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Items: 1 to 50 of 230

1.

WRN helicase is a synthetic lethal target in microsatellite unstable cancers.

Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ.

Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10.

PMID:
30971823
2.

USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.

Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang C, Kozono D, Parmar K, Yusufzai T, Zheng N, D'Andrea AD.

Mol Cell. 2018 Dec 20;72(6):925-941.e4. doi: 10.1016/j.molcel.2018.10.045.

PMID:
30576655
3.

Update on the Diagnosis and Management of Wilson Disease.

Roberts EA.

Curr Gastroenterol Rep. 2018 Nov 5;20(12):56. doi: 10.1007/s11894-018-0660-7. Review.

PMID:
30397835
4.

Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.

Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ Jr, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD.

Cancer Discov. 2018 Nov;8(11):1404-1421. doi: 10.1158/2159-8290.CD-18-0474. Epub 2018 Sep 13.

PMID:
30213835
5.

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.

Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB.

J Biol Chem. 2018 Jul 20;293(29):11341-11357. doi: 10.1074/jbc.RA117.000441. Epub 2018 Jun 1.

PMID:
29858247
6.

DynaSim: A MATLAB Toolbox for Neural Modeling and Simulation.

Sherfey JS, Soplata AE, Ardid S, Roberts EA, Stanley DA, Pittman-Polletta BR, Kopell NJ.

Front Neuroinform. 2018 Mar 15;12:10. doi: 10.3389/fninf.2018.00010. eCollection 2018.

7.

Wilson disease in children.

Roberts EA, Socha P.

Handb Clin Neurol. 2017;142:141-156. doi: 10.1016/B978-0-444-63625-6.00012-4. Review.

PMID:
28433098
8.

Acetylcholine Release in Prefrontal Cortex Promotes Gamma Oscillations and Theta-Gamma Coupling during Cue Detection.

Howe WM, Gritton HJ, Lusk NA, Roberts EA, Hetrick VL, Berke JD, Sarter M.

J Neurosci. 2017 Mar 22;37(12):3215-3230. doi: 10.1523/JNEUROSCI.2737-16.2017. Epub 2017 Feb 17.

9.

Early Posthepatoportoenterostomy Predictors of Native Liver Survival in Biliary Atresia.

Nightingale S, Stormon MO, O'Loughlin EV, Shun A, Thomas G, Benchimol EI, Day AS, Adams S, Shi E, Ooi CY, Kamath BM, Fecteau A, Langer JC, Roberts EA, Ling SC, Ng VL.

J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):203-209. doi: 10.1097/MPG.0000000000001289.

PMID:
28107282
10.

Covalently deposited dyes: a new chromogen paradigm that facilitates analysis of multiple biomarkers in situ.

Day WA, Lefever MR, Ochs RL, Pedata A, Behman LJ, Ashworth-Sharpe J, Johnson DD, May EJ, Grille JG, Roberts EA, Kosmeder JW, Morrison LE.

Lab Invest. 2017 Jan;97(1):104-113. doi: 10.1038/labinvest.2016.115. Epub 2016 Nov 21.

11.

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.

Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein LS.

Cell Rep. 2016 Oct 11;17(3):759-773. doi: 10.1016/j.celrep.2016.09.034.

12.

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits.

Kondabolu K, Roberts EA, Bucklin M, McCarthy MM, Kopell N, Han X.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3159-68. doi: 10.1073/pnas.1605658113. Epub 2016 May 16.

13.

Standardization of Guidelines for Patient Photograph Deidentification.

Roberts EA, Troiano C, Spiegel JH.

Ann Plast Surg. 2016 Jun;76(6):611-4. doi: 10.1097/SAP.0000000000000817.

PMID:
27015333
14.

Broadening the implications of gene discovery.

Roberts EA.

Hepatology. 2016 Jun;63(6):1765-7. doi: 10.1002/hep.28474. Epub 2016 Mar 22. No abstract available.

PMID:
26822144
15.

Controversies and Variation in Diagnosing and Treating Children With Wilson Disease: Results of an International Survey.

Sturm E, Piersma FE, Tanner MS, Socha P, Roberts EA, Shneider BL.

J Pediatr Gastroenterol Nutr. 2016 Jul;63(1):82-7. doi: 10.1097/MPG.0000000000001102.

PMID:
26720766
16.

Incidence and Characteristics of Autoimmune Hepatitis.

Jiménez-Rivera C, Ling SC, Ahmed N, Yap J, Aglipay M, Barrowman N, Graitson S, Critch J, Rashid M, Ng VL, Roberts EA, Brill H, Dowhaniuk JK, Bruce G, Bax K, Deneau M, Guttman OR, Schreiber RA, Martin S, Alvarez F.

Pediatrics. 2015 Nov;136(5):e1237-48. doi: 10.1542/peds.2015-0578. Epub 2015 Oct 19.

17.

Optogenetics and deep brain stimulation neurotechnologies.

Kondabolu K, Kowalski MM, Roberts EA, Han X.

Handb Exp Pharmacol. 2015;228:441-50. doi: 10.1007/978-3-319-16522-6_15. Review.

PMID:
25977092
18.

Well-differentiated hepatocellular neoplasm of uncertain malignant potential--reply.

Bedossa P, Burt AD, Brunt E, Callea F, Clouston AD, Dienes HP, Goodman ZD, Gouw AS, Hubscher SG, Roberts EA, Roskams T, Terracciano L, Tiniakos DG, Torbenson MS, Wanless IR.

Hum Pathol. 2015 Apr;46(4):635-6. doi: 10.1016/j.humpath.2014.10.030. Epub 2014 Dec 31. No abstract available.

PMID:
25732109
19.

Fair pricing of "old" orphan drugs: considerations for Canada's orphan drug policy.

Roberts EA, Herder M, Hollis A.

CMAJ. 2015 Apr 7;187(6):422-425. doi: 10.1503/cmaj.140308. Epub 2015 Feb 23. Review. No abstract available.

20.

Costly choices for treating Wilson's disease.

Schilsky ML, Roberts EA, Hahn S, Askari F.

Hepatology. 2015 Apr;61(4):1106-8. doi: 10.1002/hep.27663. Epub 2015 Mar 10. No abstract available.

21.

Metalloproteomics: focus on metabolic issues relating to metals.

Roberts EA, Sarkar B.

Curr Opin Clin Nutr Metab Care. 2014 Sep;17(5):425-30. doi: 10.1097/MCO.0000000000000085. Review.

PMID:
25010543
22.

The trientine crisis in Canada: a call to advocacy.

Chandok N, Roberts EA.

Can J Gastroenterol Hepatol. 2014 Apr;28(4):184. No abstract available.

23.

Well-differentiated hepatocellular neoplasm of uncertain malignant potential: proposal for a new diagnostic category.

Bedossa P, Burt AD, Brunt EM, Callea F, Clouston AD, Dienes HP, Goodman ZD, Gouw AS, Hubscher SG, Roberts EA, Roskams T, Terracciano L, Tiniakos DG, Torbenson MS, Wanless IR.

Hum Pathol. 2014 Mar;45(3):658-60. doi: 10.1016/j.humpath.2013.09.020. Epub 2013 Nov 21. No abstract available.

PMID:
24529331
24.

Pathology of the liver sinusoids.

Brunt EM, Gouw AS, Hubscher SG, Tiniakos DG, Bedossa P, Burt AD, Callea F, Clouston AD, Dienes HP, Goodman ZD, Roberts EA, Roskams T, Terracciano L, Torbenson MS, Wanless IR.

Histopathology. 2014 Jun;64(7):907-20. doi: 10.1111/his.12364. Epub 2014 Mar 8. Review.

PMID:
24393125
25.

"Not so rare" Wilson disease.

Roberts EA.

Clin Res Hepatol Gastroenterol. 2013 Jun;37(3):219-21. doi: 10.1016/j.clinre.2013.03.007. Epub 2013 May 24. No abstract available.

PMID:
23707004
26.

Chronic hepatitis B virus (HBV) infection in children: 25 years' experience.

Popalis C, Yeung LT, Ling SC, Ng V, Roberts EA.

J Viral Hepat. 2013 Apr;20(4):e20-6. doi: 10.1111/jvh.12019. Epub 2012 Nov 19.

PMID:
23490385
27.

Persistence of the Gypsy Moth Pheromone, Disparlure, in the Environment in Various Climates.

Onufrieva KS, Thorpe KW, Hickman AD, Leonard DS, Roberts EA, Tobin PC.

Insects. 2013 Jan 14;4(1):104-16. doi: 10.3390/insects4010104.

28.

Genetics of Wilson's disease: a clinical perspective.

Kumar SS, Kurian G, Eapen CE, Roberts EA.

Indian J Gastroenterol. 2012 Dec;31(6):285-93. doi: 10.1007/s12664-012-0237-6. Epub 2012 Sep 1. Review.

PMID:
22941676
29.

Using metalloproteomics to investigate the cellular physiology of copper in hepatocytes.

Roberts EA.

Metallomics. 2012 Jul;4(7):633-40. doi: 10.1039/c2mt20019h. Epub 2012 May 23. Review.

PMID:
22618634
30.

NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents.

Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB; North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):838-55. doi: 10.1097/MPG.0b013e318258328d.

PMID:
22487950
31.

Defining Wilson disease phenotypes: from the patient to the bench and back again.

Ferenci P, Roberts EA.

Gastroenterology. 2012 Apr;142(4):692-6. doi: 10.1053/j.gastro.2012.02.035. No abstract available.

PMID:
22480881
32.

Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.

Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS.

Hum Mol Genet. 2012 Jun 15;21(12):2651-62. doi: 10.1093/hmg/dds090. Epub 2012 Mar 21.

33.

Autoimmune hepatitis from the paediatric perspective.

Roberts EA.

Liver Int. 2011 Nov;31(10):1424-31. doi: 10.1111/j.1478-3231.2011.02603.x. Epub 2011 Aug 31. Review.

PMID:
22093323
34.

Strategic plan of the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and Diabetes.

Sherman PM, Makarchuk MJ, Belanger P, Roberts EA.

Can J Gastroenterol. 2011 Oct;25(10):560-4.

35.

Biliary atresia with associated structural malformations in Canadian infants.

Guttman OR, Roberts EA, Schreiber RA, Barker CC, Ng VL; Canadian Pediatric Hepatology Research Group.

Liver Int. 2011 Nov;31(10):1485-93. doi: 10.1111/j.1478-3231.2011.02578.x. Epub 2011 Aug 8.

PMID:
21819536
36.

Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight.

Yap JY, O'Connor C, Mager DR, Taylor G, Roberts EA.

Clin Res Hepatol Gastroenterol. 2011 Jun;35(6-7):500-5. doi: 10.1016/j.clinre.2011.04.001. Epub 2011 May 19.

PMID:
21600867
37.

The changing face of hepatitis in boys with haemophilia associated with increased prevalence of obesity.

Revel-Vilk S, Komvilaisak P, Blanchette V, Stain AM, Floros G, Cochrane A, Blanchette C, Hang M, Roberts EA, Ling SC.

Haemophilia. 2011 Jul;17(4):689-94. doi: 10.1111/j.1365-2516.2010.02477.x. Epub 2011 Mar 21.

PMID:
21418443
38.

Lysosomal positioning coordinates cellular nutrient responses.

Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC.

Nat Cell Biol. 2011 Apr;13(4):453-60. doi: 10.1038/ncb2204. Epub 2011 Mar 13.

39.

Commentary.

Roberts EA.

Clin Chem. 2011 Mar;57(3):386-7. doi: 10.1373/clinchem.2010.158097. No abstract available.

40.

Zinc toxicity: from "no, never" to "hardly ever".

Roberts EA.

Gastroenterology. 2011 Apr;140(4):1132-5. doi: 10.1053/j.gastro.2011.02.028. Epub 2011 Feb 22. No abstract available.

PMID:
21349360
41.

The puzzle posed by COMMD1, a newly discovered protein binding Cu(II).

Sarkar B, Roberts EA.

Metallomics. 2011 Jan;3(1):20-7.

PMID:
21275100
42.

Biliary atresia in Canada: the effect of centre caseload experience on outcome.

Schreiber RA, Barker CC, Roberts EA, Martin SR; Canadian Pediatric Hepatology Research Group.

J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):61-5. doi: 10.1097/MPG.0b013e3181d67e5e.

PMID:
20543720
43.

Dietary and physical activity patterns in children with fatty liver.

Mager DR, Patterson C, So S, Rogenstein CD, Wykes LJ, Roberts EA.

Eur J Clin Nutr. 2010 Jun;64(6):628-35. doi: 10.1038/ejcn.2010.35. Epub 2010 Mar 10.

PMID:
20216561
44.

Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties.

Ponpuak M, Davis AS, Roberts EA, Delgado MA, Dinkins C, Zhao Z, Virgin HW 4th, Kyei GB, Johansen T, Vergne I, Deretic V.

Immunity. 2010 Mar 26;32(3):329-41. doi: 10.1016/j.immuni.2010.02.009. Epub 2010 Mar 4.

45.

Derivation of a clinical prediction rule for the noninvasive diagnosis of varices in children.

Gana JC, Turner D, Roberts EA, Ling SC.

J Pediatr Gastroenterol Nutr. 2010 Feb;50(2):188-93. doi: 10.1097/MPG.0b013e3181b64437. Erratum in: J Pediatr Gastroenterol Nutr. 2013 Apr;56(4):459.

PMID:
19966576
46.

Current issues in the management of paediatric viral hepatitis.

Yeung LT, Roberts EA.

Liver Int. 2010 Jan;30(1):5-18. doi: 10.1111/j.1478-3231.2009.02145.x. Epub 2009 Oct 19. Review.

PMID:
19840256
47.

Sequential antiviral and iron chelation treatment in a teenage boy with congenital anemia, chronic hepatitis C, and secondary hemosiderosis.

Yap J, O'Connor C, Kirby M, Guindi M, Roberts EA.

J Pediatr Gastroenterol Nutr. 2009 Mar;48(3):382-5. No abstract available.

PMID:
19274798
48.
49.

Clinicopathologic spectrum of massive and submassive hepatic necrosis in infants and children.

Kirsch R, Yap J, Roberts EA, Cutz E.

Hum Pathol. 2009 Apr;40(4):516-26. doi: 10.1016/j.humpath.2008.07.018. Epub 2009 Jan 3.

PMID:
19121848
50.

Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages.

Harris J, Master SS, De Haro SA, Delgado M, Roberts EA, Hope JC, Keane J, Deretic V.

Vet Immunol Immunopathol. 2009 Mar 15;128(1-3):37-43. doi: 10.1016/j.vetimm.2008.10.293. Epub 2008 Oct 17.

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