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Items: 44


Bringing Light to Transcription: The Optogenetics Repertoire.

de Mena L, Rizk P, Rincon-Limas DE.

Front Genet. 2018 Nov 2;9:518. doi: 10.3389/fgene.2018.00518. eCollection 2018. Review.


Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer's disease.

Martín-Peña A, Rincón-Limas DE, Fernandez-Fúnez P.

Sci Rep. 2018 Jul 2;8(1):9915. doi: 10.1038/s41598-018-28341-w.


Lmx1a is required for the development of the ovarian stem cell niche in Drosophila.

Allbee AW, Rincon-Limas DE, Biteau B.

Development. 2018 Apr 25;145(8). pii: dev163394. doi: 10.1242/dev.163394.


Short Aβ peptides attenuate Aβ42 toxicity in vivo.

Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE.

J Exp Med. 2018 Jan 2;215(1):283-301. doi: 10.1084/jem.20170600. Epub 2017 Dec 5.


Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer's disease.

Martin-Peña A, Rincon-Limas DE, Fernandez-Funez P.

Sci Rep. 2017 Sep 12;7(1):11268. doi: 10.1038/s41598-017-11594-2.


A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.

Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF.

PLoS One. 2017 May 3;12(5):e0173565. doi: 10.1371/journal.pone.0173565. eCollection 2017.


Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity.

Fernandez-Funez P, Sanchez-Garcia J, Rincon-Limas DE.

Curr Opin Genet Dev. 2017 Jun;44:141-148. doi: 10.1016/j.gde.2017.03.013. Epub 2017 Apr 14. Review.


secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids.

De Mena L, Chhangani D, Fernandez-Funez P, Rincon-Limas DE.

Fly (Austin). 2017 Jul 3;11(3):179-184. doi: 10.1080/19336934.2017.1291104. Epub 2017 Feb 6.


Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila.

Fernandez-Funez P, Sanchez-Garcia J, de Mena L, Zhang Y, Levites Y, Khare S, Golde TE, Rincon-Limas DE.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5212-21. doi: 10.1073/pnas.1608045113. Epub 2016 Aug 16.


A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila.

Sanchez-Garcia J, Jensen K, Zhang Y, Rincon-Limas DE, Fernandez-Funez P.

Neurobiol Dis. 2016 Nov;95:204-9. doi: 10.1016/j.nbd.2016.07.025. Epub 2016 Jul 28.


Data set of interactomes and metabolic pathways of proteins differentially expressed in brains with Alzheimer׳s disease.

Minjarez B, Calderón-González KG, Valero Rustarazo ML, Herrera-Aguirre ME, Labra-Barrios ML, Rincon-Limas DE, Sánchez Del Pino MM, Mena R, Luna-Arias JP.

Data Brief. 2016 May 6;7:1707-19. doi: 10.1016/j.dib.2016.04.071. eCollection 2016 Jun.


Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry.

Minjarez B, Calderón-González KG, Rustarazo ML, Herrera-Aguirre ME, Labra-Barrios ML, Rincon-Limas DE, Del Pino MM, Mena R, Luna-Arias JP.

J Proteomics. 2016 Apr 29;139:103-21. doi: 10.1016/j.jprot.2016.03.022. Epub 2016 Mar 21.


Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease.

Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, de Mena L, Khare S, Golde TE, Levites Y, Rincon-Limas DE.

Hum Mol Genet. 2015 Nov 1;24(21):6093-105. doi: 10.1093/hmg/ddv321. Epub 2015 Aug 7.


Modeling the complex pathology of Alzheimer's disease in Drosophila.

Fernandez-Funez P, de Mena L, Rincon-Limas DE.

Exp Neurol. 2015 Dec;274(Pt A):58-71. doi: 10.1016/j.expneurol.2015.05.013. Epub 2015 May 27. Review.


KCNC3(R420H), a K(+) channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking.

Gallego-Iradi C, Bickford JS, Khare S, Hall A, Nick JA, Salmasinia D, Wawrowsky K, Bannykh S, Huynh DP, Rincon-Limas DE, Pulst SM, Nick HS, Fernandez-Funez P, Waters MF.

Neurobiol Dis. 2014 Nov;71:270-9. doi: 10.1016/j.nbd.2014.08.020. Epub 2014 Aug 22.


Launching Hsp70 neuroprotection: two drugs better than one.

Fernandez-Funez P, Rincon-Limas DE.

Cell Cycle. 2014;13(11):1657-8. doi: 10.4161/cc.29148. Epub 2014 May 8. No abstract available.


Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.

Zhang Y, Casas-Tinto S, Rincon-Limas DE, Fernandez-Funez P.

PLoS One. 2014 Feb 11;9(2):e88522. doi: 10.1371/journal.pone.0088522. eCollection 2014.


Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.

Sanchez-Garcia J, Arbelaez D, Jensen K, Rincon-Limas DE, Fernandez-Funez P.

Hum Mol Genet. 2013 Nov 1;22(21):4253-66. doi: 10.1093/hmg/ddt276. Epub 2013 Jun 13.


p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila.

Zhang Y, Arcia S, Perez B, Fernandez-Funez P, Rincon-Limas DE.

Mol Biol Rep. 2013 Sep;40(9):5407-15. doi: 10.1007/s11033-013-2639-7. Epub 2013 May 17.


Purification of transcripts and metabolites from Drosophila heads.

Jensen K, Sanchez-Garcia J, Williams C, Khare S, Mathur K, Graze RM, Hahn DA, McIntyre LM, Rincon-Limas DE, Fernandez-Funez P.

J Vis Exp. 2013 Mar 15;(73):e50245. doi: 10.3791/50245.


Differential activation of the ER stress factor XBP1 by oligomeric assemblies.

Castillo-Carranza DL, Zhang Y, Guerrero-Muñoz MJ, Kayed R, Rincon-Limas DE, Fernandez-Funez P.

Neurochem Res. 2012 Aug;37(8):1707-17. doi: 10.1007/s11064-012-0780-7. Epub 2012 Apr 21.


Drosophila models of proteinopathies: the little fly that could.

Rincon-Limas DE, Jensen K, Fernandez-Funez P.

Curr Pharm Des. 2012;18(8):1108-22. Review.


Pulling rabbits to reveal the secrets of the prion protein.

Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, Jensen K, Zou WQ, Rincon-Limas DE.

Commun Integr Biol. 2011 May;4(3):262-6. doi: 10.4161/cib.4.3.15054. Epub 2011 May 1.


Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.

Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP.

J Biol Chem. 2011 Apr 29;286(17):15095-105. doi: 10.1074/jbc.M110.199356. Epub 2011 Mar 10.


The ER stress factor XBP1s prevents amyloid-beta neurotoxicity.

Casas-Tinto S, Zhang Y, Sanchez-Garcia J, Gomez-Velazquez M, Rincon-Limas DE, Fernandez-Funez P.

Hum Mol Genet. 2011 Jun 1;20(11):2144-60. doi: 10.1093/hmg/ddr100. Epub 2011 Mar 9.


Sequence-dependent prion protein misfolding and neurotoxicity.

Fernandez-Funez P, Zhang Y, Casas-Tinto S, Xiao X, Zou WQ, Rincon-Limas DE.

J Biol Chem. 2010 Nov 19;285(47):36897-908. doi: 10.1074/jbc.M110.174391. Epub 2010 Sep 3.


Exploring prion protein biology in flies: genetics and beyond.

Rincon-Limas DE, Casas-Tinto S, Fernandez-Funez P.

Prion. 2010 Jan-Mar;4(1):1-8. Epub 2010 Jan 30.


In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms.

Fernandez-Funez P, Casas-Tinto S, Zhang Y, Gómez-Velazquez M, Morales-Garza MA, Cepeda-Nieto AC, Castilla J, Soto C, Rincon-Limas DE.

PLoS Genet. 2009 Jun;5(6):e1000507. doi: 10.1371/journal.pgen.1000507. Epub 2009 Jun 5.


Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.

Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J.

Hum Mol Genet. 2008 Feb 1;17(3):376-90. Epub 2007 Nov 5.


Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome.

Bergman CM, Pfeiffer BD, Rincón-Limas DE, Hoskins RA, Gnirke A, Mungall CJ, Wang AM, Kronmiller B, Pacleb J, Park S, Stapleton M, Wan K, George RA, de Jong PJ, Botas J, Rubin GM, Celniker SE.

Genome Biol. 2002;3(12):RESEARCH0086. Epub 2002 Dec 30.


Conservation of the expression and function of apterous orthologs in Drosophila and mammals.

Rincón-Limas DE, Lu CH, Canal I, Calleja M, Rodríguez-Esteban C, Izpisúa-Belmonte JC, Botas J.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2165-70.


The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing.

Fernández-Fúnez P, Lu CH, Rincón-Limas DE, García-Bellido A, Botas J.

EMBO J. 1998 Dec 1;17(23):6846-53.


Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.

Rodriguez-Esteban C, Schwabe JW, Peña JD, Rincon-Limas DE, Magallón J, Botas J, Izpisúa Belmonte JC.

Development. 1998 Oct;125(20):3925-34.


Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity.

Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C.

Differentiation. 1998 Jul;63(3):151-7.


Ubiquitous and neuronal DNA-binding proteins interact with a negative regulatory element of the human hypoxanthine phosphoribosyltransferase gene.

Rincón-Limas DE, Amaya-Manzanares F, Niño-Rosales ML, Yu Y, Yang TP, Patel PI.

Mol Cell Biol. 1995 Dec;15(12):6561-71.


5'-flanking sequences of the human HPRT gene direct neuronal expression in the brain of transgenic mice.

Rincón-Limas DE, Geske RS, Xue JJ, Hsu CY, Overbeek PA, Patel PI.

J Neurosci Res. 1994 Jun 15;38(3):259-67.


HGH isoforms: cDNA expression, adipogenic activity and production in cell culture.

Rincón-Limas DE, Reséndez-Pérez D, Ortíz-López R, Alvídrez-Quihui LE, Castro-MuñozLedo F, Kuri-Harcuch W, Martínez-Rodríguez HG, Barrera-Saldaña HA.

Biochim Biophys Acta. 1993 Feb 20;1172(1-2):49-54.


Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia.

Sanders AR, Rincon-Limas DE, Chakraborty R, Grandchamp B, Hamilton JD, Fann WE, Patel PI.

Schizophr Res. 1993 Jan;8(3):211-21.


Two MspI RFLPs at the D17S258 locus.

Franco B, Rincon-Limas D, Nakamura Y, Patel PI, Lupski JR.

Nucleic Acids Res. 1990 Dec 11;18(23):7196. No abstract available.


Three polymorphisms at the D17S29 locus.

Ray R, Rincon-Limas D, Wright RA, Davis SN, Lupski JR, Patel PI.

Nucleic Acids Res. 1990 Aug 25;18(16):4958. No abstract available.


New vectors for the efficient expression of mammalian genes in cultured cells.

Ramírez-Solís R, Reséndez-Pérez D, Alvidrez-Quihui LE, Rincón-Limas DE, Varela-Martínez R, Martínez-Rodríguez HG, Barrera-Saldaña HA.

Gene. 1990 Mar 15;87(2):291-4.


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