-3.


Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.

Roberts JK, Westphal S, Sparks MA.

Semin Dial. 2015 Sep-Oct;28(5):525-9. doi: 10.1111/sdi.12400. Epub 2015 Jun 21.


Oxygen Delivery in Septic Shock.

Roberts JK, Disselkamp M, Yataco AC.

Ann Am Thorac Soc. 2015 Jun;12(6):952-5. doi: 10.1513/AnnalsATS.201501-069CC. No abstract available.


Predictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates.

Stockmann C, Hersh AL, Roberts JK, Bhongsatiern J, Korgenski EK, Spigarelli MG, Sherwin CM, Frymoyer A.

Infect Dis Ther. 2015 Jun;4(2):187-98. doi: 10.1007/s40121-015-0067-9. Epub 2015 May 22.


Darbepoetin administration to neonates undergoing cooling for encephalopathy: a safety and pharmacokinetic trial.

Baserga MC, Beachy JC, Roberts JK, Ward RM, DiGeronimo RJ, Walsh WF, Ohls RK, Anderson J, Mayock DE, Juul SE, Christensen RD, Loertscher MC, Stockmann C, Sherwin CM, Spigarelli MG, Yoder BA.

Pediatr Res. 2015 Sep;78(3):315-22. doi: 10.1038/pr.2015.101. Epub 2015 May 21.


Population Pharmacokinetics of Darbepoetin Alfa in Conjunction with Hypothermia for the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy.

Roberts JK, Stockmann C, Ward RM, Beachy J, Baserga MC, Spigarelli MG, Sherwin CM.

Clin Pharmacokinet. 2015 Dec;54(12):1237-44. doi: 10.1007/s40262-015-0286-y.


Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.

Stockmann C, Reilly CA, Fassl B, Gaedigk R, Nkoy F, Stone B, Roberts JK, Uchida DA, Leeder JS, Sherwin CM, Spigarelli MG, Yost GS, Ward RM.

J Allergy Clin Immunol. 2015 Aug;136(2):505-7. doi: 10.1016/j.jaci.2015.02.009. Epub 2015 Mar 29. No abstract available.


Implementation of an Enhanced Recovery Pathway After Pancreaticoduodenectomy in Patients with Low Drain Fluid Amylase.

Sutcliffe RP, Hamoui M, Isaac J, Marudanayagam R, Mirza DF, Muiesan P, Roberts JK.

World J Surg. 2015 Aug;39(8):2023-30. doi: 10.1007/s00268-015-3051-3.


Clinical pharmacokinetics of inhaled antimicrobials.

Stockmann C, Roberts JK, Yellepeddi VK, Sherwin CM.

Clin Pharmacokinet. 2015 May;54(5):473-92. doi: 10.1007/s40262-015-0250-x. Review.


Optimal design in pediatric pharmacokinetic and pharmacodynamic clinical studies.

Roberts JK, Stockmann C, Balch A, Yu T, Ward RM, Spigarelli MG, Sherwin CM.

Paediatr Anaesth. 2015 Mar;25(3):222-30. doi: 10.1111/pan.12575. Epub 2015 Jan 9. Review.


The management of acute coronary syndromes in patients with chronic kidney disease.

Roberts JK, McCullough PA.

Adv Chronic Kidney Dis. 2014 Nov;21(6):472-9. doi: 10.1053/j.ackd.2014.08.005. Epub 2014 Oct 24. Review.


Clinical pharmacokinetics and pharmacodynamics of ganciclovir and valganciclovir in children with cytomegalovirus infection.

Stockmann C, Roberts JK, Knackstedt ED, Spigarelli MG, Sherwin CM.

Expert Opin Drug Metab Toxicol. 2015 Feb;11(2):205-19. doi: 10.1517/17425255.2015.988139. Epub 2014 Nov 27. Review.


Vancomycin pharmacokinetic models: informing the clinical management of drug-resistant bacterial infections.

Stockmann C, Roberts JK, Yu T, Constance JE, Knibbe CA, Spigarelli MG, Sherwin CM.

Expert Rev Anti Infect Ther. 2014 Nov;12(11):1371-88. doi: 10.1586/14787210.2014.966081. Review.


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