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Items: 46

1.

Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration.

Sparks SM, Spearing PK, Diaz CJ, Cowan DJ, Jayawickreme C, Chen G, Rimele TJ, Generaux C, Harston LT, Roller SG.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4673-4677. doi: 10.1016/j.bmcl.2017.09.008. Epub 2017 Sep 7.

PMID:
28916340
2.

Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.

Evans KA, Budzik BW, Ross SA, Wisnoski DD, Jin J, Rivero RA, Vimal M, Szewczyk GR, Jayawickreme C, Moncol DL, Rimele TJ, Armour SL, Weaver SP, Griffin RJ, Tadepalli SM, Jeune MR, Shearer TW, Chen ZB, Chen L, Anderson DL, Becherer JD, De Los Frailes M, Colilla FJ.

J Med Chem. 2009 Dec 24;52(24):7962-5. doi: 10.1021/jm901434t.

PMID:
19902954
3.

1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists.

Sherrill RG, Berman JM, Birkemo L, Croom DK, Dezube M, Ervin GN, Grizzle MK, James MK, Johnson MF, Queen KL, Rimele TJ, Vanmiddlesworth F, Sugg EE.

Bioorg Med Chem Lett. 2001 May 7;11(9):1145-8.

PMID:
11354363
4.

New methods for screening and drug characterization. Foreword.

Rimele TJ.

J Pharmacol Toxicol Methods. 1999 Dec;42(4):175-6. No abstract available.

PMID:
11033432
5.

3-[2-(N-phenylacetamide)]-1,5-benzodiazepines: orally active, binding selective CCK-A agonists.

Willson TM, Henke BR, Momtahen TM, Myers PL, Sugg EE, Unwalla RJ, Croom DK, Dougherty RW, Grizzle MK, Johnson MF, Queen KL, Rimele TJ, Yingling JD, James MK.

J Med Chem. 1996 Jul 19;39(15):3030-4.

PMID:
8709137
6.
7.

Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger".

Aquino CJ, Armour DR, Berman JM, Birkemo LS, Carr RA, Croom DK, Dezube M, Dougherty RW Jr, Ervin GN, Grizzle MK, Head JE, Hirst GC, James MK, Johnson MF, Miller LJ, Queen KL, Rimele TJ, Smith DN, Sugg EE.

J Med Chem. 1996 Jan 19;39(2):562-9.

PMID:
8558528
8.

Secretion of cyclic GMP by cultured epithelial and fibroblast cell lines in response to nitric oxide.

Patel MJ, Wypij DM, Rose DA, Rimele TJ, Wiseman JS.

J Pharmacol Exp Ther. 1995 Apr;273(1):16-25.

PMID:
7536242
9.

BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors.

Goetz AS, King HK, Ward SD, True TA, Rimele TJ, Saussy DL Jr.

Eur J Pharmacol. 1995 Jan 16;272(2-3):R5-6.

PMID:
7713154
10.

CCK-A receptor selective antagonists derived from the CCK-A receptor selective tetrapeptide agonist Boc-Trp-Lys(Tac)-Asp-MePhe-NH2 (A-71623).

Sugg EE, Kimery MJ, Ding JM, Kenakin DC, Miller LJ, Queen KL, Rimele TJ.

J Med Chem. 1995 Jan 6;38(1):207-11.

PMID:
7837233
11.

Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes.

Goetz AS, Lutz MW, Rimele TJ, Saussy DL Jr.

J Pharmacol Exp Ther. 1994 Dec;271(3):1228-33.

PMID:
7996431
12.

Rat peritoneal neutrophils selectively relax vascular smooth muscle.

Rimele TJ, Armstrong SJ, Grimes D, Sturm RJ.

J Pharmacol Exp Ther. 1991 Sep;258(3):963-71.

PMID:
1679853
13.

Potential regulatory role of inflammatory cells on local vascular smooth muscle tone.

Sturm RJ, Holloway DA, Buckley S, Osborne MC, Grimes D, Weichman BM, Rimele TJ.

Agents Actions. 1989 Jun;27(3-4):414-7.

PMID:
2801332
14.

Structure-activity relationships of 1H-indole-7-carboxamides as a novel series of selective alpha 1-adrenoceptor agonists.

Rimele TJ, Caggiano TJ, Buckley SK, Dustman WJ, Schmid J, Heaslip RJ, Grimes D, Asselin AA.

Arzneimittelforschung. 1989 Feb;39(2):187-95.

PMID:
2567168
15.

Comparison of the beta-adrenoceptor affinity and selectivity of cetamolol, atenolol, betaxolol, and ICI-118,551.

Rimele TJ, Henry DE, Giesa FR, Buckley SK, Geiger G, Heaslip RJ, Lee DK, Grimes D.

J Cardiovasc Pharmacol. 1988 Aug;12(2):208-17.

PMID:
2459552
16.

Interaction of neutrophils with vascular smooth muscle: identification of a neutrophil-derived relaxing factor.

Rimele TJ, Sturm RJ, Adams LM, Henry DE, Heaslip RJ, Weichman BM, Grimes D.

J Pharmacol Exp Ther. 1988 Apr;245(1):102-11.

PMID:
3129547
17.

Antisecretory and antiulcer activities of a potent new histamine H2-receptor antagonist with an intermediate duration of action.

Borella L, Russell J, Rimele TJ, Grimes D, Failli A, Mir GN.

Arzneimittelforschung. 1988 Mar;38(3):366-72.

PMID:
2898247
18.

Co-regulation of tracheal tone by cyclic AMP- and cyclic GMP-dependent mechanisms.

Heaslip RJ, Giesa FR, Rimele TJ, Grimes D.

J Pharmacol Exp Ther. 1987 Dec;243(3):1018-26.

PMID:
2826752
19.

In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound.

Grimes D, Rimele TJ, Henry DE, Heaslip RJ, Geiger G, Lee DK, Metcalf G.

J Cardiovasc Pharmacol. 1987 Sep;10(3):249-58.

PMID:
2444771
20.

Demonstration of the beta 2-adrenoceptor intrinsic efficacy of AY-28,925 using the PGF2 alpha-contracted guinea-pig trachea.

Heaslip RJ, Giesa FR, Rimele TJ, Grimes D.

Eur J Pharmacol. 1987 Jun 4;137(2-3):179-84.

PMID:
2886349
21.

Tissue-dependent alpha adrenoceptor activity of buspirone and related compounds.

Rimele TJ, Henry DE, Lee DK, Geiger G, Heaslip RJ, Grimes D.

J Pharmacol Exp Ther. 1987 Jun;241(3):771-8.

PMID:
3037069
22.

Flunarizine and alpha-adrenergic responses in isolated canine saphenous veins.

Daskalopoulos DA, Rimele TJ, Flavahan NA, Vanhoutte PM.

Gen Pharmacol. 1987;18(2):193-6.

PMID:
2883070
23.

In vitro characterization of the adrenoceptor activity of AY-28,925.

Rimele TJ, Heaslip RJ, Lee DK, Grimes D.

J Pharmacol Exp Ther. 1986 Oct;239(1):1-8.

PMID:
2876089
24.

Sensitivity of the PGF2 alpha-versus carbachol-contracted trachea to relaxation by salbutamol, forskolin and prenalterol.

Heaslip RJ, Giesa FR, Rimele TJ, Grimes D.

Eur J Pharmacol. 1986 Aug 22;128(1-2):73-9.

PMID:
3019740
25.

Indole-phenol bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analogue of labetalol.

Asselin AA, Humber LG, Crosilla D, Oshiro G, Wojdan A, Grimes D, Heaslip RJ, Rimele TJ, Shaw CC.

J Med Chem. 1986 Jun;29(6):1009-15.

PMID:
3012084
26.

Nimodipine and inhibition of alpha adrenergic activation of the isolated canine saphenous vein.

Cooke JP, Rimele TJ, Flavahan NA, Vanhoutte PM.

J Pharmacol Exp Ther. 1985 Sep;234(3):598-602.

PMID:
2863368
27.

Respiratory epithelium inhibits bronchial smooth muscle tone.

Flavahan NA, Aarhus LL, Rimele TJ, Vanhoutte PM.

J Appl Physiol (1985). 1985 Mar;58(3):834-8.

PMID:
3980388
28.

Lipoxygenase and calcium entry in vascular smooth muscle.

Vanhoutte PM, Rimele TJ, Flavahan NA.

J Cardiovasc Pharmacol. 1985;7 Suppl 6:S47-52.

PMID:
2414595
29.

Pharmacology of bucindolol in isolated canine vascular smooth muscle.

Rimele TJ, Aarhus LL, Lorenz RR, Rooke TW, Vanhoutte PM.

J Pharmacol Exp Ther. 1984 Nov;231(2):317-25.

PMID:
6149305
30.
31.

Contractions of the canine coronary artery in calcium-free solution.

Rooke TW, Rimele TJ, Vanhoutte PM.

Am J Physiol. 1984 Aug;247(2 Pt 2):H259-63.

PMID:
6589964
32.

Calcium entry and the contraction of vascular smooth muscle.

Vanhoutte PM, Rimele TJ, Rooke TW.

Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:569-73. Review. No abstract available.

PMID:
6145334
33.

Relaxation of canine saphenous vein following brief transmural nerve stimulation.

Rooke TW, Rimele TJ, Vanhoutte PM.

Am J Physiol. 1983 Dec;245(6):H1073-6.

PMID:
6318571
34.

Effects of buflomedil on the responsiveness of canine vascular smooth muscle.

Vanhoutte PM, Aarhus LL, Coen E, Lorenz RR, Rimele TJ, Verbeuren TJ.

J Pharmacol Exp Ther. 1983 Dec;227(3):613-20.

PMID:
6140306
35.

Alpha-1 adrenoceptors and calcium in isolated canine coronary arteries.

Rimele TJ, Rooke TW, Aarhus LL, Vanhoutte PM.

J Pharmacol Exp Ther. 1983 Sep;226(3):668-72.

PMID:
6136598
37.

Effect of thymoxamine on the human pupil.

Lee DA, Rimele TJ, Brubaker RF, Nagataki S, Vanhoutte PM.

Exp Eye Res. 1983 May;36(5):655-62.

PMID:
6221938
38.

Studies on rat intestinal epithelial cell receptors for serotonin and opiates.

Gaginella TS, Rimele TJ, Wietecha M.

J Physiol. 1983 Feb;335:101-11.

39.

In vivo identification of muscarinic receptors on rat colonic epithelial cells. Binding of [3H]-quinuclidinyl benzilate.

Rimele TJ, Gaginella TS.

Naunyn Schmiedebergs Arch Pharmacol. 1982 Apr;319(1):18-21.

PMID:
7110368
40.
41.

Role of the endothelium in the control of vascular smooth muscle function.

Vanhoutte PM, Rimele TJ.

J Physiol (Paris). 1982-1983;78(7):681-6. Review. No abstract available.

PMID:
6764647
42.

Calcium and alpha-adrenoceptors in activation of vascular smooth muscle.

Vanhoutte PM, Rimele TJ.

J Cardiovasc Pharmacol. 1982;4 Suppl 3:S280-6. Review.

PMID:
6184553
43.

Evidence for muscarinic receptors on rat colonic epithelial cells: binding of [3H]quinuclidinyl benzilate.

Rimele TJ, O'Dorisio MS, Gaginella TS.

J Pharmacol Exp Ther. 1981 Aug;218(2):426-34.

PMID:
7252842
44.

Muscarinic receptors in the human pyloric sphincter: comparison with other species.

Gaginella TS, Rimele TJ, O'Dorisio TM.

Gen Pharmacol. 1981;12(2):93-6. No abstract available.

PMID:
7202999
45.

Pharmacologic identification of muscarinic receptors in the pylorus of the cat by binding of [3H]-quinuclidinyl benzilate.

Gaginella TS, Rimele TJ, O'Dorisio TM, Dorff RJ.

Life Sci. 1980 May 12;26(19):1599-608. No abstract available.

PMID:
7382732
46.

Characterization of muscarinic cholinergic receptors in the lower esophageal sphincter of the cat: binding of [3H]quinuclidinyl benzilate.

Rimele TJ, Rogers WA, Gaginella TS.

Gastroenterology. 1979 Dec;77(6):1225-34. No abstract available.

PMID:
499710

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