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Relationship between renal CD68+ infiltrates and the oxford classification of iga nephropathy.

Soares MF, Genitsch V, Chakera A, Smith A, MacEwen C, Bellur SS, Roberts ISD.

Histopathology. 2018 Oct 10. doi: 10.1111/his.13768. [Epub ahead of print]


Outcome measures in clinical trials of treatments for acute severe haemorrhage.

Brenner A, Arribas M, Cuzick J, Jairath V, Stanworth S, Ker K, Shakur-Still H, Roberts I.

Trials. 2018 Oct 1;19(1):533. doi: 10.1186/s13063-018-2900-4.


Women's work in UK clinical trials is undervalued.

Roberts I.

Lancet. 2018 Sep 1;392(10149):732. doi: 10.1016/S0140-6736(18)31540-X. No abstract available.


Histologic Classification of IgA Nephropathy: Past, Present, and Future.

Soares MFS, Roberts ISD.

Semin Nephrol. 2018 Sep;38(5):477-484. doi: 10.1016/j.semnephrol.2018.05.017. Review.


Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial.

Roberts I, Belli A, Brenner A, Chaudhri R, Fawole B, Harris T, Jooma R, Mahmood A, Shokunbi T, Shakur H; CRASH-3 trial collaborators.

Wellcome Open Res. 2018 Jul 20;3:86. doi: 10.12688/wellcomeopenres.14700.1. eCollection 2018.


Understanding and predicting disease relationships through similarity fusion.

Oerton E, Roberts I, Lewis PSH, Guilliams T, Bender A.

Bioinformatics. 2018 Aug 30. doi: 10.1093/bioinformatics/bty754. [Epub ahead of print]


Finding Better Ways to Prevent Postpartum Hemorrhage.

Shakur-Still H, Roberts I.

N Engl J Med. 2018 Aug 23;379(8):790-792. doi: 10.1056/NEJMe1808500. No abstract available.


Colloids versus crystalloids for fluid resuscitation in critically ill people.

Lewis SR, Pritchard MW, Evans DJ, Butler AR, Alderson P, Smith AF, Roberts I.

Cochrane Database Syst Rev. 2018 Aug 3;8:CD000567. doi: 10.1002/14651858.CD000567.pub7. Review.


Should hydroxyethyl starch be banned? - Authors' reply.

Roberts I, Shakur H, Bellomo R, Bion J, Finfer S, Hunt B, Myburgh J, Perner A, Reinhart K.

Lancet. 2018 Jul 14;392(10142):119. doi: 10.1016/S0140-6736(18)31179-6. No abstract available.


Release of cell wall phenolic esters during hydrothermal pretreatment of rice husk and rice straw.

Wu J, Collins SRA, Elliston A, Wellner N, Dicks J, Roberts IN, Waldron KW.

Biotechnol Biofuels. 2018 Jun 11;11:162. doi: 10.1186/s13068-018-1157-1. eCollection 2018.


Eavesdropping and crosstalk between secreted quorum sensing peptide signals that regulate bacteriocin production in Streptococcus pneumoniae.

Miller EL, Kjos M, Abrudan MI, Roberts IS, Veening JW, Rozen DE.

ISME J. 2018 Oct;12(10):2363-2375. doi: 10.1038/s41396-018-0178-x. Epub 2018 Jun 13.


The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial.

Brenner A, Shakur-Still H, Chaudhri R, Fawole B, Arulkumaran S, Roberts I; WOMAN Trial Collaborators.

BMC Pregnancy Childbirth. 2018 Jun 7;18(1):215. doi: 10.1186/s12884-018-1855-5.


Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: analysis of data from the WOMAN trial.

Huque S, Roberts I, Fawole B, Chaudhri R, Arulkumaran S, Shakur-Still H.

BMC Pregnancy Childbirth. 2018 May 29;18(1):186. doi: 10.1186/s12884-018-1829-7.


Repurposing available drugs for neurodevelopmental disorders: The fragile X experience.

Tranfaglia MR, Thibodeaux C, Mason DJ, Brown D, Roberts I, Smith R, Guilliams T, Cogram P.

Neuropharmacology. 2018 May 4. pii: S0028-3908(18)30203-X. doi: 10.1016/j.neuropharm.2018.05.004. [Epub ahead of print] Review.


Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Sprigg N, Flaherty K, Appleton JP, Al-Shahi Salman R, Bereczki D, Beridze M, Christensen H, Ciccone A, Collins R, Czlonkowska A, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Krishnan K, Laska AC, Law ZK, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Seiffge D, Scutt P, Thanabalan J, Werring D, Whynes D, Bath PM; TICH-2 Investigators.

Lancet. 2018 May 26;391(10135):2107-2115. doi: 10.1016/S0140-6736(18)31033-X. Epub 2018 May 16.


Twenty-four-hour normothermic perfusion of discarded human kidneys with urine recirculation.

Weissenbacher A, Lo Faro L, Boubriak O, Soares MF, Roberts IS, Hunter JP, Voyce D, Mikov N, Cook A, Ploeg RJ, Coussios CC, Friend PJ.

Am J Transplant. 2018 May 14. doi: 10.1111/ajt.14932. [Epub ahead of print]


Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage.

Roberts I, Shakur H, Fawole B, Kuti M, Olayemi O, Bello A, Ogunbode O, Kotila T, Aimakhu CO, Olutogun T, Hunt BJ, Huque S.

BMC Pregnancy Childbirth. 2018 May 9;18(1):143. doi: 10.1186/s12884-018-1794-1.


Manipulation of host and parasite microbiotas: Survival strategies during chronic nematode infection.

White EC, Houlden A, Bancroft AJ, Hayes KS, Goldrick M, Grencis RK, Roberts IS.

Sci Adv. 2018 Mar 14;4(3):eaap7399. doi: 10.1126/sciadv.aap7399. eCollection 2018 Mar.


Optimising conditions for bioethanol production from rice husk and rice straw: effects of pre-treatment on liquor composition and fermentation inhibitors.

Wu J, Elliston A, Le Gall G, Colquhoun IJ, Collins SRA, Wood IP, Dicks J, Roberts IN, Waldron KW.

Biotechnol Biofuels. 2018 Mar 9;11:62. doi: 10.1186/s13068-018-1062-7. eCollection 2018.


Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices.

Bajema IM, Wilhelmus S, Alpers CE, Bruijn JA, Colvin RB, Cook HT, D'Agati VD, Ferrario F, Haas M, Jennette JC, Joh K, Nast CC, Noël LH, Rijnink EC, Roberts ISD, Seshan SV, Sethi S, Fogo AB.

Kidney Int. 2018 Apr;93(4):789-796. doi: 10.1016/j.kint.2017.11.023. Epub 2018 Feb 16.


Hydroxyethyl starch solutions and patient harm.

Roberts I, Shakur H, Bellomo R, Bion J, Finfer S, Hunt B, Myburgh J, Perner A, Reinhart K.

Lancet. 2018 Feb 24;391(10122):736. doi: 10.1016/S0140-6736(18)30255-1. Epub 2018 Feb 12. No abstract available.


Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial.

Dineen RA, Pszczolkowski S, Flaherty K, Law ZK, Morgan PS, Roberts I, Werring DJ, Salman RA, England T, Bath PM, Sprigg N.

BMJ Open. 2018 Feb 3;8(2):e019930. doi: 10.1136/bmjopen-2017-019930. Erratum in: BMJ Open. 2018 Apr 20;8(4):e019930corr1.


The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis.

Ker K, Prieto-Merino D, Sprigg N, Mahmood A, Bath P, Kang Law Z, Flaherty K, Roberts I.

Wellcome Open Res. 2017 Dec 20;2:120. doi: 10.12688/wellcomeopenres.13262.2. eCollection 2017.


Tranexamic acid for treatment of women with post-partum haemorrhage in Nigeria and Pakistan: a cost-effectiveness analysis of data from the WOMAN trial.

Li B, Miners A, Shakur H, Roberts I; WOMAN Trial Collaborators.

Lancet Glob Health. 2018 Feb;6(2):e222-e228. doi: 10.1016/S2214-109X(17)30467-9.


Post-partum haemorrhage and tranexamic acid: a global issue.

Hibbs SP, Roberts I, Shakur-Still H, Hunt BJ.

Br J Haematol. 2018 Mar;180(6):799-807. doi: 10.1111/bjh.15073. Epub 2018 Jan 9. Review.


Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface.

Dubaissi E, Rousseau K, Hughes GW, Ridley C, Grencis RK, Roberts IS, Thornton DJ.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):726-731. doi: 10.1073/pnas.1713539115. Epub 2018 Jan 8.


Three tandem promoters, together with IHF, regulate growth phase dependent expression of the Escherichia coli kps capsule gene cluster.

Jia J, King JE, Goldrick MC, Aldawood E, Roberts IS.

Sci Rep. 2017 Dec 20;7(1):17924. doi: 10.1038/s41598-017-17891-0.


Study protocol for statin web-based investigation of side effects (StatinWISE): a series of randomised controlled N-of-1 trials comparing atorvastatin and placebo in UK primary care.

Herrett E, Williamson E, Beaumont D, Prowse D, Youssouf N, Brack K, Armitage J, Goldacre B, MacDonald T, Staa TV, Roberts I, Shakur-Still H, Smeeth L.

BMJ Open. 2017 Dec 1;7(12):e016604. doi: 10.1136/bmjopen-2017-016604.


Detecting macroecological patterns in bacterial communities across independent studies of global soils.

Ramirez KS, Knight CG, de Hollander M, Brearley FQ, Constantinides B, Cotton A, Creer S, Crowther TW, Davison J, Delgado-Baquerizo M, Dorrepaal E, Elliott DR, Fox G, Griffiths RI, Hale C, Hartman K, Houlden A, Jones DL, Krab EJ, Maestre FT, McGuire KL, Monteux S, Orr CH, van der Putten WH, Roberts IS, Robinson DA, Rocca JD, Rowntree J, Schlaeppi K, Shepherd M, Singh BK, Straathof AL, Bhatnagar JM, Thion C, van der Heijden MGA, de Vries FT.

Nat Microbiol. 2018 Feb;3(2):189-196. doi: 10.1038/s41564-017-0062-x. Epub 2017 Nov 20.


Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.

Gayet-Ageron A, Prieto-Merino D, Ker K, Shakur H, Ageron FX, Roberts I; Antifibrinolytic Trials Collaboration.

Lancet. 2018 Jan 13;391(10116):125-132. doi: 10.1016/S0140-6736(17)32455-8. Epub 2017 Nov 7.


LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae.

Lamprinaki D, Beasy G, Zhekova A, Wittmann A, James S, Dicks J, Iwakura Y, Saijo S, Wang X, Chow CW, Roberts I, Korcsmaros T, Mayer U, Wileman T, Kawasaki N.

Front Immunol. 2017 Oct 25;8:1397. doi: 10.3389/fimmu.2017.01397. eCollection 2017.


Yeast diversity in relation to the production of fuels and chemicals.

Wu J, Elliston A, Le Gall G, Colquhoun IJ, Collins SRA, Dicks J, Roberts IN, Waldron KW.

Sci Rep. 2017 Oct 27;7(1):14259. doi: 10.1038/s41598-017-14641-0.


Pherotype Polymorphism in Streptococcus pneumoniae Has No Obvious Effects on Population Structure and Recombination.

Miller EL, Evans BA, Cornejo OE, Roberts IS, Rozen DE.

Genome Biol Evol. 2017 Oct 1;9(10):2546-2559. doi: 10.1093/gbe/evx188.


Tranexamic acid for post-partum haemorrhage in the WOMAN trial - Authors' reply.

Roberts I, Shakur H.

Lancet. 2017 Sep 30;390(10102):1584. doi: 10.1016/S0140-6736(17)31942-6. Epub 2017 Sep 28. No abstract available.


Listeria monocytogenes has both a bd-type and an aa3 -type terminal oxidase which allow growth in different oxygen levels and both are important in infection.

Corbett D, Goldrick M, Fernandes VE, Davidge K, Poole RK, Andrew PW, Cavet J, Roberts IS.

Infect Immun. 2017 Aug 14. pii: IAI.00354-17. doi: 10.1128/IAI.00354-17. [Epub ahead of print]


Saccharomyces jurei sp. nov., isolation and genetic identification of a novel yeast species from Quercus robur.

Naseeb S, James SA, Alsammar H, Michaels CJ, Gini B, Nueno-Palop C, Bond CJ, McGhie H, Roberts IN, Delneri D.

Int J Syst Evol Microbiol. 2017 Jun;67(6):2046-2052. doi: 10.1099/ijsem.0.002013. Epub 2017 Jun 22.


Differential effects of the Glasgow Coma Scale Score and its Components: An analysis of 54,069 patients with traumatic brain injury.

Reith FCM, Lingsma HF, Gabbe BJ, Lecky FE, Roberts I, Maas AIR.

Injury. 2017 Sep;48(9):1932-1943. doi: 10.1016/j.injury.2017.05.038. Epub 2017 Jun 1.


Whole-genome sequencing identifies homozygous BRCA2 deletion guiding treatment in dedifferentiated prostate cancer.

Purshouse K, Schuh A, Fairfax BP, Knight S, Antoniou P, Dreau H, Popitsch N, Gatter K, Roberts I, Browning L, Traill Z, Kerr D, Verrill C, Tuthill M, Taylor JC, Protheroe A.

Cold Spring Harb Mol Case Stud. 2017 May;3(3):a001362. doi: 10.1101/mcs.a001362.


Statistical analysis plan for the WOMAN-ETAPlaT study: Effect of tranexamic acid on platelet function and thrombin generation.

Dallaku K, Shakur H, Edwards P, Beaumont D, Roberts I, Huque S, Delius M, Mansmann U.

Wellcome Open Res. 2016 Dec 15;1:30. doi: 10.12688/wellcomeopenres.10105.2.


Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group.

Trimarchi H, Barratt J, Cattran DC, Cook HT, Coppo R, Haas M, Liu ZH, Roberts IS, Yuzawa Y, Zhang H, Feehally J; IgAN Classification Working Group of the International IgA Nephropathy Network and the Renal Pathology Society; Conference Participants.

Kidney Int. 2017 May;91(5):1014-1021. doi: 10.1016/j.kint.2017.02.003. Epub 2017 Mar 22. Review.


Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): protocol and statistical analysis plan for a randomized controlled trial.

Shakur H, Fawole B, Kuti M, Olayemi O, Bello A, Ogunbode O, Kotila T, Aimakhu CO, Huque S, Gregg M, Roberts I.

Wellcome Open Res. 2016 Dec 16;1:31. doi: 10.12688/wellcomeopenres.10383.1.


IgA nephropathy: an update.

Soares MF, Roberts IS.

Curr Opin Nephrol Hypertens. 2017 May;26(3):165-171. doi: 10.1097/MNH.0000000000000312. Review.


Clinical information has low sensitivity for postmortem diagnosis of heart valve disease.

Coffey S, Harper AR, Cairns BJ, Roberts IS, Prendergast BD.

Heart. 2017 Jul;103(13):1031-1035. doi: 10.1136/heartjnl-2016-310718. Epub 2017 Feb 9.


Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms.

Roberts I, Edwards P, Prieto D, Joshi M, Mahmood A, Ker K, Shakur H.

Trials. 2017 Jan 31;18(1):48. doi: 10.1186/s13063-016-1750-1.


Effects of tranexamic acid on platelet function and thrombin generation (ETAPlaT): WOMAN trial sub-study.

Dallaku K, Shakur H, Roberts I, Edwards P, Beaumont D, Delius M, Siegmund B, Gliozheni O, Tasha I, Cenameri S, Mansmann U.

Wellcome Open Res. 2016 Dec 15;1:29. doi: 10.12688/wellcomeopenres.9964.1.


Safetxt: a pilot randomised controlled trial of an intervention delivered by mobile phone to increase safer sex behaviours in young people.

McCarthy OL, French RS, Baraitser P, Roberts I, Rathod SD, Devries K, Bailey JV, Edwards P, Wellings K, Michie S, Free C.

BMJ Open. 2016 Dec 23;6(12):e013045. doi: 10.1136/bmjopen-2016-013045.


Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease.

Challis RC, Ring T, Xu Y, Wong EK, Flossmann O, Roberts IS, Ahmed S, Wetherall M, Salkus G, Brocklebank V, Fester J, Strain L, Wilson V, Wood KM, Marchbank KJ, Santibanez-Koref M, Goodship TH, Kavanagh D.

J Am Soc Nephrol. 2017 Apr;28(4):1084-1091. doi: 10.1681/ASN.2015101189. Epub 2016 Dec 14.


Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy.

Bellur SS, Lepeytre F, Vorobyeva O, Troyanov S, Cook HT, Roberts IS; International IgA Nephropathy Working Group.

Kidney Int. 2017 Jan;91(1):235-243. doi: 10.1016/j.kint.2016.09.029. Epub 2016 Dec 1.

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