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Items: 41


GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.

Luan HH, Wang A, Hilliard BK, Carvalho F, Rosen CE, Ahasic AM, Herzog EL, Kang I, Pisani MA, Yu S, Zhang C, Ring AM, Young LH, Medzhitov R.

Cell. 2019 Aug 22;178(5):1231-1244.e11. doi: 10.1016/j.cell.2019.07.033. Epub 2019 Aug 8.


Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade.

Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF.

Melanoma Res. 2019 Jun 12. doi: 10.1097/CMR.0000000000000629. [Epub ahead of print]


Long-Term Lung Function and Exercise Capacity in Postinfectious chILD.

Sisman Y, Buchvald FF, Ring AM, Wassilew K, Nielsen KG.

Pediatr Allergy Immunol Pulmonol. 2019 Mar 1;32(1):4-11. doi: 10.1089/ped.2018.0973. Epub 2019 Mar 28.


A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology.

Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW.

Cell. 2019 May 16;177(5):1217-1231.e18. doi: 10.1016/j.cell.2019.03.036. Epub 2019 Apr 18.


One-year evolution and variability in multiple-breath washout indices in children and young adults with primary ciliary dyskinesia.

Kobbernagel HE, Green K, Ring AM, Buchvald FF, Rosthøj S, Gustafsson PM, Nielsen KG.

Eur Clin Respir J. 2019 Mar 26;6(1):1591841. doi: 10.1080/20018525.2019.1591841. eCollection 2019.


Fitness and lung function in children with primary ciliary dyskinesia and cystic fibrosis.

Ring AM, Buchvald FF, Holgersen MG, Green K, Nielsen KG.

Respir Med. 2018 Jun;139:79-85. doi: 10.1016/j.rmed.2018.05.001. Epub 2018 May 3.


Yeast surface display platform for rapid discovery of conformationally selective nanobodies.

McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC.

Nat Struct Mol Biol. 2018 Mar;25(3):289-296. doi: 10.1038/s41594-018-0028-6. Epub 2018 Feb 12.


Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy.

Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, Ring AM, Weissman IL, Maute RL.

Nat Immunol. 2018 Jan;19(1):76-84. doi: 10.1038/s41590-017-0004-z. Epub 2017 Nov 27.


Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585. doi: 10.1073/pnas.1710877114. Epub 2017 Nov 20.


PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.

Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, Tsai JM, Sinha R, Corey D, Ring AM, Connolly AJ, Weissman IL.

Nature. 2017 May 25;545(7655):495-499. doi: 10.1038/nature22396. Epub 2017 May 17.


Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Ho CCM, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC.

Cell. 2017 Mar 9;168(6):1041-1052.e18. doi: 10.1016/j.cell.2017.02.011.


Practical Immuno-PET Radiotracer Design Considerations for Human Immune Checkpoint Imaging.

Mayer AT, Natarajan A, Gordon SR, Maute RL, McCracken MN, Ring AM, Weissman IL, Gambhir SS.

J Nucl Med. 2017 Apr;58(4):538-546. doi: 10.2967/jnumed.116.177659. Epub 2016 Dec 15.


Cardiopulmonary Exercise Testing in Fontan Patients With and Without Isomerism (Heterotaxy) as Compared to Patients With Primary Ciliary Dyskinesia and Subjects With Structurally Normal Hearts.

Loomba RS, Danduran M, Nielsen KG, Ring AM, Kovach J, Anderson RH.

Pediatr Cardiol. 2017 Feb;38(2):410-417. doi: 10.1007/s00246-016-1531-3. Epub 2016 Nov 23.


Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.

Weiskopf K, Anderson KL, Ito D, Schnorr PJ, Tomiyasu H, Ring AM, Bloink K, Efe J, Rue S, Lowery D, Barkal A, Prohaska S, McKenna KM, Cornax I, O'Brien TD, O'Sullivan MG, Weissman IL, Modiano JF.

Cancer Immunol Res. 2016 Dec;4(12):1072-1087. Epub 2016 Nov 14.


Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.

Pascolutti R, Sun X, Kao J, Maute RL, Ring AM, Bowman GR, Kruse AC.

Structure. 2016 Oct 4;24(10):1719-1728. doi: 10.1016/j.str.2016.06.026. Epub 2016 Sep 8.


Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy.

Chhabra A, Ring AM, Weiskopf K, Schnorr PJ, Gordon S, Le AC, Kwon HS, Ring NG, Volkmer J, Ho PY, Tseng S, Weissman IL, Shizuru JA.

Sci Transl Med. 2016 Aug 10;8(351):351ra105. doi: 10.1126/scitranslmed.aae0501.


CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.

Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, Guerston H, Barkal A, Trapani F, George J, Poirier JT, Gardner EE, Miles LA, de Stanchina E, Lofgren SM, Vogel H, Winslow MM, Dive C, Thomas RK, Rudin CM, van de Rijn M, Majeti R, Garcia KC, Weissman IL, Sage J.

J Clin Invest. 2016 Jul 1;126(7):2610-20. doi: 10.1172/JCI81603. Epub 2016 Jun 13.


Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.

Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6506-14. doi: 10.1073/pnas.1519623112. Epub 2015 Nov 10.


Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ.

Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018.


Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC.

Immunity. 2015 May 19;42(5):815-25. doi: 10.1016/j.immuni.2015.04.015.


"Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis.

Ho CC, Guo N, Sockolosky JT, Ring AM, Weiskopf K, Özkan E, Mori Y, Weissman IL, Garcia KC.

J Biol Chem. 2015 May 15;290(20):12650-63. doi: 10.1074/jbc.M115.648220. Epub 2015 Apr 2.


Cytokine therapy reverses NK cell anergy in MHC-deficient tumors.

Ardolino M, Azimi CS, Iannello A, Trevino TN, Horan L, Zhang L, Deng W, Ring AM, Fischer S, Garcia KC, Raulet DH.

J Clin Invest. 2014 Nov;124(11):4781-94. doi: 10.1172/JCI74337. Epub 2014 Oct 20.


Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants.

Weiskopf K, Ring AM, Schnorr PJ, Volkmer JP, Volkmer AK, Weissman IL, Garcia KC.

Oncoimmunology. 2013 Sep 1;2(9):e25773. Epub 2013 Jul 29.


Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK.

Nature. 2013 Dec 5;504(7478):101-6. doi: 10.1038/nature12735. Epub 2013 Nov 20.


Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.

Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK.

Nature. 2013 Oct 24;502(7472):575-579. doi: 10.1038/nature12572. Epub 2013 Sep 22.


Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.

Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK, Ozkan E, Fernhoff NB, van de Rijn M, Weissman IL, Garcia KC.

Science. 2013 Jul 5;341(6141):88-91. doi: 10.1126/science.1238856. Epub 2013 May 30.


Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC.

Nat Immunol. 2012 Dec;13(12):1187-95. doi: 10.1038/ni.2449. Epub 2012 Oct 28.


Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC.

Nature. 2012 Mar 25;484(7395):529-33. doi: 10.1038/nature10975.


WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.

Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP.

J Biol Chem. 2011 Aug 26;286(34):30171-80. doi: 10.1074/jbc.M111.222893. Epub 2011 Jul 6.


Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.

San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4384-9. doi: 10.1073/pnas.0813238106. Epub 2009 Feb 24.


Molecular physiology of the WNK kinases.

Kahle KT, Ring AM, Lifton RP.

Annu Rev Physiol. 2008;70:329-55. Review.


The effect of a prolonged time interval between antenatal corticosteroid administration and delivery on outcomes in preterm neonates: a cohort study.

Ring AM, Garland JS, Stafeil BR, Carr MH, Peckman GS, Pircon RA.

Am J Obstet Gynecol. 2007 May;196(5):457.e1-6.


An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.

Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, Lifton RP.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4025-9. Epub 2007 Feb 22.


WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.

Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4020-4. Epub 2007 Feb 26.


Multiphasic screening: panacea or diagnostic nightmare?

Ring AM.

JAMA. 1985 Sep 20;254(11):1499. No abstract available.


Letter: Programs for the programmable calculator in the laboratory.

Ring AM.

Am J Clin Pathol. 1974 Apr;61(4):575-6. No abstract available.


The concept of benign metastasizing hydatidiform moles.

Ring AM.

Am J Clin Pathol. 1972 Aug;58(2):111-7. No abstract available.


Patient identification in blood transfusions.

Ring AM.

JAMA. 1972 Mar 6;219(10):1340. No abstract available.


Metastasizing retroperitoneal fibroxanthoma (malignant fibroxanthoma).

Rosas-Uribe A, Ring AM, Rappaport H.

Cancer. 1970 Oct;26(4):827-31. No abstract available.


Isolated regional enteritis of the appendix.

Ring AM.

Int Surg. 1970 Oct;54(4):290-4. No abstract available.


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