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Items: 38

1.

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.

Gaspari S, Purushothaman I, Cogliani V, Sakloth F, Neve RL, Howland D, Ring RH, Ross EM, Shen L, Zachariou V.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2085-E2094. doi: 10.1073/pnas.1707887115. Epub 2018 Feb 12.

2.

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

C Yuen RK, Merico D, Bookman M, L Howe J, Thiruvahindrapuram B, Patel RV, Whitney J, Deflaux N, Bingham J, Wang Z, Pellecchia G, Buchanan JA, Walker S, Marshall CR, Uddin M, Zarrei M, Deneault E, D'Abate L, Chan AJ, Koyanagi S, Paton T, Pereira SL, Hoang N, Engchuan W, Higginbotham EJ, Ho K, Lamoureux S, Li W, MacDonald JR, Nalpathamkalam T, Sung WW, Tsoi FJ, Wei J, Xu L, Tasse AM, Kirby E, Van Etten W, Twigger S, Roberts W, Drmic I, Jilderda S, Modi BM, Kellam B, Szego M, Cytrynbaum C, Weksberg R, Zwaigenbaum L, Woodbury-Smith M, Brian J, Senman L, Iaboni A, Doyle-Thomas K, Thompson A, Chrysler C, Leef J, Savion-Lemieux T, Smith IM, Liu X, Nicolson R, Seifer V, Fedele A, Cook EH, Dager S, Estes A, Gallagher L, Malow BA, Parr JR, Spence SJ, Vorstman J, Frey BJ, Robinson JT, Strug LJ, Fernandez BA, Elsabbagh M, Carter MT, Hallmayer J, Knoppers BM, Anagnostou E, Szatmari P, Ring RH, Glazer D, Pletcher MT, Scherer SW.

Nat Neurosci. 2017 Apr;20(4):602-611. doi: 10.1038/nn.4524. Epub 2017 Mar 6.

3.

Genome-wide characteristics of de novo mutations in autism.

Yuen RK, Merico D, Cao H, Pellecchia G, Alipanahi B, Thiruvahindrapuram B, Tong X, Sun Y, Cao D, Zhang T, Wu X, Jin X, Zhou Z, Liu X, Nalpathamkalam T, Walker S, Howe JL, Wang Z, MacDonald JR, Chan A, D'Abate L, Deneault E, Siu MT, Tammimies K, Uddin M, Zarrei M, Wang M, Li Y, Wang J, Wang J, Yang H, Bookman M, Bingham J, Gross SS, Loy D, Pletcher M, Marshall CR, Anagnostou E, Zwaigenbaum L, Weksberg R, Fernandez BA, Roberts W, Szatmari P, Glazer D, Frey BJ, Ring RH, Xu X, Scherer SW.

NPJ Genom Med. 2016 Aug 3;1:160271-1602710.

4.

Whole-genome sequencing of quartet families with autism spectrum disorder.

Yuen RK, Thiruvahindrapuram B, Merico D, Walker S, Tammimies K, Hoang N, Chrysler C, Nalpathamkalam T, Pellecchia G, Liu Y, Gazzellone MJ, D'Abate L, Deneault E, Howe JL, Liu RS, Thompson A, Zarrei M, Uddin M, Marshall CR, Ring RH, Zwaigenbaum L, Ray PN, Weksberg R, Carter MT, Fernandez BA, Roberts W, Szatmari P, Scherer SW.

Nat Med. 2015 Feb;21(2):185-91. doi: 10.1038/nm.3792. Epub 2015 Jan 26.

PMID:
25621899
5.

Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives.

Kas MJ, Glennon JC, Buitelaar J, Ey E, Biemans B, Crawley J, Ring RH, Lajonchere C, Esclassan F, Talpos J, Noldus LP, Burbach JP, Steckler T.

Psychopharmacology (Berl). 2014 Mar;231(6):1125-46. doi: 10.1007/s00213-013-3268-5. Epub 2013 Sep 19. Review.

PMID:
24048469
6.

Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing.

Jiang YH, Yuen RK, Jin X, Wang M, Chen N, Wu X, Ju J, Mei J, Shi Y, He M, Wang G, Liang J, Wang Z, Cao D, Carter MT, Chrysler C, Drmic IE, Howe JL, Lau L, Marshall CR, Merico D, Nalpathamkalam T, Thiruvahindrapuram B, Thompson A, Uddin M, Walker S, Luo J, Anagnostou E, Zwaigenbaum L, Ring RH, Wang J, Lajonchere C, Wang J, Shih A, Szatmari P, Yang H, Dawson G, Li Y, Scherer SW.

Am J Hum Genet. 2013 Aug 8;93(2):249-63. doi: 10.1016/j.ajhg.2013.06.012. Epub 2013 Jul 11.

7.

Social attention: a possible early indicator of efficacy in autism clinical trials.

Dawson G, Bernier R, Ring RH.

J Neurodev Disord. 2012 May 17;4(1):11. doi: 10.1186/1866-1955-4-11.

8.

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.

Hughes ZA, Neal SJ, Smith DL, Sukoff Rizzo SJ, Pulicicchio CM, Lotarski S, Lu S, Dwyer JM, Brennan J, Olsen M, Bender CN, Kouranova E, Andree TH, Harrison JE, Whiteside GT, Springer D, O'Neil SV, Leonard SK, Schechter LE, Dunlop J, Rosenzweig-Lipson S, Ring RH.

Neuropharmacology. 2013 Mar;66:202-14. doi: 10.1016/j.neuropharm.2012.04.007. Epub 2012 Apr 21.

PMID:
22551786
9.

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.

Silverman JL, Smith DG, Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN.

Sci Transl Med. 2012 Apr 25;4(131):131ra51. doi: 10.1126/scitranslmed.3003501.

10.
11.

Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus.

Monopoli MP, Raghnaill MN, Loscher JS, O'Sullivan NC, Pangalos MN, Ring RH, von Schack D, Dunn MJ, Regan CM, Pennington S, Murphy KJ.

Proteomics. 2011 Nov;11(21):4189-201. doi: 10.1002/pmic.201100072. Epub 2011 Oct 17.

PMID:
22002935
12.

Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis.

Stephenson DT, O'Neill SM, Narayan S, Tiwari A, Arnold E, Samaroo HD, Du F, Ring RH, Campbell B, Pletcher M, Vaidya VA, Morton D.

Mol Autism. 2011 May 16;2(1):7. doi: 10.1186/2040-2392-2-7.

13.

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, Di L, Platt BJ, Neal S, Dwyer JM, Bender CN, Zhang J, Lock T, Kowal D, Kramer A, Randall A, Huselton C, Vishwanathan K, Tse SY, Butera J, Ring RH, Rosenzweig-Lipson S, Hughes ZA, Dunlop J.

J Pharmacol Exp Ther. 2011 Jul;338(1):345-52. doi: 10.1124/jpet.110.177378. Epub 2011 Apr 20.

PMID:
21508084
14.

A complicated picture of oxytocin action in the central nervous system revealed.

Ring RH.

Biol Psychiatry. 2011 May 1;69(9):818-9. doi: 10.1016/j.biopsych.2011.03.020. No abstract available.

PMID:
21497680
15.

Immunohistochemical localization of the neuropeptide S receptor in the rat central nervous system.

Leonard SK, Ring RH.

Neuroscience. 2011 Jan 13;172:153-63. doi: 10.1016/j.neuroscience.2010.10.020. Epub 2010 Oct 13.

PMID:
20950671
16.

Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.

Chanda PK, Gao Y, Mark L, Btesh J, Strassle BW, Lu P, Piesla MJ, Zhang MY, Bingham B, Uveges A, Kowal D, Garbe D, Kouranova EV, Ring RH, Bates B, Pangalos MN, Kennedy JD, Whiteside GT, Samad TA.

Mol Pharmacol. 2010 Dec;78(6):996-1003. doi: 10.1124/mol.110.068304. Epub 2010 Sep 20.

PMID:
20855465
17.

Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.

Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M, Shen R, Zhang MY, Strassle BW, Lu P, Mark L, Piesla MJ, Deng K, Kouranova EV, Ring RH, Whiteside GT, Bates B, Walsh FS, Williams G, Pangalos MN, Samad TA, Doherty P.

J Neurosci. 2010 Feb 10;30(6):2017-24. doi: 10.1523/JNEUROSCI.5693-09.2010.

18.

Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat.

Murphy KJ, Ter Horst JP, Cassidy AW, DeSouza IE, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, Lukasz B, Moran MP, McCabe OM, Wantuch CM, Hughes ZA, Mulvany SK, Higgins DG, Pangalos MN, Marquis KL, O'Connor WT, Ring RH, von Schack D, Regan CM.

J Neurochem. 2010 May;113(3):601-14. doi: 10.1111/j.1471-4159.2010.06617.x. Epub 2010 Jan 24.

19.

Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders.

Hughes ZA, Liu F, Marquis K, Muniz L, Pangalos MN, Ring RH, Whiteside GT, Brandon NJ.

Curr Mol Pharmacol. 2009 Nov;2(3):215-36. Review.

PMID:
20021460
20.

Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia.

Han MH, Renthal W, Ring RH, Rahman Z, Psifogeorgou K, Howland D, Birnbaum S, Young K, Neve R, Nestler EJ, Zachariou V.

Biol Psychiatry. 2010 Apr 15;67(8):761-9. doi: 10.1016/j.biopsych.2009.08.041. Epub 2009 Nov 14.

21.

Neuropeptides. Editorial.

Ring RH.

Neuropharmacology. 2010 Jan;58(1):1. doi: 10.1016/j.neuropharm.2009.08.015. No abstract available.

PMID:
19887230
22.

Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist.

Ring RH, Schechter LE, Leonard SK, Dwyer JM, Platt BJ, Graf R, Grauer S, Pulicicchio C, Resnick L, Rahman Z, Sukoff Rizzo SJ, Luo B, Beyer CE, Logue SF, Marquis KL, Hughes ZA, Rosenzweig-Lipson S.

Neuropharmacology. 2010 Jan;58(1):69-77. doi: 10.1016/j.neuropharm.2009.07.016. Epub 2009 Jul 15.

PMID:
19615387
23.

Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse.

Balu DT, Hodes GE, Hill TE, Ho N, Rahman Z, Bender CN, Ring RH, Dwyer JM, Rosenzweig-Lipson S, Hughes ZA, Schechter LE, Lucki I.

J Pharmacol Toxicol Methods. 2009 Mar-Apr;59(2):100-7. doi: 10.1016/j.vascn.2008.12.002. Epub 2008 Dec 14.

24.

Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: correlation with hyperpolarization-activated current gating.

Kouranova EV, Strassle BW, Ring RH, Bowlby MR, Vasilyev DV.

Neuroscience. 2008 Jun 2;153(4):1008-19. doi: 10.1016/j.neuroscience.2008.03.032. Epub 2008 Mar 22.

PMID:
18450385
25.

Inhibition of uptake 2 (or extraneuronal monoamine transporter) by normetanephrine potentiates the neurochemical effects of venlafaxine.

Rahman Z, Ring RH, Young K, Platt B, Lin Q, Schechter LE, Rosenzweig-Lipson S, Beyer CE.

Brain Res. 2008 Apr 8;1203:68-78. doi: 10.1016/j.brainres.2008.01.062. Epub 2008 Feb 5.

PMID:
18321472
26.

Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders.

Leonard SK, Dwyer JM, Sukoff Rizzo SJ, Platt B, Logue SF, Neal SJ, Malberg JE, Beyer CE, Schechter LE, Rosenzweig-Lipson S, Ring RH.

Psychopharmacology (Berl). 2008 May;197(4):601-11. doi: 10.1007/s00213-008-1080-4. Epub 2008 Mar 3.

PMID:
18311561
27.

Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon.

Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE.

Neuropeptides. 2007 Oct;41(5):307-20. Epub 2007 Jul 16.

PMID:
17637475
28.

Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects.

Malberg JE, Platt B, Rizzo SJ, Ring RH, Lucki I, Schechter LE, Rosenzweig-Lipson S.

Neuropsychopharmacology. 2007 Nov;32(11):2360-8. Epub 2007 Mar 7.

29.

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

Riddell DR, Zhou H, Comery TA, Kouranova E, Lo CF, Warwick HK, Ring RH, Kirksey Y, Aschmies S, Xu J, Kubek K, Hirst WD, Gonzales C, Chen Y, Murphy E, Leonard S, Vasylyev D, Oganesian A, Martone RL, Pangalos MN, Reinhart PH, Jacobsen JS.

Mol Cell Neurosci. 2007 Apr;34(4):621-8. Epub 2007 Jan 25.

PMID:
17336088
30.

Differentiating antidepressants of the future: efficacy and safety.

Rosenzweig-Lipson S, Beyer CE, Hughes ZA, Khawaja X, Rajarao SJ, Malberg JE, Rahman Z, Ring RH, Schechter LE.

Pharmacol Ther. 2007 Jan;113(1):134-53. Epub 2006 Sep 27. Review.

PMID:
17010443
31.

Innovative approaches for the development of antidepressant drugs: current and future strategies.

Schechter LE, Ring RH, Beyer CE, Hughes ZA, Khawaja X, Malberg JE, Rosenzweig-Lipson S.

NeuroRx. 2005 Oct;2(4):590-611. Review.

32.

Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications.

Ring RH, Malberg JE, Potestio L, Ping J, Boikess S, Luo B, Schechter LE, Rizzo S, Rahman Z, Rosenzweig-Lipson S.

Psychopharmacology (Berl). 2006 Apr;185(2):218-25. Epub 2006 Jan 18.

PMID:
16418825
33.
34.
35.

The Cdkn1a gene (p21Waf1/Cip1) is an inflammatory response gene in the mouse central nervous system.

Ring RH, Valo Z, Gao C, Barish ME, Singer-Sam J.

Neurosci Lett. 2003 Oct 23;350(2):73-6.

PMID:
12972156
36.

High-throughput confirmation of differential display PCR results using reverse Northern blotting.

Dilks DW, Ring RH, Khawaja XZ, Novak TJ, Aston C.

J Neurosci Methods. 2003 Feb 15;123(1):47-54.

PMID:
12581848
37.

Failure to detect Chlamydia pneumoniae in the late-onset Alzheimer's brain.

Ring RH, Lyons JM.

J Clin Microbiol. 2000 Jul;38(7):2591-4.

38.

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