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Alveolar Macrophage Dysfunction and Increased PD-1 Expression During Chronic SIV Infection of Rhesus Macaques.

Hunegnaw R, Mushtaq Z, Enyindah-Asonye G, Hoang T, Robert-Guroff M.

Front Immunol. 2019 Jul 3;10:1537. doi: 10.3389/fimmu.2019.01537. eCollection 2019.


High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer.

Morales-Kastresana A, Musich TA, Welsh JA, Telford W, Demberg T, Wood JCS, Bigos M, Ross CD, Kachynski A, Dean A, Felton EJ, Van Dyke J, Tigges J, Toxavidis V, Parks DR, Overton WR, Kesarwala AH, Freeman GJ, Rosner A, Perfetto SP, Pasquet L, Terabe M, McKinnon K, Kapoor V, Trepel JB, Puri A, Kobayashi H, Yung B, Chen X, Guion P, Choyke P, Knox SJ, Ghiran I, Robert-Guroff M, Berzofsky JA, Jones JC.

J Extracell Vesicles. 2019 Jun 19;8(1):1597603. doi: 10.1080/20013078.2019.1597603. eCollection 2019.


Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1.

Lewis GK, Ackerman ME, Scarlatti G, Moog C, Robert-Guroff M, Kent SJ, Overbaugh J, Reeves RK, Ferrari G, Thyagarajan B.

Front Immunol. 2019 May 10;10:1025. doi: 10.3389/fimmu.2019.01025. eCollection 2019. Review.


Replicating Adenovirus-SIV Immunization of Rhesus Macaques Induces Mucosal Dendritic Cell Activation and Function Leading to Rectal Immune Responses.

Ko EJ, Helmold Hait S, Enyindah-Asonye G, Rahman MA, Hoang T, Robert-Guroff M.

Front Immunol. 2019 Apr 12;10:779. doi: 10.3389/fimmu.2019.00779. eCollection 2019.


A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques.

Enyindah-Asonye G, Nwankwo A, Hogge C, Rahman MA, Helmold Hait S, Hunegnaw R, Ko EJ, Hoang T, Venzon DJ, Robert-Guroff M.

Front Immunol. 2019 Mar 19;10:511. doi: 10.3389/fimmu.2019.00511. eCollection 2019.


Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response.

Sui Y, Lewis GK, Wang Y, Berckmueller K, Frey B, Dzutsev A, Vargas-Inchaustegui D, Mohanram V, Musich T, Shen X, DeVico A, Fouts T, Venzon D, Kirk J, Waters RC, Talton J, Klinman D, Clements J, Tomaras GD, Franchini G, Robert-Guroff M, Trinchieri G, Gallo RC, Berzofsky JA.

J Clin Invest. 2019 Mar 1;129(3):1314-1328. doi: 10.1172/JCI122110. Epub 2019 Feb 18.


Accelerating HIV vaccine development using non-human primate models.

Rahman MA, Robert-Guroff M.

Expert Rev Vaccines. 2019 Jan;18(1):61-73. doi: 10.1080/14760584.2019.1557521. Epub 2018 Dec 17. Review.


Early T Follicular Helper Cell Responses and Germinal Center Reactions Are Associated with Viremia Control in Immunized Rhesus Macaques.

Helmold Hait S, Vargas-Inchaustegui DA, Musich T, Mohanram V, Tuero I, Venzon DJ, Bear J, Rosati M, Vaccari M, Franchini G, Felber BK, Pavlakis GN, Robert-Guroff M.

J Virol. 2019 Feb 5;93(4). pii: e01687-18. doi: 10.1128/JVI.01687-18. Print 2019 Feb 15.


Neutrophil Vaccination Dynamics and Their Capacity To Mediate B Cell Help in Rhesus Macaques.

Musich T, Rahman MA, Mohanram V, Miller-Novak L, Demberg T, Venzon DJ, Felber BK, Franchini G, Pavlakis GN, Robert-Guroff M.

J Immunol. 2018 Oct 15;201(8):2287-2302. doi: 10.4049/jimmunol.1800677. Epub 2018 Sep 14.


Analysis of Complement-Mediated Lysis of Simian Immunodeficiency Virus (SIV) and SIV-Infected Cells Reveals Sex Differences in Vaccine-Induced Immune Responses in Rhesus Macaques.

Miller-Novak LK, Das J, Musich TA, Demberg T, Weiner JA, Venzon DJ, Mohanram V, Vargas-Inchaustegui DA, Tuero I, Ackerman ME, Alter G, Robert-Guroff M.

J Virol. 2018 Sep 12;92(19). pii: e00721-18. doi: 10.1128/JVI.00721-18. Print 2018 Oct 1.


Associations of Simian Immunodeficiency Virus (SIV)-Specific Follicular CD8+ T Cells with Other Follicular T Cells Suggest Complex Contributions to SIV Viremia Control.

Rahman MA, McKinnon KM, Karpova TS, Ball DA, Venzon DJ, Fan W, Kang G, Li Q, Robert-Guroff M.

J Immunol. 2018 Apr 15;200(8):2714-2726. doi: 10.4049/jimmunol.1701403. Epub 2018 Mar 5.


A Report of the 24th Annual Congress on Women's Health-Workshop on Transforming Women's Health: From Research to Practice.

Plank-Bazinet JL, Sampson A, Kornstein SG, Germino GG, Robert-Guroff M, Gilman SE, Wetherington CL, Cook N, Cornelison TL, Begg L, Clayton JA.

J Womens Health (Larchmt). 2018 Jan;27(1):115-120. doi: 10.1089/jwh.2017.29016.orwh.


Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus-Controlling Macaques.

Vargas-Inchaustegui DA, Helmold Hait S, Chung HK, Narola J, Hoang T, Robert-Guroff M.

J Immunol. 2017 Nov 1;199(9):3202-3211. doi: 10.4049/jimmunol.1700586. Epub 2017 Sep 25.


Labeling Extracellular Vesicles for Nanoscale Flow Cytometry.

Morales-Kastresana A, Telford B, Musich TA, McKinnon K, Clayborne C, Braig Z, Rosner A, Demberg T, Watson DC, Karpova TS, Freeman GJ, DeKruyff RH, Pavlakis GN, Terabe M, Robert-Guroff M, Berzofsky JA, Jones JC.

Sci Rep. 2017 May 12;7(1):1878. doi: 10.1038/s41598-017-01731-2.


Flow virometric sorting and analysis of HIV quasispecies from plasma.

Musich T, Jones JC, Keele BF, Jenkins LMM, Demberg T, Uldrick TS, Yarchoan R, Robert-Guroff M.

JCI Insight. 2017 Feb 23;2(4):e90626. doi: 10.1172/jci.insight.90626.


Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner.

Musich T, Li L, Liu L, Zolla-Pazner S, Robert-Guroff M, Gorny MK.

J Virol. 2017 Mar 29;91(8). pii: e02325-16. doi: 10.1128/JVI.02325-16. Print 2017 Apr 15.


Influence of Plasma Cell Niche Factors on the Recruitment and Maintenance of IRF4hi Plasma Cells and Plasmablasts in Vaccinated, Simian Immunodeficiency Virus-Infected Rhesus Macaques with Low and High Viremia.

Shaw JM, Miller-Novak LK, Mohanram V, McKinnon K, Demberg T, Vargas-Inchaustegui DA, Venzon D, Robert-Guroff M.

J Virol. 2017 Jan 31;91(4). pii: e01727-16. doi: 10.1128/JVI.01727-16. Print 2017 Feb 15.


Mucosal and Systemic γδ+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection.

Tuero I, Venzon D, Robert-Guroff M.

J Immunol. 2016 Dec 15;197(12):4686-4695. Epub 2016 Nov 4.


Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition.

Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G.

Nat Med. 2016 Oct 6;22(10):1192. doi: 10.1038/nm1016-1192a. No abstract available.


Evaluation of Functional NK Cell Responses in Vaccinated and SIV-Infected Rhesus Macaques.

Vargas-Inchaustegui DA, Ying O, Demberg T, Robert-Guroff M.

Front Immunol. 2016 Aug 31;7:340. doi: 10.3389/fimmu.2016.00340. eCollection 2016.


Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition.

Gordon SN, Liyanage NP, Doster MN, Vaccari M, Vargas-Inchaustegui DA, Pegu P, Schifanella L, Shen X, Tomaras GD, Rao M, Billings EA, Schwartz J, Prado I, Bobb K, Zhang W, Montefiori DC, Foulds KE, Ferrari G, Robert-Guroff M, Roederer M, Phan TB, Forthal DN, Stablein DM, Phogat S, Venzon DJ, Fouts T, Franchini G.

J Immunol. 2016 Oct 1;197(7):2726-37. doi: 10.4049/jimmunol.1600674. Epub 2016 Sep 2.


B Cell Responses Associated with Vaccine-Induced Delayed SIVmac251 Acquisition in Female Rhesus Macaques.

Mohanram V, Demberg T, Musich T, Tuero I, Vargas-Inchaustegui DA, Miller-Novak L, Venzon D, Robert-Guroff M.

J Immunol. 2016 Sep 15;197(6):2316-24. doi: 10.4049/jimmunol.1600544. Epub 2016 Aug 17.


Beyond Oncolytics: E1B55K-Deleted Adenovirus as a Vaccine Delivery Vector.

Thomas MA, Nyanhete T, Tuero I, Venzon D, Robert-Guroff M.

PLoS One. 2016 Jul 8;11(7):e0158505. doi: 10.1371/journal.pone.0158505. eCollection 2016.


Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition.

Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G.

Nat Med. 2016 Jul;22(7):762-70. doi: 10.1038/nm.4105. Epub 2016 May 30. Erratum in: Nat Med. 2016 Oct 6;22(10 ):1192.


New developments in an old strategy: heterologous vector primes and envelope protein boosts in HIV vaccine design.

Musich T, Robert-Guroff M.

Expert Rev Vaccines. 2016 Aug;15(8):1015-27. doi: 10.1586/14760584.2016.1158108. Epub 2016 Mar 16. Review.


The Yin and Yang of ADCC-Mediating Antibodies.

Robert-Guroff M.

EBioMedicine. 2016 Jan 8;3:10-11. doi: 10.1016/j.ebiom.2016.01.003. eCollection 2016 Jan. No abstract available.


Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.

Vargas-Inchaustegui DA, Demers A, Shaw JM, Kang G, Ball D, Tuero I, Musich T, Mohanram V, Demberg T, Karpova TS, Li Q, Robert-Guroff M.

J Immunol. 2016 Feb 15;196(4):1700-10. doi: 10.4049/jimmunol.1502137. Epub 2016 Jan 15.


Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge.

Tuero I, Mohanram V, Musich T, Miller L, Vargas-Inchaustegui DA, Demberg T, Venzon D, Kalisz I, Kalyanaraman VS, Pal R, Ferrari MG, LaBranche C, Montefiori DC, Rao M, Vaccari M, Franchini G, Barnett SW, Robert-Guroff M.

PLoS Pathog. 2015 Aug 12;11(8):e1005101. doi: 10.1371/journal.ppat.1005101. eCollection 2015 Aug.


B-Cells and the Use of Non-Human Primates for Evaluation of HIV Vaccine Candidates.

Demberg T, Robert-Guroff M.

Curr HIV Res. 2015;13(6):462-78. Review.


Loss of marginal zone B-cells in SHIVSF162P4 challenged rhesus macaques despite control of viremia to low or undetectable levels in chronic infection.

Demberg T, Mohanram V, Musich T, Brocca-Cofano E, McKinnon KM, Venzon D, Robert-Guroff M.

Virology. 2015 Oct;484:323-33. doi: 10.1016/j.virol.2015.06.022. Epub 2015 Jul 4.


Two-Year Follow-Up of Macaques Developing Intermittent Control of the Human Immunodeficiency Virus Homolog Simian Immunodeficiency Virus SIVmac251 in the Chronic Phase of Infection.

Shytaj IL, Nickel G, Arts E, Farrell N, Biffoni M, Pal R, Chung HK, LaBranche C, Montefiori D, Vargas-Inchaustegui D, Robert-Guroff M, Lewis MG, Sacha JB, Palamara AT, Savarino A.

J Virol. 2015 Aug;89(15):7521-35. doi: 10.1128/JVI.00396-15. Epub 2015 May 13.


Purification and functional characterization of mucosal IgA from vaccinated and SIV-infected rhesus macaques.

Musich T, Demberg T, Morgan IL, Estes JD, Franchini G, Robert-Guroff M.

Clin Immunol. 2015 Jun;158(2):127-39. doi: 10.1016/j.clim.2015.03.020. Epub 2015 Apr 1.


HIV-1 CD4-induced (CD4i) gp120 epitope vaccines promote B and T-cell responses that contribute to reduced viral loads in rhesus macaques.

Thomas MA, Tuero I, Demberg T, Vargas-Inchaustegui DA, Musich T, Xiao P, Venzon D, LaBranche C, Montefiori DC, DiPasquale J, Reed SG, DeVico A, Fouts T, Lewis GK, Gallo RC, Robert-Guroff M.

Virology. 2014 Dec;471-473:81-92. doi: 10.1016/j.virol.2014.10.001. Epub 2014 Oct 28.


Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia.

Gordon SN, Doster MN, Kines RC, Keele BF, Brocca-Cofano E, Guan Y, Pegu P, Liyanage NP, Vaccari M, Cuburu N, Buck CB, Ferrari G, Montefiori D, Piatak M Jr, Lifson JD, Xenophontos AM, Venzon D, Robert-Guroff M, Graham BS, Lowy DR, Schiller JT, Franchini G.

J Immunol. 2014 Dec 15;193(12):6172-83. doi: 10.4049/jimmunol.1401504. Epub 2014 Nov 14.


Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus.

Lakhashe SK, Byrareddy SN, Zhou M, Bachler BC, Hemashettar G, Hu SL, Villinger F, Else JG, Stock S, Lee SJ, Vargas-Inchaustegui DA, Cofano EB, Robert-Guroff M, Johnson WE, Polonis VR, Forthal DN, Loret EP, Rasmussen RA, Ruprecht RM.

Vaccine. 2014 Nov 12;32(48):6527-36. doi: 10.1016/j.vaccine.2014.08.065. Epub 2014 Sep 20.


Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques.

Valentin A, McKinnon K, Li J, Rosati M, Kulkarni V, Pilkington GR, Bear J, Alicea C, Vargas-Inchaustegui DA, Jean Patterson L, Pegu P, Liyanage NP, Gordon SN, Vaccari M, Wang Y, Hogg AE, Frey B, Sui Y, Reed SG, Sardesai NY, Berzofsky JA, Franchini G, Robert-Guroff M, Felber BK, Pavlakis GN.

Clin Immunol. 2014 Nov;155(1):91-107. doi: 10.1016/j.clim.2014.09.005. Epub 2014 Sep 16.


Infection with host-range mutant adenovirus 5 suppresses innate immunity and induces systemic CD4+ T cell activation in rhesus macaques.

Qureshi H, Genescà M, Fritts L, McChesney MB, Robert-Guroff M, Miller CJ.

PLoS One. 2014 Sep 9;9(9):e106004. doi: 10.1371/journal.pone.0106004. eCollection 2014.


Challenges in mucosal HIV vaccine development: lessons from non-human primate models.

Tuero I, Robert-Guroff M.

Viruses. 2014 Aug 15;6(8):3129-58. doi: 10.3390/v6083129. Review.


Improved flow-based method for HIV/SIV envelope-specific memory B-cell evaluation in rhesus macaques.

Mohanram V, Demberg T, Tuero I, Vargas-Inchaustegui D, Pavlakis GN, Felber BK, Robert-Guroff M.

J Immunol Methods. 2014 Oct;412:78-84. doi: 10.1016/j.jim.2014.06.012. Epub 2014 Jun 19.


Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.

Vargas-Inchaustegui DA, Tuero I, Mohanram V, Musich T, Pegu P, Valentin A, Sui Y, Rosati M, Bear J, Venzon DJ, Kulkarni V, Alicea C, Pilkington GR, Liyanage NP, Demberg T, Gordon SN, Wang Y, Hogg AE, Frey B, Patterson LJ, DiPasquale J, Montefiori DC, Sardesai NY, Reed SG, Berzofsky JA, Franchini G, Felber BK, Pavlakis GN, Robert-Guroff M.

Clin Immunol. 2014 Aug;153(2):308-22. doi: 10.1016/j.clim.2014.05.008. Epub 2014 Jun 4.


Phenotypes and distribution of mucosal memory B-cell populations in the SIV/SHIV rhesus macaque model.

Demberg T, Mohanram V, Venzon D, Robert-Guroff M.

Clin Immunol. 2014 Aug;153(2):264-76. doi: 10.1016/j.clim.2014.04.017. Epub 2014 May 9.


Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose.

Sholukh AM, Byrareddy SN, Shanmuganathan V, Hemashettar G, Lakhashe SK, Rasmussen RA, Watkins JD, Vyas HK, Thorat S, Brandstoetter T, Mukhtar MM, Yoon JK, Novembre FJ, Villinger F, Landucci G, Forthal DN, Ratcliffe S, Tuero I, Robert-Guroff M, Polonis VR, Bilska M, Montefiori DC, Johnson WE, Ertl HC, Ruprecht RM.

Retrovirology. 2014 Jan 20;11:8. doi: 10.1186/1742-4690-11-8.


Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir.

Moniuszko M, Liyanage NP, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, Dabrowska M, Robert-Guroff M, Silvestri G, Stevenson M, McCune J, Franchini G.

AIDS Res Hum Retroviruses. 2015 Jan;31(1):115-26. doi: 10.1089/AID.2013.0220.


Rhesus macaque rectal and duodenal tissues exhibit B-cell sub-populations distinct from peripheral blood that continuously secrete antigen-specific IgA in short-term explant cultures.

Thomas MA, Demberg T, Vargas-Inchaustegui DA, Xiao P, Tuero I, Venzon D, Weiss D, Treece J, Robert-Guroff M.

Vaccine. 2014 Feb 7;32(7):872-80. doi: 10.1016/j.vaccine.2013.12.014. Epub 2013 Dec 25.


Immune targeting of PD-1(hi) expressing cells during and after antiretroviral therapy in SIV-infected rhesus macaques.

Vargas-Inchaustegui DA, Xiao P, Hogg AE, Demberg T, McKinnon K, Venzon D, Brocca-Cofano E, Dipasquale J, Lee EM, Hudacik L, Pal R, Sui Y, Berzofsky JA, Liu L, Langermann S, Robert-Guroff M.

Virology. 2013 Dec;447(1-2):274-84. doi: 10.1016/j.virol.2013.09.015. Epub 2013 Oct 9.


Fc receptor-mediated immune responses: new tools but increased complexity in HIV prevention.

Vargas-Inchaustegui DA, Robert-Guroff M.

Curr HIV Res. 2013 Jul;11(5):407-20.


Effects of the deletion of early region 4 (E4) open reading frame 1 (orf1), orf1-2, orf1-3 and orf1-4 on virus-host cell interaction, transgene expression, and immunogenicity of replicating adenovirus HIV vaccine vectors.

Thomas MA, Song R, Demberg T, Vargas-Inchaustegui DA, Venzon D, Robert-Guroff M.

PLoS One. 2013 Oct 15;8(10):e76344. doi: 10.1371/journal.pone.0076344. eCollection 2013.


High-throughput profiling of anti-glycan humoral responses to SIV vaccination and challenge.

Campbell CT, Llewellyn SR, Demberg T, Morgan IL, Robert-Guroff M, Gildersleeve JC.

PLoS One. 2013 Sep 23;8(9):e75302. doi: 10.1371/journal.pone.0075302. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/fd9f4a65-3f27-46cd-8ed0-6c9b8ba7f83b. Damberg, Thorsten [corrected to Demberg, Thorsten].


Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques.

Demberg T, Brocca-Cofano E, Kuate S, Aladi S, Vargas-Inchaustegui DA, Venzon D, Kalisz I, Kalyanaraman VS, Lee EM, Pal R, DiPasquale J, Ruprecht RM, Montefiori DC, Srivastava I, Barnett SW, Robert-Guroff M.

Virology. 2013 Jun 5;440(2):210-21. doi: 10.1016/j.virol.2013.02.024. Epub 2013 Mar 22.

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