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Items: 41


Molecular Studies of the Protein Complexes Involving Cis-Prenyltransferase in Guayule (Parthenium argentatum), an Alternative Rubber-Producing Plant.

Lakusta AM, Kwon M, Kwon EG, Stonebloom S, Scheller HV, Ro DK.

Front Plant Sci. 2019 Feb 25;10:165. doi: 10.3389/fpls.2019.00165. eCollection 2019.


Increased sesqui- and triterpene production by co-expression of HMG-CoA reductase and biotin carboxyl carrier protein in tobacco (Nicotiana benthamiana).

Lee AR, Kwon M, Kang MK, Kim J, Kim SU, Ro DK.

Metab Eng. 2019 Mar;52:20-28. doi: 10.1016/j.ymben.2018.10.008. Epub 2018 Oct 31.


Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea - tuning the scopolamine production.

Fischer C, Kwon M, Ro DK, van Belkum MJ, Vederas JC.

Medchemcomm. 2018 May 2;9(5):888-892. doi: 10.1039/c8md00090e. eCollection 2018 May 1.


Molecular cloning and functional characterization of three terpene synthases from unripe fruit of black pepper (Piper nigrum).

Jin Z, Kwon M, Lee AR, Ro DK, Wungsintaweekul J, Kim SU.

Arch Biochem Biophys. 2018 Jan 15;638:35-40. doi: 10.1016/ Epub 2017 Dec 14.


Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis.

Gou J, Hao F, Huang C, Kwon M, Chen F, Li C, Liu C, Ro DK, Tang H, Zhang Y.

Plant J. 2018 Jan;93(1):92-106. doi: 10.1111/tpj.13760. Epub 2017 Nov 30.


Functional identification of a Lippia dulcis bornyl diphosphate synthase that contains a duplicated, inhibitory arginine-rich motif.

Hurd MC, Kwon M, Ro DK.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):963-968. doi: 10.1016/j.bbrc.2017.06.147. Epub 2017 Jun 24.


The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism.

Liu X, Liu Y, Huang P, Ma Y, Qing Z, Tang Q, Cao H, Cheng P, Zheng Y, Yuan Z, Zhou Y, Liu J, Tang Z, Zhuo Y, Zhang Y, Yu L, Huang J, Yang P, Peng Q, Zhang J, Jiang W, Zhang Z, Lin K, Ro DK, Chen X, Xiong X, Shang Y, Huang S, Zeng J.

Mol Plant. 2017 Jul 5;10(7):975-989. doi: 10.1016/j.molp.2017.05.007. Epub 2017 May 26.


Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3.

Zhong Y, Xue X, Liu Z, Ma Y, Zeng K, Han L, Qi J, Ro DK, Bak S, Huang S, Zhou Y, Shang Y.

Mol Plant. 2017 Jul 5;10(7):1000-1003. doi: 10.1016/j.molp.2017.02.005. Epub 2017 Mar 2. No abstract available.


Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae.

Zhou Y, Ma Y, Zeng J, Duan L, Xue X, Wang H, Lin T, Liu Z, Zeng K, Zhong Y, Zhang S, Hu Q, Liu M, Zhang H, Reed J, Moses T, Liu X, Huang P, Qing Z, Liu X, Tu P, Kuang H, Zhang Z, Osbourn A, Ro DK, Shang Y, Huang S.

Nat Plants. 2016 Nov 28;2:16183. doi: 10.1038/nplants.2016.183.


Biosynthesis of the psychotropic plant diterpene salvinorin A: Discovery and characterization of the Salvia divinorum clerodienyl diphosphate synthase.

Pelot KA, Mitchell R, Kwon M, Hagelthorn DM, Wardman JF, Chiang A, Bohlmann J, Ro DK, Zerbe P.

Plant J. 2017 Mar;89(5):885-897. doi: 10.1111/tpj.13427. Epub 2017 Feb 6.


Discovery of germacrene A synthases in Barnadesia spinosa: The first committed step in sesquiterpene lactone biosynthesis in the basal member of the Asteraceae.

Nguyen TD, Faraldos JA, Vardakou M, Salmon M, O'Maille PE, Ro DK.

Biochem Biophys Res Commun. 2016 Oct 28;479(4):622-627. doi: 10.1016/j.bbrc.2016.09.165. Epub 2016 Oct 1.


cis-Prenyltransferase and Polymer Analysis from a Natural Rubber Perspective.

Kwon M, Kwon EJ, Ro DK.

Methods Enzymol. 2016;576:121-45. doi: 10.1016/bs.mie.2016.02.026. Epub 2016 Mar 24.


Identification and characterization of two bisabolene synthases from linear glandular trichomes of sunflower (Helianthus annuus L., Asteraceae).

Aschenbrenner AK, Kwon M, Conrad J, Ro DK, Spring O.

Phytochemistry. 2016 Apr;124:29-37. doi: 10.1016/j.phytochem.2016.01.009. Epub 2016 Feb 12.


Silencing the lettuce homologs of small rubber particle protein does not influence natural rubber biosynthesis in lettuce (Lactuca sativa).

Chakrabarty R, Qu Y, Ro DK.

Phytochemistry. 2015 May;113:121-9. doi: 10.1016/j.phytochem.2014.12.003. Epub 2014 Dec 29.


A lettuce (Lactuca sativa) homolog of human Nogo-B receptor interacts with cis-prenyltransferase and is necessary for natural rubber biosynthesis.

Qu Y, Chakrabarty R, Tran HT, Kwon EJ, Kwon M, Nguyen TD, Ro DK.

J Biol Chem. 2015 Jan 23;290(4):1898-914. doi: 10.1074/jbc.M114.616920. Epub 2014 Dec 4.


Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis).

Kwon M, Cochrane SA, Vederas JC, Ro DK.

FEBS Lett. 2014 Dec 20;588(24):4597-603. doi: 10.1016/j.febslet.2014.10.031. Epub 2014 Nov 4.


Variation in capsidiol sensitivity between Phytophthora infestans and Phytophthora capsici is consistent with their host range.

Giannakopoulou A, Schornack S, Bozkurt TO, Haart D, Ro DK, Faraldos JA, Kamoun S, O'Maille PE.

PLoS One. 2014 Sep 9;9(9):e107462. doi: 10.1371/journal.pone.0107462. eCollection 2014.


Characterization of proanthocyanidin metabolism in pea (Pisum sativum) seeds.

Ferraro K, Jin AL, Nguyen TD, Reinecke DM, Ozga JA, Ro DK.

BMC Plant Biol. 2014 Sep 16;14:238. doi: 10.1186/s12870-014-0238-y.


Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest.

Xiao M, Zhang Y, Chen X, Lee EJ, Barber CJ, Chakrabarty R, Desgagné-Penix I, Haslam TM, Kim YB, Liu E, MacNevin G, Masada-Atsumi S, Reed DW, Stout JM, Zerbe P, Zhang Y, Bohlmann J, Covello PS, De Luca V, Page JE, Ro DK, Martin VJ, Facchini PJ, Sensen CW.

J Biotechnol. 2013 Jul 10;166(3):122-34. doi: 10.1016/j.jbiotec.2013.04.004. Epub 2013 Apr 16.


De novo synthesis of high-value plant sesquiterpenoids in yeast.

Nguyen TD, MacNevin G, Ro DK.

Methods Enzymol. 2012;517:261-78. doi: 10.1016/B978-0-12-404634-4.00013-9.


Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin.

Pickel B, Drew DP, Manczak T, Weitzel C, Simonsen HT, Ro DK.

Biochem J. 2012 Dec 1;448(2):261-71. doi: 10.1042/BJ20120654.


Molecular cloning and characterization of (+)-epi-α-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis.

Attia M, Kim SU, Ro DK.

Arch Biochem Biophys. 2012 Nov 1;527(1):37-44. doi: 10.1016/ Epub 2012 Jul 31.


Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).

Pyle BW, Tran HT, Pickel B, Haslam TM, Gao Z, MacNevin G, Vederas JC, Kim SU, Ro DK.

FEBS J. 2012 Sep;279(17):3136-46. doi: 10.1111/j.1742-4658.2012.08692.x. Epub 2012 Jul 25.


Response of sunflower (Helianthus annuus L.) leaf surface defenses to exogenous methyl jasmonate.

Rowe HC, Ro DK, Rieseberg LH.

PLoS One. 2012;7(5):e37191. doi: 10.1371/journal.pone.0037191. Epub 2012 May 18.


Synthetic biosystems for the production of high-value plant metabolites.

Facchini PJ, Bohlmann J, Covello PS, De Luca V, Mahadevan R, Page JE, Ro DK, Sensen CW, Storms R, Martin VJ.

Trends Biotechnol. 2012 Mar;30(3):127-31. doi: 10.1016/j.tibtech.2011.10.001. Epub 2011 Dec 29.


Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism.

Ikezawa N, Göpfert JC, Nguyen DT, Kim SU, O'Maille PE, Spring O, Ro DK.

J Biol Chem. 2011 Jun 17;286(24):21601-11. doi: 10.1074/jbc.M110.216804. Epub 2011 Apr 22.


Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.

Barriuso J, Nguyen DT, Li JW, Roberts JN, MacNevin G, Chaytor JL, Marcus SL, Vederas JC, Ro DK.

J Am Chem Soc. 2011 Jun 1;133(21):8078-81. doi: 10.1021/ja201138v. Epub 2011 Apr 15.


Biochemical conservation and evolution of germacrene A oxidase in asteraceae.

Nguyen DT, Göpfert JC, Ikezawa N, Macnevin G, Kathiresan M, Conrad J, Spring O, Ro DK.

J Biol Chem. 2010 May 28;285(22):16588-98. doi: 10.1074/jbc.M110.111757. Epub 2010 Mar 29.


Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes.

Göpfert JC, Macnevin G, Ro DK, Spring O.

BMC Plant Biol. 2009 Jul 6;9:86. doi: 10.1186/1471-2229-9-86.


Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid.

Ro DK, Ouellet M, Paradise EM, Burd H, Eng D, Paddon CJ, Newman JD, Keasling JD.

BMC Biotechnol. 2008 Nov 4;8:83. doi: 10.1186/1472-6750-8-83.


Engineering Escherichia coli for production of functionalized terpenoids using plant P450s.

Chang MC, Eachus RA, Trieu W, Ro DK, Keasling JD.

Nat Chem Biol. 2007 May;3(5):274-7. Epub 2007 Apr 15.


Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids.

Shiba Y, Paradise EM, Kirby J, Ro DK, Keasling JD.

Metab Eng. 2007 Mar;9(2):160-8. Epub 2006 Nov 17.


Production of the antimalarial drug precursor artemisinic acid in engineered yeast.

Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, Keasling JD.

Nature. 2006 Apr 13;440(7086):940-3.


Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase.

Ro DK, Arimura G, Lau SY, Piers E, Bohlmann J.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):8060-5. Epub 2005 May 23.


Characterization of a root-specific Arabidopsis terpene synthase responsible for the formation of the volatile monoterpene 1,8-cineole.

Chen F, Ro DK, Petri J, Gershenzon J, Bohlmann J, Pichersky E, Tholl D.

Plant Physiol. 2004 Aug;135(4):1956-66. Epub 2004 Aug 6.


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