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Items: 1 to 50 of 398

1.

Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.

Roberts AB, Gu X, Buffa JA, Hurd AG, Wang Z, Zhu W, Gupta N, Skye SM, Cody DB, Levison BS, Barrington WT, Russell MW, Reed JM, Duzan A, Lang JM, Fu X, Li L, Myers AJ, Rachakonda S, DiDonato JA, Brown JM, Gogonea V, Lusis AJ, Garcia-Garcia JC, Hazen SL.

Nat Med. 2018 Sep;24(9):1407-1417. doi: 10.1038/s41591-018-0128-1. Epub 2018 Aug 6.

2.

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.

Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, Romano KA, Han Y, Obeid S, Lüscher TF, Allayee H, Rey FE, DiDonato JA, Fiehn O, Tang WHW, Hazen SL.

JCI Insight. 2018 Mar 22;3(6). pii: 99096. doi: 10.1172/jci.insight.99096.

3.

Blue-fingered diver: case report.

Cable R, Weaver LK, Roberts AB, Goodman G, Deru K.

Undersea Hyperb Med. 2016 Nov-Dec;43(7):835-840.

PMID:
28777521
4.

Long-Term Outcomes of Fistula First Initiative in an Urban University Hospital-Is It Still Relevant?

Greenberg J, Jayarajan S, Reddy S, Schmieder FA, Roberts AB, van Bemmelen PS, Lee J, Choi ET.

Vasc Endovascular Surg. 2017 Apr;51(3):125-130. doi: 10.1177/1538574417692454. Epub 2017 Jan 1.

5.

The Discovery and Early Days of TGF-β: A Historical Perspective.

Moses HL, Roberts AB, Derynck R.

Cold Spring Harb Perspect Biol. 2016 Jul 1;8(7). pii: a021865. doi: 10.1101/cshperspect.a021865. Review.

6.

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.

Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL.

Cell. 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055.

7.

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.

Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, Frye SV, Zamboni WC, Pepe-Ranney C, Mani S, Kelly L, Redinbo MR.

Chem Biol. 2015 Sep 17;22(9):1238-49. doi: 10.1016/j.chembiol.2015.08.005. Epub 2015 Sep 10.

8.

Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050.

Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS.

J Immunol. 2014 Apr 1;192(7):2939-52. No abstract available.

9.

Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity.

Roberts AB, Wallace BD, Venkatesh MK, Mani S, Redinbo MR.

Mol Pharmacol. 2013 Aug;84(2):208-17. doi: 10.1124/mol.113.085852. Epub 2013 May 20.

10.

Transient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-Beta mediated mechanism in a mouse xenograft model of breast cancer.

Stuelten CH, Busch JI, Tang B, Flanders KC, Oshima A, Sutton E, Karpova TS, Roberts AB, Wakefield LM, Niederhuber JE.

PLoS One. 2010 Mar 23;5(3):e9832. doi: 10.1371/journal.pone.0009832.

11.

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.

Rajagopal R, Huang J, Dattilo LK, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC.

Dev Biol. 2009 Nov 15;335(2):305-16. doi: 10.1016/j.ydbio.2009.08.027. Epub 2009 Sep 3.

12.

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.

Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC.

Development. 2009 May;136(10):1741-50. doi: 10.1242/dev.034082. Epub 2009 Apr 15.

13.

Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.

Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG.

J Biol Chem. 2009 May 1;284(18):12246-57. doi: 10.1074/jbc.M805379200. Epub 2009 Mar 5.

14.

Acute wounds accelerate tumorigenesis by a T cell-dependent mechanism.

Stuelten CH, Barbul A, Busch JI, Sutton E, Katz R, Sato M, Wakefield LM, Roberts AB, Niederhuber JE.

Cancer Res. 2008 Sep 15;68(18):7278-82. doi: 10.1158/0008-5472.CAN-08-1842.

15.

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.

Rajagopal R, Dattilo LK, Kaartinen V, Deng CX, Umans L, Zwijsen A, Roberts AB, Bottinger EP, Beebe DC.

Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4953-60. doi: 10.1167/iovs.08-2217. Epub 2008 Jun 19.

16.

Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection.

Flanders KC, Ho BM, Arany PR, Stuelten C, Mamura M, Paterniti MO, Sowers A, Mitchell JB, Roberts AB.

Am J Pathol. 2008 Jul;173(1):68-76. doi: 10.2353/ajpath.2008.070937. Epub 2008 May 23.

17.

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.

Orvis GD, Jamin SP, Kwan KM, Mishina Y, Kaartinen VM, Huang S, Roberts AB, Umans L, Huylebroeck D, Zwijsen A, Wang D, Martin JF, Behringer RR.

Biol Reprod. 2008 Jun;78(6):994-1001. doi: 10.1095/biolreprod.107.066605. Epub 2008 Mar 5.

18.
19.

Lentiviral reporter constructs for fluorescence tracking of the temporospatial pattern of Smad3 signaling.

Stuelten CH, Kamaraju AK, Wakefield LM, Roberts AB.

Biotechniques. 2007 Sep;43(3):289-90, 292, 294.

20.

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.

Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R.

Nat Med. 2007 Aug;13(8):952-61. Epub 2007 Jul 29.

PMID:
17660828
21.

Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts.

Arany PR, Flanders KC, DeGraff W, Cook J, Mitchell JB, Roberts AB.

J Dermatol Sci. 2007 Oct;48(1):35-42. Epub 2007 Jul 12.

22.

Controlled study of brief personalized assessment-feedback for drinkers interested in self-help.

Wild TC, Cunningham JA, Roberts AB.

Addiction. 2007 Feb;102(2):241-50.

PMID:
17222278
23.

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.

Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga SI, Jen J, Perkins ND, Lechleider RJ, Roberts AB.

Mol Cell. 2006 Dec 8;24(5):771-783. doi: 10.1016/j.molcel.2006.11.006.

24.

Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure.

Arany PR, Flanders KC, Kobayashi T, Kuo CK, Stuelten C, Desai KV, Tuan R, Rennard SI, Roberts AB.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9250-5. Epub 2006 Jun 5.

25.

Smad4-expression is decreased in breast cancer tissues: a retrospective study.

Stuelten CH, Buck MB, Dippon J, Roberts AB, Fritz P, Knabbe C.

BMC Cancer. 2006 Jan 26;6:25.

26.

Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.

Roberts AB, Tian F, Byfield SD, Stuelten C, Ooshima A, Saika S, Flanders KC.

Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):19-27. Epub 2005 Nov 11. Review.

PMID:
16290023
27.

Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells.

Saika S, Yamanaka O, Ikeda K, Kim-Mitsuyama S, Flanders KC, Yoo J, Roberts AB, Nishikawa-Ishida I, Ohnishi Y, Muragaki Y, Ooshima A.

Lab Invest. 2005 Jul;85(7):838-50.

28.

Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali.

Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB.

Am J Pathol. 2005 May;166(5):1405-18.

29.

Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta.

Stuelten CH, DaCosta Byfield S, Arany PR, Karpova TS, Stetler-Stevenson WG, Roberts AB.

J Cell Sci. 2005 May 15;118(Pt 10):2143-53. Epub 2005 Apr 26.

30.
31.
32.

Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3.

Stramer BM, Austin JS, Roberts AB, Fini ME.

J Cell Physiol. 2005 Apr;203(1):226-32.

PMID:
15521071
34.

Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis.

Sauer B, Vogler R, Zimmermann K, Fujii M, Anzano MB, Schäfer-Korting M, Roberts AB, Kleuser B.

J Invest Dermatol. 2004 Nov;123(5):840-9.

35.

Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression.

Tan NS, Michalik L, Di-Poï N, Ng CY, Mermod N, Roberts AB, Desvergne B, Wahli W.

EMBO J. 2004 Oct 27;23(21):4211-21. Epub 2004 Oct 7.

36.

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE, Byfield S, Felici A, Flanders KC, Walz TM, Roberts AB, Aplan PD, Balis FM, Letterio JJ.

N Engl J Med. 2004 Aug 5;351(6):552-9.

37.

Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice.

Saika S, Kono-Saika S, Tanaka T, Yamanaka O, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Yoo J, Flanders KC, Roberts AB.

Lab Invest. 2004 Oct;84(10):1245-58.

38.

Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis.

Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, Lavery C, Margetts PJ, Roberts AB, Gauldie J.

J Immunol. 2004 Aug 1;173(3):2099-108.

39.

Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice.

Saika S, Ikeda K, Yamanaka O, Sato M, Muragaki Y, Ohnishi Y, Ooshima A, Nakajima Y, Namikawa K, Kiyama H, Flanders KC, Roberts AB.

Lab Invest. 2004 Oct;84(10):1259-70.

40.

Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes.

Sauer B, Vogler R, von Wenckstern H, Fujii M, Anzano MB, Glick AB, Schäfer-Korting M, Roberts AB, Kleuser B.

J Biol Chem. 2004 Sep 10;279(37):38471-9. Epub 2004 Jul 9.

41.
42.

Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.

Tian F, Byfield SD, Parks WT, Stuelten CH, Nemani D, Zhang YE, Roberts AB.

Cancer Res. 2004 Jul 1;64(13):4523-30.

43.

Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice.

Falanga V, Schrayer D, Cha J, Butmarc J, Carson P, Roberts AB, Kim SJ.

Wound Repair Regen. 2004 May-Jun;12(3):320-6.

PMID:
15225210
44.

Alcohol problems and interest in self-help: a population study of Alberta adults.

Wild TC, Roberts AB, Cunningham J, Schopflocher D, Pazderka-Robinson H.

Can J Public Health. 2004 Mar-Apr;95(2):127-32.

PMID:
15074903
45.

Lateral signaling enhances TGF-beta response complexity.

Byfield SD, Roberts AB.

Trends Cell Biol. 2004 Mar;14(3):107-11. Review.

PMID:
15055198
46.

The effect of methadone treatment on the quantity and quality of human fetal movement.

Wouldes TA, Roberts AB, Pryor JE, Bagnall C, Gunn TR.

Neurotoxicol Teratol. 2004 Jan-Feb;26(1):23-34.

PMID:
15001211
47.

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

DaCosta Byfield S, Major C, Laping NJ, Roberts AB.

Mol Pharmacol. 2004 Mar;65(3):744-52.

PMID:
14978253
48.

Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.

Saika S, Kono-Saika S, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Flanders KC, Yoo J, Anzano M, Liu CY, Kao WW, Roberts AB.

Am J Pathol. 2004 Feb;164(2):651-63.

49.

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A.

J Biol Chem. 2004 Apr 9;279(15):15167-76. Epub 2004 Jan 19.

50.

Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis.

Lewis J, Burstein E, Reffey SB, Bratton SB, Roberts AB, Duckett CS.

J Biol Chem. 2004 Mar 5;279(10):9023-9. Epub 2003 Dec 29.

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