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Items: 29

1.

In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF-00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor.

Ripp SL, Mukherjee A, Eng H, Stock T, Fleishaker D, Checchio T, Tammara B.

Clin Pharmacol Drug Dev. 2018 Mar;7(3):244-255. doi: 10.1002/cpdd.411. Epub 2017 Nov 7.

2.

Effect of moxidectin on CYP3A4 activity as evaluated by oral midazolam pharmacokinetics in healthy subjects.

Korth-Bradley JM, Parks V, Wagner F, Chalon S, Gourley I, Matschke K, Gossart S, Ripp SL, Fleckenstein L.

Clin Pharmacol Drug Dev. 2014 Mar;3(2):151-7. doi: 10.1002/cpdd.81. Epub 2013 Oct 22.

PMID:
27128460
3.

DHEA metabolites activate estrogen receptors alpha and beta.

Miller KK, Al-Rayyan N, Ivanova MM, Mattingly KA, Ripp SL, Klinge CM, Prough RA.

Steroids. 2013 Jan;78(1):15-25. doi: 10.1016/j.steroids.2012.10.002. Epub 2012 Nov 2.

4.

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

Orr ST, Ripp SL, Ballard TE, Henderson JL, Scott DO, Obach RS, Sun H, Kalgutkar AS.

J Med Chem. 2012 Jun 14;55(11):4896-933. doi: 10.1021/jm300065h. Epub 2012 Mar 27. Review. No abstract available.

PMID:
22409598
5.

Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: a combination study design in support of a Paediatric Investigation Plan.

Cross DM, Chmielewski G, Lewis EM, Liu L, Modesitt MS, Ripp SL, Sawaryn CM, Bowman CJ.

Regul Toxicol Pharmacol. 2012 Jun;63(1):29-39. doi: 10.1016/j.yrtph.2012.02.004. Epub 2012 Feb 16.

PMID:
22343256
6.

Tissue distribution of anidulafungin in neonatal rats.

Ripp SL, Aram JA, Bowman CJ, Chmielewski G, Conte U, Cross DM, Gao H, Lewis EM, Lin J, Liu P, Schlamm HT.

Birth Defects Res B Dev Reprod Toxicol. 2012 Feb;95(1):89-94. doi: 10.1002/bdrb.20347. Epub 2012 Feb 6.

PMID:
22311649
7.

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.

Sharma R, Strelevitz TJ, Gao H, Clark AJ, Schildknegt K, Obach RS, Ripp SL, Spracklin DK, Tremaine LM, Vaz AD.

Drug Metab Dispos. 2012 Mar;40(3):625-34. doi: 10.1124/dmd.111.042770. Epub 2011 Dec 21.

PMID:
22190693
8.

Evaluation of models for predicting drug-drug interactions due to induction.

Fahmi OA, Ripp SL.

Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1399-416. doi: 10.1517/17425255.2010.516251. Review.

PMID:
20955108
9.

Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.

Antipas AS, Blumberg LC, Brissette WH, Brown MF, Casavant JM, Doty JL, Driscoll J, Harris TM, Jones CS, McCurdy SP, McElroy E, Mitton-Fry M, Munchhof MJ, Reim DA, Reiter LA, Ripp SL, Shavnya A, Smeets MI, Trevena KA.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4069-72. doi: 10.1016/j.bmcl.2010.05.087. Epub 2010 May 26.

PMID:
20558059
10.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Magee TV, Ripp SL, Li B, Buzon RA, Chupak L, Dougherty TJ, Finegan SM, Girard D, Hagen AE, Falcone MJ, Farley KA, Granskog K, Hardink JR, Huband MD, Kamicker BJ, Kaneko T, Knickerbocker MJ, Liras JL, Marra A, Medina I, Nguyen TT, Noe MC, Obach RS, O'Donnell JP, Penzien JB, Reilly UD, Schafer JR, Shen Y, Stone GG, Strelevitz TJ, Sun J, Tait-Kamradt A, Vaz AD, Whipple DA, Widlicka DW, Wishka DG, Wolkowski JP, Flanagan ME.

J Med Chem. 2009 Dec 10;52(23):7446-57. doi: 10.1021/jm900729s.

PMID:
19775168
11.

The identification of orally bioavailable thrombopoietin agonists.

Munchhof MJ, Antipas AS, Blumberg LC, Brissette WH, Brown MF, Casavant JM, Doty JL, Driscoll J, Harris TM, Wolf-Gouveia LA, Jones CS, Li Q, Linde RG, Lira PD, Marfat A, McElroy E, Mitton-Fry M, McCurdy SP, Reiter LA, Ripp SL, Shavnya A, Thomasco LM, Trevena KA.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1428-30. doi: 10.1016/j.bmcl.2009.01.032. Epub 2009 Jan 15.

PMID:
19186055
12.
13.

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL.

Chem Res Toxicol. 2007 Dec;20(12):1954-65. Epub 2007 Oct 13.

PMID:
17935300
14.

Pyrimidine benzamide-based thrombopoietin receptor agonists.

Reiter LA, Subramanyam C, Mangual EJ, Jones CS, Smeets MI, Brissette WH, McCurdy SP, Lira PD, Linde RG, Li Q, Zhang F, Antipas AS, Blumberg LC, Doty JL, Driscoll JP, Munchhof MJ, Ripp SL, Shavnya A, Shepard RM, Sperger D, Thomasco LM, Trevena KA, Wolf-Gouveia LA, Zhang L.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5447-54. Epub 2007 Jul 31.

PMID:
17707640
15.

The time to move cytochrome p450 induction into mainstream pharmacology is long overdue.

Smith DA, Dickins M, Fahmi OA, Iwasaki K, Lee C, Obach RS, Padbury G, De Morais SM, Ripp SL, Stevens J, Voorman R, Youdim K.

Drug Metab Dispos. 2007 Apr;35(4):697-8. No abstract available.

PMID:
17384203
16.

Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases.

Krause RJ, Glocke SC, Sicuri AR, Ripp SL, Elfarra AA.

Chem Res Toxicol. 2006 Dec;19(12):1643-9.

17.

Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS, de Morais SM.

Drug Metab Dispos. 2006 Oct;34(10):1742-8. Epub 2006 Jul 12.

PMID:
16837568
18.

Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals.

Riddick DS, Lee C, Bhathena A, Timsit YE, Cheng PY, Morgan ET, Prough RA, Ripp SL, Miller KK, Jahan A, Chiang JY.

Drug Metab Dispos. 2004 Apr;32(4):367-75. Review.

PMID:
15039287
19.

Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450.

Miller KK, Cai J, Ripp SL, Pierce WM Jr, Rushmore TH, Prough RA.

Drug Metab Dispos. 2004 Mar;32(3):305-13.

PMID:
14977864
20.

Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: identification of the negative regulatory region of the gene.

Ripp SL, Falkner KC, Pendleton ML, Tamasi V, Prough RA.

Mol Pharmacol. 2003 Jul;64(1):113-22.

PMID:
12815167
21.

Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?

Robinzon B, Michael KK, Ripp SL, Winters SJ, Prough RA.

Arch Biochem Biophys. 2003 Apr 15;412(2):251-8.

PMID:
12667489
22.
23.

Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.

Ripp SL, Fitzpatrick JL, Peters JM, Prough RA.

Drug Metab Dispos. 2002 May;30(5):570-5.

PMID:
11950789
24.

Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.

Fitzpatrick JL, Ripp SL, Smith NB, Pierce WM Jr, Prough RA.

Arch Biochem Biophys. 2001 May 15;389(2):278-87.

PMID:
11339818
25.

Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors.

Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL, Ripp SL, Falkner KC, Ge NL, Levine A, Elferink CJ.

Drug Metab Dispos. 2001 May;29(5):623-33. Review.

PMID:
11302926
26.
27.

Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes.

Ripp SL, Itagaki K, Philpot RM, Elfarra AA.

Drug Metab Dispos. 1999 Jan;27(1):46-52.

PMID:
9884308
29.

Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalyst.

Krause RJ, Ripp SL, Sausen PJ, Overby LH, Philpot RM, Elfarra AA.

Arch Biochem Biophys. 1996 Sep 1;333(1):109-16.

PMID:
8806760

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