Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 95

1.

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.

MacLachlan BJ, Dolton G, Papakyriakou A, Greenshields-Watson A, Mason GH, Schauenburg A, Besneux M, Szomolay B, Elliott T, Sewell AK, Gallimore A, Rizkallah P, Cole DK, Godkin A.

J Biol Chem. 2019 Dec 27;294(52):20246-20258. doi: 10.1074/jbc.RA119.009437. Epub 2019 Oct 16.

2.

Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor.

Baker AT, Mundy RM, Davies JA, Rizkallah PJ, Parker AL.

Sci Adv. 2019 Sep 4;5(9):eaax3567. doi: 10.1126/sciadv.aax3567. eCollection 2019 Sep.

3.

Crystal Structure and Biophysical Analysis of Furfural-Detoxifying Aldehyde Reductase from Clostridium beijerinckii.

Scott AF, Cresser-Brown J, Williams TL, Rizkallah PJ, Jin Y, Luk LY, Allemann RK.

Appl Environ Microbiol. 2019 Jul 18;85(15). pii: e00978-19. doi: 10.1128/AEM.00978-19. Print 2019 Aug 1.

4.

TCR-induced alteration of primary MHC peptide anchor residue.

Madura F, Rizkallah PJ, Legut M, Holland CJ, Fuller A, Bulek A, Schauenburg AJ, Trimby A, Hopkins JR, Wells SA, Godkin A, Miles JJ, Sami M, Li Y, Liddy N, Jakobsen BK, Loveridge EJ, Cole DK, Sewell AK.

Eur J Immunol. 2019 Jul;49(7):1052-1066. doi: 10.1002/eji.201948085. Epub 2019 May 27.

5.

A Noncanonical Chromophore Reveals Structural Rearrangements of the Light-Oxygen-Voltage Domain upon Photoactivation.

Kalvaitis ME, Johnson LA, Mart RJ, Rizkallah P, Allemann RK.

Biochemistry. 2019 Jun 4;58(22):2608-2616. doi: 10.1021/acs.biochem.9b00255. Epub 2019 May 17.

PMID:
31082213
6.

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma.

Galloway SAE, Dolton G, Attaf M, Wall A, Fuller A, Rius C, Bianchi V, Theaker S, Lloyd A, Caillaud ME, Svane IM, Donia M, Cole DK, Szomolay B, Rizkallah P, Sewell AK.

Front Immunol. 2019 Mar 13;10:319. doi: 10.3389/fimmu.2019.00319. eCollection 2019.

7.

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions.

Baker AT, Greenshields-Watson A, Coughlan L, Davies JA, Uusi-Kerttula H, Cole DK, Rizkallah PJ, Parker AL.

Nat Commun. 2019 Feb 14;10(1):741. doi: 10.1038/s41467-019-08599-y.

8.

[Brainstem anesthesia after a peribulbar injection of ropivacaine].

Fakhoury H, Karam H, Rizkallah P, Cherfan C, Arej N.

J Fr Ophtalmol. 2018 Dec;41(10):e493-e494. doi: 10.1016/j.jfo.2018.03.018. Epub 2018 Nov 16. French. No abstract available.

PMID:
30449645
9.

Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies.

Uusi-Kerttula H, Davies JA, Thompson JM, Wongthida P, Evgin L, Shim KG, Bradshaw A, Baker AT, Rizkallah PJ, Jones R, Hanna L, Hudson E, Vile RG, Chester JD, Parker AL.

Clin Cancer Res. 2018 Sep 1;24(17):4215-4224. doi: 10.1158/1078-0432.CCR-18-1089. Epub 2018 May 24.

10.

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

Tungatt K, Dolton G, Morgan SB, Attaf M, Fuller A, Whalley T, Hemmink JD, Porter E, Szomolay B, Montoya M, Hammond JA, Miles JJ, Cole DK, Townsend A, Bailey M, Rizkallah PJ, Charleston B, Tchilian E, Sewell AK.

PLoS Pathog. 2018 May 17;14(5):e1007017. doi: 10.1371/journal.ppat.1007017. eCollection 2018 May.

11.

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.

Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK.

Front Immunol. 2018 Apr 11;9:674. doi: 10.3389/fimmu.2018.00674. eCollection 2018.

12.

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Miles JJ, Tan MP, Dolton G, Edwards ES, Galloway SA, Laugel B, Clement M, Makinde J, Ladell K, Matthews KK, Watkins TS, Tungatt K, Wong Y, Lee HS, Clark RJ, Pentier JM, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah PJ, Gras S, Rossjohn J, Burrows SR, Cole DK, Price DA, Sewell AK.

J Clin Invest. 2018 Apr 2;128(4):1569-1580. doi: 10.1172/JCI91512. Epub 2018 Mar 12.

13.

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.

Cole DK, Fuller A, Dolton G, Zervoudi E, Legut M, Miles K, Blanchfield L, Madura F, Holland CJ, Bulek AM, Bridgeman JS, Miles JJ, Schauenburg AJA, Beck K, Evavold BD, Rizkallah PJ, Sewell AK.

Front Immunol. 2017 Nov 10;8:1503. doi: 10.3389/fimmu.2017.01503. eCollection 2017.

14.

T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.

Bovay A, Zoete V, Dolton G, Bulek AM, Cole DK, Rizkallah PJ, Fuller A, Beck K, Michielin O, Speiser DE, Sewell AK, Fuertes Marraco SA.

Eur J Immunol. 2018 Feb;48(2):258-272. doi: 10.1002/eji.201747082. Epub 2017 Dec 11.

15.

Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle.

Hartley AM, Worthy HL, Reddington SC, Rizkallah PJ, Jones DD.

Chem Sci. 2016 Oct 1;7(10):6484-6491. doi: 10.1039/c6sc00944a. Epub 2016 Jun 29.

16.

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.

MacLachlan BJ, Greenshields-Watson A, Mason GH, Schauenburg AJ, Bianchi V, Rizkallah PJ, Sewell AK, Fuller A, Cole DK.

J Vis Exp. 2017 Feb 6;(120). doi: 10.3791/54991.

17.

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

Cole DK, van den Berg HA, Lloyd A, Crowther MD, Beck K, Ekeruche-Makinde J, Miles JJ, Bulek AM, Dolton G, Schauenburg AJ, Wall A, Fuller A, Clement M, Laugel B, Rizkallah PJ, Wooldridge L, Sewell AK.

J Biol Chem. 2017 Jan 20;292(3):802-813. doi: 10.1074/jbc.M116.741603. Epub 2016 Nov 30.

18.

Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.

Nomikos M, Thanassoulas A, Beck K, Theodoridou M, Kew J, Kashir J, Calver BL, Matthews E, Rizkallah P, Sideratou Z, Nounesis G, Lai FA.

FEBS J. 2016 Dec;283(24):4502-4514. doi: 10.1111/febs.13939. Epub 2016 Nov 15.

19.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Sep 1;126(9):3626. doi: 10.1172/JCI89919. Epub 2016 Aug 15. No abstract available.

20.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Jun 1;126(6):2191-204. doi: 10.1172/JCI85679. Epub 2016 May 16. Erratum in: J Clin Invest. 2016 Sep 1;126(9):3626.

21.

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.

Bianchi V, Bulek A, Fuller A, Lloyd A, Attaf M, Rizkallah PJ, Dolton G, Sewell AK, Cole DK.

J Biol Chem. 2016 Apr 22;291(17):8951-9. doi: 10.1074/jbc.M115.707414. Epub 2016 Feb 25.

22.

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

Raman MC, Rizkallah PJ, Simmons R, Donnellan Z, Dukes J, Bossi G, Le Provost GS, Todorov P, Baston E, Hickman E, Mahon T, Hassan N, Vuidepot A, Sami M, Cole DK, Jakobsen BK.

Sci Rep. 2016 Jan 13;6:18851. doi: 10.1038/srep18851.

23.

Conformationally restricted calpain inhibitors.

Adams SE, Robinson EJ, Miller DJ, Rizkallah PJ, Hallett MB, Allemann RK.

Chem Sci. 2015 Dec 1;6(12):6865-6871. doi: 10.1039/c5sc01158b. Epub 2015 Aug 24.

24.

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.

Motozono C, Pearson JA, De Leenheer E, Rizkallah PJ, Beck K, Trimby A, Sewell AK, Wong FS, Cole DK.

J Biol Chem. 2015 Jul 31;290(31):18924-33. doi: 10.1074/jbc.M114.622522. Epub 2015 Jun 17.

25.

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.

Kløverpris HN, Cole DK, Fuller A, Carlson J, Beck K, Schauenburg AJ, Rizkallah PJ, Buus S, Sewell AK, Goulder P.

Retrovirology. 2015 Feb 20;12:20. doi: 10.1186/s12977-015-0149-5.

26.

A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.

Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A.

Mol Immunol. 2015 Mar;64(1):170-6. doi: 10.1016/j.molimm.2014.11.010. Epub 2014 Dec 19.

27.

Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides.

Madura F, Rizkallah PJ, Holland CJ, Fuller A, Bulek A, Godkin AJ, Schauenburg AJ, Cole DK, Sewell AK.

Eur J Immunol. 2015 Feb;45(2):584-91. doi: 10.1002/eji.201445114. Epub 2014 Dec 28.

28.

CD8+ T-cell recognition of a synthetic epitope formed by t-butyl modification.

Reid RA, Redman JE, Rizkallah P, Fegan C, Pepper C, Man S.

Immunology. 2014 Oct 5. doi: 10.1111/imm.12398. [Epub ahead of print]

29.

The structural basis of differential inhibition of human calpain by indole and phenyl α-mercaptoacrylic acids.

Adams SE, Rizkallah PJ, Miller DJ, Robinson EJ, Hallett MB, Allemann RK.

J Struct Biol. 2014 Sep;187(3):236-241. doi: 10.1016/j.jsb.2014.07.004. Epub 2014 Jul 30.

PMID:
25086406
30.

Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein.

Arpino JA, Rizkallah PJ, Jones DD.

Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2152-62. doi: 10.1107/S139900471401267X. Epub 2014 Jul 25.

31.

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death.

Nomikos M, Thanassoulas A, Beck K, Vassilakopoulou V, Hu H, Calver BL, Theodoridou M, Kashir J, Blayney L, Livaniou E, Rizkallah P, Nounesis G, Lai FA.

FEBS Lett. 2014 Aug 25;588(17):2898-902. doi: 10.1016/j.febslet.2014.07.007. Epub 2014 Jul 15.

32.

Random single amino acid deletion sampling unveils structural tolerance and the benefits of helical registry shift on GFP folding and structure.

Arpino JA, Reddington SC, Halliwell LM, Rizkallah PJ, Jones DD.

Structure. 2014 Jun 10;22(6):889-98. doi: 10.1016/j.str.2014.03.014. Epub 2014 May 22.

33.

Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01.

Motozono C, Kuse N, Sun X, Rizkallah PJ, Fuller A, Oka S, Cole DK, Sewell AK, Takiguchi M.

J Immunol. 2014 Apr 1;192(7):3428-34. doi: 10.4049/jimmunol.1302667. Epub 2014 Mar 5.

34.

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.

Cole DK, Miles KM, Madura F, Holland CJ, Schauenburg AJ, Godkin AJ, Bulek AM, Fuller A, Akpovwa HJ, Pymm PG, Liddy N, Sami M, Li Y, Rizkallah PJ, Jakobsen BK, Sewell AK.

J Biol Chem. 2014 Jan 10;289(2):628-38. doi: 10.1074/jbc.M113.522110. Epub 2013 Nov 6.

35.

Genetically encoding phenyl azide chemistry: new uses and ideas for classical biochemistry.

Reddington S, Watson P, Rizkallah P, Tippmann E, Jones DD.

Biochem Soc Trans. 2013 Oct;41(5):1177-82. doi: 10.1042/BST20130094. Review.

PMID:
24059505
36.

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.

Cole DK, Sami M, Scott DR, Rizkallah PJ, Borbulevych OY, Todorov PT, Moysey RK, Jakobsen BK, Boulter JM, Baker BM, Yi Li.

Front Immunol. 2013 Jun 26;4:168. doi: 10.3389/fimmu.2013.00168. eCollection 2013.

37.

T-cell receptor specificity maintained by altered thermodynamics.

Madura F, Rizkallah PJ, Miles KM, Holland CJ, Bulek AM, Fuller A, Schauenburg AJ, Miles JJ, Liddy N, Sami M, Li Y, Hossain M, Baker BM, Jakobsen BK, Sewell AK, Cole DK.

J Biol Chem. 2013 Jun 28;288(26):18766-75. doi: 10.1074/jbc.M113.464560. Epub 2013 May 22.

38.

Different photochemical events of a genetically encoded phenyl azide define and modulate GFP fluorescence.

Reddington SC, Rizkallah PJ, Watson PD, Pearson R, Tippmann EM, Jones DD.

Angew Chem Int Ed Engl. 2013 Jun 3;52(23):5974-7. doi: 10.1002/anie.201301490. Epub 2013 Apr 25.

PMID:
23620472
39.

Peptide length determines the outcome of TCR/peptide-MHCI engagement.

Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJ, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK, Wooldridge L.

Blood. 2013 Feb 14;121(7):1112-23. doi: 10.1182/blood-2012-06-437202. Epub 2012 Dec 18.

40.

Crystal structure of enhanced green fluorescent protein to 1.35 Å resolution reveals alternative conformations for Glu222.

Arpino JA, Rizkallah PJ, Jones DD.

PLoS One. 2012;7(10):e47132. doi: 10.1371/journal.pone.0047132. Epub 2012 Oct 16.

41.

Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.

Holland CJ, Rizkallah PJ, Vollers S, Calvo-Calle JM, Madura F, Fuller A, Sewell AK, Stern LJ, Godkin A, Cole DK.

Sci Rep. 2012;2:629. doi: 10.1038/srep00629. Epub 2012 Sep 4.

42.

T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.

Ekeruche-Makinde J, Clement M, Cole DK, Edwards ES, Ladell K, Miles JJ, Matthews KK, Fuller A, Lloyd KA, Madura F, Dolton GM, Pentier J, Lissina A, Gostick E, Baxter TK, Baker BM, Rizkallah PJ, Price DA, Wooldridge L, Sewell AK.

J Biol Chem. 2012 Oct 26;287(44):37269-81. doi: 10.1074/jbc.M112.386409. Epub 2012 Sep 5.

43.

TCR/pMHC Optimized Protein crystallization Screen.

Bulek AM, Madura F, Fuller A, Holland CJ, Schauenburg AJ, Sewell AK, Rizkallah PJ, Cole DK.

J Immunol Methods. 2012 Aug 31;382(1-2):203-10. doi: 10.1016/j.jim.2012.06.007. Epub 2012 Jun 15.

44.

A partially interpenetrated metal-organic framework for selective hysteretic sorption of carbon dioxide.

Yang S, Lin X, Lewis W, Suyetin M, Bichoutskaia E, Parker JE, Tang CC, Allan DR, Rizkallah PJ, Hubberstey P, Champness NR, Thomas KM, Blake AJ, Schröder M.

Nat Mater. 2012 Jun 3;11(8):710-6. doi: 10.1038/nmat3343.

PMID:
22660661
45.

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.

Bulek AM, Cole DK, Skowera A, Dolton G, Gras S, Madura F, Fuller A, Miles JJ, Gostick E, Price DA, Drijfhout JW, Knight RR, Huang GC, Lissin N, Molloy PE, Wooldridge L, Jakobsen BK, Rossjohn J, Peakman M, Rizkallah PJ, Sewell AK.

Nat Immunol. 2012 Jan 15;13(3):283-9. doi: 10.1038/ni.2206.

46.

Construction and crystal structure of recombinant STNV capsids.

Lane SW, Dennis CA, Lane CL, Trinh CH, Rizkallah PJ, Stockley PG, Phillips SE.

J Mol Biol. 2011 Oct 14;413(1):41-50. doi: 10.1016/j.jmb.2011.07.062. Epub 2011 Aug 3.

PMID:
21839089
47.

Highly porous and robust scandium-based metal-organic frameworks for hydrogen storage.

Ibarra IA, Yang S, Lin X, Blake AJ, Rizkallah PJ, Nowell H, Allan DR, Champness NR, Hubberstey P, Schröder M.

Chem Commun (Camb). 2011 Aug 7;47(29):8304-6. doi: 10.1039/c1cc11168j. Epub 2011 Jun 20.

PMID:
21691622
48.

Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.

Miles JJ, Bulek AM, Cole DK, Gostick E, Schauenburg AJ, Dolton G, Venturi V, Davenport MP, Tan MP, Burrows SR, Wooldridge L, Price DA, Rizkallah PJ, Sewell AK.

PLoS Pathog. 2010 Nov 18;6(11):e1001198. doi: 10.1371/journal.ppat.1001198.

49.

Tripodal 4-pyridyl-derived host ligands and their metallo-supramolecular chemistry: stella octangula and bowl-shaped assemblies.

Ronson TK, Carruthers C, Fisher J, Brotin T, Harding LP, Rizkallah PJ, Hardie MJ.

Inorg Chem. 2010 Jan 18;49(2):675-85. doi: 10.1021/ic901972h.

PMID:
20000713
50.

Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.

Cole DK, Yuan F, Rizkallah PJ, Miles JJ, Gostick E, Price DA, Gao GF, Jakobsen BK, Sewell AK.

J Biol Chem. 2009 Oct 2;284(40):27281-9. doi: 10.1074/jbc.M109.022509. Epub 2009 Jul 15.

Supplemental Content

Loading ...
Support Center