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Items: 1 to 50 of 123

1.

Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.

Penas C, Maloof ME, Stathias V, Long J, Tan SK, Mier J, Fang Y, Valdes C, Rodriguez-Blanco J, Chiang CM, Robbins DJ, Liebl DJ, Lee JK, Hatten ME, Clarke J, Ayad NG.

Nat Commun. 2019 Jul 10;10(1):3028. doi: 10.1038/s41467-019-10799-5.

PMID:
31292434
2.

Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells.

Cabel CR, Alizadeh E, Robbins DJ, Ahmed Y, Lee E, Thorne CA.

Dev Cell. 2019 Jun 17;49(6):827-828. doi: 10.1016/j.devcel.2019.05.039. No abstract available.

PMID:
31211991
3.

Regulation of GLI1 by cis DNA elements and epigenetic marks.

Taylor R, Long J, Yoon JW, Childs R, Sylvestersen KB, Nielsen ML, Leong KF, Iannaccone S, Walterhouse DO, Robbins DJ, Iannaccone P.

DNA Repair (Amst). 2019 Jul;79:10-21. doi: 10.1016/j.dnarep.2019.04.011. Epub 2019 May 2.

4.

Long-term Results of Spine Stapling for AIS to Skeletal Maturity and Beyond.

Haber LL, Adams TM, Briski DC, Celestre PC, Robbins DJ, Waldron SR.

J Pediatr Orthop. 2019 Apr 9. doi: 10.1097/BPO.0000000000001389. [Epub ahead of print]

PMID:
30973475
5.

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.

Winterbottom EF, Moroishi Y, Halchenko Y, Armstrong DA, Beach PJ, Nguyen QP, Capobianco AJ, Ayad NG, Marsit CJ, Li Z, Karagas MR, Robbins DJ.

Environ Health. 2019 Feb 28;18(1):18. doi: 10.1186/s12940-019-0455-9.

6.

A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.

Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ.

Clin Cancer Res. 2019 Feb 15;25(4):1379-1388. doi: 10.1158/1078-0432.CCR-18-1319. Epub 2018 Nov 28.

PMID:
30487124
7.

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.

Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E.

Dev Cell. 2018 Mar 12;44(5):566-581.e8. doi: 10.1016/j.devcel.2018.02.013.

8.

Casein kinase1α activators, a precision weapon for CRC.

Li B, Lee E, Robbins DJ.

Oncotarget. 2017 Oct 19;8(57):96462-96463. doi: 10.18632/oncotarget.21892. eCollection 2017 Nov 14. No abstract available.

9.

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.

Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ.

Oncogene. 2017 Nov 9;36(45):6306-6314. doi: 10.1038/onc.2017.232. Epub 2017 Jul 17.

10.

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ.

Sci Signal. 2017 Jun 27;10(485). pii: eaak9916. doi: 10.1126/scisignal.aak9916.

11.

Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.

Jin K, Zhou W, Han X, Wang Z, Li B, Jeffries S, Tao W, Robbins DJ, Capobianco AJ.

Cancer Res. 2017 Aug 15;77(16):4228-4237. doi: 10.1158/0008-5472.CAN-16-3156. Epub 2017 Jun 16.

12.

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression.

Winterbottom EF, Koestler DC, Fei DL, Wika E, Capobianco AJ, Marsit CJ, Karagas MR, Robbins DJ.

Environ Health. 2017 Jun 14;16(1):59. doi: 10.1186/s12940-017-0267-8.

13.

Notch Represses Transcription by PRC2 Recruitment to the Ternary Complex.

Han X, Ranganathan P, Tzimas C, Weaver KL, Jin K, Astudillo L, Zhou W, Zhu X, Li B, Robbins DJ, Capobianco AJ.

Mol Cancer Res. 2017 Sep;15(9):1173-1183. doi: 10.1158/1541-7786.MCR-17-0241. Epub 2017 Jun 5.

14.

p16 loss rescues functional decline of Brca1-deficient mammary stem cells.

Scott A, Bai F, Chan HL, Liu S, Slingerland JM, Robbins DJ, Capobianco AJ, Pei XH.

Cell Cycle. 2017 Apr 18;16(8):759-764. doi: 10.1080/15384101.2017.1295185. Epub 2017 Feb 22.

15.

Top 10 Facts You Need to Know about Carotid Artery Disease.

Robbins DJ, Mitchell ME.

J Miss State Med Assoc. 2017 Jan;58(1):8-9. No abstract available.

PMID:
30398722
16.

p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.

Scott A, Bai F, Chan HL, Liu S, Ma J, Slingerland JM, Robbins DJ, Capobianco AJ, Pei XH.

Oncotarget. 2016 Dec 20;7(51):84496-84507. doi: 10.18632/oncotarget.13015.

17.

Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.

Liu S, Chan HL, Bai F, Ma J, Scott A, Robbins DJ, Capobianco AJ, Zhu P, Pei XH.

Oncotarget. 2016 Sep 27;7(39):64007-64020. doi: 10.18632/oncotarget.11746.

18.

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.

Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E.

Cell Rep. 2016 May 31;15(9):1920-9. doi: 10.1016/j.celrep.2016.04.070. Epub 2016 May 19.

19.

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.

Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD Jr, Capobianco AJ.

Cancer Res. 2016 Jun 15;76(12):3593-603. doi: 10.1158/0008-5472.CAN-16-0061. Epub 2016 Apr 13.

20.

Epigenome-Wide Assessment of DNA Methylation in the Placenta and Arsenic Exposure in the New Hampshire Birth Cohort Study (USA).

Green BB, Karagas MR, Punshon T, Jackson BP, Robbins DJ, Houseman EA, Marsit CJ.

Environ Health Perspect. 2016 Aug;124(8):1253-60. doi: 10.1289/ehp.1510437. Epub 2016 Jan 15.

21.

Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner.

Li B, Giambelli C, Tang B, Winterbottom E, Long J, Jin K, Wang Z, Fei DL, Nguyen DM, Athar M, Wang B, Subbarayan PR, Wang L, Rai P, Ardalan B, Capobianco AJ, Robbins DJ.

Mol Pharmacol. 2016 Feb;89(2):226-32. doi: 10.1124/mol.115.100867. Epub 2015 Nov 16.

22.

Sonic Hedgehog: a lipid speciated hormone?

Long J, Winterbottom E, Robbins DJ.

Oncotarget. 2015 Aug 14;6(23):19340-1. No abstract available.

23.

GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth.

Winterbottom EF, Fei DL, Koestler DC, Giambelli C, Wika E, Capobianco AJ, Lee E, Marsit CJ, Karagas MR, Robbins DJ.

EBioMedicine. 2015 May 1;2(6):536-43. doi: 10.1016/j.ebiom.2015.04.019. eCollection 2015 Jun.

24.

Quantitative Immunoblotting of Endogenous Hedgehog Pathway Components.

Farzan SF, Robbins DJ.

Methods Mol Biol. 2015;1322:93-104. doi: 10.1007/978-1-4939-2772-2_9.

PMID:
26179042
25.

Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.

Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, Finkelstein D, Han JL, Long J, Li B, Robbins DJ, Malumbres M, Roussel MF, Roush WR, Hatten ME, Ayad NG.

Cell Rep. 2015 Apr 14;11(2):249-60. doi: 10.1016/j.celrep.2015.03.016. Epub 2015 Apr 2.

26.

Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties.

Long J, Tokhunts R, Old WM, Houel S, Rodgriguez-Blanco J, Singh S, Schilling N, J Capobianco A, Ahn NG, Robbins DJ.

Cell Rep. 2015 Mar 3;10(8):1280-1287. doi: 10.1016/j.celrep.2015.01.058. Epub 2015 Feb 26.

27.

The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage.

Lindley LE, Curtis KM, Sanchez-Mejias A, Rieger ME, Robbins DJ, Briegel KJ.

Development. 2015 Mar 1;142(5):893-904. doi: 10.1242/dev.110403. Epub 2015 Feb 5.

28.

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ.

J Biol Chem. 2014 Dec 19;289(51):35494-502. doi: 10.1074/jbc.M114.595348. Epub 2014 Oct 29.

29.

Epigenetic pathways and glioblastoma treatment: insights from signaling cascades.

Allen BK, Stathias V, Maloof ME, Vidovic D, Winterbottom EF, Capobianco AJ, Clarke J, Schurer S, Robbins DJ, Ayad NG.

J Cell Biochem. 2015 Mar;116(3):351-63. doi: 10.1002/jcb.24990. Review.

PMID:
25290986
30.

BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development.

Bai F, Chan HL, Scott A, Smith MD, Fan C, Herschkowitz JI, Perou CM, Livingstone AS, Robbins DJ, Capobianco AJ, Pei XH.

Cancer Res. 2014 Nov 1;74(21):6161-72. doi: 10.1158/0008-5472.CAN-14-1119. Epub 2014 Sep 19.

31.

Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma.

Wang Z, Da Silva TG, Jin K, Han X, Ranganathan P, Zhu X, Sanchez-Mejias A, Bai F, Li B, Fei DL, Weaver K, Carpio RV, Moscowitz AE, Koshenkov VP, Sanchez L, Sparling L, Pei XH, Franceschi D, Ribeiro A, Robbins DJ, Livingstone AS, Capobianco AJ.

Cancer Res. 2014 Nov 1;74(21):6364-74. doi: 10.1158/0008-5472.CAN-14-2051. Epub 2014 Aug 27.

32.

NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

Weaver KL, Alves-Guerra MC, Jin K, Wang Z, Han X, Ranganathan P, Zhu X, DaSilva T, Liu W, Ratti F, Demarest RM, Tzimas C, Rice M, Vasquez-Del Carpio R, Dahmane N, Robbins DJ, Capobianco AJ.

Cancer Res. 2014 Sep 1;74(17):4741-51. doi: 10.1158/0008-5472.CAN-14-1547. Epub 2014 Jul 18.

33.

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways.

Patel A, Burton DG, Halvorsen K, Balkan W, Reiner T, Perez-Stable C, Cohen A, Munoz A, Giribaldi MG, Singh S, Robbins DJ, Nguyen DM, Rai P.

Oncogene. 2015 May 14;34(20):2586-96. doi: 10.1038/onc.2014.195. Epub 2014 Jul 14.

34.

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

Li B, Flaveny CA, Giambelli C, Fei DL, Han L, Hang BI, Bai F, Pei XH, Nose V, Burlingame O, Capobianco AJ, Orton D, Lee E, Robbins DJ.

PLoS One. 2014 Jul 8;9(7):e101969. doi: 10.1371/journal.pone.0101969. eCollection 2014.

35.

Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ.

Cancer Res. 2014 Sep 1;74(17):4811-21. doi: 10.1158/0008-5472.CAN-14-0317. Epub 2014 Jul 3.

36.

All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.

Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E.

Cancer Biol Ther. 2014 Apr;15(4):463-72. doi: 10.4161/cbt.27821. Epub 2014 Feb 4.

37.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

38.

Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption.

Srivastava RK, Li C, Chaudhary SC, Ballestas ME, Elmets CA, Robbins DJ, Matalon S, Deshane JS, Afaq F, Bickers DR, Athar M.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):879-87. doi: 10.1016/j.taap.2013.08.004. Epub 2013 Aug 14.

39.

Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study.

Fei DL, Koestler DC, Li Z, Giambelli C, Sanchez-Mejias A, Gosse JA, Marsit CJ, Karagas MR, Robbins DJ.

Environ Health. 2013 Jul 16;12:58. doi: 10.1186/1476-069X-12-58.

40.

The Hedgehog signal transduction network.

Robbins DJ, Fei DL, Riobo NA.

Sci Signal. 2012 Oct 16;5(246):re6. doi: 10.1126/scisignal.2002906. Review.

41.

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E.

Int J Oncol. 2012 Nov;41(5):1751-61. doi: 10.3892/ijo.2012.1599. Epub 2012 Aug 22.

42.

Hedgehog signaling regulates bladder cancer growth and tumorigenicity.

Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, Rodriguez-Blanco J, Tokhunts R, Giambelli C, Briegel KJ, Schulz WA, Gandolfi AJ, Karagas M, Zimmers TA, Jorda M, Bejarano P, Capobianco AJ, Robbins DJ.

Cancer Res. 2012 Sep 1;72(17):4449-58. Epub 2012 Jul 19.

43.

The hedgehog processing pathway is required for NSCLC growth and survival.

Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D, Singh S, Black KE, Wang Z, Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, Lam WL, Dmitrovsky E, Capobianco AJ, Robbins DJ.

Oncogene. 2013 May 2;32(18):2335-45. doi: 10.1038/onc.2012.243. Epub 2012 Jun 25.

44.

The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival: an analysis of the Survival, Epidemiology, and End Results database.

Saeed AM, Toonkel R, Glassberg MK, Nguyen D, Hu JJ, Zimmers TA, Robbins DJ, Koniaris LG, Lally BE.

Cancer. 2012 Sep 15;118(18):4495-501. doi: 10.1002/cncr.26686. Epub 2012 Apr 23.

45.

Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs.

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E.

Bioorg Med Chem. 2012 Mar 15;20(6):1869-77. doi: 10.1016/j.bmc.2011.12.044. Epub 2011 Dec 30. Review.

46.

Short-term and long-term weight management results of a large employer-sponsored wellness program.

Scoggins JF, Sakumoto KN, Schaefer KS, Bascom B, Robbins DJ, Whalen CL.

J Occup Environ Med. 2011 Nov;53(11):1215-20. doi: 10.1097/JOM.0b013e3182338676.

PMID:
22068128
47.

A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts.

Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E.

J Biomol Screen. 2011 Oct;16(9):995-1006. doi: 10.1177/1087057111416657. Epub 2011 Aug 21.

48.

Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.

Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ.

Cancer Res. 2011 Jul 1;71(13):4454-63. doi: 10.1158/0008-5472.CAN-10-2313. Epub 2011 May 12.

49.

Assembly of a Notch transcriptional activation complex requires multimerization.

Vasquez-Del Carpio R, Kaplan FM, Weaver KL, VanWye JD, Alves-Guerra MC, Robbins DJ, Capobianco AJ.

Mol Cell Biol. 2011 Apr;31(7):1396-408. doi: 10.1128/MCB.00360-10. Epub 2011 Jan 18.

50.

Repurposing an old anti-fungal drug as a Hedgehog inhibitor.

Giambelli C, Fei DL, Wang H, Robbins DJ.

Protein Cell. 2010 May;1(5):417-8. doi: 10.1007/s13238-010-0063-5. No abstract available.

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