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Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner.

Kaul R, Risinger AL, Mooberry SL.

Br J Cancer. 2019 Sep 4. doi: 10.1038/s41416-019-0556-9. [Epub ahead of print]


Correction: Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130CAS/Src inhibition by eribulin.

Dybdal-Hargreaves NF, Risinger AL, Mooberry SL.

Oncotarget. 2019 Jul 23;10(45):4719-4720. doi: 10.18632/oncotarget.27100. eCollection 2019 Jul 23.


Fluorescence spectral shape analysis for nucleotide identification.

Huang Y, Li Z, Risinger AL, Enslow BT, Zeman CJ 4th, Gong J, Yang Y, Schanze KS.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15386-15391. doi: 10.1073/pnas.1820713116. Epub 2019 Jul 15.


Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype.

Grant CV, Carver CM, Hastings SD, Ramachandran K, Muniswamy M, Risinger AL, Beutler JA, Mooberry SL.

Breast Cancer Res Treat. 2019 Sep;177(2):345-355. doi: 10.1007/s10549-019-05324-7. Epub 2019 Jun 22.


Vortioxetine reverses medial prefrontal cortex-mediated cognitive deficits in male rats induced by castration as a model of androgen deprivation therapy for prostate cancer.

Sharp AM, Lertphinyowong S, Yee SS, Paredes D, Gelfond J, Johnson-Pais TL, Leach RJ, Liss M, Risinger AL, Sullivan AC, Thompson IM, Morilak DA.

Psychopharmacology (Berl). 2019 May 28. doi: 10.1007/s00213-019-05274-4. [Epub ahead of print]


Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF.

Int J Mol Sci. 2019 Mar 20;20(6). pii: E1392. doi: 10.3390/ijms20061392.


In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway.

Carter AC, Petersen CL, Wendt KL, Helff SK, Risinger AL, Mooberry SL, Cichewicz RH.

J Nat Prod. 2019 Apr 26;82(4):886-894. doi: 10.1021/acs.jnatprod.8b00974. Epub 2019 Mar 13.


Microtubule-Targeting Drugs: More than Antimitotics.

Kaul R, Risinger AL, Mooberry SL.

J Nat Prod. 2019 Mar 22;82(3):680-685. doi: 10.1021/acs.jnatprod.9b00105. Epub 2019 Mar 5.


Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.

Cai S, Risinger AL, Petersen CL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH.

J Nat Prod. 2019 Apr 26;82(4):928-936. doi: 10.1021/acs.jnatprod.8b01015. Epub 2019 Mar 4.


Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers.

Du L, Risinger AL, Yee SS, Ola ARB, Zammiello CL, Cichewicz RH, Mooberry SL.

J Nat Prod. 2019 Mar 22;82(3):583-588. doi: 10.1021/acs.jnatprod.8b01036. Epub 2019 Feb 25.


Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.

Pavana RK, Shah K, Gentile T, Dybdal-Hargreaves NF, Risinger AL, Mooberry SL, Hamel E, Gangjee A.

Bioorg Med Chem. 2018 Nov 1;26(20):5470-5478. doi: 10.1016/j.bmc.2018.09.025. Epub 2018 Sep 21.


Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin.

Dybdal-Hargreaves NF, Risinger AL, Mooberry SL.

Oncotarget. 2017 Dec 31;9(5):5545-5561. doi: 10.18632/oncotarget.23798. eCollection 2018 Jan 19. Erratum in: Oncotarget. 2019 Jul 23;10(45):4719-4720.


Taccalonolide Microtubule Stabilizers Generated Using Semisynthesis Define the Effects of Mono Acyloxy Moieties at C-7 or C-15 and Disubstitutions at C-7 and C-25.

Ola ARB, Risinger AL, Du L, Zammiello CL, Peng J, Cichewicz RH, Mooberry SL.

J Nat Prod. 2018 Mar 23;81(3):579-593. doi: 10.1021/acs.jnatprod.7b00967. Epub 2018 Jan 23.


Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy.

LoCoco PM, Risinger AL, Smith HR, Chavera TS, Berg KA, Clarke WP.

Elife. 2017 Nov 10;6. pii: e29626. doi: 10.7554/eLife.29626.


Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.

Du L, Risinger AL, Mitchell CA, You J, Stamps BW, Pan N, King JB, Bopassa JC, Judge SIV, Yang Z, Stevenson BS, Cichewicz RH.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8957-E8966. doi: 10.1073/pnas.1707565114. Epub 2017 Oct 10.


A Stereocontrolled Annulation of the Taccalonolide Epoxy Lactone onto the Molecular Framework of trans-Androsterone.

Danielsson J, Sun DX, Chen XY, Risinger AL, Mooberry SL, Sorensen EJ.

Org Lett. 2017 Sep 15;19(18):4892-4895. doi: 10.1021/acs.orglett.7b02349. Epub 2017 Aug 29.


Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.

Risinger AL, Li J, Du L, Benavides R, Robles AJ, Cichewicz RH, Kuhn JG, Mooberry SL.

J Nat Prod. 2017 Feb 24;80(2):409-414. doi: 10.1021/acs.jnatprod.6b00944. Epub 2017 Jan 23.


Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.

Rohena CC, Risinger AL, Devambatla RK, Dybdal-Hargreaves NF, Kaul R, Choudhary S, Gangjee A, Mooberry SL.

Molecules. 2016 Dec 2;21(12). pii: E1661.


Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species.

Mourshid SS, Badr JM, Risinger AL, Mooberry SL, Youssef DT.

Z Naturforsch C. 2016 Nov 1;71(11-12):387-392. doi: 10.1515/znc-2015-0242.


Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.

Mino RE, Rogers SL, Risinger AL, Rohena C, Banerjee S, Bhat MA.

J Cell Sci. 2016 Sep 1;129(17):3282-94. doi: 10.1242/jcs.187294. Epub 2016 Jul 15.


Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.

Cai S, Risinger AL, Nair S, Peng J, Anderson TJ, Du L, Powell DR, Mooberry SL, Cichewicz RH.

J Nat Prod. 2016 Mar 25;79(3):490-8. doi: 10.1021/acs.jnatprod.5b00874. Epub 2015 Dec 21.


Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.

Rohena CC, Telang NS, Da C, Risinger AL, Sikorski JA, Kellogg GE, Gupton JT, Mooberry SL.

Mol Pharmacol. 2016 Feb;89(2):287-96. doi: 10.1124/mol.115.101592. Epub 2015 Dec 11. Erratum in: Mol Pharmacol. 2016 Sep;90(3):411-2.


Prevalence of overweight/obesity and fitness level in preschool children from the north compared with the south of Europe: an exploration with two countries.

Cadenas-Sanchez C, Nyström C, Sanchez-Delgado G, Martinez-Tellez B, Mora-Gonzalez J, Risinger AS, Ruiz JR, Ortega FB, Löf M.

Pediatr Obes. 2016 Oct;11(5):403-10. doi: 10.1111/ijpo.12079. Epub 2015 Nov 9.


Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time.

Risinger AL, Dybdal-Hargreaves NF, Mooberry SL.

Anticancer Res. 2015 Nov;35(11):5845-50.


α- and β-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.

Lee B, Bohmann J, Reeves T, Levenson C, Risinger AL.

J Nat Prod. 2015 Jun 26;78(6):1357-62. doi: 10.1021/acs.jnatprod.5b00207. Epub 2015 May 20.


Eribulin mesylate: mechanism of action of a unique microtubule-targeting agent.

Dybdal-Hargreaves NF, Risinger AL, Mooberry SL.

Clin Cancer Res. 2015 Jun 1;21(11):2445-52. doi: 10.1158/1078-0432.CCR-14-3252. Epub 2015 Apr 2. Review.


2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens.

Youssef DT, Shaala LA, Mohamed GA, Ibrahim SR, Banjar ZM, Badr JM, McPhail KL, Risinger AL, Mooberry SL.

Nat Prod Res. 2015;29(8):703-9. doi: 10.1080/14786419.2014.982647. Epub 2014 Nov 25.


Didemnaketals f and g, new bioactive spiroketals from a red sea ascidian didemnum species.

Shaala LA, Youssef DT, Ibrahim SR, Mohamed GA, Badr JM, Risinger AL, Mooberry SL.

Mar Drugs. 2014 Sep 25;12(9):5021-34. doi: 10.3390/md12095021.


A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.

Du L, Risinger AL, King JB, Powell DR, Cichewicz RH.

J Nat Prod. 2014 Jul 25;77(7):1753-7. doi: 10.1021/np500387h. Epub 2014 Jul 7.


Synthetic reactions with rare taccalonolides reveal the value of C-22,23 epoxidation for microtubule stabilizing potency.

Peng J, Risinger AL, Li J, Mooberry SL.

J Med Chem. 2014 Jul 24;57(14):6141-9. doi: 10.1021/jm500619j. Epub 2014 Jul 2.


The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation.

Risinger AL, Riffle SM, Lopus M, Jordan MA, Wilson L, Mooberry SL.

Mol Cancer. 2014 Feb 28;13:41. doi: 10.1186/1476-4598-13-41.


Taccalonolide microtubule stabilizers.

Li J, Risinger AL, Mooberry SL.

Bioorg Med Chem. 2014 Sep 15;22(18):5091-6. doi: 10.1016/j.bmc.2014.01.012. Epub 2014 Jan 15. Review.


Structure-activity relationships of retro-dihydrochalcones isolated from Tacca sp.

Peng J, Risinger AL, Da C, Fest GA, Kellogg GE, Mooberry SL.

J Nat Prod. 2013 Dec 27;76(12):2189-94. doi: 10.1021/np4005085. Epub 2013 Dec 4.


The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions.

Risinger AL, Peng J, Rohena CC, Aguilar HR, Frantz DE, Mooberry SL.

J Nat Prod. 2013 Oct 25;76(10):1923-9. doi: 10.1021/np4005079. Epub 2013 Oct 2.


Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.

Risinger AL, Li J, Bennett MJ, Rohena CC, Peng J, Schriemer DC, Mooberry SL.

Cancer Res. 2013 Nov 15;73(22):6780-92. doi: 10.1158/0008-5472.CAN-13-1346. Epub 2013 Sep 18.


Hydrolysis reactions of the taccalonolides reveal structure-activity relationships.

Li J, Peng J, Risinger AL, Mooberry SL.

J Nat Prod. 2013 Jul 26;76(7):1369-75. doi: 10.1021/np400435t. Epub 2013 Jul 15.


Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers.

Li J, Risinger AL, Peng J, Chen Z, Hu L, Mooberry SL.

J Am Chem Soc. 2011 Nov 30;133(47):19064-7. doi: 10.1021/ja209045k. Epub 2011 Nov 8.


Identification and biological activities of new taccalonolide microtubule stabilizers.

Peng J, Risinger AL, Fest GA, Jackson EM, Helms G, Polin LA, Mooberry SL.

J Med Chem. 2011 Sep 8;54(17):6117-24. doi: 10.1021/jm200757g. Epub 2011 Aug 11.


Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel.

Risinger AL, Mooberry SL.

Cell Cycle. 2011 Jul 1;10(13):2162-71. Epub 2011 Jul 1.


The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability.

Risinger AL, Natarajan M, Thomas CR Jr, Mooberry SL.

Cancer Lett. 2011 Aug 1;307(1):104-111. doi: 10.1016/j.canlet.2011.03.022. Epub 2011 Apr 19.


ELR510444, a novel microtubule disruptor with multiple mechanisms of action.

Risinger AL, Westbrook CD, Encinas A, Mülbaier M, Schultes CM, Wawro S, Lewis JD, Janssen B, Giles FJ, Mooberry SL.

J Pharmacol Exp Ther. 2011 Mar;336(3):652-60. doi: 10.1124/jpet.110.175331. Epub 2010 Dec 9.


Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.

Gangjee A, Zhao Y, Lin L, Raghavan S, Roberts EG, Risinger AL, Hamel E, Mooberry SL.

J Med Chem. 2010 Nov 25;53(22):8116-28. doi: 10.1021/jm101010n. Epub 2010 Oct 25. Erratum in: J Med Chem. 2011 Feb 10;54(3):913.


Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.

Peng J, Jackson EM, Babinski DJ, Risinger AL, Helms G, Frantz DE, Mooberry SL.

J Nat Prod. 2010 Sep 24;73(9):1590-2. doi: 10.1021/np100350s.


Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.

Lee L, Robb LM, Lee M, Davis R, Mackay H, Chavda S, Babu B, O'Brien EL, Risinger AL, Mooberry SL, Lee M.

J Med Chem. 2010 Jan 14;53(1):325-34. doi: 10.1021/jm901268n.


Taccalonolides: Novel microtubule stabilizers with clinical potential.

Risinger AL, Mooberry SL.

Cancer Lett. 2010 May 1;291(1):14-9. doi: 10.1016/j.canlet.2009.09.020. Epub 2009 Oct 31. Review.


Microtubule dynamics as a target in oncology.

Risinger AL, Giles FJ, Mooberry SL.

Cancer Treat Rev. 2009 May;35(3):255-61. doi: 10.1016/j.ctrv.2008.11.001. Epub 2008 Dec 30. Review.


The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms.

Risinger AL, Jackson EM, Polin LA, Helms GL, LeBoeuf DA, Joe PA, Hopper-Borge E, Ludueña RF, Kruh GD, Mooberry SL.

Cancer Res. 2008 Nov 1;68(21):8881-8. doi: 10.1158/0008-5472.CAN-08-2037.


Different ubiquitin signals act at the Golgi and plasma membrane to direct GAP1 trafficking.

Risinger AL, Kaiser CA.

Mol Biol Cell. 2008 Jul;19(7):2962-72. doi: 10.1091/mbc.E07-06-0627. Epub 2008 Apr 23.


Activity-dependent reversible inactivation of the general amino acid permease.

Risinger AL, Cain NE, Chen EJ, Kaiser CA.

Mol Biol Cell. 2006 Oct;17(10):4411-9. Epub 2006 Aug 2.


Mapping chromatin structure in vivo using DNA methyltransferases.

Jessen WJ, Dhasarathy A, Hoose SA, Carvin CD, Risinger AL, Kladde MP.

Methods. 2004 May;33(1):68-80.


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