Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 214

1.

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.

Sigoillot M, Overtus M, Grodecka M, Scholl D, Garcia-Pino A, Laeremans T, He L, Pardon E, Hildebrandt E, Urbatsch I, Steyaert J, Riordan JR, Govaerts C.

Nat Commun. 2019 Jun 14;10(1):2636. doi: 10.1038/s41467-019-10714-y.

2.

Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.

Fay JF, Aleksandrov LA, Jensen TJ, Cui LL, Kousouros JN, He L, Aleksandrov AA, Gingerich DS, Riordan JR, Chen JZ.

Biochemistry. 2018 Oct 30;57(43):6234-6246. doi: 10.1021/acs.biochem.8b00763. Epub 2018 Oct 16.

PMID:
30281975
3.

R-Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator.

Aleksandrov LA, Fay JF, Riordan JR.

Biochemistry. 2018 Aug 28;57(34):5073-5075. doi: 10.1021/acs.biochem.8b00646. Epub 2018 Aug 15.

PMID:
30109929
4.

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.

Wang C, Aleksandrov AA, Yang Z, Forouhar F, Proctor EA, Kota P, An J, Kaplan A, Khazanov N, Boël G, Stockwell BR, Senderowitz H, Dokholyan NV, Riordan JR, Brouillette CG, Hunt JF.

J Biol Chem. 2018 Nov 16;293(46):17685-17704. doi: 10.1074/jbc.RA117.000819. Epub 2018 Jun 14.

PMID:
29903914
5.

Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.

Yang Z, Hildebrandt E, Jiang F, Aleksandrov AA, Khazanov N, Zhou Q, An J, Mezzell AT, Xavier BM, Ding H, Riordan JR, Senderowitz H, Kappes JC, Brouillette CG, Urbatsch IL.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1193-1204. doi: 10.1016/j.bbamem.2018.02.006. Epub 2018 Feb 7.

6.

The cubicon method for concentrating membrane proteins in the cubic mesophase.

Ma P, Weichert D, Aleksandrov LA, Jensen TJ, Riordan JR, Liu X, Kobilka BK, Caffrey M.

Nat Protoc. 2017 Sep;12(9):1745-1762. doi: 10.1038/nprot.2017.057. Epub 2017 Aug 3.

PMID:
28771236
7.

Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.

Vernon RM, Chong PA, Lin H, Yang Z, Zhou Q, Aleksandrov AA, Dawson JE, Riordan JR, Brouillette CG, Thibodeau PH, Forman-Kay JD.

J Biol Chem. 2017 Aug 25;292(34):14147-14164. doi: 10.1074/jbc.M116.772335. Epub 2017 Jun 27.

8.

Transmembrane helical interactions in the CFTR channel pore.

Das J, Aleksandrov AA, Cui L, He L, Riordan JR, Dokholyan NV.

PLoS Comput Biol. 2017 Jun 22;13(6):e1005594. doi: 10.1371/journal.pcbi.1005594. eCollection 2017 Jun.

9.

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.

Gakhal AK, Jensen TJ, Bozoky Z, Roldan A, Lukacs GL, Forman-Kay J, Riordan JR, Sidhu SS.

MAbs. 2016 Aug-Sep;8(6):1167-76. doi: 10.1080/19420862.2016.1186320. Epub 2016 May 16.

10.

Potential sites of CFTR activation by tyrosine kinases.

Billet A, Jia Y, Jensen TJ, Hou YX, Chang XB, Riordan JR, Hanrahan JW.

Channels (Austin). 2016;10(3):247-51. doi: 10.1080/19336950.2015.1126010. Epub 2015 Dec 8.

11.

Thermal stability of purified and reconstituted CFTR in a locked open channel conformation.

Aleksandrov LA, Jensen TJ, Cui L, Kousouros JN, He L, Aleksandrov AA, Riordan JR.

Protein Expr Purif. 2015 Dec;116:159-66. doi: 10.1016/j.pep.2015.09.018. Epub 2015 Sep 15.

12.

Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation.

Billet A, Jia Y, Jensen T, Riordan JR, Hanrahan JW.

FASEB J. 2015 Sep;29(9):3945-53. doi: 10.1096/fj.15-273151. Epub 2015 Jun 10.

13.

Erratum to: A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface.

Hildebrandt E, Ding H, Mulky A, Dai Q, Aleksandrov AA, Bajrami B, Diego PA, Wu X, Ray M, Naren AP, Riordan JR, Yao X, DeLucas LJ, Urbatsch IL, Kappes JC.

Mol Biotechnol. 2015 May;57(5):406. doi: 10.1007/s12033-015-9857-2. No abstract available.

PMID:
25808031
14.

Rational Coupled Dynamics Network Manipulation Rescues Disease-Relevant Mutant Cystic Fibrosis Transmembrane Conductance Regulator.

Proctor EA, Kota P, Aleksandrov AA, He L, Riordan JR, Dokholyan NV.

Chem Sci. 2015 Feb;6(2):1237-1246.

15.

A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface.

Hildebrandt E, Mulky A, Ding H, Dai Q, Aleksandrov AA, Bajrami B, Diego PA, Wu X, Ray M, Naren AP, Riordan JR, Yao X, DeLucas LJ, Urbatsch IL, Kappes JC.

Mol Biotechnol. 2015 May;57(5):391-405. doi: 10.1007/s12033-014-9830-5. Erratum in: Mol Biotechnol. 2015 May;57(5):406.

16.

Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane.

McShane AJ, Bajrami B, Ramos AA, Diego-Limpin PA, Farrokhi V, Coutermarsh BA, Stanton BA, Jensen T, Riordan JR, Wetmore D, Joseloff E, Yao X.

J Proteome Res. 2014 Nov 7;13(11):4676-85. doi: 10.1021/pr5006795. Epub 2014 Oct 3.

17.

Restoration of NBD1 thermal stability is necessary and sufficient to correct ∆F508 CFTR folding and assembly.

He L, Aleksandrov AA, An J, Cui L, Yang Z, Brouillette CG, Riordan JR.

J Mol Biol. 2015 Jan 16;427(1):106-20. doi: 10.1016/j.jmb.2014.07.026. Epub 2014 Jul 30.

18.

Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains.

Yang Z, Wang C, Zhou Q, An J, Hildebrandt E, Aleksandrov LA, Kappes JC, DeLucas LJ, Riordan JR, Urbatsch IL, Hunt JF, Brouillette CG.

Protein Sci. 2014 Jun;23(6):769-89. doi: 10.1002/pro.2460. Epub 2014 May 3.

19.

Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.

He L, Kota P, Aleksandrov AA, Cui L, Jensen T, Dokholyan NV, Riordan JR.

FASEB J. 2013 Feb;27(2):536-45. doi: 10.1096/fj.12-216119. Epub 2012 Oct 26. Erratum in: FASEB J. 2014 Jun;28(6):2737.

20.

Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.

Aleksandrov AA, Kota P, Cui L, Jensen T, Alekseev AE, Reyes S, He L, Gentzsch M, Aleksandrov LA, Dokholyan NV, Riordan JR.

J Mol Biol. 2012 May 25;419(1-2):41-60. doi: 10.1016/j.jmb.2012.03.001. Epub 2012 Mar 8.

21.

Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration.

Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R.

FASEB J. 2012 Feb;26(2):533-45. doi: 10.1096/fj.11-192377. Epub 2011 Oct 11.

22.

The cystic fibrosis transmembrane conductance regulator (CFTR): three-dimensional structure and localization of a channel gate.

Rosenberg MF, O'Ryan LP, Hughes G, Zhao Z, Aleksandrov LA, Riordan JR, Ford RC.

J Biol Chem. 2011 Dec 9;286(49):42647-54. doi: 10.1074/jbc.M111.292268. Epub 2011 Sep 19.

23.

Domain location within the cystic fibrosis transmembrane conductance regulator protein investigated by electron microscopy and gold labelling.

Zhang L, Aleksandrov LA, Riordan JR, Ford RC.

Biochim Biophys Acta. 2011 Jan;1808(1):399-404. doi: 10.1016/j.bbamem.2010.08.012. Epub 2010 Aug 19.

24.

Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR.

Aleksandrov AA, Kota P, Aleksandrov LA, He L, Jensen T, Cui L, Gentzsch M, Dokholyan NV, Riordan JR.

J Mol Biol. 2010 Aug 13;401(2):194-210. doi: 10.1016/j.jmb.2010.06.019. Epub 2010 Jun 16.

25.

Restoration of domain folding and interdomain assembly by second-site suppressors of the DeltaF508 mutation in CFTR.

He L, Aleksandrov LA, Cui L, Jensen TJ, Nesbitt KL, Riordan JR.

FASEB J. 2010 Aug;24(8):3103-12. doi: 10.1096/fj.09-141788. Epub 2010 Mar 16.

26.

Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures.

Cholon DM, O'Neal WK, Randell SH, Riordan JR, Gentzsch M.

Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L304-14. doi: 10.1152/ajplung.00016.2009. Epub 2009 Dec 11.

27.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE.

Nat Chem Biol. 2010 Jan;6(1):25-33. doi: 10.1038/nchembio.275. Epub 2009 Dec 6.

28.

Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding.

Zhang L, Aleksandrov LA, Zhao Z, Birtley JR, Riordan JR, Ford RC.

J Struct Biol. 2009 Sep;167(3):242-51. doi: 10.1016/j.jsb.2009.06.004. Epub 2009 Jun 12.

PMID:
19524678
29.

Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator.

Aleksandrov AA, Cui L, Riordan JR.

J Physiol. 2009 Jun 15;587(Pt 12):2875-86. doi: 10.1113/jphysiol.2009.170258. Epub 2009 Apr 29.

30.

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.

Hegedus T, Aleksandrov A, Mengos A, Cui L, Jensen TJ, Riordan JR.

Biochim Biophys Acta. 2009 Jun;1788(6):1341-9. doi: 10.1016/j.bbamem.2009.03.015. Epub 2009 Mar 26.

31.

Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.

Pathak AK, Pathak V, Suling WJ, Riordan JR, Gurcha SS, Besra GS, Reynolds RC.

Bioorg Med Chem. 2009 Jan 15;17(2):872-81. doi: 10.1016/j.bmc.2008.11.027. Epub 2008 Nov 18.

32.

Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking.

Wang X, Koulov AV, Kellner WA, Riordan JR, Balch WE.

Traffic. 2008 Nov;9(11):1878-93. doi: 10.1111/j.1600-0854.2008.00806.x. Epub 2008 Jul 30.

33.

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator.

Chang XB, Mengos A, Hou YX, Cui L, Jensen TJ, Aleksandrov A, Riordan JR, Gentzsch M.

J Cell Sci. 2008 Sep 1;121(Pt 17):2814-23. doi: 10.1242/jcs.028951. Epub 2008 Aug 5.

34.

Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating.

He L, Aleksandrov AA, Serohijos AW, Hegedus T, Aleksandrov LA, Cui L, Dokholyan NV, Riordan JR.

J Biol Chem. 2008 Sep 26;283(39):26383-90. doi: 10.1074/jbc.M803894200. Epub 2008 Jul 25.

35.

Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2).

Aleksandrov L, Aleksandrov A, Riordan JR.

Biochem J. 2008 Nov 15;416(1):129-36. doi: 10.1042/BJ20081068.

PMID:
18605986
36.

Diminished self-chaperoning activity of the DeltaF508 mutant of CFTR results in protein misfolding.

Serohijos AW, Hegedus T, Riordan JR, Dokholyan NV.

PLoS Comput Biol. 2008 Feb 29;4(2):e1000008. doi: 10.1371/journal.pcbi.1000008.

37.

Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR.

Hegedus T, Serohijos AW, Dokholyan NV, He L, Riordan JR.

J Mol Biol. 2008 May 16;378(5):1052-63. doi: 10.1016/j.jmb.2008.03.033. Epub 2008 Mar 26.

38.

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.

Serohijos AW, Hegedus T, Aleksandrov AA, He L, Cui L, Dokholyan NV, Riordan JR.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3256-61. doi: 10.1073/pnas.0800254105. Epub 2008 Feb 27.

39.

CFTR function and prospects for therapy.

Riordan JR.

Annu Rev Biochem. 2008;77:701-26. doi: 10.1146/annurev.biochem.75.103004.142532. Review.

PMID:
18304008
40.

The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine.

Malmberg EK, Pelaseyed T, Petersson AC, Seidler UE, De Jonge H, Riordan JR, Hansson GC.

Biochem J. 2008 Mar 1;410(2):283-9.

PMID:
17990980
41.

Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.

Pathak AK, Pathak V, Riordan JR, Suling WJ, Gurcha SS, Besra GS, Reynolds RC.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4527-30. Epub 2007 Jun 6.

42.

Misassembled mutant DeltaF508 CFTR in the distal secretory pathway alters cellular lipid trafficking.

Gentzsch M, Choudhury A, Chang XB, Pagano RE, Riordan JR.

J Cell Sci. 2007 Feb 1;120(Pt 3):447-55. Epub 2007 Jan 9.

43.

Domain interdependence in the biosynthetic assembly of CFTR.

Cui L, Aleksandrov L, Chang XB, Hou YX, He L, Hegedus T, Gentzsch M, Aleksandrov A, Balch WE, Riordan JR.

J Mol Biol. 2007 Jan 26;365(4):981-94. Epub 2006 Nov 10.

PMID:
17113596
44.

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR 3rd, Balch WE.

Cell. 2006 Nov 17;127(4):803-15.

45.

CFTR (ABCC7) is a hydrolyzable-ligand-gated channel.

Aleksandrov AA, Aleksandrov LA, Riordan JR.

Pflugers Arch. 2007 Feb;453(5):693-702. Epub 2006 Sep 26. Review.

PMID:
17021796
46.

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive.

Hegedus T, Aleksandrov A, Cui L, Gentzsch M, Chang XB, Riordan JR.

Biochim Biophys Acta. 2006 May;1758(5):565-72. Epub 2006 Mar 31.

47.

The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.

Cui L, Aleksandrov L, Hou YX, Gentzsch M, Chen JH, Riordan JR, Aleksandrov AA.

J Physiol. 2006 Apr 15;572(Pt 2):347-58. Epub 2006 Feb 16.

48.

SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis.

Grubb BR, Gabriel SE, Mengos A, Gentzsch M, Randell SH, Van Heeckeren AM, Knowles MR, Drumm ML, Riordan JR, Boucher RC.

Am J Respir Cell Mol Biol. 2006 Mar;34(3):355-63. Epub 2005 Nov 11.

49.

Crystallographic and single-particle analyses of native- and nucleotide-bound forms of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

Awayn NH, Rosenberg MF, Kamis AB, Aleksandrov LA, Riordan JR, Ford RC.

Biochem Soc Trans. 2005 Nov;33(Pt 5):996-9.

PMID:
16246030
50.

Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia.

Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, Boucher RC.

Mol Biol Cell. 2005 May;16(5):2154-67. Epub 2005 Feb 16.

Supplemental Content

Loading ...
Support Center