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Items: 48

1.

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.

Ignarski M, Rill C, Kaiser RWJ, Kaldirim M, Neuhaus R, Esmaillie R, Li X, Klein C, Bohl K, Petersen M, Frese CK, Höhne M, Atanassov I, Rinschen MM, Höpker K, Schermer B, Benzing T, Dieterich C, Fabretti F, Müller RU.

J Am Soc Nephrol. 2019 Mar 13. pii: ASN.2018090914. doi: 10.1681/ASN.2018090914. [Epub ahead of print]

PMID:
30867249
2.

Identification of bioactive metabolites using activity metabolomics.

Rinschen MM, Ivanisevic J, Giera M, Siuzdak G.

Nat Rev Mol Cell Biol. 2019 Feb 27. doi: 10.1038/s41580-019-0108-4. [Epub ahead of print] Review.

PMID:
30814649
3.

Bevacizumab-associated glomerular microangiopathy.

Person F, Rinschen MM, Brix SR, Wulf S, Noriega MLM, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz OM, Reinhard L, Hoxha E, Zipfel PF, Bräsen JH, Wiech T.

Mod Pathol. 2018 Dec 14. doi: 10.1038/s41379-018-0186-4. [Epub ahead of print]

PMID:
30552416
4.

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM.

Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3.

PMID:
30522767
5.

Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.

Irmak D, Fatima A, Gutiérrez-Garcia R, Rinschen MM, Wagle P, Altmüller J, Arrigoni L, Hummel B, Klein C, Frese CK, Sawarkar R, Rada-Iglesias A, Vilchez D.

Hum Mol Genet. 2018 Dec 1;27(23):4117-4134. doi: 10.1093/hmg/ddy304.

PMID:
30452683
6.

The podocyte protease web: uncovering the gatekeepers of glomerular disease.

Rinschen MM, Huesgen PF, Koch RE.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1812-F1816. doi: 10.1152/ajprenal.00380.2018. Epub 2018 Sep 19.

PMID:
30230368
7.

From Molecules to Mechanisms: Functional Proteomics and Its Application to Renal Tubule Physiology.

Rinschen MM, Limbutara K, Knepper MA, Payne DM, Pisitkun T.

Physiol Rev. 2018 Oct 1;98(4):2571-2606. doi: 10.1152/physrev.00057.2017. Review.

PMID:
30182799
8.

Urine-derived cells: a promising diagnostic tool in Fabry disease patients.

Slaats GG, Braun F, Hoehne M, Frech LE, Blomberg L, Benzing T, Schermer B, Rinschen MM, Kurschat CE.

Sci Rep. 2018 Jul 23;8(1):11042. doi: 10.1038/s41598-018-29240-w.

9.

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC.

Exp Mol Med. 2018 Jun 28;50(6):75. doi: 10.1038/s12276-018-0108-z.

10.

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB.

Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059.

11.

Protein half-life determines expression of proteostatic networks in podocyte differentiation.

Schroeter CB, Koehler S, Kann M, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM.

FASEB J. 2018 Sep;32(9):4696-4713. doi: 10.1096/fj.201701307R. Epub 2018 Apr 25.

PMID:
29694247
12.

Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM.

Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Epub 2018 Mar 9.

PMID:
29530281
13.

Quantification of molecular heterogeneity in kidney tissue by targeted proteomics.

Hoyer KJR, Dittrich S, Bartram MP, Rinschen MM.

J Proteomics. 2019 Feb 20;193:85-92. doi: 10.1016/j.jprot.2018.03.001. Epub 2018 Mar 6.

PMID:
29522878
14.

Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells.

Staubach S, Wenzel A, Beck BB, Rinschen MM, Müller S, Hanisch FG.

Proteomics. 2018 Apr;18(7):e1700456. doi: 10.1002/pmic.201700456. Epub 2018 Mar 13.

PMID:
29436780
15.

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6.

16.

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

Rinschen MM, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T.

J Am Soc Nephrol. 2017 Oct;28(10):2867-2878. doi: 10.1681/ASN.2016101119. Epub 2017 Jul 19.

17.

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.

Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B.

EMBO Rep. 2017 Sep;18(9):1521-1535. doi: 10.15252/embr.201643846. Epub 2017 Jul 14.

18.

YAP-mediated mechanotransduction determines the podocyte's response to damage.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165.

PMID:
28400537
19.

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.

Koehler S, Brähler S, Braun F, Hagmann H, Rinschen MM, Späth MR, Höhne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT.

Kidney Int. 2017 Jun;91(6):1510-1517. doi: 10.1016/j.kint.2016.12.011. Epub 2017 Feb 7.

PMID:
28187984
20.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Kind J, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB.

JCI Insight. 2016 Jun 16;1(9). pii: 86177. doi: 10.1172/jci.insight.86177.

21.

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation.

Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT.

Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C404-17. doi: 10.1152/ajpcell.00121.2016. Epub 2016 Jun 29.

22.

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells.

Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F.

J Am Soc Nephrol. 2017 Jan;28(1):230-241. doi: 10.1681/ASN.2015111224. Epub 2016 Jun 13.

23.

Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations.

Laghmani K, Beck BB, Yang SS, Seaayfan E, Wenzel A, Reusch B, Vitzthum H, Priem D, Demaretz S, Bergmann K, Duin LK, Göbel H, Mache C, Thiele H, Bartram MP, Dombret C, Altmüller J, Nürnberg P, Benzing T, Levtchenko E, Seyberth HW, Klaus G, Yigit G, Lin SH, Timmer A, de Koning TJ, Scherjon SA, Schlingmann KP, Bertrand MJ, Rinschen MM, de Backer O, Konrad M, Kömhoff M.

N Engl J Med. 2016 May 12;374(19):1853-63. doi: 10.1056/NEJMoa1507629. Epub 2016 Apr 27.

24.

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

Gandhirajan RK, Jain M, Walla B, Johnsen M, Bartram MP, Huynh Anh M, Rinschen MM, Benzing T, Schermer B.

J Biol Chem. 2016 May 27;291(22):11596-607. doi: 10.1074/jbc.M115.712539. Epub 2016 Apr 5.

25.

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

Borgal L, Rinschen MM, Dafinger C, Liebrecht VI, Abken H, Benzing T, Schermer B.

Cell Cycle. 2016;15(8):1034-45. doi: 10.1080/15384101.2016.1152429.

26.

Altered lipid metabolism in the aging kidney identified by three layered omic analysis.

Braun F, Rinschen MM, Bartels V, Frommolt P, Habermann B, Hoeijmakers JH, Schumacher B, Dollé ME, Müller RU, Benzing T, Schermer B, Kurschat CE.

Aging (Albany NY). 2016 Mar;8(3):441-57.

27.

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T.

Hum Mol Genet. 2016 Apr 1;25(7):1328-44. doi: 10.1093/hmg/ddw016. Epub 2016 Jan 19.

28.

Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS.

Bartram MP, Habbig S, Pahmeyer C, Höhne M, Weber LT, Thiele H, Altmüller J, Kottoor N, Wenzel A, Krueger M, Schermer B, Benzing T, Rinschen MM, Beck BB.

Hum Mol Genet. 2016 Mar 15;25(6):1152-64. doi: 10.1093/hmg/ddv638. Epub 2016 Jan 5.

PMID:
26740551
29.

Water transport running deep. Focus on "Deep proteomic profiling of vasopressin-sensitive collecting duct cells".

Rinschen MM.

Am J Physiol Cell Physiol. 2015 Dec 15;309(12):C783-4. doi: 10.1152/ajpcell.00280.2015. Epub 2015 Sep 30. No abstract available.

30.

(Sugar-) Sweet Biomarkers? Clinical Proteomics Enters Sepsis Research.

Rinschen MM.

Crit Care Med. 2015 Oct;43(10):2245-6. doi: 10.1097/CCM.0000000000001220. No abstract available.

PMID:
26376247
31.

Proteomic analysis of the kidney filtration barrier--Problems and perspectives.

Rinschen MM, Benzing T, Limbutara K, Pisitkun T.

Proteomics Clin Appl. 2015 Dec;9(11-12):1053-68. doi: 10.1002/prca.201400201. Epub 2015 Aug 11. Review.

PMID:
25907645
32.

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.

Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA.

Development. 2015 Apr 1;142(7):1254-66. doi: 10.1242/dev.119735.

33.

Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.

Rinschen MM, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maaß M, Bartram MP, Lamkemeyer T, Schermer B, Benzing T, Brinkkoetter PT.

Proteomics. 2015 Apr;15(7):1326-31. doi: 10.1002/pmic.201400235. Epub 2015 Jan 19.

PMID:
25420462
34.

Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity.

Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, Schermer B.

J Biol Chem. 2014 Sep 19;289(38):26344-56. doi: 10.1074/jbc.M114.562165. Epub 2014 Aug 6.

35.

A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin.

Schurek EM, Völker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, Höhne M.

J Biol Chem. 2014 Apr 18;289(16):11262-71. doi: 10.1074/jbc.M113.521773. Epub 2014 Mar 4.

36.

The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.

Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, LaRiviere WB, Schermer B, Pei YP, Torres VE, Weimbs T.

J Am Soc Nephrol. 2014 Aug;25(8):1737-48. doi: 10.1681/ASN.2013091026. Epub 2014 Feb 27.

37.

Label-free quantitative proteomic analysis of the YAP/TAZ interactome.

Kohli P, Bartram MP, Habbig S, Pahmeyer C, Lamkemeyer T, Benzing T, Schermer B, Rinschen MM.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C805-18. doi: 10.1152/ajpcell.00339.2013. Epub 2014 Feb 26.

38.

Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again.

Rinschen MM, Schermer B, Benzing T.

J Am Soc Nephrol. 2014 Jun;25(6):1140-7. doi: 10.1681/ASN.2013101037. Epub 2014 Feb 20. Review.

39.

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier.

Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T.

J Am Soc Nephrol. 2014 Jul;25(7):1509-22. doi: 10.1681/ASN.2013070760. Epub 2014 Feb 7.

40.

Characterization of a short isoform of the kidney protein podocin in human kidney.

Völker LA, Schurek EM, Rinschen MM, Tax J, Schutte BA, Lamkemeyer T, Ungrue D, Schermer B, Benzing T, Höhne M.

BMC Nephrol. 2013 May 6;14:102. doi: 10.1186/1471-2369-14-102.

41.

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner.

Gharbi H, Fabretti F, Bharill P, Rinschen MM, Brinkkötter S, Frommolt P, Burst V, Schermer B, Benzing T, Müller RU.

Aging Cell. 2013 Aug;12(4):593-603. doi: 10.1111/acel.12081. Epub 2013 May 15.

42.

Quantitative proteomics identifies vasopressin-responsive nuclear proteins in collecting duct cells.

Schenk LK, Bolger SJ, Luginbuhl K, Gonzales PA, Rinschen MM, Yu MJ, Hoffert JD, Pisitkun T, Knepper MA.

J Am Soc Nephrol. 2012 Jun;23(6):1008-18. doi: 10.1681/ASN.2011070738. Epub 2012 Mar 22.

43.

Different effects of CsA and FK506 on aquaporin-2 abundance in rat primary cultured collecting duct cells.

Rinschen MM, Klokkers J, Pavenstädt H, Neugebauer U, Schlatter E, Edemir B.

Pflugers Arch. 2011 Oct;462(4):611-22. doi: 10.1007/s00424-011-0994-6. Epub 2011 Jul 20.

PMID:
21773745
44.

Cyclosporin-A induced toxicity in rat renal collecting duct cells: interference with enhanced hypertonicity induced apoptosis.

Schenk LK, Rinschen MM, Klokkers J, Kurian SM, Neugebauer U, Salomon DR, Pavenstaedt H, Schlatter E, Edemir B.

Cell Physiol Biochem. 2010;26(6):887-900. doi: 10.1159/000323998. Epub 2011 Jan 4.

45.

Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells.

Gunaratne R, Braucht DW, Rinschen MM, Chou CL, Hoffert JD, Pisitkun T, Knepper MA.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15653-8. doi: 10.1073/pnas.1007424107. Epub 2010 Aug 16.

46.

Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters.

Hwang S, Gunaratne R, Rinschen MM, Yu MJ, Pisitkun T, Hoffert JD, Fenton RA, Knepper MA, Chou CL.

Am J Physiol Renal Physiol. 2010 Sep;299(3):F559-67. doi: 10.1152/ajprenal.00617.2009. Epub 2010 Jun 24.

47.

Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells.

Rinschen MM, Yu MJ, Wang G, Boja ES, Hoffert JD, Pisitkun T, Knepper MA.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3882-7. doi: 10.1073/pnas.0910646107. Epub 2010 Feb 5.

48.

Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct.

Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2441-6. doi: 10.1073/pnas.0813002106. Epub 2009 Feb 3.

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