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The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production.

Bessou M, Lopez J, Gadet R, Deygas M, Popgeorgiev N, Poncet D, Nougarède A, Billard P, Mikaelian I, Gonzalo P, Rimokh R, Gillet G.

Oncogene. 2020 Feb 17. doi: 10.1038/s41388-020-1212-9. [Epub ahead of print]


Improved Androgen Receptor Splice Variant 7 Detection Using a Highly Sensitive Assay to Predict Resistance to Abiraterone or Enzalutamide in Metastatic Prostate Cancer Patients.

Maillet D, Allioli N, Peron J, Plesa A, Decaussin-Petrucci M, Tartas S, Ruffion A, Crouzet S, Rimokh R, Gillet PG, Freyer G, Vlaeminck-Guillem V.

Eur Urol Oncol. 2019 Oct 29. pii: S2588-9311(19)30136-1. doi: 10.1016/j.euo.2019.08.010. [Epub ahead of print]


BH4-mimetics and -antagonists: an emerging class of Bcl-2 protein modulators for cancer therapy.

Nougarède A, Rimokh R, Gillet G.

Oncotarget. 2018 Oct 19;9(82):35291-35292. doi: 10.18632/oncotarget.26250. eCollection 2018 Oct 19. No abstract available.


Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen.

Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I.

Nat Commun. 2018 Oct 31;9(1):4545. doi: 10.1038/s41467-018-06988-3.


Improved IRE1 and PERK Pathway Sensors for Multiplex Endoplasmic Reticulum Stress Assay Reveal Stress Response to Nuclear Dyes Used for Image Segmentation.

Nougarède A, Tesnière C, Ylanko J, Rimokh R, Gillet G, Andrews DW.

Assay Drug Dev Technol. 2018 Aug/Sep;16(6):350-360. doi: 10.1089/adt.2018.862. Epub 2018 Aug 8.


Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10.

Nougarede A, Popgeorgiev N, Kassem L, Omarjee S, Borel S, Mikaelian I, Lopez J, Gadet R, Marcillat O, Treilleux I, Villoutreix BO, Rimokh R, Gillet G.

Cancer Res. 2018 Mar 15;78(6):1404-1417. doi: 10.1158/0008-5472.CAN-17-0846. Epub 2018 Jan 12.


Mitochondrial Ca2+ uptake controls actin cytoskeleton dynamics during cell migration.

Prudent J, Popgeorgiev N, Gadet R, Deygas M, Rimokh R, Gillet G.

Sci Rep. 2016 Nov 9;6:36570. doi: 10.1038/srep36570.


MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma.

Bonnin N, Armandy E, Carras J, Ferrandon S, Battiston-Montagne P, Aubry M, Guihard S, Meyronet D, Foy JP, Saintigny P, Ledrappier S, Jung A, Rimokh R, Rodriguez-Lafrasse C, Poncet D.

Oncotarget. 2016 Jul 12;7(28):44023-44038. doi: 10.18632/oncotarget.9829.


The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition.

Ruff M, Leyme A, Le Cann F, Bonnier D, Le Seyec J, Chesnel F, Fattet L, Rimokh R, Baffet G, Théret N.

PLoS One. 2015 Sep 25;10(9):e0139179. doi: 10.1371/journal.pone.0139179. eCollection 2015.


TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients.

Kassem L, Deygas M, Fattet L, Lopez J, Goulvent T, Lavergne E, Chabaud S, Carrabin N, Chopin N, Bachelot T, Gillet G, Treilleux I, Rimokh R.

BMC Cancer. 2015 Jun 4;15:453. doi: 10.1186/s12885-015-1471-y.


DICER1 and FOXL2 mutations in ovarian sex cord-stromal tumours: a GINECO Group study.

Goulvent T, Ray-Coquard I, Borel S, Haddad V, Devouassoux-Shisheboran M, Vacher-Lavenu MC, Pujade-Laurraine E, Savina A, Maillet D, Gillet G, Treilleux I, Rimokh R.

Histopathology. 2016 Jan;68(2):279-85. doi: 10.1111/his.12747. Epub 2015 Jul 21.


17β-estradiol inhibits spreading of metastatic cells from granulosa cell tumors through a non-genomic mechanism involving GPER1.

François CM, Wargnier R, Petit F, Goulvent T, Rimokh R, Treilleux I, Ray-Coquard I, Zazzu V, Cohen-Tannoudji J, Guigon CJ.

Carcinogenesis. 2015 May;36(5):564-73. doi: 10.1093/carcin/bgv041. Epub 2015 Mar 30.


Combination of a discovery LC-MS/MS analysis and a label-free quantification for the characterization of an epithelial-mesenchymal transition signature.

Biarc J, Gonzalo P, Mikaelian I, Fattet L, Deygas M, Gillet G, Lemoine J, Rimokh R.

J Proteomics. 2014 Oct 14;110:183-94. doi: 10.1016/j.jprot.2014.05.026. Epub 2014 Jun 12.


SRC: marker or actor in prostate cancer aggressiveness.

Vlaeminck-Guillem V, Gillet G, Rimokh R.

Front Oncol. 2014 Aug 18;4:222. doi: 10.3389/fonc.2014.00222. eCollection 2014. Review.


RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation.

Dardenne E, Polay Espinoza M, Fattet L, Germann S, Lambert MP, Neil H, Zonta E, Mortada H, Gratadou L, Deygas M, Chakrama FZ, Samaan S, Desmet FO, Tranchevent LC, Dutertre M, Rimokh R, Bourgeois CF, Auboeuf D.

Cell Rep. 2014 Jun 26;7(6):1900-13. doi: 10.1016/j.celrep.2014.05.010. Epub 2014 Jun 6.


Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.

Edmond V, Dufour F, Poiroux G, Shoji K, Malleter M, Fouqué A, Tauzin S, Rimokh R, Sergent O, Penna A, Dupuy A, Levade T, Theret N, Micheau O, Ségui B, Legembre P.

Oncogene. 2015 Feb 19;34(8):996-1005. doi: 10.1038/onc.2014.55. Epub 2014 Mar 17.


The Bcl-2 homolog Nrz inhibits binding of IP3 to its receptor to control calcium signaling during zebrafish epiboly.

Bonneau B, Nougarède A, Prudent J, Popgeorgiev N, Peyriéras N, Rimokh R, Gillet G.

Sci Signal. 2014 Feb 11;7(312):ra14. doi: 10.1126/scisignal.2004480.


Impact of a second opinion using expression and molecular analysis of FOXL2 for sex cord-stromal tumors. A study of the GINECO group & the TMRO network.

Maillet D, Goulvent T, Rimokh R, Vacher-Lavenu MC, Pautier P, Alexandre J, Pujade-Laurraine E, Devouassoux-Shisheboran M, Treilleux I, Ray-Coquard I, Savina A.

Gynecol Oncol. 2014 Jan;132(1):181-7. doi: 10.1016/j.ygyno.2013.10.013. Epub 2013 Oct 22.


Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism.

Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M.

Cancer Res. 2013 Nov 15;73(22):6621-31. doi: 10.1158/0008-5472.CAN-13-0560. Epub 2013 Sep 27.


Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish.

Prudent J, Popgeorgiev N, Bonneau B, Thibaut J, Gadet R, Lopez J, Gonzalo P, Rimokh R, Manon S, Houart C, Herbomel P, Aouacheria A, Gillet G.

Nat Commun. 2013;4:2330. doi: 10.1038/ncomms3330.


TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling.

Fattet L, Ay AS, Bonneau B, Jallades L, Mikaelian I, Treilleux I, Gillet G, Hesling C, Rimokh R.

J Cell Sci. 2013 Aug 15;126(Pt 16):3713-23. doi: 10.1242/jcs.126748. Epub 2013 Jun 20.


Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition.

Hesling C, Lopez J, Fattet L, Gonzalo P, Treilleux I, Blanchard D, Losson R, Goffin V, Pigat N, Puisieux A, Mikaelian I, Gillet G, Rimokh R.

Development. 2013 Jan 1;140(1):167-75. doi: 10.1242/dev.085068. Epub 2012 Nov 15.


ZNF217 is a marker of poor prognosis in breast cancer that drives epithelial-mesenchymal transition and invasion.

Vendrell JA, Thollet A, Nguyen NT, Ghayad SE, Vinot S, Bièche I, Grisard E, Josserand V, Coll JL, Roux P, Corbo L, Treilleux I, Rimokh R, Cohen PA.

Cancer Res. 2012 Jul 15;72(14):3593-606. doi: 10.1158/0008-5472.CAN-11-3095. Epub 2012 May 16.


Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach.

Andrieux G, Fattet L, Le Borgne M, Rimokh R, Théret N.

PLoS One. 2012;7(3):e33761. doi: 10.1371/journal.pone.0033761. Epub 2012 Mar 23.


Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

Lopez J, Hesling C, Prudent J, Popgeorgiev N, Gadet R, Mikaelian I, Rimokh R, Gillet G, Gonzalo P.

Cell Death Differ. 2012 Sep;19(9):1459-69. doi: 10.1038/cdd.2012.21. Epub 2012 Mar 2.


Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells.

Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J, Vanbelle C, Morel AP, Gillet G, Mikaelian I, Rimokh R.

EMBO Rep. 2011 Jul 1;12(7):665-72. doi: 10.1038/embor.2011.78.


Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers.

Garcia AI, Buisson M, Bertrand P, Rimokh R, Rouleau E, Lopez BS, Lidereau R, Mikaélian I, Mazoyer S.

EMBO Mol Med. 2011 May;3(5):279-90. doi: 10.1002/emmm.201100136. Epub 2011 Apr 5.


The NIP7 protein is required for accurate pre-rRNA processing in human cells.

Morello LG, Hesling C, Coltri PP, Castilho BA, Rimokh R, Zanchin NI.

Nucleic Acids Res. 2011 Jan;39(2):648-65. doi: 10.1093/nar/gkq758. Epub 2010 Aug 26.


Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.

Grelier G, Voirin N, Ay AS, Cox DG, Chabaud S, Treilleux I, Léon-Goddard S, Rimokh R, Mikaelian I, Venoux C, Puisieux A, Lasset C, Moyret-Lalle C.

Br J Cancer. 2009 Aug 18;101(4):673-83. doi: 10.1038/sj.bjc.6605193.


Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.

Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, Kaniewski B, Marie JC, Lepinasse F, Martel S, Goddard-Leon S, Iovanna JL, Dubus P, Garcia S, Puisieux A, Rimokh R, Bardeesy N, Scoazec JY, Losson R, Bartholin L.

PLoS Genet. 2009 Jul;5(7):e1000575. doi: 10.1371/journal.pgen.1000575. Epub 2009 Jul 24. Erratum in: PLoS Genet. 2009 Aug;5(8). doi: 10.1371/annotation/7941c465-532f-4b42-b541-72d0810943b9. Kaniewsky, Bastien [corrected to Kaniewski, Bastien].


iNKT cell development is orchestrated by different branches of TGF-beta signaling.

Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC.

J Exp Med. 2009 Jun 8;206(6):1365-78. doi: 10.1084/jem.20090127. Epub 2009 May 18.


Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.

Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC.

Genesis. 2008 Dec;46(12):724-31. doi: 10.1002/dvg.20425.


BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.

Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V.

Blood. 2008 Oct 15;112(8):3154-63. doi: 10.1182/blood-2008-03-145326. Epub 2008 Jul 29.


AF10-dependent transcription is enhanced by its interaction with FLRG.

Forissier S, Razanajaona D, Ay AS, Martel S, Bartholin L, Rimokh R.

Biol Cell. 2007 Oct;99(10):563-71.


Silencing of FLRG, an antagonist of activin, inhibits human breast tumor cell growth.

Razanajaona D, Joguet S, Ay AS, Treilleux I, Goddard-Léon S, Bartholin L, Rimokh R.

Cancer Res. 2007 Aug 1;67(15):7223-9.


Identification of NF-kappaB responsive elements in follistatin related gene (FLRG) promoter.

Bartholin L, Guindon S, Martel S, Corbo L, Rimokh R.

Gene. 2007 May 15;393(1-2):153-62. Epub 2007 Mar 1.


A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin.

Maguer-Satta V, Forissier S, Bartholin L, Martel S, Jeanpierre S, Bachelard E, Rimokh R.

Exp Cell Res. 2006 Feb 15;312(4):434-42. Epub 2005 Dec 5.


AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner.

Hayette S, Cornillet-Lefebvre P, Tigaud I, Struski S, Forissier S, Berchet A, Doll D, Gillot L, Brahim W, Delabesse E, Magaud JP, Rimokh R.

Cancer Res. 2005 Aug 1;65(15):6521-5.


FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation.

Bartholin L, Destaing O, Forissier S, Martel S, Maguer-Satta V, Jurdic P, Rimokh R.

Biol Cell. 2005 Jul;97(7):577-88.


FLRG, member of the follistatin family, a new player in hematopoiesis.

Maguer-Satta V, Rimokh R.

Mol Cell Endocrinol. 2004 Oct 15;225(1-2):109-18. Review.


Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma.

Ciarmela P, Florio P, Sigurdardottir M, Toti P, Maguer-Satta V, Rimokh R, Altomare A, Tosi P, Petraglia F.

Eur J Endocrinol. 2004 Aug;151(2):251-7.


Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide.

Florio P, Ciarmela P, Toti P, Maguer-Satta V, Rimokh R, Buonocore G, Rossi M, Gioffrè W, Petraglia F.

Mol Cell Endocrinol. 2004 Apr 15;218(1-2):129-35.


Allele-specific binding to the -308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter.

Baseggio L, Bartholin L, Chantome A, Charlot C, Rimokh R, Salles G.

Eur J Immunogenet. 2004 Feb;31(1):15-9.


In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene.

Hayette S, Tigaud I, Callet-Bauchu E, Ffrench M, Gazzo S, Wahbi K, Callanan M, Felman P, Dumontet C, Magaud JP, Rimokh R.

Blood. 2003 Aug 15;102(4):1549-50. No abstract available.


BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.

Morel AP, Sentis S, Bianchin C, Le Romancer M, Jonard L, Rostan MC, Rimokh R, Corbo L.

J Cell Sci. 2003 Jul 15;116(Pt 14):2929-36. Epub 2003 May 27.


Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family.

Maguer-Satta V, Bartholin L, Jeanpierre S, Ffrench M, Martel S, Magaud JP, Rimokh R.

Exp Cell Res. 2003 Jan 15;282(2):110-20.


Recurrent involvement of the MLL gene in adult T-lineage acute lymphoblastic leukemia.

Hayette S, Tigaud I, Maguer-Satta V, Bartholin L, Thomas X, Charrin C, Gadoux M, Magaud JP, Rimokh R.

Blood. 2002 Jun 15;99(12):4647-9. No abstract available.


Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function.

Bartholin L, Maguer-Satta V, Hayette S, Martel S, Gadoux M, Corbo L, Magaud JP, Rimokh R.

Oncogene. 2002 Mar 28;21(14):2227-35.


FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins.

Bartholin L, Maguer-Satta V, Hayette S, Martel S, Gadoux M, Bertrand S, Corbo L, Lamadon C, Morera AM, Magaud JP, Rimokh R.

Oncogene. 2001 Sep 6;20(39):5409-19.


Expression of FLRG, a novel activin A ligand, is regulated by TGF-beta and during hematopoiesis [corrected].

Maguer-Satta V, Bartholin L, Jeanpierre S, Gadoux M, Bertrand S, Martel S, Magaud JP, Rimokh R.

Exp Hematol. 2001 Mar;29(3):301-8. Erratum in: Exp Hematol 2001 Jul;29(7):922.


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