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Intravenous iron delivers a sustained (8-week) lowering of pulmonary artery pressure during exercise in healthy older humans.

Cheng HY, Frise MC, Curtis MK, Bart NK, Petousi N, Talbot NP, Balanos GM, Robbins PA, Dorrington KL.

Physiol Rep. 2019 Aug;7(13):e14164. doi: 10.14814/phy2.14164.


Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.

Lakhal-Littleton S, Crosby A, Frise MC, Mohammad G, Carr CA, Loick PAM, Robbins PA.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13122-13130. doi: 10.1073/pnas.1822010116. Epub 2019 May 31.


Measuring lung function in airways diseases: current and emerging techniques.

Petousi N, Talbot NP, Pavord I, Robbins PA.

Thorax. 2019 Aug;74(8):797-805. doi: 10.1136/thoraxjnl-2018-212441. Epub 2019 Apr 29.


Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.

Chung YJ, Luo A, Park KC, Loonat AA, Lakhal-Littleton S, Robbins PA, Swietach P.

JCI Insight. 2019 Apr 4;4(7). pii: 125618. doi: 10.1172/jci.insight.125618. eCollection 2019 Apr 4.



Bart NK, Hungerford SL, Curtis MK, Cheng HY, Southern JL, Petousi N, Dorrington KL, Robbins PA.

J Appl Physiol (1985). 2018 Sep 6. doi: 10.1152/japplphysiol.00339.2018. [Epub ahead of print]


Potential for noninvasive assessment of lung inhomogeneity using highly precise, highly time-resolved measurements of gas exchange.

Mountain JE, Santer P, O'Neill DP, Smith NMJ, Ciaffoni L, Couper JH, Ritchie GAD, Hancock G, Whiteley JP, Robbins PA.

J Appl Physiol (1985). 2018 Mar 1;124(3):615-631. doi: 10.1152/japplphysiol.00745.2017. Epub 2017 Oct 26.


Hypercapnic Pulmonary Vasoconstriction Contributes to Regional Perfusion Distribution: Relevance to Asthma.

Dorrington KL, Talbot NP, Robbins PA.

Am J Respir Crit Care Med. 2018 Mar 1;197(5):682-683. doi: 10.1164/rccm.201707-1510LE. No abstract available.


Human hypoxic pulmonary vasoconstriction is unaltered by 8 h of preceding isocapnic hyperoxia.

Cheng HY, Croft QPP, Frise MC, Talbot NP, Petousi N, Robbins PA, Dorrington KL.

Physiol Rep. 2017 Sep;5(17). pii: e13396. doi: 10.14814/phy2.13396.


Changes in pulmonary vascular responsiveness to hypoxia.

Talbot NP, Robbins PA, Dorrington KL.

Exp Physiol. 2017 Nov 1;102(11):1561. doi: 10.1113/EP086536. No abstract available.


The interplay between iron and oxygen homeostasis with a particular focus on the heart.

Lakhal-Littleton S, Robbins PA.

J Appl Physiol (1985). 2017 Oct 1;123(4):967-973. doi: 10.1152/japplphysiol.00237.2017. Epub 2017 Aug 3. Review.


Evolutionary history of Tibetans inferred from whole-genome sequencing.

Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD.

PLoS Genet. 2017 Apr 27;13(4):e1006675. doi: 10.1371/journal.pgen.1006675. eCollection 2017 Apr.


Cardiopulmonary phenotype associated with human PHD2 mutation.

Talbot NP, Smith TG, Balanos GM, Dorrington KL, Maxwell PH, Robbins PA.

Physiol Rep. 2017 Apr;5(7). pii: e13224. doi: 10.14814/phy2.13224.


An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.

Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA.

Elife. 2016 Nov 29;5. pii: e19804. doi: 10.7554/eLife.19804.


A mechanistic physicochemical model of carbon dioxide transport in blood.

O'Neill DP, Robbins PA.

J Appl Physiol (1985). 2017 Feb 1;122(2):283-295. doi: 10.1152/japplphysiol.00318.2016. Epub 2016 Nov 23.


Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations.

Camps C, Petousi N, Bento C, Cario H, Copley RR, McMullin MF, van Wijk R, Ratcliffe PJ, Robbins PA, Taylor JC; WGS500 Consortium.

Haematologica. 2016 Nov;101(11):1306-1318. Epub 2016 Sep 20.


Malignancy Rate, Number Needed to Treat, and Positive Predictive Value for Breast MRI.

Kennedy JS, Robbins PA.

Am Surg. 2016 Sep;82(9):815-9.


In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care.

Ciaffoni L, O'Neill DP, Couper JH, Ritchie GA, Hancock G, Robbins PA.

Sci Adv. 2016 Aug 10;2(8):e1600560. doi: 10.1126/sciadv.1600560. eCollection 2016 Aug.


Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.

Armitage AE, Lim PJ, Frost JN, Pasricha SR, Soilleux EJ, Evans E, Morovat A, Santos A, Diaz R, Biggs D, Davies B, Gileadi U, Robbins PA, Lakhal-Littleton S, Drakesmith H.

J Innate Immun. 2016;8(5):517-28. doi: 10.1159/000447713. Epub 2016 Jul 16.


The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.

Slingo M, Cole M, Carr C, Curtis MK, Dodd M, Giles L, Heather LC, Tyler D, Clarke K, Robbins PA.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H759-67. doi: 10.1152/ajpheart.00912.2015. Epub 2016 Jul 15.


Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia.

Bart NK, Curtis MK, Cheng HY, Hungerford SL, McLaren R, Petousi N, Dorrington KL, Robbins PA.

J Appl Physiol (1985). 2016 Aug 1;121(2):537-44. doi: 10.1152/japplphysiol.00032.2016. Epub 2016 Jul 14.


Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.

Nicod J, Davies RW, Cai N, Hassett C, Goodstadt L, Cosgrove C, Yee BK, Lionikaite V, McIntyre RE, Remme CA, Lodder EM, Gregory JS, Hough T, Joynson R, Phelps H, Nell B, Rowe C, Wood J, Walling A, Bopp N, Bhomra A, Hernandez-Pliego P, Callebert J, Aspden RM, Talbot NP, Robbins PA, Harrison M, Fray M, Launay JM, Pinto YM, Blizard DA, Bezzina CR, Adams DJ, Franken P, Weaver T, Wells S, Brown SD, Potter PK, Klenerman P, Lionikas A, Mott R, Flint J.

Nat Genet. 2016 Aug;48(8):912-8. doi: 10.1038/ng.3595. Epub 2016 Jul 4.


Clinical iron deficiency disturbs normal human responses to hypoxia.

Frise MC, Cheng HY, Nickol AH, Curtis MK, Pollard KA, Roberts DJ, Ratcliffe PJ, Dorrington KL, Robbins PA.

J Clin Invest. 2016 Jun 1;126(6):2139-50. doi: 10.1172/JCI85715. Epub 2016 May 3.


On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, Schofield CJ, Ratcliffe PJ, Neubauer S, Robbins PA, Clarke K.

FASEB J. 2016 Aug;30(8):2684-97. doi: 10.1096/fj.201500094R. Epub 2016 Apr 21.


Suppression of plasma hepcidin by venesection during steady-state hypoxia.

Talbot NP, Smith TG, Lakhal-Littleton S, Gülsever C, Rivera-Ch M, Dorrington KL, Mole DR, Robbins PA.

Blood. 2016 Mar 3;127(9):1206-7. doi: 10.1182/blood-2015-05-647404. Epub 2016 Jan 15. No abstract available.


The pulmonary vasculature--lessons from Tibetans and from rare diseases of oxygen sensing.

Frise MC, Robbins PA.

Exp Physiol. 2015 Nov;100(11):1233-41. doi: 10.1113/expphysiol.2014.080507. Epub 2014 Oct 18. Review.


Non-contact measurement of oxygen saturation with an RGB camera.

Guazzi AR, Villarroel M, Jorge J, Daly J, Frise MC, Robbins PA, Tarassenko L.

Biomed Opt Express. 2015 Aug 11;6(9):3320-38. doi: 10.1364/BOE.6.003320. eCollection 2015 Sep 1.


Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.

Hodson EJ, Nicholls LG, Turner PJ, Llyr R, Fielding JW, Douglas G, Ratnayaka I, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T.

J Physiol. 2016 Mar 1;594(5):1179-95. doi: 10.1113/JP271050. Epub 2015 Oct 6.


A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA.

BMJ Open. 2015 Jul 6;5(7):e007911. doi: 10.1136/bmjopen-2015-007911.


Iron, oxygen, and the pulmonary circulation.

Frise MC, Robbins PA.

J Appl Physiol (1985). 2015 Dec 15;119(12):1421-31. doi: 10.1152/japplphysiol.00179.2015. Epub 2015 Jun 11. Review.


Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G.

Nat Genet. 2015 Jul;47(7):717-726. doi: 10.1038/ng.3304. Epub 2015 May 18.


Determinants of ventilation and pulmonary artery pressure during early acclimatization to hypoxia in humans.

Fatemian M, Herigstad M, Croft QP, Formenti F, Cardenas R, Wheeler C, Smith TG, Friedmannova M, Dorrington KL, Robbins PA.

J Physiol. 2016 Mar 1;594(5):1197-213. doi: 10.1113/JP270061. Epub 2015 Jun 5.


Does amifostine reduce metabolic rate? Effect of the drug on gas exchange and acute ventilatory hypoxic response in humans.

Pandit JJ, Allen C, Little E, Formenti F, Harris AL, Robbins PA.

Pharmaceuticals (Basel). 2015 Apr 16;8(2):186-95. doi: 10.3390/ph8020186.


Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.

Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1812.


Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans.

Talbot NP, Croft QP, Curtis MK, Turner BE, Dorrington KL, Robbins PA, Smith TG.

Physiol Rep. 2014 Dec 11;2(12). pii: e12220. doi: 10.14814/phy2.12220. Print 2014 Dec 1.


Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness.

Cole AM, Petousi N, Cavalleri GL, Robbins PA.

High Alt Med Biol. 2014 Dec;15(4):497-9. doi: 10.1089/ham.2014.1036.


RF noise induced laser perturbation for improving the performance of non-resonant cavity enhanced absorption spectroscopy.

Ciaffoni L, Couper J, Hancock G, Peverall R, Robbins PA, Ritchie GA.

Opt Express. 2014 Jul 14;22(14):17030-8. doi: 10.1364/OE.22.017030.


Erythrocytosis associated with a novel missense mutation in the BPGM gene.

Petousi N, Copley RR, Lappin TR, Haggan SE, Bento CM, Cario H, Percy MJ; WGS Consortium, Ratcliffe PJ, Robbins PA, McMullin MF.

Haematologica. 2014 Oct;99(10):e201-4. doi: 10.3324/haematol.2014.109306. Epub 2014 Jul 11. No abstract available.


Genome-scale methods converge on key mitochondrial genes for the survival of human cardiomyocytes in hypoxia.

Edwards LM, Sigurdsson MI, Robbins PA, Weale ME, Cavalleri GL, Montgomery HE, Thiele I.

Circ Cardiovasc Genet. 2014 Aug;7(4):407-15. doi: 10.1161/CIRCGENETICS.113.000269. Epub 2014 May 29.


The peripheral actions of the central neuropeptide somatostatin on control of breathing: effect on metabolic rate and chemoreflex responses in humans.

Pandit JJ, Wordsworth H, Little E, Formenti F, Robbins PA.

Prog Brain Res. 2014;209:331-40. doi: 10.1016/B978-0-444-63274-6.00017-5.


Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.

Petousi N, Robbins PA.

J Appl Physiol (1985). 2014 Apr 1;116(7):875-84. doi: 10.1152/japplphysiol.00605.2013. Epub 2013 Nov 7. Review.


Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6.


The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia.

Slingo ME, Turner PJ, Christian HC, Buckler KJ, Robbins PA.

J Appl Physiol (1985). 2014 Apr 1;116(7):885-92. doi: 10.1152/japplphysiol.00530.2013. Epub 2013 Sep 12.


Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia.

Petousi N, Croft QP, Cavalleri GL, Cheng HY, Formenti F, Ishida K, Lunn D, McCormack M, Shianna KV, Talbot NP, Ratcliffe PJ, Robbins PA.

J Appl Physiol (1985). 2014 Apr 1;116(7):893-904. doi: 10.1152/japplphysiol.00535.2013. Epub 2013 Sep 12.


Variations in alveolar partial pressure for carbon dioxide and oxygen have additive not synergistic acute effects on human pulmonary vasoconstriction.

Croft QP, Formenti F, Talbot NP, Lunn D, Robbins PA, Dorrington KL.

PLoS One. 2013 Jul 31;8(7):e67886. doi: 10.1371/journal.pone.0067886. Print 2013.


Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ.

J Physiol. 2013 Jul 15;591(14):3565-77. doi: 10.1113/jphysiol.2012.247254. Epub 2013 May 20.


Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.

Huerta-Sánchez E, Degiorgio M, Pagani L, Tarekegn A, Ekong R, Antao T, Cardona A, Montgomery HE, Cavalleri GL, Robbins PA, Weale ME, Bradman N, Bekele E, Kivisild T, Tyler-Smith C, Nielsen R.

Mol Biol Evol. 2013 Aug;30(8):1877-88. doi: 10.1093/molbev/mst089. Epub 2013 May 10.


Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension.

Howard LS, Watson GM, Wharton J, Rhodes CJ, Chan K, Khengar R, Robbins PA, Kiely DG, Condliffe R, Elliott CA, Pepke-Zaba J, Sheares K, Morrell NW, Davies R, Ashby D, Gibbs JS, Wilkins MR.

Pulm Circ. 2013 Jan;3(1):100-7. doi: 10.4103/2045-8932.109923.


Dexamethasone mimics aspects of physiological acclimatization to 8 hours of hypoxia but suppresses plasma erythropoietin.

Liu C, Croft QP, Kalidhar S, Brooks JT, Herigstad M, Smith TG, Dorrington KL, Robbins PA.

J Appl Physiol (1985). 2013 Apr;114(7):948-56. doi: 10.1152/japplphysiol.01414.2012. Epub 2013 Feb 7.


Commercial air travel and in-flight pulmonary hypertension.

Smith TG, Chang RW, Robbins PA, Dorrington KL.

Aviat Space Environ Med. 2013 Jan;84(1):65-7.


Pulmonary artery pressure increases during commercial air travel in healthy passengers.

Smith TG, Talbot NP, Chang RW, Wilkinson E, Nickol AH, Newman DG, Robbins PA, Dorrington KL.

Aviat Space Environ Med. 2012 Jul;83(7):673-6.


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