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Items: 50


Cancer-Associated Mutations but No Cancer: Insights into the Early Steps of Carcinogenesis and Implications for Early Cancer Detection.

Kennedy SR, Zhang Y, Risques RA.

Trends Cancer. 2019 Sep;5(9):531-540. doi: 10.1016/j.trecan.2019.07.007. Epub 2019 Aug 22. Review.


Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.

Salk JJ, Loubet-Senear K, Maritschnegg E, Valentine CC, Williams LN, Higgins JE, Horvat R, Vanderstichele A, Nachmanson D, Baker KT, Emond MJ, Loter E, Tretiakova M, Soussi T, Loeb LA, Zeillinger R, Speiser P, Risques RA.

Cell Rep. 2019 Jul 2;28(1):132-144.e3. doi: 10.1016/j.celrep.2019.05.109.


Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer.

Baker KT, Nachmanson D, Kumar S, Emond MJ, Ussakli C, Brentnall TA, Kennedy SR, Risques RA.

Mol Cancer Res. 2019 Feb;17(2):488-498. doi: 10.1158/1541-7786.MCR-18-0520. Epub 2018 Nov 16.


Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS).

Nachmanson D, Lian S, Schmidt EK, Hipp MJ, Baker KT, Zhang Y, Tretiakova M, Loubet-Senear K, Kohrn BF, Salk JJ, Kennedy SR, Risques RA.

Genome Res. 2018 Oct;28(10):1589-1599. doi: 10.1101/gr.235291.118. Epub 2018 Sep 19.


Seshat: A Web service for accurate annotation, validation, and analysis of TP53 variants generated by conventional and next-generation sequencing.

Tikkanen T, Leroy B, Fournier JL, Risques RA, Malcikova J, Soussi T.

Hum Mutat. 2018 Jul;39(7):925-933. doi: 10.1002/humu.23543. Epub 2018 May 17.


All's well that ends well: why large species have short telomeres.

Risques RA, Promislow DEL.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160448. doi: 10.1098/rstb.2016.0448.


Aging and the rise of somatic cancer-associated mutations in normal tissues.

Risques RA, Kennedy SR.

PLoS Genet. 2018 Jan 4;14(1):e1007108. doi: 10.1371/journal.pgen.1007108. eCollection 2018 Jan. Review.


Precancer in ulcerative colitis: the role of the field effect and its clinical implications.

Baker KT, Salk JJ, Brentnall TA, Risques RA.

Carcinogenesis. 2018 Jan 12;39(1):11-20. doi: 10.1093/carcin/bgx117. Review.


Magellanic penguin telomeres do not shorten with age with increased reproductive effort, investment, and basal corticosterone.

Cerchiara JA, Risques RA, Prunkard D, Smith JR, Kane OJ, Boersma PD.

Ecol Evol. 2017 Jun 15;7(15):5682-5691. doi: 10.1002/ece3.3128. eCollection 2017 Aug.


Telomeres shorten and then lengthen before fledging in Magellanic penguins (Spheniscus magellanicus).

Cerchiara JA, Risques RA, Prunkard D, Smith JR, Kane OJ, Boersma PD.

Aging (Albany NY). 2017 Feb 8;9(2):487-493. doi: 10.18632/aging.101172.


Werner syndrome through the lens of tissue and tumour genomics.

Tokita M, Kennedy SR, Risques RA, Chun SG, Pritchard C, Oshima J, Liu Y, Bryant-Greenwood PK, Welcsh P, Monnat RJ.

Sci Rep. 2016 Aug 25;6:32038. doi: 10.1038/srep32038.


Leukocyte telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinoma.

Wennerström EC, Risques RA, Prunkard D, Giffen C, Corley DA, Murray LJ, Whiteman DC, Wu AH, Bernstein L, Ye W, Chow WH, Vaughan TL, Liao LM.

Cancer Med. 2016 Sep;5(9):2657-65. doi: 10.1002/cam4.810. Epub 2016 Jul 6.


Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues.

Krimmel JD, Schmitt MW, Harrell MI, Agnew KJ, Kennedy SR, Emond MJ, Loeb LA, Swisher EM, Risques RA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6005-10. doi: 10.1073/pnas.1601311113. Epub 2016 May 5.


Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study.

Glei DA, Goldman N, Risques RA, Rehkopf DH, Dow WH, Rosero-Bixby L, Weinstein M.

PLoS One. 2016 Apr 6;11(4):e0152486. doi: 10.1371/journal.pone.0152486. eCollection 2016.


Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett's esophagus.

Hardikar S, Song X, Risques RA, Montine TJ, Duggan C, Blount PL, Reid BJ, Anderson GL, Kratz M, White E, Vaughan TL.

BMC Obes. 2015 Sep 10;2:32. doi: 10.1186/s40608-015-0063-3. eCollection 2015.


Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study.

Sanders AE, Divaris K, Naorungroj S, Heiss G, Risques RA.

J Clin Periodontol. 2015 Jan;42(1):12-20. doi: 10.1111/jcpe.12337. Epub 2014 Dec 26.


Shorter Ends, Faster End? Leukocyte Telomere Length and Mortality Among Older Taiwanese.

Glei DA, Goldman N, Weinstein M, Risques RA.

J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1490-8. doi: 10.1093/gerona/glu191. Epub 2014 Oct 17.


Detecting ultralow-frequency mutations by Duplex Sequencing.

Kennedy SR, Schmitt MW, Fox EJ, Kohrn BF, Salk JJ, Ahn EH, Prindle MJ, Kuong KJ, Shen JC, Risques RA, Loeb LA.

Nat Protoc. 2014 Nov;9(11):2586-606. doi: 10.1038/nprot.2014.170. Epub 2014 Oct 9. Erratum in: Nat Protoc. 2014 Dec;9(12):2903.



Risques RA, Ussakli C, Salk JJ, Rabinovitch PS, Brentnall TA.

J Natl Cancer Inst. 2014 Feb;106(2):djt437. doi: 10.1093/jnci/djt437. Epub 2014 Jan 8. No abstract available.


Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.

Salk JJ, Bansal A, Lai LA, Crispin DA, Ussakli CH, Horwitz MS, Bronner MP, Brentnall TA, Loeb LA, Rabinovitch PS, Risques RA.

Inflamm Bowel Dis. 2013 Nov;19(12):2593-602. doi: 10.1097/MIB.0b013e3182a87640.


Mitochondria and tumor progression in ulcerative colitis.

Ussakli CH, Ebaee A, Binkley J, Brentnall TA, Emond MJ, Rabinovitch PS, Risques RA.

J Natl Cancer Inst. 2013 Aug 21;105(16):1239-48. doi: 10.1093/jnci/djt167. Epub 2013 Jul 12.


DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.

Saha B, Zitnik G, Johnson S, Nguyen Q, Risques RA, Martin GM, Oshima J.

Front Genet. 2013 Jul 5;4:129. doi: 10.3389/fgene.2013.00129. eCollection 2013.


Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women.

Mason C, Risques RA, Xiao L, Duggan CR, Imayama I, Campbell KL, Kong A, Foster-Schubert KE, Wang CY, Alfano CM, Blackburn GL, Rabinovitch PS, McTiernan A.

Obesity (Silver Spring). 2013 Dec;21(12):E549-54. doi: 10.1002/oby.20509. Epub 2013 Jul 29.


Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer.

Lai LA, Risques RA, Bronner MP, Rabinovitch PS, Crispin D, Chen R, Brentnall TA.

Cancer Lett. 2012 Jul 28;320(2):180-8. doi: 10.1016/j.canlet.2012.02.031. Epub 2012 Mar 2.


Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

Risques RA, Lai LA, Himmetoglu C, Ebaee A, Li L, Feng Z, Bronner MP, Al-Lahham B, Kowdley KV, Lindor KD, Rabinovitch PS, Brentnall TA.

Cancer Res. 2011 Mar 1;71(5):1669-79. doi: 10.1158/0008-5472.CAN-10-1966.


Leukocyte telomere length is associated with disability in older u.s. Population.

Risques RA, Arbeev KG, Yashin AI, Ukraintseva SV, Martin GM, Rabinovitch PS, Oshima J.

J Am Geriatr Soc. 2010 Jul;58(7):1289-98. doi: 10.1111/j.1532-5415.2010.02948.x. Epub 2010 Jun 23.


Telomere length, pre-eclampsia, and gestational diabetes.

Harville EW, Williams MA, Qiu CF, Mejia J, Risques RA.

BMC Res Notes. 2010 Apr 23;3:113. doi: 10.1186/1756-0500-3-113.


Clonal expansions in ulcerative colitis identify patients with neoplasia.

Salk JJ, Salipante SJ, Risques RA, Crispin DA, Li L, Bronner MP, Brentnall TA, Rabinovitch PS, Horwitz MS, Loeb LA.

Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20871-6. doi: 10.1073/pnas.0909428106. Epub 2009 Nov 19.


Quantitative fluorescence in situ hybridization (QFISH) of telomere lengths in tissue and cells.

O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Rabinovitch PS.

Curr Protoc Cytom. 2005 Aug;Chapter 12:Unit 12.6. doi: 10.1002/0471142956.cy1206s33.


Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage.

Risques RA, Lai LA, Brentnall TA, Li L, Feng Z, Gallaher J, Mandelson MT, Potter JD, Bronner MP, Rabinovitch PS.

Gastroenterology. 2008 Aug;135(2):410-8. doi: 10.1053/j.gastro.2008.04.008. Epub 2008 Apr 15.


Assessment of gene expression in many samples using vertical arrays.

Risques RA, Rondeau G, Judex M, McClelland M, Welsh J.

Nucleic Acids Res. 2008 Jun;36(10):e60. doi: 10.1093/nar/gkn263. Epub 2008 May 12.


Leukocyte telomere length predicts cancer risk in Barrett's esophagus.

Risques RA, Vaughan TL, Li X, Odze RD, Blount PL, Ayub K, Gallaher JL, Reid BJ, Rabinovitch PS.

Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2649-55.


Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.

Huang S, Risques RA, Martin GM, Rabinovitch PS, Oshima J.

Exp Cell Res. 2008 Jan 1;314(1):82-91. Epub 2007 Aug 16.


Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers.

Rodriguez J, Frigola J, Vendrell E, Risques RA, Fraga MF, Morales C, Moreno V, Esteller M, Capellà G, Ribas M, Peinado MA.

Cancer Res. 2006 Sep 1;66(17):8462-9468.


Cancer surveillance in inflammatory bowel disease: new molecular approaches.

Risques RA, Rabinovitch PS, Brentnall TA.

Curr Opin Gastroenterol. 2006 Jul;22(4):382-90. Review.


Genetic clonal diversity predicts progression to esophageal adenocarcinoma.

Maley CC, Galipeau PC, Finley JC, Wongsurawat VJ, Li X, Sanchez CA, Paulson TG, Blount PL, Risques RA, Rabinovitch PS, Reid BJ.

Nat Genet. 2006 Apr;38(4):468-73. Epub 2006 Mar 26.


Telomere length in the colon declines with age: a relation to colorectal cancer?

O'Sullivan J, Risques RA, Mandelson MT, Chen L, Brentnall TA, Bronner MP, Macmillan MP, Feng Z, Siebert JR, Potter JD, Rabinovitch PS.

Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):573-7.


Genomic determinants of prognosis in colorectal cancer.

Vendrell E, Morales C, Risques RA, Capellà G, Peinado MA.

Cancer Lett. 2005 Apr 18;221(1):1-9. Review.


Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms.

O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Moskovitz AH, Gryaznov S, Harley CB, Rabinovitch PS.

Cytometry A. 2004 Apr;58(2):120-31.


Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer.

Risques RA, Moreno V, Ribas M, Marcuello E, Capellà G, Peinado MA.

Cancer Res. 2003 Nov 1;63(21):7206-14.


Common genetic evolutionary pathways in familial adenomatous polyposis tumors.

Tarafa G, Prat E, Risques RA, González S, Camps J, Grau M, Guinó E, Moreno V, Esteller M, Herman JG, Germà JR, Miró R, Peinado MA, Capellá G.

Cancer Res. 2003 Sep 15;63(18):5731-7.


Assessment of cumulated genetic alterations in colorectal cancer.

Risques RA, Ribas M, Peinado MA.

Histol Histopathol. 2003 Oct;18(4):1289-99. doi: 10.14670/HH-18.1289. Review.


Microarray analysis using RNA arbitrarily primed PCR.

Ringquist S, Rondeau G, Risques RA, Higashiyama T, Wang YP, Porwollik S, Boyle D, McClelland M, Welsh J.

Methods Mol Biol. 2003;226:245-54. No abstract available.


Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS).

Frigola J, Ribas M, Risques RA, Peinado MA.

Nucleic Acids Res. 2002 Apr 1;30(7):e28.


Redefining the significance of aneuploidy in the prognostic assessment of colorectal cancer.

Risques RA, Moreno V, Marcuello E, Petriz J, Cancelas JA, Sancho FJ, Torregrosa A, Capella G, Peinado MA.

Lab Invest. 2001 Mar;81(3):307-15.


K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.

Esteller M, González S, Risques RA, Marcuello E, Mangues R, Germà JR, Herman JG, Capellà G, Peinado MA.

J Clin Oncol. 2001 Jan 15;19(2):299-304.


Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: two mutational patterns and a locus associated with poorer survival.

Arribas R, Ribas M, Risques RA, Masramon L, Tórtola S, Marcuello E, Aiza G, Miró R, Capellà G, Peinado MA.

Clin Cancer Res. 1999 Nov;5(11):3454-9.


Overall deregulation in gene expression as a novel indicator of tumor aggressiveness in colorectal cancer.

Tórtola S, Marcuello E, Risques RA, González S, Aiza G, Capellà G, Peinado MA.

Oncogene. 1999 Jul 29;18(30):4383-7.


Tracking recurrent quantitative genomic alterations in colorectal cancer: allelic losses in chromosome 4 correlate with tumor aggressiveness.

Arribas R, Risques RA, Gonzalez-Garcia I, Masramon L, Aiza G, Ribas M, Capellà G, Peinado MA.

Lab Invest. 1999 Feb;79(2):111-22.


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