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Associations Between Multimorbidity and Cerebrospinal Fluid Amyloid: A Cross-Sectional Analysis of the European Prevention of Alzheimer's Dementia (EPAD) V500.0 Cohort.

Stirland LE, Russ TC, Ritchie CW, Muniz-Terrera G; EPAD Consortium.

J Alzheimers Dis. 2019;71(2):703-711. doi: 10.3233/JAD-190222.


Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.

Hillary RF, McCartney DL, Harris SE, Stevenson AJ, Seeboth A, Zhang Q, Liewald DC, Evans KL, Ritchie CW, Tucker-Drob EM, Wray NR, McRae AF, Visscher PM, Deary IJ, Marioni RE.

Nat Commun. 2019 Jul 18;10(1):3160. doi: 10.1038/s41467-019-11177-x.


Correction: GWAS on family history of Alzheimer's disease.

Marioni RE, Harris SE, Zhang Q, McRae AF, Hagenaars SP, Hill WD, Davies G, Ritchie CW, Gale CR, Starr JM, Goate AM, Porteous DJ, Yang J, Evans KL, Deary IJ, Wray NR, Visscher PM.

Transl Psychiatry. 2019 Jun 6;9(1):161. doi: 10.1038/s41398-019-0498-2.


Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort.

Jutten RJ, Harrison JE, Lee Meeuw Kjoe PR, Ingala S, Vreeswijk R, van Deelen RAJ, de Jong FJ, Opmeer EM, Aleman A, Ritchie CW, Scheltens P, Sikkes SAM.

Alzheimers Res Ther. 2019 May 15;11(1):45. doi: 10.1186/s13195-019-0500-5.


Protocol for a conversation-based analysis study: PREVENT-ED investigates dialogue features that may help predict dementia onset in later life.

de la Fuente Garcia S, Ritchie CW, Luz S.

BMJ Open. 2019 Mar 27;9(3):e026254. doi: 10.1136/bmjopen-2018-026254.


Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease.

Koychev I, Lawson J, Chessell T, Mackay C, Gunn R, Sahakian B, Rowe JB, Thomas AJ, Rochester L, Chan D, Tom B, Malhotra P, Ballard C, Chessell I, Ritchie CW, Raymont V, Leroi I, Lengyel I, Murray M, Thomas DL, Gallacher J, Lovestone S.

BMJ Open. 2019 Mar 23;9(3):e024498. doi: 10.1136/bmjopen-2018-024498.


Primum non nocere: a call for balance when reporting on CTE.

Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, Folkerth RD, Gentleman S, Giza CC, Grady MS, Helmy A, Herceg M, Holton JL, Howell D, Hutchinson PJ, Iacono D, Iglesias JE, Ikonomovic MD, Johnson VE, Keene CD, Kofler JK, Koliatsos VE, Lee EB, Levin H, Lifshitz J, Ling H, Loane DJ, Love S, Maas AI, Marklund N, Master CL, McElvenny DM, Meaney DF, Menon DK, Montine TJ, Mouzon B, Mufson EJ, Ojo JO, Prins M, Revesz T, Ritchie CW, Smith C, Sylvester R, Tang CY, Trojanowski JQ, Urankar K, Vink R, Wellington C, Wilde EA, Wilson L, Yeates K, Smith DH.

Lancet Neurol. 2019 Mar;18(3):231-233. doi: 10.1016/S1474-4422(19)30020-1. Epub 2019 Feb 12. No abstract available. Erratum in: Lancet Neurol. 2019 Apr;18(4):e3.


European Prevention of Alzheimer's Dementia Longitudinal Cohort Study (EPAD LCS): study protocol.

Solomon A, Kivipelto M, Molinuevo JL, Tom B, Ritchie CW; EPAD Consortium.

BMJ Open. 2019 Feb 19;8(12):e021017. doi: 10.1136/bmjopen-2017-021017.


Participant outcomes and preferences in Alzheimer's disease clinical trials: The electronic Person-Specific Outcome Measure (ePSOM) development program.

Saunders S, Muniz-Terrera G, Watson J, Clarke CL, Luz S, Evans AR, Ritchie CW.

Alzheimers Dement (N Y). 2018 Dec 12;4:694-702. doi: 10.1016/j.trci.2018.10.013. eCollection 2018. Review.


Non-professional caregiver burden is associated with the severity of patients' cognitive impairment.

Black CM, Ritchie CW, Khandker RK, Wood R, Jones E, Hu X, Ambegaonkar BM.

PLoS One. 2018 Dec 6;13(12):e0204110. doi: 10.1371/journal.pone.0204110. eCollection 2018.


Models for dementia risk prediction: so much activity brings a need for coordination and clarity.

Ritchie CW, Muniz-Terrera G.

J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):372. doi: 10.1136/jnnp-2018-318944. Epub 2018 Nov 2. No abstract available.


Research participants as collaborators: Background, experience and policies from the PREVENT Dementia and EPAD programmes.

Gregory S, Wells K, Forysth K, Latto C, Szyra H, Saunders S, Ritchie CW, Milne R.

Dementia (London). 2018 Nov;17(8):1045-1054. doi: 10.1177/1471301218789307.


A brain boost to fight Alzheimer's disease.

Spires-Jones TL, Ritchie CW.

Science. 2018 Sep 7;361(6406):975-976. doi: 10.1126/science.aau8060. No abstract available.


Allocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer's Disease: The PREVENT Dementia Study.

Ritchie K, Carrière I, Howett D, Su L, Hornberger M, O'Brien JT, Ritchie CW, Chan D.

J Alzheimers Dis. 2018;65(3):885-896. doi: 10.3233/JAD-180432.


Correction to: The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease.

Ritchie CW, Russ TC, Banerjee S, Barber B, Boaden A, Fox NC, Holmes C, Isaacs JD, Leroi I, Lovestone S, Norton M, O'Brien J, Pearson J, Perry R, Pickett J, Waldman AD, Wong WL, Rossor MN, Burns A.

Alzheimers Res Ther. 2018 Jul 30;10(1):73. doi: 10.1186/s13195-018-0372-0.


Real-World, Multinational, Retrospective Observational Survey of the ADAS-Cog and Associations with Healthcare Resource Utilization in Patients with Alzheimer's Disease.

Ritchie CW, Khandker RK, Pike J, Black CM, Jones E, Ambegaonkar BM.

J Alzheimers Dis. 2018;64(3):899-910. doi: 10.3233/JAD-180306.


Lifestyle and neurodegeneration in midlife as expressed on functional magnetic resonance imaging: A systematic review.

Topiwala H, Terrera GM, Stirland L, Saunderson K, Russ TC, Dozier MF, Ritchie CW.

Alzheimers Dement (N Y). 2018 May 3;4:182-194. doi: 10.1016/j.trci.2018.04.001. eCollection 2018. Review.


Memory assessment services and health-related quality of life: 1-year follow-up.

Park MH, Smith SC, Ritchie CW, Hendriks AAJ, Black N.

Int J Geriatr Psychiatry. 2018 May 30. doi: 10.1002/gps.4913. [Epub ahead of print]


A novel cognitive-functional composite measure to detect changes in early Alzheimer's disease: Test-retest reliability and feasibility.

Jutten RJ, Harrison J, Lee Meeuw Kjoe PR, Opmeer EM, Schoonenboom NSM, de Jong FJ, Ritchie CW, Scheltens P, Sikkes SAM.

Alzheimers Dement (Amst). 2017 Dec 27;10:153-160. doi: 10.1016/j.dadm.2017.12.002. eCollection 2018.


GWAS on family history of Alzheimer's disease.

Marioni RE, Harris SE, Zhang Q, McRae AF, Hagenaars SP, Hill WD, Davies G, Ritchie CW, Gale CR, Starr JM, Goate AM, Porteous DJ, Yang J, Evans KL, Deary IJ, Wray NR, Visscher PM.

Transl Psychiatry. 2018 May 18;8(1):99. doi: 10.1038/s41398-018-0150-6. Erratum in: Transl Psychiatry. 2019 Jun 6;9(1):161.


Peripheral Retinal Imaging Biomarkers for Alzheimer's Disease: A Pilot Study.

Csincsik L, MacGillivray TJ, Flynn E, Pellegrini E, Papanastasiou G, Barzegar-Befroei N, Csutak A, Bird AC, Ritchie CW, Peto T, Lengyel I.

Ophthalmic Res. 2018;59(4):182-192. doi: 10.1159/000487053. Epub 2018 Apr 5.


European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials.

Vermunt L, Veal CD, Ter Meulen L, Chrysostomou C, van der Flier W, Frisoni GB, Guessous I, Kivipelto M, Marizzoni M, Martinez-Lage P, Molinuevo JL, Porteous D, Ritchie K, Scheltens P, Ousset PJ, Ritchie CW, Luscan G, Brookes AJ, Visser PJ.

Alzheimers Dement. 2018 Jun;14(6):837-842. doi: 10.1016/j.jalz.2018.02.010. Epub 2018 Mar 28.


Systems Biology Methods for Alzheimer's Disease Research Toward Molecular Signatures, Subtypes, and Stages and Precision Medicine: Application in Cohort Studies and Trials.

Castrillo JI, Lista S, Hampel H, Ritchie CW.

Methods Mol Biol. 2018;1750:31-66. doi: 10.1007/978-1-4939-7704-8_3.


Quantifying the Diagnostic Pathway for Patients with Cognitive Impairment: Real-World Data from Seven European and North American Countries.

Ritchie CW, Black CM, Khandker RK, Wood R, Jones E, Hu X, Ambegaonkar BM.

J Alzheimers Dis. 2018;62(1):457-466. doi: 10.3233/JAD-170864.


Brexit, the junior doctor contract, and medical student intentions.

Borchert RJ, Le HBT, Ritchie CW.

Lancet Public Health. 2017 Jul;2(7):e306. doi: 10.1016/S2468-2667(17)30097-X. Epub 2017 May 24. No abstract available.


Evolution and future directions for the concept of mild cognitive impairment.

Saunders S, Ritchie K, Russ TC, Muniz-Terrera G, Ritchie CW.

Int Psychogeriatr. 2018 Oct;30(10):1431-1434. doi: 10.1017/S1041610217002812. Epub 2017 Dec 13.


Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease.

Stefaniak JD, Su L, Mak E, Sheikh-Bahaei N, Wells K, Ritchie K, Waldman A, Ritchie CW, O'Brien JT.

Alzheimers Dement. 2018 Feb;14(2):253-258. doi: 10.1016/j.jalz.2017.08.017. Epub 2017 Nov 21.


The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease.

Ritchie CW, Russ TC, Banerjee S, Barber B, Boaden A, Fox NC, Holmes C, Isaacs JD, Leroi I, Lovestone S, Norton M, O'Brien J, Pearson J, Perry R, Pickett J, Waldman AD, Wong WL, Rossor MN, Burns A.

Alzheimers Res Ther. 2017 Oct 26;9(1):85. doi: 10.1186/s13195-017-0312-4. Erratum in: Alzheimers Res Ther. 2018 Jul 30;10(1):73.


A composite measure of cognitive and functional progression in Alzheimer's disease: Design of the Capturing Changes in Cognition study.

Jutten RJ, Harrison J, de Jong FJ, Aleman A, Ritchie CW, Scheltens P, Sikkes SAM.

Alzheimers Dement (N Y). 2017 Feb 9;3(1):130-138. doi: 10.1016/j.trci.2017.01.004. eCollection 2017 Jan.


Big data and data repurposing - using existing data to answer new questions in vascular dementia research.

Doubal FN, Ali M, Batty GD, Charidimou A, Eriksdotter M, Hofmann-Apitius M, Kim YH, Levine DA, Mead G, Mucke HAM, Ritchie CW, Roberts CJ, Russ TC, Stewart R, Whiteley W, Quinn TJ.

BMC Neurol. 2017 Apr 17;17(1):72. doi: 10.1186/s12883-017-0841-2.


The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study.

Ritchie K, Carrière I, Su L, O'Brien JT, Lovestone S, Wells K, Ritchie CW.

Alzheimers Dement. 2017 Oct;13(10):1089-1097. doi: 10.1016/j.jalz.2017.02.008. Epub 2017 Mar 30.


Change in Health-related Quality of Life After Referral to Memory Assessment Services.

Park MH, Smith SC, Chrysanthaki T, Neuburger J, Ritchie CW, Hendriks AAJ, Black N.

Alzheimer Dis Assoc Disord. 2017 Jul-Sep;31(3):192-199. doi: 10.1097/WAD.0000000000000190.


Is the effectiveness of memory assessment services associated with their structural and process characteristics?

Park MH, Black N, Ritchie CW, Hendriks AAJ, Smith SC.

Int J Geriatr Psychiatry. 2018 Jan;33(1):75-84. doi: 10.1002/gps.4675. Epub 2017 Feb 7.


Alcohol and Alzheimer's Disease-Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer's Disease?

Venkataraman A, Kalk N, Sewell G, Ritchie CW, Lingford-Hughes A.

Alcohol Alcohol. 2017 Mar 9;52(2):151-158. doi: 10.1093/alcalc/agw092. Review. Erratum in: Alcohol Alcohol. 2017 Mar 9;52(2):158.


ABT-126 monotherapy in mild-to-moderate Alzheimer's dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension.

Gault LM, Lenz RA, Ritchie CW, Meier A, Othman AA, Tang Q, Berry S, Pritchett Y, Robieson WZ.

Alzheimers Res Ther. 2016 Oct 18;8(1):44.


Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project.

Ritchie K, Ropacki M, Albala B, Harrison J, Kaye J, Kramer J, Randolph C, Ritchie CW.

Alzheimers Dement. 2017 Feb;13(2):186-195. doi: 10.1016/j.jalz.2016.07.154. Epub 2016 Oct 1.


Detecting cognitive changes in preclinical Alzheimer's disease: A review of its feasibility.

Mortamais M, Ash JA, Harrison J, Kaye J, Kramer J, Randolph C, Pose C, Albala B, Ropacki M, Ritchie CW, Ritchie K.

Alzheimers Dement. 2017 Apr;13(4):468-492. doi: 10.1016/j.jalz.2016.06.2365. Epub 2016 Oct 1. Review.


A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer's disease and Parkinson's disease.

McGhee DJ, Ritchie CW, Zajicek JP, Counsell CE.

BMC Neurol. 2016 Jun 16;16:92. doi: 10.1186/s12883-016-0606-3. Review.


The clinical picture of Alzheimer's disease in the decade before diagnosis: clinical and biomarker trajectories.

Ritchie K, Carrière I, Berr C, Amieva H, Dartigues JF, Ancelin ML, Ritchie CW.

J Clin Psychiatry. 2016 Mar;77(3):e305-11. doi: 10.4088/JCP.15m09989.


Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project.

Ritchie CW, Molinuevo JL, Truyen L, Satlin A, Van der Geyten S, Lovestone S; European Prevention of Alzheimer's Dementia (EPAD) Consortium.

Lancet Psychiatry. 2016 Feb;3(2):179-86. doi: 10.1016/S2215-0366(15)00454-X. Epub 2015 Dec 10. Review.


Is late-onset Alzheimer's disease really a disease of midlife?

Ritchie K, Ritchie CW, Yaffe K, Skoog I, Scarmeas N.

Alzheimers Dement (N Y). 2015 Jul 26;1(2):122-130. doi: 10.1016/j.trci.2015.06.004. eCollection 2015 Sep. Review.


A phase 2 randomized, controlled trial of the α7 agonist ABT-126 in mild-to-moderate Alzheimer's dementia.

Gault LM, Ritchie CW, Robieson WZ, Pritchett Y, Othman AA, Lenz RA.

Alzheimers Dement (N Y). 2015 Jun 23;1(1):81-90. doi: 10.1016/j.trci.2015.06.001. eCollection 2015 Jun.


Dementia trials and dementia tribulations: methodological and analytical challenges in dementia research.

Ritchie CW, Terrera GM, Quinn TJ.

Alzheimers Res Ther. 2015 Mar 18;7(1):31. doi: 10.1186/s13195-015-0113-6. eCollection 2015.


Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative.

Noel-Storr AH, McCleery JM, Richard E, Ritchie CW, Flicker L, Cullum SJ, Davis D, Quinn TJ, Hyde C, Rutjes AW, Smailagic N, Marcus S, Black S, Blennow K, Brayne C, Fiorivanti M, Johnson JK, Köpke S, Schneider LS, Simmons A, Mattsson N, Zetterberg H, Bossuyt PM, Wilcock G, McShane R.

Neurology. 2014 Jul 22;83(4):364-73. doi: 10.1212/WNL.0000000000000621. Epub 2014 Jun 18.


Souvenaid®: a new approach to management of early Alzheimer's disease.

Ritchie CW, Bajwa J, Coleman G, Hope K, Jones RW, Lawton M, Marven M, Passmore P.

J Nutr Health Aging. 2014 Mar;18(3):291-9. doi: 10.1007/s12603-013-0411-2.


A systematic review of biomarkers for disease progression in Alzheimer's disease.

McGhee DJ, Ritchie CW, Thompson PA, Wright DE, Zajicek JP, Counsell CE.

PLoS One. 2014 Feb 18;9(2):e88854. doi: 10.1371/journal.pone.0088854. eCollection 2014. Review. Erratum in: PLoS One. 2014;9(5):e97960.


The association between C-reactive protein and delirium in 710 acute elderly hospital admissions.

Ritchie CW, Newman TH, Leurent B, Sampson EL.

Int Psychogeriatr. 2014 May;26(5):717-24. doi: 10.1017/S1041610213002433. Epub 2014 Jan 24.


The PREVENT research programme--a novel research programme to identify and manage midlife risk for dementia: the conceptual framework.

Ritchie CW, Wells K, Ritchie K.

Int Rev Psychiatry. 2013 Dec;25(6):748-54. doi: 10.3109/09540261.2013.869195. Review.


Prospective cohort studies in dementia.

Ames D, Ritchie CW.

Int Rev Psychiatry. 2013 Dec;25(6):647-9. doi: 10.3109/09540261.2013.872954. No abstract available.


Clinical Trials for Alzheimer's Disease Turned a Corner in 2013'.

Ritchie CW.

J Prev Alzheimers Dis. 2014;1(2):71-73. doi: 10.14283/jpad.2014.14. No abstract available.


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