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Items: 43

1.

A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.

Keeffe JR, Van Rompay KKA, Olsen PC, Wang Q, Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MR, Bjorkman PJ, Nussenzweig MC, Robbiani DF.

Cell Rep. 2018 Nov 6;25(6):1385-1394.e7. doi: 10.1016/j.celrep.2018.10.031.

2.

Correction: RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks.

Rommel PC, Oliveira TY, Nussenzweig MC, Robbiani DF.

J Exp Med. 2017 Jul 3;214(7):2167. doi: 10.1084/jem.2016163806092017c. Epub 2017 Jun 15. No abstract available.

3.

Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.

Robbiani DF, Bozzacco L, Keeffe JR, Khouri R, Olsen PC, Gazumyan A, Schaefer-Babajew D, Avila-Rios S, Nogueira L, Patel R, Azzopardi SA, Uhl LFK, Saeed M, Sevilla-Reyes EE, Agudelo M, Yao KH, Golijanin J, Gristick HB, Lee YE, Hurley A, Caskey M, Pai J, Oliveira T, Wunder EA Jr, Sacramento G, Nery N Jr, Orge C, Costa F, Reis MG, Thomas NM, Eisenreich T, Weinberger DM, de Almeida ARP, West AP Jr, Rice CM, Bjorkman PJ, Reyes-Teran G, Ko AI, MacDonald MR, Nussenzweig MC.

Cell. 2017 May 4;169(4):597-609.e11. doi: 10.1016/j.cell.2017.04.024.

4.

RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks.

Rommel PC, Oliveira TY, Nussenzweig MC, Robbiani DF.

J Exp Med. 2017 Mar 6;214(3):815-831. doi: 10.1084/jem.20161638. Epub 2017 Feb 8. Erratum in: J Exp Med. 2017 Jun 15;:.

5.

The cell cycle restricts activation-induced cytidine deaminase activity to early G1.

Wang Q, Kieffer-Kwon KR, Oliveira TY, Mayer CT, Yao K, Pai J, Cao Z, Dose M, Casellas R, Jankovic M, Nussenzweig MC, Robbiani DF.

J Exp Med. 2017 Jan;214(1):49-58. doi: 10.1084/jem.20161649. Epub 2016 Dec 20.

6.

Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.

Casellas R, Basu U, Yewdell WT, Chaudhuri J, Robbiani DF, Di Noia JM.

Nat Rev Immunol. 2016 Mar;16(3):164-76. doi: 10.1038/nri.2016.2. Epub 2016 Feb 22. Review.

7.

A New Way to Diversify Antibodies by DNA Transposition.

Robbiani DF, Nussenzweig MC.

Cell. 2016 Feb 11;164(4):601-2. doi: 10.1016/j.cell.2016.01.031.

8.

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW.

Nature. 2015 Sep 3;525(7567):134-139. doi: 10.1038/nature14970. Epub 2015 Aug 26.

9.

Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.

Robbiani DF, Deroubaix S, Feldhahn N, Oliveira TY, Callen E, Wang Q, Jankovic M, Silva IT, Rommel PC, Bosque D, Eisenreich T, Nussenzweig A, Nussenzweig MC.

Cell. 2015 Aug 13;162(4):727-37. doi: 10.1016/j.cell.2015.07.019.

10.

Epigenetic targeting of activation-induced cytidine deaminase.

Wang Q, Oliveira T, Jankovic M, Silva IT, Hakim O, Yao K, Gazumyan A, Mayer CT, Pavri R, Casellas R, Nussenzweig MC, Robbiani DF.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18667-72. doi: 10.1073/pnas.1420575111. Epub 2014 Dec 15.

11.

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, Liang G, Tang Z, Mathé E, Benner C, Dubois W, Nelson S, Vian L, Oliveira TY, Jankovic M, Hakim O, Gazumyan A, Pavri R, Awasthi P, Song B, Liu G, Chen L, Zhu S, Feigenbaum L, Staudt L, Murre C, Ruan Y, Robbiani DF, Pan-Hammarström Q, Nussenzweig MC, Casellas R.

Cell. 2014 Dec 18;159(7):1524-37. doi: 10.1016/j.cell.2014.11.013. Epub 2014 Dec 4.

12.

miR-217 is an oncogene that enhances the germinal center reaction.

de Yébenes VG, Bartolomé-Izquierdo N, Nogales-Cadenas R, Pérez-Durán P, Mur SM, Martínez N, Di Lisio L, Robbiani DF, Pascual-Montano A, Cañamero M, Piris MA, Ramiro AR.

Blood. 2014 Jul 10;124(2):229-39. doi: 10.1182/blood-2013-12-543611. Epub 2014 May 21.

13.

Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.

Rommel PC, Bosque D, Gitlin AD, Croft GF, Heintz N, Casellas R, Nussenzweig MC, Kriaucionis S, Robbiani DF.

PLoS One. 2013 Jul 8;8(7):e69208. doi: 10.1371/journal.pone.0069208. Print 2013.

14.

Identification of early replicating fragile sites that contribute to genome instability.

Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.

Cell. 2013 Jan 31;152(3):620-32. doi: 10.1016/j.cell.2013.01.006. Epub 2013 Jan 24. Review.

15.

Role of 53BP1 oligomerization in regulating double-strand break repair.

Lottersberger F, Bothmer A, Robbiani DF, Nussenzweig MC, de Lange T.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2146-51. doi: 10.1073/pnas.1222617110. Epub 2013 Jan 23.

16.

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.

Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC.

Science. 2013 Feb 8;339(6120):711-5. doi: 10.1126/science.1230624. Epub 2013 Jan 10.

17.

RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle.

Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R.

Cell Rep. 2013 Jan 31;3(1):138-47. doi: 10.1016/j.celrep.2012.12.006. Epub 2013 Jan 3.

18.

53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma.

Jankovic M, Feldhahn N, Oliveira TY, Silva IT, Kieffer-Kwon KR, Yamane A, Resch W, Klein I, Robbiani DF, Casellas R, Nussenzweig MC.

Mol Cell. 2013 Feb 21;49(4):623-31. doi: 10.1016/j.molcel.2012.11.029. Epub 2013 Jan 3.

19.

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.

Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM Jr, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF.

J Exp Med. 2013 Jan 14;210(1):115-23. doi: 10.1084/jem.20121975. Epub 2012 Dec 17.

20.

RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.

Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.

J Biol Chem. 2012 Nov 23;287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.

21.

Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase.

Robbiani DF, Nussenzweig MC.

Annu Rev Pathol. 2013 Jan 24;8:79-103. doi: 10.1146/annurev-pathol-020712-164004. Epub 2012 Sep 4. Review.

PMID:
22974238
22.

The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.

Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC.

EMBO J. 2012 Oct 17;31(20):4045-56. doi: 10.1038/emboj.2012.247. Epub 2012 Aug 31.

23.

DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.

Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, Nussenzweig A, Hager GL, Nussenzweig MC, Casellas R.

Nature. 2012 Feb 7;484(7392):69-74. doi: 10.1038/nature10909.

24.

Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.

Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, Nakahashi H, Di Virgilio M, Bothmer A, Nussenzweig A, Robbiani DF, Casellas R, Nussenzweig MC.

Cell. 2011 Sep 30;147(1):95-106. doi: 10.1016/j.cell.2011.07.048.

25.

Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC.

Mol Cell. 2011 May 6;42(3):319-29. doi: 10.1016/j.molcel.2011.03.019.

26.

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.

Yamane A, Resch W, Kuo N, Kuchen S, Li Z, Sun HW, Robbiani DF, McBride K, Nussenzweig MC, Casellas R.

Nat Immunol. 2011 Jan;12(1):62-9. doi: 10.1038/ni.1964. Epub 2010 Nov 28.

27.

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.

Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC.

J Exp Med. 2010 Apr 12;207(4):855-65. doi: 10.1084/jem.20100244. Epub 2010 Apr 5.

28.

Role of the translocation partner in protection against AID-dependent chromosomal translocations.

Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):187-92. doi: 10.1073/pnas.0908946107. Epub 2009 Dec 4.

29.

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.

Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC.

Mol Cell. 2009 Nov 25;36(4):631-41. doi: 10.1016/j.molcel.2009.11.007.

30.

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.

Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062.

31.

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.

Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC.

Immunity. 2008 May;28(5):630-8. doi: 10.1016/j.immuni.2008.04.002. Epub 2008 May 1.

32.

AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

Chesi M, Robbiani DF, Sebag M, Chng WJ, Affer M, Tiedemann R, Valdez R, Palmer SE, Haas SS, Stewart AK, Fonseca R, Kremer R, Cattoretti G, Bergsagel PL.

Cancer Cell. 2008 Feb;13(2):167-80. doi: 10.1016/j.ccr.2008.01.007.

33.

A role for AID in chromosome translocations between c-myc and the IgH variable region.

Dorsett Y, Robbiani DF, Jankovic M, Reina-San-Martin B, Eisenreich TR, Nussenzweig MC.

J Exp Med. 2007 Sep 3;204(9):2225-32. Epub 2007 Aug 27. Erratum in: J Exp Med. 2007 Oct;204(10):2491.

34.

Osteopontin dysregulation and lytic bone lesions in multiple myeloma.

Robbiani DF, Colon K, Ely S, Ely S, Chesi M, Bergsagel PL.

Hematol Oncol. 2007 Mar;25(1):16-20.

PMID:
17044113
35.

Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation.

McBride KM, Gazumyan A, Woo EM, Barreto VM, Robbiani DF, Chait BT, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8798-803. Epub 2006 May 24.

36.

Maintained rules of development in a mouse B-cell tumor.

Robbiani DF, Colon K, Affer M, Chesi M, Bergsagel PL.

Leukemia. 2005 Jul;19(7):1278-80. No abstract available.

PMID:
15843816
37.

Bone lesions in molecular subtypes of multiple myeloma.

Robbiani DF, Chesi M, Bergsagel PL.

N Engl J Med. 2004 Jul 8;351(2):197-8. No abstract available.

PMID:
15247367
38.

Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma.

Trudel S, Ely S, Farooqi Y, Affer M, Robbiani DF, Chesi M, Bergsagel PL.

Blood. 2004 May 1;103(9):3521-8. Epub 2004 Jan 8.

39.

Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells.

Beaulieu S, Robbiani DF, Du X, Rodrigues E, Ignatius R, Wei Y, Ponath P, Young JW, Pope M, Steinman RM, Mojsov S.

J Immunol. 2002 Sep 15;169(6):2925-36.

40.

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.

Chesi M, Brents LA, Ely SA, Bais C, Robbiani DF, Mesri EA, Kuehl WM, Bergsagel PL.

Blood. 2001 Feb 1;97(3):729-36.

41.

The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes.

Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ.

Cell. 2000 Nov 22;103(5):757-68.

42.

Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo.

Randolph GJ, Inaba K, Robbiani DF, Steinman RM, Muller WA.

Immunity. 1999 Dec;11(6):753-61.

43.

Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis.

Uguccioni M, Gionchetti P, Robbiani DF, Rizzello F, Peruzzo S, Campieri M, Baggiolini M.

Am J Pathol. 1999 Aug;155(2):331-6.

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