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Animal to human translation: a systematic scoping review of reported concordance rates.

Leenaars CHC, Kouwenaar C, Stafleu FR, Bleich A, Ritskes-Hoitinga M, De Vries RBM, Meijboom FLB.

J Transl Med. 2019 Jul 15;17(1):223. doi: 10.1186/s12967-019-1976-2. Review.

Free Article

The evidence for the physiological effects of lactate on the cerebral microcirculation: a systematic review.

Hollyer TR, Bordoni L, Kousholt BS, van Luijk J, Ritskes-Hoitinga M, Østergaard L.

J Neurochem. 2019 Mar;148(6):712-730. doi: 10.1111/jnc.14633. Epub 2019 Jan 24.


Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail.

Pound P, Ritskes-Hoitinga M.

J Transl Med. 2018 Nov 7;16(1):304. doi: 10.1186/s12967-018-1678-1. Review.


Improving animal research reporting standards: HARRP, the first step of a unified approach by ICLAS to improve animal research reporting standards worldwide.

Osborne N, Avey MT, Anestidou L, Ritskes-Hoitinga M, Griffin G.

EMBO Rep. 2018 May;19(5). pii: e46069. doi: 10.15252/embr.201846069. Epub 2018 Apr 17. No abstract available.


Correction: A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction.

Hesen NA, Riksen NP, Aalders B, Brouwer MAE, Ritskes-Hoitinga M, El Messaoudi S, Wever KE.

PLoS One. 2018 Apr 9;13(4):e0195858. doi: 10.1371/journal.pone.0195858. eCollection 2018.


Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies.

Hooijmans CR, de Vries RBM, Ritskes-Hoitinga M, Rovers MM, Leeflang MM, IntHout J, Wever KE, Hooft L, de Beer H, Kuijpers T, Macleod MR, Sena ES, Ter Riet G, Morgan RL, Thayer KA, Rooney AA, Guyatt GH, Schünemann HJ, Langendam MW; GRADE Working Group.

PLoS One. 2018 Jan 11;13(1):e0187271. doi: 10.1371/journal.pone.0187271. eCollection 2018. Review.


Improving the conduct, reporting, and appraisal of animal research.

Ritskes-Hoitinga M, Wever K.

BMJ. 2018 Jan 10;360:j4935. doi: 10.1136/bmj.j4935. No abstract available.


Letter to the editor - round table unites to tackle culture change in an effort to improve animal research reporting.

Osborne NJ, Ritskes-Hoitinga M, Ahluwahlia A, Alam S, Brown M, Henderson H, de Leeuw W, Marsh J, Moher D, van Oort E, Rawle F, Riederer BM, Sanchez-Morgado J, Sena ES, Struthers C, Westmore M, Avey MT, Kalman R, O'Connor A, Sargeant J, Petrie A, Smith A.

BMC Vet Res. 2017 Nov 7;13(1):314. doi: 10.1186/s12917-017-1235-9.


A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction.

Hesen NA, Riksen NP, Aalders B, Brouwer MA, Ritskes-Hoitinga M, El Messaoudi S, Wever KE.

PLoS One. 2017 Aug 23;12(8):e0183664. doi: 10.1371/journal.pone.0183664. eCollection 2017. Review. Erratum in: PLoS One. 2018 Apr 9;13(4):e0195858.


A systematic review of discomfort due to toe or ear clipping in laboratory rodents.

Wever KE, Geessink FJ, Brouwer MAE, Tillema A, Ritskes-Hoitinga M.

Lab Anim. 2017 Dec;51(6):583-600. doi: 10.1177/0023677217705912. Epub 2017 Apr 21. Review.


The usefulness of systematic reviews of animal studies: shooting the messenger.

Hooijmans CR, Wever KE, Ritskes-Hoitinga M, Scheffer GJ.

Paediatr Anaesth. 2016 Aug;26(8):852-3. doi: 10.1111/pan.12938. No abstract available.


Ibogaine and addiction in the animal model, a systematic review and meta-analysis.

Belgers M, Leenaars M, Homberg JR, Ritskes-Hoitinga M, Schellekens AF, Hooijmans CR.

Transl Psychiatry. 2016 May 31;6(5):e826. doi: 10.1038/tp.2016.71. Review.


A Systematic Review of the Modifying Effect of Anaesthetic Drugs on Metastasis in Animal Models for Cancer.

Hooijmans CR, Geessink FJ, Ritskes-Hoitinga M, Scheffer GJ.

PLoS One. 2016 May 26;11(5):e0156152. doi: 10.1371/journal.pone.0156152. eCollection 2016. Review.


Preclinical Evidence for the Efficacy of Ischemic Postconditioning against Renal Ischemia-Reperfusion Injury, a Systematic Review and Meta-Analysis.

Jonker SJ, Menting TP, Warlé MC, Ritskes-Hoitinga M, Wever KE.

PLoS One. 2016 Mar 10;11(3):e0150863. doi: 10.1371/journal.pone.0150863. eCollection 2016. Review.


Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies.

Wever KE, Hooijmans CR, Riksen NP, Sterenborg TB, Sena ES, Ritskes-Hoitinga M, Warlé MC.

PLoS One. 2015 Nov 18;10(11):e0142021. doi: 10.1371/journal.pone.0142021. eCollection 2015.


A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation.

Kleikers PW, Hooijmans C, Göb E, Langhauser F, Rewell SS, Radermacher K, Ritskes-Hoitinga M, Howells DW, Kleinschnitz C, Schmidt HH.

Sci Rep. 2015 Aug 27;5:13428. doi: 10.1038/srep13428.


A systematic review and meta-analysis of the ability of analgesic drugs to reduce metastasis in experimental cancer models.

Hooijmans CR, Geessink FJ, Ritskes-Hoitinga M, Scheffer GJ.

Pain. 2015 Oct;156(10):1835-44. doi: 10.1097/j.pain.0000000000000296. Review.


Systematic review of experimental studies on intestinal anastomosis.

Yauw ST, Wever KE, Hoesseini A, Ritskes-Hoitinga M, van Goor H.

Br J Surg. 2015 Jun;102(7):726-34. doi: 10.1002/bjs.9776. Epub 2015 Apr 2. Review.


Meta-analyses of animal studies: an introduction of a valuable instrument to further improve healthcare.

Hooijmans CR, IntHout J, Ritskes-Hoitinga M, Rovers MM.

ILAR J. 2014;55(3):418-26. doi: 10.1093/ilar/ilu042. Review.


Scientific uses of animals: harm-benefit analysis and complementary approaches to implementing the three Rs.

Griffin G, Clark JM, Zurlo J, Ritskes-Hoitinga M.

Rev Sci Tech. 2014 Apr;33(1):265-72.


Tissue engineering in animal models for urinary diversion: a systematic review.

Sloff M, de Vries R, Geutjes P, IntHout J, Ritskes-Hoitinga M, Oosterwijk E, Feitz W.

PLoS One. 2014 Jun 25;9(6):e98734. doi: 10.1371/journal.pone.0098734. eCollection 2014. Review. Erratum in: PLoS One. 2014;9(8):e105484.


Towards the future.

Ritskes-Hoitinga M.

Lab Anim. 2014 Jul;48(3):270. Epub 2014 Jun 17. No abstract available.


Systematic reviews of preclinical animal studies can make significant contributions to health care and more transparent translational medicine.

Ritskes-Hoitinga M, Leenaars M, Avey M, Rovers M, Scholten R.

Cochrane Database Syst Rev. 2014 Mar 28;(3):ED000078. doi: 10.1002/14651858.ED000078. No abstract available.


Systematic reviews of animal studies; missing link in translational research?

van Luijk J, Bakker B, Rovers MM, Ritskes-Hoitinga M, de Vries RB, Leenaars M.

PLoS One. 2014 Mar 26;9(3):e89981. doi: 10.1371/journal.pone.0089981. eCollection 2014.


SYRCLE's risk of bias tool for animal studies.

Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW.

BMC Med Res Methodol. 2014 Mar 26;14:43. doi: 10.1186/1471-2288-14-43.


Progress in using systematic reviews of animal studies to improve translational research.

Hooijmans CR, Ritskes-Hoitinga M.

PLoS Med. 2013;10(7):e1001482. doi: 10.1371/journal.pmed.1001482. Epub 2013 Jul 16. No abstract available.


Updated version of the Embase search filter for animal studies.

de Vries RB, Hooijmans CR, Tillema A, Leenaars M, Ritskes-Hoitinga M.

Lab Anim. 2014 Jan;48(1):88. doi: 10.1177/0023677213494374. Epub 2013 Jul 8. No abstract available.


Mechanical ventilation of mice under general anesthesia during experimental procedures.

van den Brink I, van de Pol F, Vaneker M, Kox M, Schellekens WJ, Ritskes-Hoitinga M, Scheffer GJ.

Lab Anim (NY). 2013 Jul;42(7):253-7. doi: 10.1038/laban.252.


Towards evidence-based translational research: the pros and cons of conducting systematic reviews of animal studies.

van Luijk J, Leenaars M, Hooijmans C, Wever K, de Vries R, Ritskes-Hoitinga M.

ALTEX. 2013;30(2):256-7. doi: 10.14573/altex.2013.2.256. No abstract available.


Assessing the application of the 3Rs: a survey among animal welfare officers in The Netherlands.

van Luijk J, Cuijpers Y, van der Vaart L, de Roo TC, Leenaars M, Ritskes-Hoitinga M.

Lab Anim. 2013 Jul;47(3):210-9.


The potential of tissue engineering for developing alternatives to animal experiments: a systematic review.

de Vries RB, Leenaars M, Tra J, Huijbregtse R, Bongers E, Jansen JA, Gordijn B, Ritskes-Hoitinga M.

J Tissue Eng Regen Med. 2015 Jul;9(7):771-8. doi: 10.1002/term.1703. Epub 2013 Apr 3. Review.


The effects of probiotic supplementation on experimental acute pancreatitis: a systematic review and meta-analysis.

Hooijmans CR, de Vries RB, Rovers MM, Gooszen HG, Ritskes-Hoitinga M.

PLoS One. 2012;7(11):e48811. doi: 10.1371/journal.pone.0048811. Epub 2012 Nov 13. Review.


Outcomes of a Dutch workshop on improvements for the 3Rs in daily practice.

van Luijk J, Leenaars M, van Dongen AM, van der Vaart L, Ritskes-Hoitinga M.

ALTEX. 2012;29(4):440-3. doi: 10.14573/altex.2012.4.440.


An initiative to facilitate well-informed decision-making in laboratory animal research: report of the First International Symposium on Systematic Reviews in Laboratory Animal Science.

Hooijmans CR, Rovers M, de Vries RB, Leenaars M, Ritskes-Hoitinga M.

Lab Anim. 2012 Oct;46(4):356-7. doi: 10.1258/la.2012.012052. Epub 2012 Sep 11. No abstract available.


Reducing the number of laboratory animals used in tissue engineering research by restricting the variety of animal models. Articular cartilage tissue engineering as a case study.

de Vries RB, Buma P, Leenaars M, Ritskes-Hoitinga M, Gordijn B.

Tissue Eng Part B Rev. 2012 Dec;18(6):427-35. doi: 10.1089/ten.TEB.2012.0059. Epub 2012 Jun 25. Review.


Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis.

Wever KE, Menting TP, Rovers M, van der Vliet JA, Rongen GA, Masereeuw R, Ritskes-Hoitinga M, Hooijmans CR, Warlé M.

PLoS One. 2012;7(2):e32296. doi: 10.1371/journal.pone.0032296. Epub 2012 Feb 28. Review.


The influence of food restriction versus ad libitum feeding of chow and purified diets on variation in body weight, growth and physiology of female Wistar rats.

Moraal M, Leenaars PP, Arnts H, Smeets K, Savenije BS, Curfs JH, Ritskes-Hoitinga M.

Lab Anim. 2012 Apr;46(2):101-7. doi: 10.1258/la.2011.011011. Epub 2012 Jan 31.


Assessing the search for information on Three Rs methods, and their subsequent implementation: a national survey among scientists in the Netherlands.

van Luijk J, Cuijpers Y, van der Vaart L, Leenaars M, Ritskes-Hoitinga M.

Altern Lab Anim. 2011 Oct;39(5):429-47.


A step-by-step guide to systematically identify all relevant animal studies.

Leenaars M, Hooijmans CR, van Veggel N, ter Riet G, Leeflang M, Hooft L, van der Wilt GJ, Tillema A, Ritskes-Hoitinga M.

Lab Anim. 2012 Jan;46(1):24-31. doi: 10.1258/la.2011.011087. Epub 2011 Oct 28. Review.


The effects of long-term omega-3 fatty acid supplementation on cognition and Alzheimer's pathology in animal models of Alzheimer's disease: a systematic review and meta-analysis.

Hooijmans CR, Pasker-de Jong PC, de Vries RB, Ritskes-Hoitinga M.

J Alzheimers Dis. 2012;28(1):191-209. doi: 10.3233/JAD-2011-111217. Review.


A search filter for increasing the retrieval of animal studies in Embase.

de Vries RB, Hooijmans CR, Tillema A, Leenaars M, Ritskes-Hoitinga M.

Lab Anim. 2011 Oct;45(4):268-70. doi: 10.1258/la.2011.011056. Epub 2011 Sep 2.


Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines.

Hooijmans CR, de Vries R, Leenaars M, Curfs J, Ritskes-Hoitinga M.

Br J Pharmacol. 2011 Mar;162(6):1259-60. doi: 10.1111/j.1476-5381.2010.01128.x.


The Gold Standard Publication Checklist (GSPC) for improved design, reporting and scientific quality of animal studies GSPC versus ARRIVE guidelines.

Hooijmans C, de Vries R, Leenaars M, Ritskes-Hoitinga M.

Lab Anim. 2011 Jan;45(1):61. doi: 10.1258/la.2010.010130. Epub 2010 Nov 18. No abstract available.


Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed.

Hooijmans CR, Tillema A, Leenaars M, Ritskes-Hoitinga M.

Lab Anim. 2010 Jul;44(3):170-5. doi: 10.1258/la.2010.009117. Epub 2010 Jun 15.


Assessing the search for and implementation of the Three Rs: a survey among scientists.

Leenaars M, Savenije B, Nagtegaal A, van der Vaart L, Ritskes-Hoitinga M.

Altern Lab Anim. 2009 Jul;37(3):297-303.


S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice.

Hooijmans CR, Blom HJ, Oppenraaij-Emmerzaal D, Ritskes-Hoitinga M, Kiliaan AJ.

Neurol Sci. 2009 Oct;30(5):439-45. doi: 10.1007/s10072-009-0110-2. Epub 2009 Jun 30.


An interview study of phenotypic characterization of genetically-modified mice.

Thon R, Vondeling H, Lassen J, Hansen AK, Ritskes-Hoitinga M.

Lab Anim. 2009 Jul;43(3):278-83. doi: 10.1258/la.2008.0080058. Epub 2009 Feb 23.


Suppression of noxious-induced c-fos expression in the rat lumbar spinal cord by isoflurane alone or combined with fentanyl.

Sommers MG, Nguyen NK, Veening JG, Vissers KC, Ritskes-Hoitinga M, van Egmond J.

Anesth Analg. 2008 Apr;106(4):1303-8, table of contents. doi: 10.1213/ane.0b013e3181678831.


The impact of tail tip amputation and ink tattoo on C57BL/6JBomTac mice.

Sørensen DB, Stub C, Jensen HE, Ritskes-Hoitinga M, Hjorth P, Ottesen JL, Hansen AK.

Lab Anim. 2007 Jan;41(1):19-29.


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