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Items: 1 to 50 of 133

1.

Aging and drug discovery.

Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2018 Nov 13;10(11):3079-3088. doi: 10.18632/aging.101646.

2.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

Hirose M, Schilf P, Gupta Y, Zarse K, Künstner A, Fähnrich A, Busch H, Yin J, Wright MN, Ziegler A, Vallier M, Belheouane M, Baines JF, Tautz D, Johann K, Oelkrug R, Mittag J, Lehnert H, Othman A, Jöhren O, Schwaninger M, Prehn C, Adamski J, Shima K, Rupp J, Häsler R, Fuellen G, Köhling R, Ristow M, Ibrahim SM.

Sci Rep. 2018 Apr 12;8(1):5872. doi: 10.1038/s41598-018-24290-6.

3.

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.

Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M.

Cell Metab. 2018 Apr 3;27(4):914-925.e5. doi: 10.1016/j.cmet.2018.02.004. Epub 2018 Mar 15.

PMID:
29551589
4.

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.

Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C.

Nat Commun. 2018 Jan 30;9(1):327. doi: 10.1038/s41467-017-02395-2.

5.

Animal models of obesity and diabetes mellitus.

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.

Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Review.

PMID:
29348476
6.

Lipid and Carbohydrate Metabolism in Caenorhabditis elegans.

Watts JL, Ristow M.

Genetics. 2017 Oct;207(2):413-446. doi: 10.1534/genetics.117.300106. Review.

7.

Dietary Carbohydrates Impair Healthspan and Promote Mortality.

Ravichandran M, Grandl G, Ristow M.

Cell Metab. 2017 Oct 3;26(4):585-587. doi: 10.1016/j.cmet.2017.09.011.

8.

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Merry TL, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer AFH, Kahn CR, Ristow M, Zarse K.

Aging Cell. 2017 Aug;16(4):761-772. doi: 10.1111/acel.12610. Epub 2017 May 22.

9.

Non-linear impact of glutathione depletion on C. elegans life span and stress resistance.

Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO.

Redox Biol. 2017 Apr;11:502-515. doi: 10.1016/j.redox.2016.12.003. Epub 2016 Dec 6.

10.

Lifespan effects of mitochondrial mutations.

Hirose M, Schilf P, Gupta Y, Wright MN, Wright MN, Jöhren O, Wagner AE, Sina C, Ziegler A, Ristow M, Ibrahim SM.

Nature. 2016 Dec 14;540(7633):E13-E14. doi: 10.1038/nature20778. No abstract available.

PMID:
27974775
11.

Insulin-IGF signaling affects cell transformation in the BALB/c 3T3 cell model.

Poburski D, Leovsky C, Boerner JB, Szimmtenings L, Ristow M, Glei M, Thierbach R.

Sci Rep. 2016 Nov 16;6:37120. doi: 10.1038/srep37120.

12.

Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.

Tschöp MH, Stumvoll M, Ristow M.

Cell Metab. 2016 Jun 14;23(6):959-960. doi: 10.1016/j.cmet.2016.05.017.

13.

A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism.

Gebauer J, Gentsch C, Mansfeld J, Schmeißer K, Waschina S, Brandes S, Klimmasch L, Zamboni N, Zarse K, Schuster S, Ristow M, Schäuble S, Kaleta C.

Cell Syst. 2016 May 25;2(5):312-22. doi: 10.1016/j.cels.2016.04.017. Epub 2016 May 19.

14.

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.

Baumgart M, Priebe S, Groth M, Hartmann N, Menzel U, Pandolfini L, Koch P, Felder M, Ristow M, Englert C, Guthke R, Platzer M, Cellerino A.

Cell Syst. 2016 Feb 24;2(2):122-32. doi: 10.1016/j.cels.2016.01.014. Epub 2016 Feb 24.

15.

Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia.

Poburski D, Boerner JB, Koenig M, Ristow M, Thierbach R.

Biol Open. 2016 May 15;5(5):654-61. doi: 10.1242/bio.017004.

16.
17.

Ageing with elegans: a research proposal to map healthspan pathways.

Luyten W, Antal P, Braeckman BP, Bundy J, Cirulli F, Fang-Yen C, Fuellen G, Leroi A, Liu Q, Martorell P, Metspalu A, Perola M, Ristow M, Saul N, Schoofs L, Siems K, Temmerman L, Smets T, Wolk A, Rattan SI.

Biogerontology. 2016 Aug;17(4):771-82. doi: 10.1007/s10522-016-9644-x. Epub 2016 Apr 4.

PMID:
27040825
18.

MicroRNA-29a in Adult Muscle Stem Cells Controls Skeletal Muscle Regeneration During Injury and Exercise Downstream of Fibroblast Growth Factor-2.

Galimov A, Merry TL, Luca E, Rushing EJ, Mizbani A, Turcekova K, Hartung A, Croce CM, Ristow M, Krützfeldt J.

Stem Cells. 2016 Mar;34(3):768-80. doi: 10.1002/stem.2281. Epub 2016 Jan 29.

19.

Mitohormesis in exercise training.

Merry TL, Ristow M.

Free Radic Biol Med. 2016 Sep;98:123-130. doi: 10.1016/j.freeradbiomed.2015.11.032. Epub 2015 Nov 30. Review.

PMID:
26654757
20.

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?

Merry TL, Ristow M.

J Physiol. 2016 Sep 15;594(18):5135-47. doi: 10.1113/JP270654. Epub 2016 Jan 18. Review.

21.

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.

Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M.

Nat Commun. 2015 Dec 1;6:10043. doi: 10.1038/ncomms10043.

22.

A dental myth bites the dust--no observable relation between the incidence of dental abscess and the weather and lunar phase: an ecological study.

Ristow O, Koerdt S, Stelzner R, Stelzner M, Johannes C, Ristow M, Hohlweg-Majert B, Pautke C.

BMC Oral Health. 2015 Feb 11;15:21. doi: 10.1186/s12903-015-0001-2.

23.

A mitochondrially encoded hormone ameliorates obesity and insulin resistance.

Zarse K, Ristow M.

Cell Metab. 2015 Mar 3;21(3):355-6. doi: 10.1016/j.cmet.2015.02.013.

24.

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.

Boucher J, Charalambous M, Zarse K, Mori MA, Kleinridders A, Ristow M, Ferguson-Smith AC, Kahn CR.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14512-7. doi: 10.1073/pnas.1415475111. Epub 2014 Sep 22.

25.

Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits.

Ristow M.

Nat Med. 2014 Jul;20(7):709-11. doi: 10.1038/nm.3624. No abstract available.

PMID:
24999941
26.

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).

Ristow M, Schmeisser K.

Dose Response. 2014 Jan 31;12(2):288-341. doi: 10.2203/dose-response.13-035.Ristow. eCollection 2014 May.

27.

Gender-specific impact of personal health parameters on individual brain aging in cognitively unimpaired elderly subjects.

Franke K, Ristow M, Gaser C; Alzheimer's Disease Neuroimaging Initiative.

Front Aging Neurosci. 2014 May 23;6:94. doi: 10.3389/fnagi.2014.00094. eCollection 2014.

28.

D-Glucosamine supplementation extends life span of nematodes and of ageing mice.

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M.

Nat Commun. 2014 Apr 8;5:3563. doi: 10.1038/ncomms4563.

29.

Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.

Segref A, Kevei É, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T.

Cell Metab. 2014 Apr 1;19(4):642-52. doi: 10.1016/j.cmet.2014.01.016.

30.

Does regular zoledronic acid change the bone turnover of the jaw in men with metastatic prostate cancer: a possible clue to the pathogenesis of bisphosphonate related osteonecrosis of the jaw?

Ristow O, Gerngroß C, Schwaiger M, Hohlweg-Majert B, Ristow M, Koerdt S, Schuster R, Otto S, Pautke C.

J Cancer Res Clin Oncol. 2014 Mar;140(3):487-93. doi: 10.1007/s00432-014-1588-4. Epub 2014 Jan 28.

PMID:
24469255
31.

Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro.

Wallert M, Mosig S, Rennert K, Funke H, Ristow M, Pellegrino RM, Cruciani G, Galli F, Lorkowski S, Birringer M.

Free Radic Biol Med. 2014 Mar;68:43-51. doi: 10.1016/j.freeradbiomed.2013.11.009. Epub 2013 Dec 1.

PMID:
24296243
32.

Extension of life span by impaired glucose metabolism in Caenorhabditis elegans is accompanied by structural rearrangements of the transcriptomic network.

Priebe S, Menzel U, Zarse K, Groth M, Platzer M, Ristow M, Guthke R.

PLoS One. 2013 Oct 30;8(10):e77776. doi: 10.1371/journal.pone.0077776. eCollection 2013.

33.

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension.

Schmeisser S, Priebe S, Groth M, Monajembashi S, Hemmerich P, Guthke R, Platzer M, Ristow M.

Mol Metab. 2013 Feb 14;2(2):92-102. doi: 10.1016/j.molmet.2013.02.002. eCollection 2013.

34.

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.

Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.

Nat Chem Biol. 2013 Nov;9(11):693-700. doi: 10.1038/nchembio.1352. Epub 2013 Sep 29.

35.

A radical opposition in body weight control.

Ristow M, Wolfrum C.

EMBO Mol Med. 2013 Aug;5(8):1147-8. doi: 10.1002/emmm.201303094. No abstract available.

36.

Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner.

Brandstädt S, Schmeisser K, Zarse K, Ristow M.

Aging (Albany NY). 2013 Apr;5(4):270-5.

37.

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension.

Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M.

Aging Cell. 2013 Jun;12(3):508-17. doi: 10.1111/acel.12076. Epub 2013 May 6.

38.

Mitochondria and metabolic homeostasis.

Cheng Z, Ristow M.

Antioxid Redox Signal. 2013 Jul 20;19(3):240-2. doi: 10.1089/ars.2013.5255. Epub 2013 Mar 28.

PMID:
23432475
39.
40.

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.

Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M.

Cell Metab. 2012 Apr 4;15(4):451-65. doi: 10.1016/j.cmet.2012.02.013.

41.

L-Theanine extends lifespan of adult Caenorhabditis elegans.

Zarse K, Jabin S, Ristow M.

Eur J Nutr. 2012 Sep;51(6):765-8. doi: 10.1007/s00394-012-0341-5. Epub 2012 Mar 16.

42.

Interview with Michael Ristow.

Ristow M.

Aging (Albany NY). 2012 Jan;4(1):2.

43.

Antioxidant supplements in exercise: worse than useless?

Gomez-Cabrera MC, Ristow M, Viña J.

Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E476-7; author reply E478-9. doi: 10.1152/ajpendo.00567.2011. No abstract available.

44.

Specific alterations of carbohydrate metabolism are associated with hepatocarcinogenesis in mitochondrially impaired mice.

Thierbach R, Florian S, Wolfrum K, Voigt A, Drewes G, Blume U, Bannasch P, Ristow M, Steinberg P.

Hum Mol Genet. 2012 Feb 1;21(3):656-63. doi: 10.1093/hmg/ddr499. Epub 2011 Nov 3.

PMID:
22052287
45.

Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species.

Schmeisser S, Zarse K, Ristow M.

Horm Metab Res. 2011 Sep;43(10):687-92. doi: 10.1055/s-0031-1286308. Epub 2011 Sep 19.

PMID:
21932172
46.

In silico evidence for gluconeogenesis from fatty acids in humans.

Kaleta C, de Figueiredo LF, Werner S, Guthke R, Ristow M, Schuster S.

PLoS Comput Biol. 2011 Jul;7(7):e1002116. doi: 10.1371/journal.pcbi.1002116. Epub 2011 Jul 21.

47.

Genetic population structure, fitness variation and the importance of population history in remnant populations of the endangered plant Silene chlorantha (Willd.) Ehrh. (Caryophyllaceae).

Lauterbach D, Ristow M, Gemeinholzer B.

Plant Biol (Stuttg). 2011 Jul;13(4):667-777. doi: 10.1111/j.1438-8677.2010.00418.x. Epub 2011 Feb 10.

PMID:
21668608
48.

Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri.

Hartmann N, Reichwald K, Wittig I, Dröse S, Schmeisser S, Lück C, Hahn C, Graf M, Gausmann U, Terzibasi E, Cellerino A, Ristow M, Brandt U, Platzer M, Englert C.

Aging Cell. 2011 Oct;10(5):824-31. doi: 10.1111/j.1474-9726.2011.00723.x. Epub 2011 Jun 27.

49.

Extending life span by increasing oxidative stress.

Ristow M, Schmeisser S.

Free Radic Biol Med. 2011 Jul 15;51(2):327-36. doi: 10.1016/j.freeradbiomed.2011.05.010. Epub 2011 May 14. Review.

50.

Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.

Beuster G, Zarse K, Kaleta C, Thierbach R, Kiehntopf M, Steinberg P, Schuster S, Ristow M.

J Biol Chem. 2011 Jun 24;286(25):22323-30. doi: 10.1074/jbc.M110.205229. Epub 2011 May 3.

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