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Items: 1 to 50 of 58


Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts.

Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM.

J Physiol. 2019 Aug;597(15):3867-3883. doi: 10.1113/JP278016. Epub 2019 Jul 11.


Antiarrhythmic mechanisms of beta blocker therapy.

Grandi E, Ripplinger CM.

Pharmacol Res. 2019 Aug;146:104274. doi: 10.1016/j.phrs.2019.104274. Epub 2019 May 14. Review.


Putting the pieces together using in vivo optical mapping.

Wang L, Ripplinger CM.

Cardiovasc Res. 2019 Sep 1;115(11):1574-1575. doi: 10.1093/cvr/cvz089. No abstract available.


Exposure to Secondhand Smoke and Arrhythmogenic Cardiac Alternans in a Mouse Model.

Wang Z, Wang L, Tapa S, Pinkerton KE, Chen CY, Ripplinger CM.

Environ Health Perspect. 2018 Dec;126(12):127001. doi: 10.1289/EHP3664.


Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality.

Lindsey ML, Jung M, Yabluchanskiy A, Cannon PL, Iyer RP, Flynn ER, DeLeon-Pennell KY, Valerio FM, Harrison CL, Ripplinger CM, Hall ME, Ma Y.

Cardiovasc Res. 2019 Feb 1;115(2):395-408. doi: 10.1093/cvr/cvy211.


The best thing since sliced bread? Optical mapping of transverse cardiac slices in the mouse heart.

Ripplinger CM.

J Physiol. 2018 Sep;596(17):3825-3826. doi: 10.1113/JP276669. Epub 2018 Jul 21. No abstract available.


Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation.

Francis Stuart SD, Wang L, Woodard WR, Ng GA, Habecker BA, Ripplinger CM.

J Physiol. 2018 Sep;596(17):3977-3991. doi: 10.1113/JP276396. Epub 2018 Aug 3.


Guidelines for experimental models of myocardial ischemia and infarction.

Lindsey ML, Bolli R, Canty JM Jr, Du XJ, Frangogiannis NG, Frantz S, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Ping P, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G.

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H812-H838. doi: 10.1152/ajpheart.00335.2017. Epub 2018 Jan 12.


Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility.

Parrish DC, Francis Stuart SD, Olivas A, Wang L, Nykjaer A, Ripplinger CM, Habecker BA.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H415-H423. doi: 10.1152/ajpheart.00300.2017. Epub 2017 Nov 3.


Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart.

Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM.

Circ Res. 2017 Dec 8;121(12):1379-1391. doi: 10.1161/CIRCRESAHA.117.312050. Epub 2017 Oct 2.


β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia.

Murphy SR, Wang L, Wang Z, Domondon P, Lang D, Habecker BA, Myles RC, Ripplinger CM.

Front Physiol. 2017 Aug 28;8:630. doi: 10.3389/fphys.2017.00630. eCollection 2017.


From drugs to devices and back again: chemical vagal nerve stimulation for the treatment of heart failure.

Ripplinger CM.

Cardiovasc Res. 2017 Sep 1;113(11):1270-1272. doi: 10.1093/cvr/cvx142. No abstract available.


Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H221-H223. doi: 10.1152/ajpheart.00329.2017. Epub 2017 Jun 16. No abstract available.


Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction.

De Jesus NM, Wang L, Lai J, Rigor RR, Francis Stuart SD, Bers DM, Lindsey ML, Ripplinger CM.

Heart Rhythm. 2017 May;14(5):727-736. doi: 10.1016/j.hrthm.2017.01.027. Epub 2017 Jan 19.


Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.

Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM.

J Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. Epub 2017 Jan 5. Review.


Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation.

Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N.

Circ Arrhythm Electrophysiol. 2016 May;9(5). pii: e003721. doi: 10.1161/CIRCEP.115.003721.


Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease.

Habecker BA, Anderson ME, Birren SJ, Fukuda K, Herring N, Hoover DB, Kanazawa H, Paterson DJ, Ripplinger CM.

J Physiol. 2016 Jul 15;594(14):3853-75. doi: 10.1113/JP271840. Epub 2016 Jun 17. Review.


Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias.

Gardner RT, Ripplinger CM, Myles RC, Habecker BA.

Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e001359. doi: 10.1161/CIRCEP.115.001359. Review. No abstract available.


The nervous heart.

Ripplinger CM, Noujaim SF, Linz D.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):199-209. doi: 10.1016/j.pbiomolbio.2015.12.015. Epub 2016 Jan 11. Review.


Recent developments in biophysics & molecular biology of heart rhythm.

Quinn TA, Ripplinger CM.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):1-2. doi: 10.1016/j.pbiomolbio.2016.01.006. Epub 2016 Jan 8. No abstract available.


Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130.

Olivas A, Gardner RT, Wang L, Ripplinger CM, Woodward WR, Habecker BA.

J Neurosci. 2016 Jan 13;36(2):479-88. doi: 10.1523/JNEUROSCI.3556-15.2016.


The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction.

Francis Stuart SD, De Jesus NM, Lindsey ML, Ripplinger CM.

J Mol Cell Cardiol. 2016 Feb;91:114-22. doi: 10.1016/j.yjmcc.2015.12.024. Epub 2015 Dec 29. Review.


Ion Channels in the Heart.

Bartos DC, Grandi E, Ripplinger CM.

Compr Physiol. 2015 Jul 1;5(3):1423-64. doi: 10.1002/cphy.c140069. Review.


Dual Vm/Ca imaging of premature ventricular contractions: bridging the gap of anatomical scales.

Ripplinger CM, Efimov IR.

Circ Arrhythm Electrophysiol. 2015 Jun;8(3):529-30. doi: 10.1161/CIRCEP.115.002916. No abstract available.


Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation.

Hammer KP, Ljubojevic S, Ripplinger CM, Pieske BM, Bers DM.

J Mol Cell Cardiol. 2015 Jul;84:1-9. doi: 10.1016/j.yjmcc.2015.03.012. Epub 2015 Mar 28.


Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart.

Myles RC, Wang L, Bers DM, Ripplinger CM.

J Physiol. 2015 Mar 15;593(6):1479-93. doi: 10.1113/jphysiol.2014.279638. Epub 2014 Oct 7.


A leap(frog) forward in understanding focal arrhythmia.

Ripplinger CM.

J Physiol. 2015 Mar 15;593(6):1383-4. doi: 10.1113/jphysiol.2014.287128. No abstract available.


Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias.

Gardner RT, Wang L, Lang BT, Cregg JM, Dunbar CL, Woodward WR, Silver J, Ripplinger CM, Habecker BA.

Nat Commun. 2015 Feb 2;6:6235. doi: 10.1038/ncomms7235.


Mouse models of cardiac conduction system markers: revealing the past, present, and future of pacemaking and conduction.

Ripplinger CM.

Trends Cardiovasc Med. 2015 Jan;25(1):10-1. doi: 10.1016/j.tcm.2014.09.007. Epub 2014 Nov 6. No abstract available.


Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation.

De Jesus NM, Wang L, Herren AW, Wang J, Shenasa F, Bers DM, Lindsey ML, Ripplinger CM.

Heart Rhythm. 2015 Jan;12(1):169-78. doi: 10.1016/j.hrthm.2014.10.007. Epub 2014 Oct 7.


In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis.

Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA.

Osteoarthritis Cartilage. 2014 Oct;22(10):1461-9. doi: 10.1016/j.joca.2014.07.011.


P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9.

DeLeon-Pennell KY, de Castro Brás LE, Iyer RP, Bratton DR, Jin YF, Ripplinger CM, Lindsey ML.

J Mol Cell Cardiol. 2014 Nov;76:218-26. doi: 10.1016/j.yjmcc.2014.09.007. Epub 2014 Sep 18.


Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation.

Wang L, Myles RC, De Jesus NM, Ohlendorf AK, Bers DM, Ripplinger CM.

Circ Res. 2014 Apr 25;114(9):1410-21. doi: 10.1161/CIRCRESAHA.114.302505. Epub 2014 Feb 25.


Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes.

Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK.

Stem Cell Reports. 2013 Nov 7;1(5):387-96. doi: 10.1016/j.stemcr.2013.10.004. eCollection 2013.


Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.

Erickson JR, Pereira L, Wang L, Han G, Ferguson A, Dao K, Copeland RJ, Despa F, Hart GW, Ripplinger CM, Bers DM.

Nature. 2013 Oct 17;502(7471):372-6. doi: 10.1038/nature12537. Epub 2013 Sep 29.


Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging.

Ripplinger CM, Kessinger CW, Li C, Kim JW, McCarthy JR, Weissleder R, Henke PK, Lin CP, Jaffer FA.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2616-24. doi: 10.1161/ATVBAHA.112.251983. Epub 2012 Sep 20.


A tissue-engineered jellyfish with biomimetic propulsion.

Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK.

Nat Biotechnol. 2012 Aug;30(8):792-7.


Contractile and electrophysiologic characterization of optimized self-organizing engineered heart tissue.

Sondergaard CS, Mathews G, Wang L, Jeffreys A, Sahota A, Wood M, Ripplinger CM, Si MS.

Ann Thorac Surg. 2012 Oct;94(4):1241-8; discussion 1249. doi: 10.1016/j.athoracsur.2012.04.098. Epub 2012 Jul 12.


Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture.

Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK.

Biomaterials. 2012 Aug;33(23):5732-41. doi: 10.1016/j.biomaterials.2012.04.043. Epub 2012 May 15.


Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia.

Myles RC, Wang L, Kang C, Bers DM, Ripplinger CM.

Circ Res. 2012 May 25;110(11):1454-64. doi: 10.1161/CIRCRESAHA.111.262345. Epub 2012 Apr 26.


Human biological pacemakers: intrinsic variability and stability.

Ripplinger CM, Bers DM.

Circulation. 2012 Feb 21;125(7):856-8. doi: 10.1161/CIRCULATIONAHA.111.086827. Epub 2012 Jan 18. No abstract available.


A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms.

Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE.

Sci Transl Med. 2011 Aug 31;3(98):98ra83. doi: 10.1126/scitranslmed.3002588.


Termination of sustained atrial flutter and fibrillation using low-voltage multiple-shock therapy.

Ambrosi CM, Ripplinger CM, Efimov IR, Fedorov VV.

Heart Rhythm. 2011 Jan;8(1):101-8. doi: 10.1016/j.hrthm.2010.10.018. Epub 2010 Oct 19.


Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction.

Li W, Ripplinger CM, Lou Q, Efimov IR.

Heart Rhythm. 2009 Jul;6(7):1020-7. doi: 10.1016/j.hrthm.2009.03.015. Epub 2009 Mar 11.


Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms.

Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ.

Circulation. 2009 Mar 17;119(10):1398-407. doi: 10.1161/CIRCULATIONAHA.108.790501. Epub 2009 Mar 2.


Bimodal biophotonic imaging of the structure-function relationship in cardiac tissue.

Hucker WJ, Ripplinger CM, Fleming CP, Fedorov VV, Rollins AM, Efimov IR.

J Biomed Opt. 2008 Sep-Oct;13(5):054012. doi: 10.1117/1.2975826.


Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: implications for low-voltage cardioversion.

Ripplinger CM, Lou Q, Li W, Hadley J, Efimov IR.

Heart Rhythm. 2009 Jan;6(1):87-97. doi: 10.1016/j.hrthm.2008.09.019. Epub 2008 Sep 23.


Quantitative panoramic imaging of epicardial electrical activity.

Lou Q, Ripplinger CM, Bayly PV, Efimov IR.

Ann Biomed Eng. 2008 Oct;36(10):1649-58. doi: 10.1007/s10439-008-9539-3. Epub 2008 Jul 25.


Quantification of cardiac fiber orientation using optical coherence tomography.

Fleming CP, Ripplinger CM, Webb B, Efimov IR, Rollins AM.

J Biomed Opt. 2008 May-Jun;13(3):030505. doi: 10.1117/1.2937470.

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