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Repression of TERRA Expression by Subtelomeric DNA Methylation Is Dependent on NRF1 Binding.

Le Berre G, Hossard V, Riou JF, Guieysse-Peugeot AL.

Int J Mol Sci. 2019 Jun 7;20(11). pii: E2791. doi: 10.3390/ijms20112791.


Energy-Dependent Three-Body Loss in 1D Bose Gases.

Zundel LA, Wilson JM, Malvania N, Xia L, Riou JF, Weiss DS.

Phys Rev Lett. 2019 Jan 11;122(1):013402. doi: 10.1103/PhysRevLett.122.013402.


Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA).

Hwang IP, Mailliet P, Hossard V, Riou JF, Bugaut A, Roger L.

Molecules. 2019 Feb 6;24(3). pii: E577. doi: 10.3390/molecules24030577.


Characterization of potential TRPP2 regulating proteins in early Xenopus embryos.

Futel M, Le Bouffant R, Buisson I, Umbhauer M, Riou JF.

J Cell Biochem. 2018 Dec;119(12):10338-10350. doi: 10.1002/jcb.27376. Epub 2018 Sep 1.


Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney.

Cosse-Etchepare C, Gervi I, Buisson I, Formery L, Schubert M, Riou JF, Umbhauer M, Le Bouffant R.

Int J Dev Biol. 2018;62(4-5):325-333. doi: 10.1387/ijdb.170260RL.


Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures.

Saintomé C, Alberti P, Guinot N, Lejault P, Chatain J, Mailliet P, Riou JF, Bugaut A.

Chem Commun (Camb). 2018 Feb 15;54(15):1897-1900. doi: 10.1039/c7cc07048a.


The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units.

Lancrey A, Safa L, Chatain J, Delagoutte E, Riou JF, Alberti P, Saintomé C.

Biochimie. 2018 Mar;146:68-72. doi: 10.1016/j.biochi.2017.11.017. Epub 2017 Nov 29.


Metabolic and genomic adaptations to winter fattening in a primate species, the grey mouse lemur (Microcebus murinus).

Terrien J, Gaudubois M, Champeval D, Zaninotto V, Roger L, Riou JF, Aujard F.

Int J Obes (Lond). 2018 Feb;42(2):221-230. doi: 10.1038/ijo.2017.195. Epub 2017 Aug 14.


Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.

Hussain T, Saha D, Purohit G, Kar A, Kishore Mukherjee A, Sharma S, Sengupta S, Dhapola P, Maji B, Vedagopuram S, Horikoshi NT, Horikoshi N, Pandita RK, Bhattacharya S, Bajaj A, Riou JF, Pandita TK, Chowdhury S.

Sci Rep. 2017 Sep 14;7(1):11541. doi: 10.1038/s41598-017-11177-1.


Id genes are essential for early heart formation.

Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR.

Genes Dev. 2017 Jul 1;31(13):1325-1338. doi: 10.1101/gad.300400.117. Epub 2017 Aug 9.


5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES.

Safa L, Gueddouda NM, Thiébaut F, Delagoutte E, Petruseva I, Lavrik O, Mendoza O, Bourdoncle A, Alberti P, Riou JF, Saintomé C.

J Biol Chem. 2016 Sep 30;291(40):21246-21256. Epub 2016 Jul 19.


Ca(2+) coding and decoding strategies for the specification of neural and renal precursor cells during development.

Moreau M, Néant I, Webb SE, Miller AL, Riou JF, Leclerc C.

Cell Calcium. 2016 Mar;59(2-3):75-83. doi: 10.1016/j.ceca.2015.12.003. Epub 2015 Dec 17. Review.


Telomere regulation during ageing and tumorigenesis of the grey mouse lemur.

Trochet D, Mergui X, Ivkovic I, Porreca RM, Gerbault-Seureau M, Sidibe A, Richard F, Londono-Vallejo A, Perret M, Aujard F, Riou JF.

Biochimie. 2015 Jun;113:100-10. doi: 10.1016/j.biochi.2015.04.002. Epub 2015 Apr 14.


TRPP2-dependent Ca2+ signaling in dorso-lateral mesoderm is required for kidney field establishment in Xenopus.

Futel M, Leclerc C, Le Bouffant R, Buisson I, Néant I, Umbhauer M, Moreau M, Riou JF.

J Cell Sci. 2015 Mar 1;128(5):888-99. doi: 10.1242/jcs.155499. Epub 2015 Jan 14.


Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development.

Buisson I, Le Bouffant R, Futel M, Riou JF, Umbhauer M.

Dev Biol. 2015 Jan 15;397(2):175-90. doi: 10.1016/j.ydbio.2014.10.022. Epub 2014 Nov 8.


Differential expression of arid5b isoforms in Xenopus laevis pronephros.

Le Bouffant R, Cunin AC, Buisson I, Cartry J, Riou JF, Umbhauer M.

Int J Dev Biol. 2014;58(5):363-8. doi: 10.1387/ijdb.140029mu.


Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability.

Safa L, Delagoutte E, Petruseva I, Alberti P, Lavrik O, Riou JF, Saintomé C.

Biochimie. 2014 Aug;103:80-8. doi: 10.1016/j.biochi.2014.04.006. Epub 2014 Apr 18.


G4 motifs affect origin positioning and efficiency in two vertebrate replicators.

Valton AL, Hassan-Zadeh V, Lema I, Boggetto N, Alberti P, Saintomé C, Riou JF, Prioleau MN.

EMBO J. 2014 Apr 1;33(7):732-46. doi: 10.1002/embj.201387506. Epub 2014 Feb 12.


Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

Cases O, Perea-Gomez A, Aguiar DP, Nykjaer A, Amsellem S, Chandellier J, Umbhauer M, Cereghini S, Madsen M, Collignon J, Verroust P, Riou JF, Creuzet SE, Kozyraki R.

J Biol Chem. 2013 Jun 7;288(23):16655-70. doi: 10.1074/jbc.M113.451070. Epub 2013 Apr 16.


Preclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors.

Vrignaud P, Sémiond D, Lejeune P, Bouchard H, Calvet L, Combeau C, Riou JF, Commerçon A, Lavelle F, Bissery MC.

Clin Cancer Res. 2013 Jun 1;19(11):2973-83. doi: 10.1158/1078-0432.CCR-12-3146. Epub 2013 Apr 15.


DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.

Douarre C, Mergui X, Sidibe A, Gomez D, Alberti P, Mailliet P, Trentesaux C, Riou JF.

Nucleic Acids Res. 2013 Apr 1;41(6):3588-99. doi: 10.1093/nar/gkt073. Epub 2013 Feb 8.


Self-trapping in an array of coupled 1D Bose gases.

Reinhard A, Riou JF, Zundel LA, Weiss DS, Li S, Rey AM, Hipolito R.

Phys Rev Lett. 2013 Jan 18;110(3):033001. Epub 2013 Jan 14.


Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells.

Sidibe A, Hamon F, Largy E, Gomez D, Teulade-Fichou MP, Trentesaux C, Riou JF.

Biochimie. 2012 Dec;94(12):2559-68. doi: 10.1016/j.biochi.2012.07.003. Epub 2012 Jul 14.


Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells.

Müller S, Sanders DA, Di Antonio M, Matsis S, Riou JF, Rodriguez R, Balasubramanian S.

Org Biomol Chem. 2012 Aug 28;10(32):6537-46. doi: 10.1039/c2ob25830g. Epub 2012 Jul 13.


Retinoic acid-dependent control of MAP kinase phosphatase-3 is necessary for early kidney development in Xenopus.

Le Bouffant R, Wang JH, Futel M, Buisson I, Umbhauer M, Riou JF.

Biol Cell. 2012 Sep;104(9):516-32. doi: 10.1111/boc.201200005. Epub 2012 Jun 21.


Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines.

Halder R, Riou JF, Teulade-Fichou MP, Frickey T, Hartig JS.

BMC Res Notes. 2012 Mar 13;5:138. doi: 10.1186/1756-0500-5-138.


An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies.

Hamon F, Largy E, Guédin-Beaurepaire A, Rouchon-Dagois M, Sidibe A, Monchaud D, Mergny JL, Riou JF, Nguyen CH, Teulade-Fichou MP.

Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8745-9. doi: 10.1002/anie.201103422. Epub 2011 Aug 2. No abstract available.


[Senescence and cellular immortality].

Trentesaux C, Riou JF.

Bull Cancer. 2010 Nov;97(11):1275-83. doi: 10.1684/bdc.2010.1205. Review. French.


Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.

Hampel SM, Sidibe A, Gunaratnam M, Riou JF, Neidle S.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6459-63. doi: 10.1016/j.bmcl.2010.09.066. Epub 2010 Sep 17.


Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation.

Laronze-Cochard M, Cochard F, Daras E, Lansiaux A, Brassart B, Vanquelef E, Prost E, Nuzillard JM, Baldeyrou B, Goosens JF, Lozach O, Meijer L, Riou JF, Henon E, Sapi J.

Org Biomol Chem. 2010 Oct 21;8(20):4625-36. doi: 10.1039/c0ob00149j. Epub 2010 Aug 24.


A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.

Gomez D, Guédin A, Mergny JL, Salles B, Riou JF, Teulade-Fichou MP, Calsou P.

Nucleic Acids Res. 2010 Nov;38(20):7187-98. doi: 10.1093/nar/gkq563. Epub 2010 Jun 22.


Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.

Arnoult N, Saintome C, Ourliac-Garnier I, Riou JF, Londoño-Vallejo A.

Genes Dev. 2009 Dec 15;23(24):2915-24. doi: 10.1101/gad.544009.


The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.

Temime-Smaali N, Guittat L, Sidibe A, Shin-ya K, Trentesaux C, Riou JF.

PLoS One. 2009 Sep 9;4(9):e6919. doi: 10.1371/journal.pone.0006919.


Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.

Lim KW, Alberti P, Guédin A, Lacroix L, Riou JF, Royle NJ, Mergny JL, Phan AT.

Nucleic Acids Res. 2009 Oct;37(18):6239-48. doi: 10.1093/nar/gkp630. Epub 2009 Aug 19.


Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline.

Mendez-Bermudez A, Hills M, Pickett HA, Phan AT, Mergny JL, Riou JF, Royle NJ.

Nucleic Acids Res. 2009 Oct;37(18):6225-38. doi: 10.1093/nar/gkp629. Epub 2009 Aug 5.


2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

El Bakali J, Klupsch F, Guédin A, Brassart B, Fontaine G, Farce A, Roussel P, Houssin R, Bernier JL, Chavatte P, Mergny JL, Riou JF, Hénichart JP.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3434-8. doi: 10.1016/j.bmcl.2009.05.025. Epub 2009 May 12.


Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.

Laronze-Cochard M, Kim YM, Brassart B, Riou JF, Laronze JY, Sapi J.

Eur J Med Chem. 2009 Oct;44(10):3880-8. doi: 10.1016/j.ejmech.2009.04.021. Epub 2009 Apr 22.


Targeting human telomerase for cancer therapeutics.

Guittat L, Alberti P, Gomez D, De Cian A, Pennarun G, Lemarteleur T, Belmokhtar C, Paterski R, Morjani H, Trentesaux C, Mandine E, Boussin F, Mailliet P, Lacroix L, Riou JF, Mergny JL.

Cytotechnology. 2004 Jun;45(1-2):75-90. doi: 10.1007/s10616-004-5127-z.


A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.

Rodriguez R, Müller S, Yeoman JA, Trentesaux C, Riou JF, Balasubramanian S.

J Am Chem Soc. 2008 Nov 26;130(47):15758-9. doi: 10.1021/ja805615w.


DNA and RNA quadruplex ligands.

De Cian A, Gros J, Guédin A, Haddi M, Lyonnais S, Guittat L, Riou JF, Trentesaux C, Saccà B, Lacroix L, Alberti P, Mergny JL.

Nucleic Acids Symp Ser (Oxf). 2008;(52):7-8. doi: 10.1093/nass/nrn004.


Mix.1/2-dependent control of FGF availability during gastrulation is essential for pronephros development in Xenopus.

Colas A, Cartry J, Buisson I, Umbhauer M, Smith JC, Riou JF.

Dev Biol. 2008 Aug 15;320(2):351-65. doi: 10.1016/j.ydbio.2008.05.547. Epub 2008 Jul 9.


Proteome alteration induced by hTERT transfection of human fibroblast cells.

Mazzucchelli GD, Gabelica V, Smargiasso N, Fléron M, Ashimwe W, Rosu F, De Pauw-Gillet MC, Riou JF, De Pauw E.

Proteome Sci. 2008 Apr 17;6:12. doi: 10.1186/1477-5956-6-12.


Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.

Temime-Smaali N, Guittat L, Wenner T, Bayart E, Douarre C, Gomez D, Giraud-Panis MJ, Londono-Vallejo A, Gilson E, Amor-Guéret M, Riou JF.

EMBO J. 2008 May 21;27(10):1513-24. doi: 10.1038/emboj.2008.74. Epub 2008 Apr 17.


Targeting telomeres and telomerase.

De Cian A, Lacroix L, Douarre C, Temime-Smaali N, Trentesaux C, Riou JF, Mergny JL.

Biochimie. 2008 Jan;90(1):131-55. Epub 2007 Jul 24. Review.


Mechanism of acridine-based telomerase inhibition and telomere shortening.

Gunaratnam M, Greciano O, Martins C, Reszka AP, Schultes CM, Morjani H, Riou JF, Neidle S.

Biochem Pharmacol. 2007 Sep 1;74(5):679-89. Epub 2007 Jun 16.


Telomerase: a dimeric ménage à trois.

Mergny JL, Lacroix L, Riou JF.

Chembiochem. 2007 Sep 3;8(13):1483-5. No abstract available.


A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells.

Brassart B, Gomez D, De Cian A, Paterski R, Montagnac A, Qui KH, Temime-Smaali N, Trentesaux C, Mergny JL, Gueritte F, Riou JF.

Mol Pharmacol. 2007 Sep;72(3):631-40. Epub 2007 Jun 22.


Guided quasicontinuous atom laser.

Guerin W, Riou JF, Gaebler JP, Josse V, Bouyer P, Aspect A.

Phys Rev Lett. 2006 Nov 17;97(20):200402. Epub 2006 Nov 13.


Affinity and selectivity of G4 ligands measured by FRET.

De Cian A, Guittat L, Shin-ya K, Riou JF, Mergny JL.

Nucleic Acids Symp Ser (Oxf). 2005;(49):235-6.


Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

Gomez D, Wenner T, Brassart B, Douarre C, O'Donohue MF, El Khoury V, Shin-Ya K, Morjani H, Trentesaux C, Riou JF.

J Biol Chem. 2006 Dec 15;281(50):38721-9. Epub 2006 Oct 17.

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