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A few ethical issues in translational research for gene and cell therapy.

Riva L, Petrini C.

J Transl Med. 2019 Nov 28;17(1):395. doi: 10.1186/s12967-019-02154-5.


Viral determinants in H5N1 influenza A virus enable productive infection of HeLa cells.

Rodriguez-Frandsen A, Martin-Sancho L, Gounder AP, Chang MW, Liu WC, De Jesus PD, von Recum-Knepper J, Dutra MS, Huffmaster NJ, Chavarria M, Mena I, Riva L, Nguyen CB, Dobariya S, Herbert KM, Benner C, Albrecht RA, García-Sastre A, Chanda SK.

J Virol. 2019 Nov 27. pii: JVI.01410-19. doi: 10.1128/JVI.01410-19. [Epub ahead of print]


Donation of Human Biological Materials in the European Union: Commodifying Solidarity in the Era of the Biotechnological Revolution?

Riva L, Resta G, Gambino A, Petrini C.

New Bioeth. 2019 Dec;25(4):349-358. doi: 10.1080/20502877.2019.1679965.


Organ Transplantation From Nonstandard Risk Donors: Midway Between Rigid and Flexible Rules.

Petrini C, Trapani S, Riva L, Floridia G, Gainotti S, Lombardini L, Masiero L, Rizzato L, Costa AN.

Transplant Proc. 2019 Nov;51(9):2856-2859. doi: 10.1016/j.transproceed.2019.02.070. Epub 2019 Oct 9.


Unproven stem cell therapies: is it my right to try?

Riva L, Campanozzi L, Vitali M, Ricci G, Tambone V.

Ann Ist Super Sanita. 2019 Apr-Jun;55(2):179-185. doi: 10.4415/ANN_19_02_10.


Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs.

Punzi S, Meliksetian M, Riva L, Marocchi F, Pruneri G, Criscitiello C, Orsi F, Spaggiari L, Casiraghi M, Della Vigna P, Luzi L, Curigliano G, Pelicci PG, Lanfrancone L.

Cells. 2019 Jun 18;8(6). pii: E605. doi: 10.3390/cells8060605.


[Heart-brain interactions].

Riva L, Urbinati S, Di Pasquale G.

G Ital Cardiol (Rome). 2019 May;20(5):265-278. doi: 10.1714/3151.31319. Italian.


Dynamic Contrast-Enhanced MR with Quantitative Perfusion Analysis of Small Bowel in Vascular Assessment between Inflammatory and Fibrotic Lesions in Crohn's Disease: A Feasibility Study.

Ippolito D, Lombardi S, Talei Franzesi C, Drago SG, Querques G, Casiraghi A, Pecorelli A, Riva L, Sironi S.

Contrast Media Mol Imaging. 2019 Feb 4;2019:1767620. doi: 10.1155/2019/1767620. eCollection 2019.


From Experimental Technique to Clinical Practice: Which Pathway in Transplant Surgery?

Petrini C, Floridia G, Riva L, Gainotti S.

Transplant Proc. 2019 Jan - Feb;51(1):96-99. doi: 10.1016/j.transproceed.2017.11.082. Epub 2018 Jun 30.


Virtual Guidance of Percutaneous Transthoracic Needle Biopsy with C-Arm Cone-Beam CT: Diagnostic Accuracy, Risk Factors and Effective Radiation Dose.

Fior D, Vacirca F, Leni D, Pagni F, Ippolito D, Riva L, Sironi S, Corso R.

Cardiovasc Intervent Radiol. 2019 May;42(5):712-719. doi: 10.1007/s00270-019-02163-3. Epub 2019 Jan 16.


Similarities and Differences Between HCV Pseudoparticle (HCVpp) and Cell Culture HCV (HCVcc) in the Study of HCV.

Riva L, Dubuisson J.

Methods Mol Biol. 2019;1911:33-45. doi: 10.1007/978-1-4939-8976-8_2. Review.


Diagnostic efficacy of model-based iterative reconstruction algorithm in an assessment of coronary artery in comparison with standard hybrid-Iterative reconstruction algorithm: dose reduction and image quality.

Ippolito D, Riva L, Talei Franzesi CR, Cangiotti C, De Vito A, Di Gennaro F, D'andrea G, Crespi A, Sironi S.

Radiol Med. 2019 May;124(5):350-359. doi: 10.1007/s11547-018-0964-6. Epub 2018 Dec 11.


Evaluation of image quality and radiation dose saving comparing knowledge model-based iterative reconstruction on 80-kV CT pulmonary angiography (CTPA) with hybrid iterative reconstruction on 100-kV CT.

Ippolito D, De Vito A, Franzesi CT, Riva L, Pecorelli A, Corso R, Crespi A, Sironi S.

Emerg Radiol. 2019 Apr;26(2):145-153. doi: 10.1007/s10140-018-1653-4. Epub 2018 Nov 10.


[Edoxaban in patients with atrial fibrillation and cancer].

Maurea N, Riva L.

G Ital Cardiol (Rome). 2018 Sep;19(9 Suppl 1):13S-19S. doi: 10.1714/2989.29923. Italian.


[Venous thromboembolism and atrial fibrillation in patients with cancer].

Maurea N, Riva L.

G Ital Cardiol (Rome). 2018 Sep;19(9 Suppl 1):3S-6S. doi: 10.1714/2989.29921. Italian. No abstract available.


"Hyperdense artery sign" in early ischemic stroke: diagnostic value of model-based reconstruction approach in comparison with standard hybrid iterative reconstruction algorithm.

Lombardi S, Riva L, Patassini M, Remida P, Capraro C, Canonico F, Franzesi CT, Ippolito D.

Neuroradiology. 2018 Dec;60(12):1273-1280. doi: 10.1007/s00234-018-2092-3. Epub 2018 Sep 8.


Blood safety policy: should cautionary policies be adopted with caution?

Riva L, Petrini C.

Blood Transfus. 2018 Sep;16(5):405-407. doi: 10.2450/2018.0135-18. No abstract available.


Diagnostic value of iterative reconstruction algorithm in low kV CT angiography (CTA) with low contrast medium volume for transcatheter aortic valve implantation (TAVI) planning: image quality and radiation dose exposure.

Talei Franzesi CR, Ippolito D, Riva L, Fior D, Cangiotti C, Sironi S.

Br J Radiol. 2018 Dec;91(1092):20170802. doi: 10.1259/bjr.20170802. Epub 2018 Aug 13.


Antithrombotic therapy for patients with an indication for oral anticoagulation undergoing percutaneous coronary intervention with stent: The case of venous thromboembolism.

Riva L, Ageno W, Di Pasquale G, Agnelli G, Rubboli A.

Int J Cardiol. 2018 Oct 15;269:75-79. doi: 10.1016/j.ijcard.2018.07.133. Epub 2018 Jul 26. Review.


No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice.

Iyer V, Boroviak K, Thomas M, Doe B, Riva L, Ryder E, Adams DJ.

PLoS Genet. 2018 Jul 9;14(7):e1007503. doi: 10.1371/journal.pgen.1007503. eCollection 2018 Jul.


Association Between Changes in Body Composition and Neoadjuvant Treatment for Pancreatic Cancer.

Sandini M, Patino M, Ferrone CR, Alvarez-Pérez CA, Honselmann KC, Paiella S, Catania M, Riva L, Tedesco G, Casolino R, Auriemma A, Salandini MC, Carrara G, Cristel G, Damascelli A, Ippolito D, D'Onofrio M, Lillemoe KD, Bassi C, Braga M, Gianotti L, Sahani D, Fernández-Del Castillo C.

JAMA Surg. 2018 Sep 1;153(9):809-815. doi: 10.1001/jamasurg.2018.0979.


Varicella-Zoster Virus ORF9p Binding to Cellular Adaptor Protein Complex 1 Is Important for Viral Infectivity.

Lebrun M, Lambert J, Riva L, Thelen N, Rambout X, Blondeau C, Thiry M, Snoeck R, Twizere JC, Dequiedt F, Andrei G, Sadzot-Delvaux C.

J Virol. 2018 Jul 17;92(15). pii: e00295-18. doi: 10.1128/JVI.00295-18. Print 2018 Aug 1.


Real-Time Elastography: Noninvasive Diagnostic Tool in the Evaluation of Liver Stiffness in Patients with Chronic Viral Hepatitis, Correlation with Histological Examination.

Ippolito D, Schiavone V, Talei Franzesi CR, Casiraghi AS, Drago SG, Riva L, Sironi S.

Dig Dis. 2018;36(4):289-297. doi: 10.1159/000480699. Epub 2018 Apr 26.


Sickle cell maculopathy: Identification of systemic risk factors, and microstructural analysis of individual retinal layers of the macula.

Dell'Arti L, Barteselli G, Riva L, Carini E, Graziadei G, Benatti E, Invernizzi A, Cappellini MD, Viola F.

PLoS One. 2018 Mar 1;13(3):e0193582. doi: 10.1371/journal.pone.0193582. eCollection 2018.


Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry.

Riva L, Song OR, Prentoe J, Helle F, L'homme L, Gattolliat CH, Vandeputte A, Fénéant L, Belouzard S, Baumert TF, Asselah T, Bukh J, Brodin P, Cocquerel L, Rouillé Y, Dubuisson J.

J Virol. 2018 Apr 27;92(10). pii: e01982-17. doi: 10.1128/JVI.01982-17. Print 2018 May 15.


[Cardiogenic shock: from pharmacological treatment to mechanical circulatory support].

Battistoni I, Marini M, Lavorgna A, Vagnarelli F, Lucà F, Biscottini E, Caretta G, Procaccini V, Riva L, Vianello G, Iacoviello M, De Maria R, Navazio A, Aspromonte N, Di Lenarda A, Gulizia MM, Valente S.

G Ital Cardiol (Rome). 2017 Oct;18(10):708-718. doi: 10.1714/2790.28260. Review. Italian.


[Cardiogenic shock: from early diagnosis to multiparameter monitoring].

Marini M, Battistoni I, Lavorgna A, Vagnarelli F, Lucà F, Biscottini E, Caretta G, Procaccini V, Riva L, Vianello G, Mortara A, Pini D, De Maria R, Aspromonte N, Di Lenarda A, Gulizia MM, Valente S.

G Ital Cardiol (Rome). 2017 Oct;18(10):696-707. doi: 10.1714/2790.28259. Review. Italian.


3D-laparoscopic anterior rectal resection in a patient with crossed fused renal ectopia: the importance of 3D imaging.

Giani A, Garancini M, Delitala A, Riva L, Gianotti L, Giardini V.

Minerva Chir. 2017 Dec;72(6):546-547. doi: 10.23736/S0026-4733.17.07363-1. No abstract available.


A handbook for the clinical cardiologist about CRT/ICD. A practical guide about how to survive during an on call shift.

Lucà F, Biscottini E, Cipolletta L, Marini M, Caretta G, Lavorgna A, Vagnarelli F, Di Fusco SA, Procaccini V, Riva L, Vianello G, De Maria R, Giardina A, Gulizia MM.

Minerva Cardioangiol. 2018 Oct;66(5):631-645. doi: 10.23736/S0026-4725.17.04476-0. Epub 2017 Aug 31. Review.


Mutations targeting the coagulation pathway are enriched in brain metastases.

Richichi C, Fornasari L, Melloni GEM, Brescia P, Patanè M, Del Bene M, Mustafa DAM, Kros JM, Pollo B, Pruneri G, Sciandivasci A, Munzone E, DiMeco F, Pelicci PG, Riva L, Pelicci G.

Sci Rep. 2017 Jul 26;7(1):6573. doi: 10.1038/s41598-017-06811-x.


[Noninvasive ventilation and sedation: evidence and practical tools for its utilization].

Battistoni I, Marini M, Caretta G, Vagnarelli F, Lucà F, Biscottini E, Lavorgna A, Procaccini V, Riva L, Vianello G, Aspromonte N, Iacoviello M, De Maria R, Valente S, Gulizia MM.

G Ital Cardiol (Rome). 2017 Jun;18(6):513-518. doi: 10.1714/2700.27612. Review. Italian.


[Hemodynamic effects of positive end-expiratory pressure].

Marini M, Caretta G, Vagnarelli F, Lucà F, Biscottini E, Lavorgna A, Procaccini V, Riva L, Vianello G, Aspromonte N, Mortara A, De Maria R, Capasso P, Valente S, Gulizia MM.

G Ital Cardiol (Rome). 2017 Jun;18(6):505-512. doi: 10.1714/2700.27611. Review. Italian.


[Noninvasive ventilation: general characteristics, indications, and review of the literature].

Vagnarelli F, Marini M, Caretta G, Lucà F, Biscottini E, Lavorgna A, Procaccini V, Riva L, Vianello G, Aspromonte N, Pini D, Navazio A, De Maria R, Valente S, Gulizia MM.

G Ital Cardiol (Rome). 2017 Jun;18(6):496-504. doi: 10.1714/2700.27610. Review. Italian.


A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data.

Melloni GEM, Mazzarella L, Bernard L, Bodini M, Russo A, Luzi L, Pelicci PG, Riva L.

Breast Cancer Res. 2017 May 31;19(1):63. doi: 10.1186/s13058-017-0854-1.


Novel replicons and trans-encapsidation systems for Hepatitis C Virus proteins live imaging and virus-host interaction proteomics.

Vlaicu O, Selescu T, Pastrama F, Munteanu C, Riva L, Dubuisson J, Rouille Y, Popescu CI.

J Virol Methods. 2017 Aug;246:42-50. doi: 10.1016/j.jviromet.2017.04.009. Epub 2017 Apr 21.


[New oral anticoagulants in patients with atrial fibrillation: efficacy and safety data from the real world].

Riva L, Di Pasquale G.

G Ital Cardiol (Rome). 2017 Mar;18(3):188-198. doi: 10.1714/2674.27396. Review. Italian.


PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias.

Ronchini C, Brozzi A, Riva L, Luzi L, Gruszka AM, Melloni GEM, Scanziani E, Dharmalingam G, Mutarelli M, Belcastro V, Lavorgna S, Rossi V, Spinelli O, Biondi A, Rambaldi A, Lo-Coco F, di Bernardo D, Pelicci PG.

Leukemia. 2017 Sep;31(9):1975-1986. doi: 10.1038/leu.2016.386. Epub 2016 Dec 27.


Antigen Masking During Fixation and Embedding, Dissected.

Scalia CR, Boi G, Bolognesi MM, Riva L, Manzoni M, DeSmedt L, Bosisio FM, Ronchi S, Leone BE, Cattoretti G.

J Histochem Cytochem. 2017 Jan;65(1):5-20. doi: 10.1369/0022155416673995. Epub 2016 Oct 23.


RNAi screens identify CHD4 as an essential gene in breast cancer growth.

D'Alesio C, Punzi S, Cicalese A, Fornasari L, Furia L, Riva L, Carugo A, Curigliano G, Criscitiello C, Pruneri G, Pelicci PG, Faretta M, Bossi D, Lanfrancone L.

Oncotarget. 2016 Dec 6;7(49):80901-80915. doi: 10.18632/oncotarget.12646.


In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF.

Cell Rep. 2016 Jun 28;16(1):133-147. doi: 10.1016/j.celrep.2016.05.063. Epub 2016 Jun 16.


In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Bossi D, Cicalese A, Dellino GI, Luzi L, Riva L, D'Alesio C, Diaferia GR, Carugo A, Cavallaro E, Piccioni R, Barberis M, Mazzarol G, Testori A, Punzi S, Pallavicini I, Tosti G, Giacó L, Melloni G, Heffernan TP, Natoli G, Draetta GF, Minucci S, Pelicci P, Lanfrancone L.

Cancer Discov. 2016 Jun;6(6):650-63. doi: 10.1158/2159-8290.CD-15-1200. Epub 2016 May 13.


[Idiopathic massive myocardial calcification: a rare cause of heart failure].

D'Angelo C, Zagnoni S, Riva L, Casella G, Pallotti MG, Di Pasquale G.

G Ital Cardiol (Rome). 2016 Feb;17(2):91-4. doi: 10.1714/2174.23492. Italian.


LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Melloni GE, de Pretis S, Riva L, Pelizzola M, Céol A, Costanza J, Müller H, Zammataro L.

BMC Bioinformatics. 2016 Feb 9;17:80. doi: 10.1186/s12859-016-0935-7.


Peak shape clustering reveals biological insights.

Cremona MA, Sangalli LM, Vantini S, Dellino GI, Pelicci PG, Secchi P, Riva L.

BMC Bioinformatics. 2015 Oct 28;16:349. doi: 10.1186/s12859-015-0787-6.


Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion.

Falson P, Bartosch B, Alsaleh K, Tews BA, Loquet A, Ciczora Y, Riva L, Montigny C, Montpellier C, Duverlie G, Pécheur EI, le Maire M, Cosset FL, Dubuisson J, Penin F.

J Virol. 2015 Oct;89(20):10333-46. doi: 10.1128/JVI.00991-15. Epub 2015 Aug 5.


Epitope recognition in the human-pig comparison model on fixed and embedded material.

Scalia CR, Gendusa R, Basciu M, Riva L, Tusa L, Musarò A, Veronese S, Formenti A, D'Angelo D, Ronzio AG, Cattoretti G, Bolognesi MM.

J Histochem Cytochem. 2015 Oct;63(10):805-22. doi: 10.1369/0022155415597738. Epub 2015 Jul 24.


INSPEcT: a computational tool to infer mRNA synthesis, processing and degradation dynamics from RNA- and 4sU-seq time course experiments.

de Pretis S, Kress T, Morelli MJ, Melloni GE, Riva L, Amati B, Pelizzola M.

Bioinformatics. 2015 Sep 1;31(17):2829-35. doi: 10.1093/bioinformatics/btv288. Epub 2015 May 7.


Mortality after admission to stroke unit for intracerebral hemorrhage: effect of age 80 and older and multimorbidity.

Forti P, Maioli F, Arnone G, Nativio V, Zagnoni S, Riva L, Pedone C, Pirazzoli GL, Coveri M, Zoli M, Di Pasquale G, Procaccianti G.

J Am Geriatr Soc. 2015 Apr;63(4):812-3. doi: 10.1111/jgs.13368. No abstract available.


Whole exome sequencing identifies driver mutations in asymptomatic computed tomography-detected lung cancers with normal karyotype.

Belloni E, Veronesi G, Rotta L, Volorio S, Sardella D, Bernard L, Pece S, Di Fiore PP, Fumagalli C, Barberis M, Spaggiari L, Pelicci PG, Riva L.

Cancer Genet. 2015 Apr;208(4):152-5. doi: 10.1016/j.cancergen.2015.02.004. Epub 2015 Feb 20.


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