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Items: 5


mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.

Castets P, Rion N, Théodore M, Falcetta D, Lin S, Reischl M, Wild F, Guérard L, Eickhorst C, Brockhoff M, Guridi M, Ibebunjo C, Cruz J, Sinnreich M, Rudolf R, Glass DJ, Rüegg MA.

Nat Commun. 2019 Jul 18;10(1):3187. doi: 10.1038/s41467-019-11227-4.


mTOR controls embryonic and adult myogenesis via mTORC1.

Rion N, Castets P, Lin S, Enderle L, Reinhard JR, Eickhorst C, Rüegg MA.

Development. 2019 Apr 8;146(7). pii: dev172460. doi: 10.1242/dev.172460.


LncRNA-encoded peptides: More than translational noise?

Rion N, Rüegg MA.

Cell Res. 2017 May;27(5):604-605. doi: 10.1038/cr.2017.35. Epub 2017 Mar 14.


Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I.

Brockhoff M, Rion N, Chojnowska K, Wiktorowicz T, Eickhorst C, Erne B, Frank S, Angelini C, Furling D, Rüegg MA, Sinnreich M, Castets P.

J Clin Invest. 2017 Feb 1;127(2):549-563. doi: 10.1172/JCI89616. Epub 2017 Jan 9.


Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.

Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M, Rüegg MA.

Cell Metab. 2013 May 7;17(5):731-44. doi: 10.1016/j.cmet.2013.03.015. Epub 2013 Apr 18.

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